#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q14457	uniprotkb:Q8UZC1	intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7	intact:EBI-6878727	psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym)	psi-mi:q8uzc1_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gladue et al. (2012)	imex:IM-20932|pubmed:22933281	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6878777|imex:IM-20932-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1	interpro:IPR033703|interpro:IPR038765|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR029053|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043128|interpro:IPR037080|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	-	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf10a)|taxid:9606(Human non-transformed breast epithelial cell line)	-	2013/06/28	2015/09/30	rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606	rogid:VxB8hCx/d8MkVcPkXGLwVyOEvcM12118	intact-crc:892865832C8B4B15|rigid:kf9Xg46dJY45RD6YHV99d5QQoPw	false	-	sufficient binding region:1108-1425	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8UZC1	uniprotkb:Q4A1L4	intact:EBI-6878727	intact:EBI-6874856|ensembl:ENSBTAP00000026531	psi-mi:q8uzc1_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:becn1_bovin(display_long)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)	psi-mi:"MI:0018"(two hybrid)	Gladue et al. (2012)	imex:IM-20932|pubmed:22933281	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6874877|imex:IM-20932-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033703|interpro:IPR038765|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR029053|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043128|interpro:IPR037080|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	ensembl:ENSBTAG00000019914(gene)|ensembl:ENSBTAT00000026531(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005634"(nucleus)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007049"(cell cycle)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|refseq:NP_001028799.1	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/06/28	2015/09/30	rogid:VxB8hCx/d8MkVcPkXGLwVyOEvcM12118	rogid:o6bnoihEIY3bRzSPCH0rDAl+q1E9913	intact-crc:110C6239E8ECC6A3|rigid:pTjzAmXkAS1XO+G0E35Z4Ik+vTk	false	sufficient binding region:1108-1425	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8UZC1	uniprotkb:Q4A1L4	intact:EBI-6878727	intact:EBI-6874856|ensembl:ENSBTAP00000026531	psi-mi:q8uzc1_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:becn1_bovin(display_long)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)	psi-mi:"MI:0018"(two hybrid)	Gladue et al. (2012)	imex:IM-20932|pubmed:22933281	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6878796|imex:IM-20932-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033703|interpro:IPR038765|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR029053|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043128|interpro:IPR037080|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	ensembl:ENSBTAG00000019914(gene)|ensembl:ENSBTAT00000026531(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005634"(nucleus)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007049"(cell cycle)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|refseq:NP_001028799.1	-	-	-	figure legend:2A and 10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/06/28	2015/09/30	rogid:VxB8hCx/d8MkVcPkXGLwVyOEvcM12118	rogid:o6bnoihEIY3bRzSPCH0rDAl+q1E9913	intact-crc:56571FD80BC7D0A6|rigid:pTjzAmXkAS1XO+G0E35Z4Ik+vTk	false	mutation disrupting interaction:1213-1215|mutation disrupting interaction:1215-1217|necessary binding region:1241-1247|necessary binding region:1234-1240|necessary binding region:1360-1366|necessary binding region:1304-1310|necessary binding region:1353-1359|necessary binding region:1367-1373|necessary binding region:1206-1212|mutation disrupting interaction:1224-1226|necessary binding region:1338-1345|mutation disrupting interaction:1220-1222|necessary binding region:1346-1352|necessary binding region:1395-1401|necessary binding region:1374-1380|necessary binding region:1381-1387|necessary binding region:1332-1338|sufficient binding region:1108-1425	sufficient binding region:1-211	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3ZBH9	uniprotkb:Q8UZC1	intact:EBI-8841619|ensembl:ENSBTAP00000003728	intact:EBI-6878727	psi-mi:mcm7_bovin(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)	psi-mi:q8uzc1_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gladue et al. (2012)	imex:IM-20932|pubmed:22933281	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-8841618|imex:IM-20932-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020516.2|ensembl:ENSBTAG00000030965(gene)|ensembl:ENSBTAT00000003728(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|interpro:IPR033762|interpro:IPR041562|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)	interpro:IPR033703|interpro:IPR038765|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR029053|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043128|interpro:IPR037080|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	-	-	-	figure legend:10c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/06/28	2015/09/30	rogid:q9cFA+wMgzVcvH07nW0VHkERdGU9913	rogid:VxB8hCx/d8MkVcPkXGLwVyOEvcM12118	intact-crc:CE6684624A9B7A29|rigid:AEHG39cTEXWbj1BnbAyiCYHumek	false	-	sufficient binding region:1108-1425	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14457	uniprotkb:Q8UZC1	intact:EBI-949378|intact:EBI-28978189|ensembl:ENSP00000355231|ensembl:ENSP00000465364|uniprotkb:O75595|uniprotkb:Q9UNA8|uniprotkb:B2R6N7	intact:EBI-6878727	psi-mi:becn1_human(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Protein GT197(gene name synonym)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)|uniprotkb:GT197(gene name synonym)	psi-mi:q8uzc1_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Gladue et al. (2012)	imex:IM-20932|pubmed:22933281	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6878809|imex:IM-20932-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000126581(gene)|ensembl:ENST00000361523(transcript)|ensembl:ENST00000590099(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:Q14457|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:3DVU|rcsb pdb:4DDP|rcsb pdb:4MI8|rcsb pdb:5EFM|rcsb pdb:5HHE|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6DCN|rcsb pdb:6DCO|rcsb pdb:6HOI|rcsb pdb:6HOJ|rcsb pdb:6HOK|rcsb pdb:7BL1|reactome:R-HSA-1632852|reactome:R-HSA-5689880|reactome:R-HSA-9679504|reactome:R-HSA-9694676|refseq:NP_003757.1|ensembl:ENSP00000355231|ensembl:ENSP00000465364|dip:DIP-44611N|refseq:NP_001300927.1|refseq:NP_001300928.1|refseq:NP_001300929.1	interpro:IPR033703|interpro:IPR038765|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR029053|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043128|interpro:IPR037080|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	-	-	-	figure legend:2C and D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf10a)|taxid:9606(Human non-transformed breast epithelial cell line)	-	2013/06/28	2015/09/30	rogid:4COK3vvpxbVYRibANONKBFVtX+Q9606	rogid:VxB8hCx/d8MkVcPkXGLwVyOEvcM12118	intact-crc:A2F532F4AD9AA4CD|rigid:kf9Xg46dJY45RD6YHV99d5QQoPw	false	-	sufficient binding region:1108-1425	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)