#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9D0J4 uniprotkb:Q13432 intact:EBI-1033319|uniprotkb:Q9WUM1|ensembl:ENSMUSP00000025893 intact:EBI-711260|uniprotkb:O95126|ensembl:ENSP00000337040|uniprotkb:F1T095|uniprotkb:A8K8G4 psi-mi:arl2_mouse(display_long)|uniprotkb:Arl2(gene name)|psi-mi:Arl2(display_short) psi-mi:u119a_human(display_long)|uniprotkb:UNC119(gene name)|psi-mi:UNC119(display_short)|uniprotkb:RG4(gene name synonym)|uniprotkb:Retinal protein 4(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Ismail et al. (2012) pubmed:22960633|imex:IM-18765|mint:MINT-8411726 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8045361|mint:MINT-8411731|imex:IM-18765-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062696.2|ensembl:ENSMUSG00000024944(gene)|ensembl:ENSMUST00000025893(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015870"(acetylcholine transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|rcsb pdb:1KSG|rcsb pdb:1KSH|rcsb pdb:1KSJ|rcsb pdb:4GOK|reactome:R-MMU-83936|reactome:R-MMU-9648002|dip:DIP-36659N|mint:MINT-8411734(identity) refseq:NP_005139.1|refseq:NP_473376.1|ensembl:ENSG00000109103(gene)|ensembl:ENST00000335765(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008289"(lipid binding)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0051233"(spindle midzone)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:2001287"(negative regulation of caveolin-mediated endocytosis)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032977|interpro:IPR037036|mint:Q13432|rcsb pdb:3GQQ|rcsb pdb:3RBQ|rcsb pdb:4GOJ|rcsb pdb:4GOK|rcsb pdb:5L7K|rcsb pdb:6H6A|refseq:NP_001317095.1|dip:DIP-42697N|mint:MINT-8411733(identity) - - - comment:homomint|comment:mint|figure legend:f2 f5 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/23 2014/10/16 rogid:zb6s8gL3Fr5kyys6iB/rrgsj7qI10090 rogid:y4vN846RQ9HzsRTMST/eac5d1Rc9606 intact-crc:C36D6421CCD9C184|rigid:GhgFPWKRJpAJIrGfXVjofQvbJC8 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9WUL7 uniprotkb:Q13432 intact:EBI-6860857|ensembl:ENSMUSP00000026009 intact:EBI-711260|uniprotkb:O95126|ensembl:ENSP00000337040|uniprotkb:F1T095|uniprotkb:A8K8G4 psi-mi:arl3_mouse(display_long)|uniprotkb:Arl3(gene name)|psi-mi:Arl3(display_short) psi-mi:u119a_human(display_long)|uniprotkb:UNC119(gene name)|psi-mi:UNC119(display_short)|uniprotkb:RG4(gene name synonym)|uniprotkb:Retinal protein 4(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Ismail et al. (2012) pubmed:22960633|imex:IM-18765|mint:MINT-8411726 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8045374|mint:MINT-8411742|imex:IM-18765-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:Q9WUL7|rcsb pdb:1FZQ|rcsb pdb:3BH6|rcsb pdb:3BH7|rcsb pdb:4GOJ|rcsb pdb:4ZI2|rcsb pdb:4ZI3|rcsb pdb:7OK7|reactome:R-MMU-5624138|ensembl:ENSMUSG00000025035(gene)|ensembl:ENSMUST00000026009(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001822"(kidney development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|refseq:NP_062692.1|dip:DIP-29025N|mint:MINT-8411744(identity) refseq:NP_005139.1|refseq:NP_473376.1|ensembl:ENSG00000109103(gene)|ensembl:ENST00000335765(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008289"(lipid binding)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0051233"(spindle midzone)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:2001287"(negative regulation of caveolin-mediated endocytosis)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032977|interpro:IPR037036|mint:Q13432|rcsb pdb:3GQQ|rcsb pdb:3RBQ|rcsb pdb:4GOJ|rcsb pdb:4GOK|rcsb pdb:5L7K|rcsb pdb:6H6A|refseq:NP_001317095.1|dip:DIP-42697N|mint:MINT-8411746(identity) - - - comment:homomint|comment:mint|figure legend:f2 f5 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/23 2014/10/16 rogid:Pv4G4Y6wahs2lvrFtlxPhmF23ew10090 rogid:y4vN846RQ9HzsRTMST/eac5d1Rc9606 intact-crc:75D652E1EF2B3DB2|rigid:qfZQPdDjpewRVaQIYbEGQS4WRIE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13432 uniprotkb:Q7Z494 intact:EBI-711260|uniprotkb:O95126|ensembl:ENSP00000337040|uniprotkb:F1T095|uniprotkb:A8K8G4 intact:EBI-2804263|uniprotkb:Q68D99|uniprotkb:Q8NCM5|uniprotkb:Q7Z493|uniprotkb:Q5JPE3|uniprotkb:Q96NK2|uniprotkb:Q5JPE6|uniprotkb:Q6NVH3|uniprotkb:Q96N70|uniprotkb:Q7Z492|uniprotkb:Q8N9R2|ensembl:ENSP00000338766 psi-mi:u119a_human(display_long)|uniprotkb:UNC119(gene name)|psi-mi:UNC119(display_short)|uniprotkb:RG4(gene name synonym)|uniprotkb:Retinal protein 4(gene name synonym) psi-mi:nphp3_human(display_long)|uniprotkb:KIAA2000(gene name synonym)|uniprotkb:NPHP3(gene name)|psi-mi:NPHP3(display_short) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ismail et al. (2012) pubmed:22960633|imex:IM-18765|mint:MINT-8411726 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8045395|mint:MINT-8411894|imex:IM-18765-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005139.1|refseq:NP_473376.1|ensembl:ENSG00000109103(gene)|ensembl:ENST00000335765(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008289"(lipid binding)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0051233"(spindle midzone)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:2001287"(negative regulation of caveolin-mediated endocytosis)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032977|interpro:IPR037036|mint:Q13432|rcsb pdb:3GQQ|rcsb pdb:3RBQ|rcsb pdb:4GOJ|rcsb pdb:4GOK|rcsb pdb:5L7K|rcsb pdb:6H6A|refseq:NP_001317095.1|dip:DIP-42697N|mint:MINT-8411898(identity) refseq:NP_694972.3|ensembl:ENSG00000113971(gene)|ensembl:ENST00000337331(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001947"(heart looping)|go:"GO:0003283"(atrial septum development)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0035469"(determination of pancreatic left/right asymmetry)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060287"(epithelial cilium movement involved in determination of left/right asymmetry)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0071908"(determination of intestine left/right asymmetry)|go:"GO:0071909"(determination of stomach left/right asymmetry)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072189"(ureter development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000167"(regulation of planar cell polarity pathway involved in neural tube closure)|rcsb pdb:5L7K|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027417|reactome:R-HSA-5624138|mint:MINT-8411896(identity) - - - comment:homomint|comment:mint|figure legend:f1c sf1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.4x10^-8(molar) 2013/01/23 2014/10/16 rogid:y4vN846RQ9HzsRTMST/eac5d1Rc9606 rogid:7SitCJ9bwhu4VXh9FjX/wWCq0UQ9606 intact-crc:B7A778F2914E9A3A|rigid:dS8YYQjIQ3JNVnKRhdX7ObPs0RI false - binding-associated region:2-10(MINT-8412007) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q13432 uniprotkb:P11488 intact:EBI-711260|uniprotkb:O95126|ensembl:ENSP00000337040|uniprotkb:F1T095|uniprotkb:A8K8G4 intact:EBI-2562736|uniprotkb:Q4VBN2|ensembl:ENSP00000232461|ensembl:ENSP00000387555 psi-mi:u119a_human(display_long)|uniprotkb:UNC119(gene name)|psi-mi:UNC119(display_short)|uniprotkb:RG4(gene name synonym)|uniprotkb:Retinal protein 4(gene name synonym) psi-mi:gnat1_human(display_long)|uniprotkb:GNAT1(gene name)|psi-mi:GNAT1(display_short)|uniprotkb:GNATR(gene name synonym)|uniprotkb:Transducin alpha-1 chain(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ismail et al. (2012) pubmed:22960633|imex:IM-18765|mint:MINT-8411726 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8045412|mint:MINT-8411904|imex:IM-18765-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005139.1|refseq:NP_473376.1|ensembl:ENSG00000109103(gene)|ensembl:ENST00000335765(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008289"(lipid binding)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0051233"(spindle midzone)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:2001287"(negative regulation of caveolin-mediated endocytosis)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032977|interpro:IPR037036|mint:Q13432|rcsb pdb:3GQQ|rcsb pdb:3RBQ|rcsb pdb:4GOJ|rcsb pdb:4GOK|rcsb pdb:5L7K|rcsb pdb:6H6A|refseq:NP_001317095.1|dip:DIP-42697N|mint:MINT-8411906(identity) refseq:NP_000163.2|refseq:NP_653082.1|ensembl:ENSG00000114349(gene)|ensembl:ENST00000232461(transcript)|ensembl:ENST00000433068(transcript)|go:"GO:0000035"(acyl binding)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009642"(response to light intensity)|go:"GO:0016020"(membrane)|go:"GO:0016056"(rhodopsin mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050917"(sensory perception of umami taste)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:3RBQ|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-418594|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|mint:MINT-8411908(identity) - - - comment:homomint|comment:mint|figure legend:f1a f1e f1f sf1 f6 sf3b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:7.0x10^-9(molar) 2013/01/23 2014/10/16 rogid:y4vN846RQ9HzsRTMST/eac5d1Rc9606 rogid:N1vTXVCPunyeaYMi9E0pX4WhwTY9606 intact-crc:7775F45A71DA219C|rigid:L5FCo9IkjoeCPPSNkwAlPkoURUA false mutation decreasing interaction:194-194(MINT-8411930) binding-associated region:2-10(MINT-8411945) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:A6NIH7 uniprotkb:Q7Z494 intact:EBI-8045435|intact:MINT-6997631|ensembl:ENSP00000344942 intact:EBI-2804263|uniprotkb:Q68D99|uniprotkb:Q8NCM5|uniprotkb:Q7Z493|uniprotkb:Q5JPE3|uniprotkb:Q96NK2|uniprotkb:Q5JPE6|uniprotkb:Q6NVH3|uniprotkb:Q96N70|uniprotkb:Q7Z492|uniprotkb:Q8N9R2|ensembl:ENSP00000338766 psi-mi:u119b_human(display_long)|uniprotkb:UNC119B(gene name)|psi-mi:UNC119B(display_short) psi-mi:nphp3_human(display_long)|uniprotkb:KIAA2000(gene name synonym)|uniprotkb:NPHP3(gene name)|psi-mi:NPHP3(display_short) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ismail et al. (2012) pubmed:22960633|imex:IM-18765|mint:MINT-8411726 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8045451|mint:MINT-8411953|imex:IM-18765-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074002.1|dip:DIP-61819N|ensembl:ENSG00000175970(gene)|ensembl:ENST00000344651(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007399"(nervous system development)|go:"GO:0008289"(lipid binding)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0060271"(cilium assembly)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR037036|rcsb pdb:7OK6|rcsb pdb:7OK7|reactome:R-HSA-5624138|mint:MINT-8411958(identity) refseq:NP_694972.3|ensembl:ENSG00000113971(gene)|ensembl:ENST00000337331(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001947"(heart looping)|go:"GO:0003283"(atrial septum development)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0035469"(determination of pancreatic left/right asymmetry)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060287"(epithelial cilium movement involved in determination of left/right asymmetry)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0071908"(determination of intestine left/right asymmetry)|go:"GO:0071909"(determination of stomach left/right asymmetry)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072189"(ureter development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000167"(regulation of planar cell polarity pathway involved in neural tube closure)|rcsb pdb:5L7K|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027417|reactome:R-HSA-5624138|mint:MINT-8411956(identity) - comment:mint|comment:homomint - comment:homomint|comment:mint|figure legend:f1d sf1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:8.0x10^-9(molar) 2013/01/23 2014/10/16 rogid:zA9g4EEAw/EhQVIxjgFlY06BZ2c9606 rogid:7SitCJ9bwhu4VXh9FjX/wWCq0UQ9606 intact-crc:F301772555B07D9F|rigid:Bj9mrP7MGiIDOpTNEML8pE0sVZc false - binding-associated region:2-10(MINT-8412003) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:A6NIH7 uniprotkb:P11488 intact:EBI-8045435|intact:MINT-6997631|ensembl:ENSP00000344942 intact:EBI-2562736|uniprotkb:Q4VBN2|ensembl:ENSP00000232461|ensembl:ENSP00000387555 psi-mi:u119b_human(display_long)|uniprotkb:UNC119B(gene name)|psi-mi:UNC119B(display_short) psi-mi:gnat1_human(display_long)|uniprotkb:GNAT1(gene name)|psi-mi:GNAT1(display_short)|uniprotkb:GNATR(gene name synonym)|uniprotkb:Transducin alpha-1 chain(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ismail et al. (2012) pubmed:22960633|imex:IM-18765|mint:MINT-8411726 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8045467|mint:MINT-8411962|imex:IM-18765-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074002.1|dip:DIP-61819N|ensembl:ENSG00000175970(gene)|ensembl:ENST00000344651(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007399"(nervous system development)|go:"GO:0008289"(lipid binding)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0060271"(cilium assembly)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR037036|rcsb pdb:7OK6|rcsb pdb:7OK7|reactome:R-HSA-5624138|mint:MINT-8411969(identity) refseq:NP_000163.2|refseq:NP_653082.1|ensembl:ENSG00000114349(gene)|ensembl:ENST00000232461(transcript)|ensembl:ENST00000433068(transcript)|go:"GO:0000035"(acyl binding)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009642"(response to light intensity)|go:"GO:0016020"(membrane)|go:"GO:0016056"(rhodopsin mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050917"(sensory perception of umami taste)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:3RBQ|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-418594|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|mint:MINT-8411965(identity) - comment:mint|comment:homomint - comment:homomint|comment:mint|figure legend:f1b sf1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.7x10^-8(molar) 2013/01/23 2014/10/16 rogid:zA9g4EEAw/EhQVIxjgFlY06BZ2c9606 rogid:N1vTXVCPunyeaYMi9E0pX4WhwTY9606 intact-crc:448F897A84B68FCC|rigid:Lzvw0/fyvDAeAGEiH/AmC0IJKHs false - binding-associated region:2-10(MINT-8411966) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q9D0J4 uniprotkb:P11488 intact:EBI-1033319|uniprotkb:Q9WUM1|ensembl:ENSMUSP00000025893 intact:EBI-2562736|uniprotkb:Q4VBN2|ensembl:ENSP00000232461|ensembl:ENSP00000387555 psi-mi:arl2_mouse(display_long)|uniprotkb:Arl2(gene name)|psi-mi:Arl2(display_short) psi-mi:gnat1_human(display_long)|uniprotkb:GNAT1(gene name)|psi-mi:GNAT1(display_short)|uniprotkb:GNATR(gene name synonym)|uniprotkb:Transducin alpha-1 chain(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ismail et al. (2012) pubmed:22960633|imex:IM-18765|mint:MINT-8411726 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8045500|mint:MINT-8411981|imex:IM-18765-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062696.2|ensembl:ENSMUSG00000024944(gene)|ensembl:ENSMUST00000025893(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015870"(acetylcholine transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|rcsb pdb:1KSG|rcsb pdb:1KSH|rcsb pdb:1KSJ|rcsb pdb:4GOK|reactome:R-MMU-83936|reactome:R-MMU-9648002|dip:DIP-36659N|mint:MINT-8411995(identity) refseq:NP_000163.2|refseq:NP_653082.1|ensembl:ENSG00000114349(gene)|ensembl:ENST00000232461(transcript)|ensembl:ENST00000433068(transcript)|go:"GO:0000035"(acyl binding)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009642"(response to light intensity)|go:"GO:0016020"(membrane)|go:"GO:0016056"(rhodopsin mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050917"(sensory perception of umami taste)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:3RBQ|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-418594|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|mint:MINT-8411984(identity) - - - comment:homomint|comment:mint|figure legend:sf3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/23 2014/10/16 rogid:zb6s8gL3Fr5kyys6iB/rrgsj7qI10090 rogid:N1vTXVCPunyeaYMi9E0pX4WhwTY9606 intact-crc:FF80067F6D379077|rigid:HUcbi+kLYzVDPbQwKsCI+zbRMy0 false mutation increasing interaction:58-58(MINT-8411997) binding-associated region:2-10(MINT-8411985) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q9D0J4 uniprotkb:Q13432 intact:EBI-1033319|uniprotkb:Q9WUM1|ensembl:ENSMUSP00000025893 intact:EBI-711260|uniprotkb:O95126|ensembl:ENSP00000337040|uniprotkb:F1T095|uniprotkb:A8K8G4 psi-mi:arl2_mouse(display_long)|uniprotkb:Arl2(gene name)|psi-mi:Arl2(display_short) psi-mi:u119a_human(display_long)|uniprotkb:UNC119(gene name)|psi-mi:UNC119(display_short)|uniprotkb:RG4(gene name synonym)|uniprotkb:Retinal protein 4(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ismail et al. (2012) pubmed:22960633|imex:IM-18765|mint:MINT-8411726 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8045500|mint:MINT-8411981|imex:IM-18765-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062696.2|ensembl:ENSMUSG00000024944(gene)|ensembl:ENSMUST00000025893(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015870"(acetylcholine transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|rcsb pdb:1KSG|rcsb pdb:1KSH|rcsb pdb:1KSJ|rcsb pdb:4GOK|reactome:R-MMU-83936|reactome:R-MMU-9648002|dip:DIP-36659N|mint:MINT-8411995(identity) refseq:NP_005139.1|refseq:NP_473376.1|ensembl:ENSG00000109103(gene)|ensembl:ENST00000335765(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008289"(lipid binding)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0051233"(spindle midzone)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:2001287"(negative regulation of caveolin-mediated endocytosis)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032977|interpro:IPR037036|mint:Q13432|rcsb pdb:3GQQ|rcsb pdb:3RBQ|rcsb pdb:4GOJ|rcsb pdb:4GOK|rcsb pdb:5L7K|rcsb pdb:6H6A|refseq:NP_001317095.1|dip:DIP-42697N|mint:MINT-8411988(identity) - - - comment:homomint|comment:mint|figure legend:sf3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/23 2014/10/16 rogid:zb6s8gL3Fr5kyys6iB/rrgsj7qI10090 rogid:y4vN846RQ9HzsRTMST/eac5d1Rc9606 intact-crc:FF80067F6D379077|rigid:HUcbi+kLYzVDPbQwKsCI+zbRMy0 false mutation increasing interaction:58-58(MINT-8411997) mutation decreasing interaction:194-194(MINT-8411989) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13432 uniprotkb:Q9WUL7 intact:EBI-711260|uniprotkb:O95126|ensembl:ENSP00000337040|uniprotkb:F1T095|uniprotkb:A8K8G4 intact:EBI-6860857|ensembl:ENSMUSP00000026009 psi-mi:u119a_human(display_long)|uniprotkb:UNC119(gene name)|psi-mi:UNC119(display_short)|uniprotkb:RG4(gene name synonym)|uniprotkb:Retinal protein 4(gene name synonym) psi-mi:arl3_mouse(display_long)|uniprotkb:Arl3(gene name)|psi-mi:Arl3(display_short) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ismail et al. (2012) pubmed:22960633|imex:IM-18765|mint:MINT-8411726 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8045527|mint:MINT-8412010|imex:IM-18765-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005139.1|refseq:NP_473376.1|ensembl:ENSG00000109103(gene)|ensembl:ENST00000335765(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008289"(lipid binding)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0051233"(spindle midzone)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:2001287"(negative regulation of caveolin-mediated endocytosis)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032977|interpro:IPR037036|mint:Q13432|rcsb pdb:3GQQ|rcsb pdb:3RBQ|rcsb pdb:4GOJ|rcsb pdb:4GOK|rcsb pdb:5L7K|rcsb pdb:6H6A|refseq:NP_001317095.1|dip:DIP-42697N|mint:MINT-8412017(identity) go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:Q9WUL7|rcsb pdb:1FZQ|rcsb pdb:3BH6|rcsb pdb:3BH7|rcsb pdb:4GOJ|rcsb pdb:4ZI2|rcsb pdb:4ZI3|rcsb pdb:7OK7|reactome:R-MMU-5624138|ensembl:ENSMUSG00000025035(gene)|ensembl:ENSMUST00000026009(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001822"(kidney development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|refseq:NP_062692.1|dip:DIP-29025N|mint:MINT-8412013(identity) - - - figure legend:sf2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.0x10^-7(molar) 2013/01/23 2014/10/16 rogid:y4vN846RQ9HzsRTMST/eac5d1Rc9606 rogid:Pv4G4Y6wahs2lvrFtlxPhmF23ew10090 intact-crc:8A370D73B7D248B9|rigid:qfZQPdDjpewRVaQIYbEGQS4WRIE false mutation decreasing interaction:194-194(MINT-8412018) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9WUL7 uniprotkb:P11488 intact:EBI-6860857|ensembl:ENSMUSP00000026009 intact:EBI-2562736|uniprotkb:Q4VBN2|ensembl:ENSP00000232461|ensembl:ENSP00000387555 psi-mi:arl3_mouse(display_long)|uniprotkb:Arl3(gene name)|psi-mi:Arl3(display_short) psi-mi:gnat1_human(display_long)|uniprotkb:GNAT1(gene name)|psi-mi:GNAT1(display_short)|uniprotkb:GNATR(gene name synonym)|uniprotkb:Transducin alpha-1 chain(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ismail et al. (2012) pubmed:22960633|imex:IM-18765|mint:MINT-8411726 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8045546|mint:MINT-8412025|imex:IM-18765-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:Q9WUL7|rcsb pdb:1FZQ|rcsb pdb:3BH6|rcsb pdb:3BH7|rcsb pdb:4GOJ|rcsb pdb:4ZI2|rcsb pdb:4ZI3|rcsb pdb:7OK7|reactome:R-MMU-5624138|ensembl:ENSMUSG00000025035(gene)|ensembl:ENSMUST00000026009(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001822"(kidney development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|refseq:NP_062692.1|dip:DIP-29025N|mint:MINT-8412028(identity) refseq:NP_000163.2|refseq:NP_653082.1|ensembl:ENSG00000114349(gene)|ensembl:ENST00000232461(transcript)|ensembl:ENST00000433068(transcript)|go:"GO:0000035"(acyl binding)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009642"(response to light intensity)|go:"GO:0016020"(membrane)|go:"GO:0016056"(rhodopsin mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050917"(sensory perception of umami taste)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:3RBQ|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-418594|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|mint:MINT-8412039(identity) - - - figure legend:f6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/23 2014/10/16 rogid:Pv4G4Y6wahs2lvrFtlxPhmF23ew10090 rogid:N1vTXVCPunyeaYMi9E0pX4WhwTY9606 intact-crc:EB503BB69D305F1E|rigid:t/afvQFpoi6lD+F9WpMzOjJPltg false binding-associated region:18-182(MINT-8412044) binding-associated region:2-10(MINT-8412041) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:Q9WUL7 uniprotkb:Q13432 intact:EBI-6860857|ensembl:ENSMUSP00000026009 intact:EBI-711260|uniprotkb:O95126|ensembl:ENSP00000337040|uniprotkb:F1T095|uniprotkb:A8K8G4 psi-mi:arl3_mouse(display_long)|uniprotkb:Arl3(gene name)|psi-mi:Arl3(display_short) psi-mi:u119a_human(display_long)|uniprotkb:UNC119(gene name)|psi-mi:UNC119(display_short)|uniprotkb:RG4(gene name synonym)|uniprotkb:Retinal protein 4(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Ismail et al. (2012) pubmed:22960633|imex:IM-18765|mint:MINT-8411726 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8045546|mint:MINT-8412025|imex:IM-18765-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:Q9WUL7|rcsb pdb:1FZQ|rcsb pdb:3BH6|rcsb pdb:3BH7|rcsb pdb:4GOJ|rcsb pdb:4ZI2|rcsb pdb:4ZI3|rcsb pdb:7OK7|reactome:R-MMU-5624138|ensembl:ENSMUSG00000025035(gene)|ensembl:ENSMUST00000026009(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001822"(kidney development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|refseq:NP_062692.1|dip:DIP-29025N|mint:MINT-8412028(identity) refseq:NP_005139.1|refseq:NP_473376.1|ensembl:ENSG00000109103(gene)|ensembl:ENST00000335765(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008289"(lipid binding)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0051233"(spindle midzone)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:2001287"(negative regulation of caveolin-mediated endocytosis)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032977|interpro:IPR037036|mint:Q13432|rcsb pdb:3GQQ|rcsb pdb:3RBQ|rcsb pdb:4GOJ|rcsb pdb:4GOK|rcsb pdb:5L7K|rcsb pdb:6H6A|refseq:NP_001317095.1|dip:DIP-42697N|mint:MINT-8412030(identity) - - - figure legend:f6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/23 2014/10/16 rogid:Pv4G4Y6wahs2lvrFtlxPhmF23ew10090 rogid:y4vN846RQ9HzsRTMST/eac5d1Rc9606 intact-crc:EB503BB69D305F1E|rigid:t/afvQFpoi6lD+F9WpMzOjJPltg false binding-associated region:18-182(MINT-8412044) mutation decreasing interaction:194-194(MINT-8412031) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)