#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:28304"	uniprotkb:Q6ZMM2-1	intact:EBI-1379423	intact:EBI-6894001	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:q6zmm2-1(display_long)|uniprotkb:ADAMTSL5(gene name)|psi-mi:ADAMTSL5(display_short)|uniprotkb:THSD6(gene name synonym)|uniprotkb:Thrombospondin type-1 domain-containing protein 6(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bader et al. (2012)	pubmed:23010571|imex:IM-20977	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6893956|imex:IM-20977-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-9075891(isoform-parent)	-	-	isoform-comment:Major.|comment:"The experiment suggests that the C-terminal fragment, which includes the NTR-module, contains the binding site(s)"	figure legend:4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/15	2014/10/16	-	rogid:ABjl0+Sv9UKjj81XE20qPCeeESQ9606	intact-crc:185DD69FB0A86831	false	-	his tag:c-c|myc tag:c-c|sufficient binding region:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
chebi:"CHEBI:28304"	uniprotkb:Q6ZMM2-1	intact:EBI-1379423	intact:EBI-6894001	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:q6zmm2-1(display_long)|uniprotkb:ADAMTSL5(gene name)|psi-mi:ADAMTSL5(display_short)|uniprotkb:THSD6(gene name synonym)|uniprotkb:Thrombospondin type-1 domain-containing protein 6(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bader et al. (2012)	pubmed:23010571|imex:IM-20977	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6893975|imex:IM-20977-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-9075891(isoform-parent)	-	-	isoform-comment:Major.|comment:"The experiment suggests that the C-terminal fragment, which includes the NTR-module, contains the binding site(s)"	figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/15	2014/10/16	-	rogid:ABjl0+Sv9UKjj81XE20qPCeeESQ9606	intact-crc:B9F82E6CB2C38D16	false	-	his tag:c-c|myc tag:c-c|sufficient binding region:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZMM2-1	uniprotkb:P35555	intact:EBI-6894001	intact:EBI-2505934|ensembl:ENSP00000325527|uniprotkb:B2RUU0|uniprotkb:Q15972|uniprotkb:Q75N87|uniprotkb:D2JYH6	psi-mi:q6zmm2-1(display_long)|uniprotkb:ADAMTSL5(gene name)|psi-mi:ADAMTSL5(display_short)|uniprotkb:THSD6(gene name synonym)|uniprotkb:Thrombospondin type-1 domain-containing protein 6(gene name synonym)	psi-mi:fbn1_human(display_long)|uniprotkb:FBN1(gene name)|psi-mi:FBN1(display_short)|uniprotkb:FBN(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bader et al. (2012)	pubmed:23010571|imex:IM-20977	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6894029|imex:IM-20977-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-9075891(isoform-parent)	ensembl:ENSG00000166147(gene)|ensembl:ENST00000316623(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001527"(microfibril)|go:"GO:0001656"(metanephros development)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008201"(heparin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035582"(sequestering of BMP in extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35555|rcsb pdb:1APJ|rcsb pdb:1EMN|rcsb pdb:1EMO|rcsb pdb:1LMJ|rcsb pdb:1UZJ|rcsb pdb:1UZK|rcsb pdb:1UZP|rcsb pdb:1UZQ|rcsb pdb:2M74|rcsb pdb:2W86|rcsb pdb:5MS9|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_000129.3|dip:DIP-29985N	-	isoform-comment:Major.	comment:"The N-terminal half of fibrillin-1, but not its C-terminal half, bound specifically to ADAMTSL5 (Fig. 8A and 8B)."	figure legend:8A, 8B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/15	2019/04/15	rogid:ABjl0+Sv9UKjj81XE20qPCeeESQ9606	rogid:YEO0ZRTezrjEAyTaos1pm2hUDXg9606	intact-crc:4AE4EDB51BFF47AE|rigid:2J5jxC7DF9PRRPbIDUtSytylNjQ	false	his tag:c-c|myc tag:c-c	sufficient binding region:17-1527|his tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35556	uniprotkb:Q6ZMM2-1	intact:EBI-6164392|ensembl:ENSP00000424571|ensembl:ENSP00000262464|uniprotkb:B4DU01|uniprotkb:Q59ES6	intact:EBI-6894001	psi-mi:fbn2_human(display_long)|uniprotkb:FBN2(gene name)|psi-mi:FBN2(display_short)	psi-mi:q6zmm2-1(display_long)|uniprotkb:ADAMTSL5(gene name)|psi-mi:ADAMTSL5(display_short)|uniprotkb:THSD6(gene name synonym)|uniprotkb:Thrombospondin type-1 domain-containing protein 6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bader et al. (2012)	pubmed:23010571|imex:IM-20977	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6894041|imex:IM-20977-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35556|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|interpro:IPR018097|ensembl:ENSG00000138829(gene)|ensembl:ENST00000262464(transcript)|ensembl:ENST00000508053(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR017878|refseq:NP_001990.2	intact:EBI-9075891(isoform-parent)	-	comment:"Both the N- and C-terminal halves of fibrillin-2 bound to ADAMTSL5; however, the binding of the N-terminal half  appeared to be much stronger than the binding of the C-terminal half (Fig. 8C and D)."	isoform-comment:Major.	figure legend:8C, 8D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/15	2014/10/16	rogid:iqBnjHuy9kU3serIc5tPWGIDzUc9606	rogid:ABjl0+Sv9UKjj81XE20qPCeeESQ9606	intact-crc:1FB4A86D74AA7B33|rigid:pTUgZVfVjjC7AKG5vG8ALLrrc64	false	his tag:c-c|sufficient binding region:1531-2771|sufficient binding region:1-1733	myc tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)