#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8CJG0	uniprotkb:Q64378	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-492796|ensembl:ENSMUSP00000078382|ensembl:ENSMUSP00000110440|ensembl:ENSMUSP00000136245|ensembl:ENSMUSP00000156418	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:fkbp5_mouse(display_long)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Fkbp5(gene name)|psi-mi:Fkbp5(display_short)|uniprotkb:Fkbp51(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_034350.1|ensembl:ENSMUSG00000024222(gene)|ensembl:ENSMUST00000079413(transcript)|ensembl:ENSMUST00000114792(transcript)|ensembl:ENSMUST00000177939(transcript)|ensembl:ENSMUST00000233102(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q64378|reactome:R-MMU-3371497|reactome:R-MMU-8939211	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:ihh8rfBDWGjo3gceXNl406Y50pU10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P54823	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-3647041|ensembl:ENSMUSP00000128421|ensembl:ENSMUSP00000149620|uniprotkb:O54979|uniprotkb:Q3UFI3|uniprotkb:Q8BW68	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:ddx6_mouse(display_long)|uniprotkb:Ddx6(gene name)|psi-mi:Ddx6(display_short)|uniprotkb:Hlr2(gene name synonym)|uniprotkb:Rck(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:Oncogene RCK homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|mint:P54823|reactome:R-MMU-430039|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|ensembl:ENSMUSG00000032097(gene)|ensembl:ENSMUST00000170489(transcript)|ensembl:ENSMUST00000217034(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_001104296.1|refseq:NP_031867.1|refseq:NP_851841.2|refseq:XP_011240693.1|refseq:XP_011240694.1|refseq:XP_017168613.1	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:Q80hxmsbz9kQgOP9Gflto87Sp/M10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q9CPN8	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-8419588|intact:MINT-1848725|uniprotkb:Q3UHZ6|uniprotkb:Q8C2J9|ensembl:ENSMUSP00000031838	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:if2b3_mouse(display_long)|uniprotkb:Igf2bp3(gene name)|psi-mi:Igf2bp3(display_short)|uniprotkb:Vickz3(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 3(gene name synonym)|uniprotkb:VICKZ family member 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_076159.3|ensembl:ENSMUSG00000029814(gene)|ensembl:ENSMUST00000031838(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034844|interpro:IPR035979|interpro:IPR036612|mint:Q9CPN8	-	-	comment:mint|function:"RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA"	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:sSSab2xJ+L+kO1qbiAbUU01YVxU10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q6A0A9	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-8327719|intact:MINT-1858841|uniprotkb:Q91Z16|uniprotkb:B3DFJ0|uniprotkb:A0PJK6|ensembl:ENSMUSP00000053877	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:f120a_mouse(display_long)|uniprotkb:Kiaa0183(gene name synonym)|uniprotkb:Ossa(gene name synonym)|uniprotkb:Oxidative stress-associated Src activator(gene name synonym)|uniprotkb:Protein FAM120A(gene name synonym)|uniprotkb:FAM120A(gene name)|psi-mi:FAM120A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_001028440.2|ensembl:ENSMUSG00000038014(gene)|ensembl:ENSMUST00000060805(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR026784|interpro:IPR029060|mint:Q6A0A9	-	-	comment:"fragmentation type: fragment"|comment:mint	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:tZj0TOhfuvvF4GaEPHI7jWpKyl810090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q91V55	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-8328840|intact:MINT-4120755|ensembl:ENSMUSP00000004554|ensembl:ENSMUSP00000104179	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q91v55_mouse(display_long)|uniprotkb:Rps5(gene name)|psi-mi:Rps5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_033121.2|ensembl:ENSMUSG00000012848(gene)|ensembl:ENSMUST00000004554(transcript)|ensembl:ENSMUST00000108539(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006412"(translation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR000235(Ribosomal protein S7)|interpro:IPR005716(Ribosomal protein S7, eukaryotic/archaeal)|interpro:IPR020606|interpro:IPR023798|interpro:IPR036823|mint:Q91V55	-	-	comment:mint	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:lRrzLUZkgOWqBeFK1dXaNScYfWM10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q99LF8	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-8313011|intact:MINT-1862273	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q99lf8_mouse(display_long)|uniprotkb:Pabpc4(gene name)|psi-mi:Pabpc4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0061515"(myeloid cell development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|go:"GO:0005829"(cytosol)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|dip:DIP-48577N|mint:Q99LF8	-	-	comment:mint	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:2nvPZn2h6NNtgKlb9bJHHhsOFQg10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:O88477	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-8419818|uniprotkb:Q8BRH1|intact:MINT-4112066|uniprotkb:Q80US9|ensembl:ENSMUSP00000013559	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:if2b1_mouse(display_long)|uniprotkb:Igf2bp1(gene name)|psi-mi:Igf2bp1(display_short)|uniprotkb:Vickz1(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 1(gene name synonym)|uniprotkb:Coding region determinant-binding protein(gene name synonym)|uniprotkb:VICKZ family member 1(gene name synonym)|uniprotkb:Zipcode-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_034081.1|dip:DIP-48578N|ensembl:ENSMUSG00000013415(gene)|ensembl:ENSMUST00000013559(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006403"(RNA localization)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010610"(regulation of mRNA stability involved in response to stress)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022013"(pallium cell proliferation in forebrain)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140059"(dendrite arborization)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034837|interpro:IPR034842|interpro:IPR035979|interpro:IPR036612|mint:O88477	-	-	comment:mint|function:"RNA-binding factor that affects mRNA nuclear export, localization, stability and translation. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulates its subcellular localization and translation. Binds both to the coding region mRNA stability determinant (CRD) and to AU-rich sequences in the 3'-UTR of the MYC mRNA. Protects the MYC and MDR-1 mRNAs from cleavage by a endoribonuclease, thus prolonging their stabilities. Binds to the 3'-UTR axonal localization signal (ALS) of TAU mRNA. Binds both to the coding region mRNA stability determinant (CRD) and to AU-rich sequences in the 3'-UTR of the CD44 mRNA (By similarity). Plays a role in regulating the stability of MYC and CD44 mRNAs (By similarity). Binds to the fourth and fifth exons of the oncofetal H19 and neuron-specific TAU mRNAs and regulates their localizations (By similarity). Binds to the adenine-rich autoregulatory sequence (ARS) 5'-UTR of the PABPC1 mRNA and is involved in its translational repression. The RNA-binding activity to ARS is stimulated by PABPC1 (By similarity). Binds to the coding sequence region of BTRC/FBW1A mRNA and mediates stabilization of BTRC/FBW1A and MYC mRNAs in response to beta-catenin signaling (By similarity). Binding to RNA employs a cooperative, sequential mechanism of homo- or heterodimerisation (By similarity). Also involved in growth or survival of lung-cancer cells (By similarity). Binds to a conserved 54-nucleotide element in the 3'-UTR of the beta actin mRNA known as the 'zipcode' (By similarity). Promotes translocation of the beta-actin mRNA to dendrites (By similarity). May act as a regulator of mRNA transport to activated synapses in response to synaptic activity"	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:TRF9+cyRXsAnqlscKWrtVgmgvmI10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P97473	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-2644020|uniprotkb:Q99M41|ensembl:ENSMUSP00000023813	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:trbp2_mouse(display_long)|uniprotkb:Tarbp2(gene name)|psi-mi:Tarbp2(display_short)|uniprotkb:Prbp(gene name synonym)|uniprotkb:TAR RNA-binding protein 2(gene name synonym)|uniprotkb:Protamine-1 RNA-binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_033345.2|ensembl:ENSMUSG00000023051(gene)|ensembl:ENSMUST00000023813(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050689"(negative regulation of defense response to virus by host)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090065"(regulation of production of siRNA involved in RNA interference)|go:"GO:1903798"(regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR028605|interpro:IPR044469|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR044470|interpro:IPR044471|reactome:R-MMU-203927|reactome:R-MMU-426486	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:YF0XnCWZNv2/AK2ONvSI+Jkwi1I10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q9JKB3-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030539|ensembl:ENSMUSP00000032309	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q9jkb3-1(display_long)|uniprotkb:Msy3l(isoform synonym)|uniprotkb:Ybx3(gene name)|psi-mi:Ybx3(display_short)|uniprotkb:Csda(gene name synonym)|uniprotkb:Msy4(gene name synonym)|uniprotkb:Cold shock domain-containing protein A(gene name synonym)|uniprotkb:DNA-binding protein A(gene name synonym)|uniprotkb:Y-box protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000030189(gene)|ensembl:ENSMUST00000032309(transcript)|intact:EBI-6393175(isoform-parent)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:I3eJeqmpBnfBbKCvGcUGsqNagC810090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q8R418	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-2644051|uniprotkb:Q8R419	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:dicer_mouse(display_long)|uniprotkb:Dicer1(gene name)|psi-mi:Dicer1(display_short)|uniprotkb:Dicer(gene name synonym)|uniprotkb:Mdcr(gene name synonym)|uniprotkb:Double-strand-specific ribonuclease mDCR-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001834"(trophectodermal cell proliferation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006396"(RNA processing)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010070"(zygote asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010626"(negative regulation of Schwann cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010660"(regulation of muscle cell apoptotic process)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0014835"(myoblast differentiation involved in skeletal muscle regeneration)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021675"(nerve development)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036404"(obsolete conversion of ds siRNA to ss siRNA)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051225"(spindle assembly)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061548"(ganglion development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070173"(regulation of enamel mineralization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0071335"(hair follicle cell proliferation)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:2000628"(regulation of miRNA metabolic process)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000999(Ribonuclease III)|go:"GO:0021522"(spinal cord motor neuron differentiation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR044441|rcsb pdb:3C4B|rcsb pdb:3C4T|interpro:IPR038248|dip:DIP-29721N|reactome:R-MMU-203927|reactome:R-MMU-426486	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:WTvPhOwCtJat0OjGAIn33JJ4ZEo10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P29341	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-773902|uniprotkb:Q99L36|ensembl:ENSMUSP00000001809	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:pabp1_mouse(display_long)|uniprotkb:Pabpc1(gene name)|psi-mi:Pabpc1(display_short)|uniprotkb:Pabp1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	dip:DIP-32127N|refseq:NP_032800.2|refseq:XP_011243641.1|ensembl:ENSMUSG00000022283(gene)|ensembl:ENSMUST00000001809(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045202"(synapse)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P29341|reactome:R-MMU-156827|reactome:R-MMU-429947|reactome:R-MMU-450408|reactome:R-MMU-72649|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:jvlQW6kphF2tkZwK72DtAXDPHvs10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q80U58-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030586|ensembl:ENSMUSP00000128292|ensembl:ENSMUSP00000131074	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q80u58-1(display_long)|uniprotkb:Pum2(gene name)|psi-mi:Pum2(display_short)|uniprotkb:Kiaa0235(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000020594(gene)|ensembl:ENSMUST00000163569(transcript)|ensembl:ENSMUST00000168361(transcript)|intact:EBI-998056(isoform-parent)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:e/dB62qP4f9FUwRvNvr21RYQh8Y10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q5M9P3	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030689	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q5m9p3_mouse(display_long)|uniprotkb:Rps19(gene name)|psi-mi:Rps19(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	interpro:IPR036390|interpro:IPR036388|interpro:IPR001266(Ribosomal protein S19e)|interpro:IPR018277|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:J/Vs5J245BPWxC/K6DabugdADCc10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q6ZQ58-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030550|ensembl:ENSMUSP00000136673	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q6zq58-1(display_long)|uniprotkb:Larp1(gene name)|psi-mi:Larp1(display_short)|uniprotkb:Kiaa0731(gene name synonym)|uniprotkb:Larp(gene name synonym)|uniprotkb:La ribonucleoprotein domain family member 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000037331(gene)|ensembl:ENSMUST00000178636(transcript)|intact:EBI-6908968(isoform-parent)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:DgxWWF7aiKBOUyGXmibtu8Wh+DU10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q3U6P5	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-6876909	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q3u6p5_mouse(display_long)|uniprotkb:Hnrnpc(gene name)|psi-mi:Hnrnpc(display_short)|uniprotkb:Hnrpc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	go:"GO:0003723"(RNA binding)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:hRyOOySi9XS/ImNLcBIyBioJHjc10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P97351	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-773982|ensembl:ENSMUSP00000029722	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:rs3a_mouse(display_long)|uniprotkb:Rps3a(gene name)|psi-mi:Rps3a(display_short)|uniprotkb:Protein TU-11(gene name synonym)|uniprotkb:Rps3a1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_058655.3|ensembl:ENSMUSG00000028081(gene)|ensembl:ENSMUST00000029722(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|interpro:IPR027500|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:pi623FvaPjjNAiN44zPHjtep4gs10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q3TA75	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030637	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q3ta75_mouse(display_long)|uniprotkb:Fxr2(gene name)|psi-mi:Fxr2(display_short)|uniprotkb:Fxr2h(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	interpro:IPR032172|interpro:IPR036612|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR040472|interpro:IPR040148|interpro:IPR041560|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:p4SnlN8QKQ7bwcbK3McWBlk5U9E10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q3TEA8-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030684|ensembl:ENSMUSP00000030541|ensembl:ENSMUSP00000132614	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q3tea8-1(display_long)|uniprotkb:Hp1bp3(gene name)|psi-mi:Hp1bp3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000028759(gene)|ensembl:ENSMUST00000030541(transcript)|ensembl:ENSMUST00000165861(transcript)|intact:EBI-6665967(isoform-parent)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:slrlB/B0DUfN8npc59xviu74mxs10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q3TFC0	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030609	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q3tfc0_mouse(display_long)|uniprotkb:Mov10(gene name)|psi-mi:Mov10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	interpro:IPR027417|interpro:IPR041677|interpro:IPR026122|interpro:IPR041679|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0035194"(post-transcriptional gene silencing by RNA)|go:"GO:0140603"(obsolete ATP hydrolysis activity)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:8mRmAvsHhM3gvq5HHtMe0VxpGK010090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q71LX8	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-2657945	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q71lx8_mouse(display_long)|uniprotkb:Hsp90ab1(gene name)|psi-mi:Hsp90ab1(display_short)|uniprotkb:Hsp84b(gene name synonym)|uniprotkb:Hspcb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_032328.2|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR020575|interpro:IPR020568|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019900"(kinase binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|interpro:IPR036890|interpro:IPR037196	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:5/MXDESVXdwuWna0s87Ap19aLMA10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q3UHK8	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-6097131|ensembl:ENSMUSP00000091595|uniprotkb:F6ZMJ4	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:tnr6a_mouse(display_long)|uniprotkb:Tnrc6a(gene name)|psi-mi:Tnrc6a(display_short)|uniprotkb:Kiaa1460(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000052707(gene)|ensembl:ENSMUST00000094053(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|reactome:R-MMU-5578749|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016442"(RISC complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR019486|interpro:IPR032226|interpro:IPR033501|interpro:IPR034924|interpro:IPR035979|rcsb pdb:5UMZ|reactome:R-MMU-426496|refseq:NP_659174.3|dip:DIP-60538N	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:o+C/dW9qoYx9+jEuDMkIX8sSXZQ10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P43274	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-913424|ensembl:ENSMUSP00000057308|uniprotkb:Q5EBH3	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:h14_mouse(display_long)|uniprotkb:H1-4(gene name)|psi-mi:H1-4(display_short)|uniprotkb:H1 VAR.2(gene name synonym)|uniprotkb:H1e(gene name synonym)|uniprotkb:H1f4(gene name synonym)|uniprotkb:Hist1h1e(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000051627(gene)|ensembl:ENSMUST00000062045(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016208"(AMP binding)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0032564"(dATP binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0098532"(histone H3-K27 trimethylation)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P43274|reactome:R-MMU-140342|reactome:R-MMU-2559584|refseq:NP_056602.1	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:RbnBt0O11C8PWtfWp8tJJxsn00A10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q8VHK9	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030648|uniprotkb:G3X8Y4|uniprotkb:Q6ZPP7|uniprotkb:Q9CSE8|ensembl:ENSMUSP00000029336	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:dhx36_mouse(display_long)|uniprotkb:Dhx36(gene name)|psi-mi:Dhx36(display_short)|uniprotkb:Ddx36(gene name synonym)|uniprotkb:Kiaa1488(gene name synonym)|uniprotkb:Mlel1(gene name synonym)|uniprotkb:DEAH box protein 36(gene name synonym)|uniprotkb:MLE-like protein 1(gene name synonym)|uniprotkb:RNA helicase associated with AU-rich element ARE(gene name synonym)|uniprotkb:DEAD/H box polypeptide 36(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:XP_011238540.1|refseq:NP_082412.2|dip:DIP-48576N|ensembl:ENSMUSG00000027770(gene)|ensembl:ENSMUST00000029336(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001503"(ossification)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902064"(regulation of transcription from RNA polymerase II promoter involved in spermatogenesis)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904582"(positive regulation of intracellular mRNA localization)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|rcsb pdb:6UP2|rcsb pdb:6UP3|rcsb pdb:6UP4|reactome:R-MMU-3134963	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:P0657u4/yuv0IRfkUpvXuvlyzBE10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:O70133-2	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030529	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:o70133-2(display_long)|uniprotkb:RNA helicase A(gene name synonym)|uniprotkb:Dhx9(gene name)|psi-mi:Dhx9(display_short)|uniprotkb:Ddx9(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-2657677(isoform-parent)	-	-	isoform-comment:Contains a phosphoserine at position 137.	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:TsOWNfREtA02pzF35vNkOZ7thOg10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P62960	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-529779|uniprotkb:P22568|uniprotkb:P27817|uniprotkb:P43482|ensembl:ENSMUSP00000078589	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:ybox1_mouse(display_long)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Ybx1(gene name)|psi-mi:Ybx1(display_short)|uniprotkb:Msy1(gene name synonym)|uniprotkb:Msy-1(gene name synonym)|uniprotkb:Yb1(gene name synonym)|uniprotkb:Nsep1(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_035862.2|dip:DIP-34256N|ensembl:ENSMUSG00000028639(gene)|ensembl:ENSMUST00000079644(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P62960|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-9017802|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:imkViHICtFj/0wQ8IDprza1b43010090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q8R081	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-647483|uniprotkb:O54789|uniprotkb:Q8K0S7|uniprotkb:Q499X2|ensembl:ENSMUSP00000049407|ensembl:ENSMUSP00000133728	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:hnrpl_mouse(display_long)|uniprotkb:Hnrpl(gene name synonym)|uniprotkb:Hnrnpl(gene name)|psi-mi:Hnrnpl(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_796275.3|refseq:XP_006539621.1|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034816|interpro:IPR034817|interpro:IPR035005|interpro:IPR035008|interpro:IPR035979|mint:Q8R081|rcsb pdb:3S01|rcsb pdb:3TYT|reactome:R-MMU-72163|reactome:R-MMU-72203|go:"GO:1990715"(mRNA CDS binding)|ensembl:ENSMUSG00000015165(gene)|ensembl:ENSMUST00000038572(transcript)|ensembl:ENSMUST00000174548(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045120"(pronucleus)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:1902416"(positive regulation of mRNA binding)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:BApt4fekoyJ285Ve13kxstcLbV010090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q8K310	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-1216295|ensembl:ENSMUSP00000125761|ensembl:ENSMUSP00000158074|ensembl:ENSMUSP00000158537	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:matr3_mouse(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_034901.2|rcsb pdb:1X4F|rcsb pdb:1X4D|ensembl:ENSMUSG00000037236(gene)|ensembl:ENSMUST00000166793(transcript)|ensembl:ENSMUST00000235199(transcript)|ensembl:ENSMUST00000237744(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:Q8K310	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:AwtFbI+oRfha+mn/v3yzG6bNXYg10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P62270	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-352460|ensembl:ENSMUSP00000008812|uniprotkb:P25232	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:rs18_mouse(display_long)|uniprotkb:Rps18(gene name)|psi-mi:Rps18(display_short)|uniprotkb:Ke-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_035426.1|ensembl:ENSMUSG00000008668(gene)|ensembl:ENSMUST00000008812(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0019843"(rRNA binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045202"(synapse)|interpro:IPR001892(Ribosomal protein S13)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR018269|interpro:IPR027437|mint:P62270|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:yOHgKM/BuvgGdqp1OEVPeuiABg810090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q3UHC0	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030559|uniprotkb:Q3UZ61|uniprotkb:Q80TB6|uniprotkb:Q8BXF9	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:tnr6c_mouse(display_long)|uniprotkb:Tnrc6c(gene name)|psi-mi:Tnrc6c(display_short)|uniprotkb:Kiaa1582(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	interpro:IPR041917|reactome:R-MMU-426496|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR032226|interpro:IPR033499|interpro:IPR035979|interpro:IPR019486|interpro:IPR026805|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|refseq:NP_932139.2|interpro:IPR034927|go:"GO:0000932"(P-body)|go:"GO:0001706"(endoderm formation)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007492"(endoderm development)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:tHEIJIqWzueFURS1XjipmksvcXg10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q61584-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030699|ensembl:ENSMUSP00000001620	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q61584-1(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-8350418(isoform-parent)|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q8VDM6-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030631|ensembl:ENSMUSP00000146263	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q8vdm6-1(display_long)|uniprotkb:Hnrnpul1(gene name)|psi-mi:Hnrnpul1(display_short)|uniprotkb:Hnrpul1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-8322348(isoform-parent)|ensembl:ENSMUSG00000040725(gene)|ensembl:ENSMUST00000206832(transcript)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:byU8hqFDp+qxXKbkevj3IJ0LpWQ10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P62264	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-2311514|uniprotkb:P06366|uniprotkb:Q544W4|ensembl:ENSMUSP00000025511|ensembl:ENSMUSP00000113081|ensembl:ENSMUSP00000113504|ensembl:ENSMUSP00000157948|ensembl:ENSMUSP00000158138	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:rs14_mouse(display_long)|uniprotkb:Rps14(gene name)|psi-mi:Rps14(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_065625.2|ensembl:ENSMUSG00000024608(gene)|ensembl:ENSMUST00000025511(transcript)|ensembl:ENSMUST00000118551(transcript)|ensembl:ENSMUST00000122279(transcript)|ensembl:ENSMUST00000235603(transcript)|ensembl:ENSMUST00000235966(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|interpro:IPR036967|mint:P62264|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:ee3bJ5JYFaZXyCCRG9Wooopyz2o10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q5SF07-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030593|ensembl:ENSMUSP00000097629	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q5sf07-1(display_long)|uniprotkb:Igf2bp2(gene name)|psi-mi:Igf2bp2(display_short)|uniprotkb:Imp2(gene name synonym)|uniprotkb:Vickz2(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 2(gene name synonym)|uniprotkb:VICKZ family member 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-9030463(isoform-parent)|ensembl:ENSMUSG00000033581(gene)|ensembl:ENSMUST00000100052(transcript)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:BT6XeYD0XIbY+BcU76G2HkE9sx010090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P07901	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-78930|ensembl:ENSMUSP00000021698|ensembl:ENSMUSP00000091921	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:hs90a_mouse(display_long)|uniprotkb:Hsp90aa1(gene name)|psi-mi:Hsp90aa1(display_short)|uniprotkb:Hsp86(gene name synonym)|uniprotkb:Hsp86-1(gene name synonym)|uniprotkb:Hspca(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Tumor-specific transplantation 86 kDa antigen(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_034610.1|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045585"(positive regulation of cytotoxic T cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097226"(sperm mitochondrial sheath)|go:"GO:0097524"(sperm plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07901|rcsb pdb:5H22|reactome:R-MMU-1227986|reactome:R-MMU-1474151|reactome:R-MMU-168928|reactome:R-MMU-2029482|reactome:R-MMU-203615|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-399954|reactome:R-MMU-4420097|reactome:R-MMU-5218920|reactome:R-MMU-5620912|reactome:R-MMU-5675482|reactome:R-MMU-6798695|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8863795|reactome:R-MMU-8939211|reactome:R-MMU-9009391|reactome:R-MMU-9013418|reactome:R-MMU-9018519|reactome:R-MMU-9652282|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032564"(dATP binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|ensembl:ENSMUSG00000021270(gene)|ensembl:ENSMUST00000021698(transcript)|ensembl:ENSMUST00000094361(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042026"(protein refolding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|dip:DIP-30975N	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:t9XAeXdXezYOtJX0wp3IY9/ZMkQ10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q3UJB9-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030678	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q3ujb9-1(display_long)|uniprotkb:Edc4(gene name)|psi-mi:Edc4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-2553526(isoform-parent)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:FVX5K/2axUrzI66j1QPmJsqpxec10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q9R0Q7	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-6913887|ensembl:ENSMUSP00000050292|uniprotkb:Q542V4|uniprotkb:Q9D7V0|uniprotkb:Q9WV83	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:tebp_mouse(display_long)|uniprotkb:Ptges3(gene name)|psi-mi:Ptges3(display_short)|uniprotkb:Sid3177(gene name synonym)|uniprotkb:Tebp(gene name synonym)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:Sid 3177(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000071072(gene)|ensembl:ENSMUST00000052798(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0002039"(p53 binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9R0Q7|reactome:R-MMU-2162123|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-8937144|reactome:R-MMU-8939211|reactome:R-MMU-9018519|refseq:NP_062740.1	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:YMwjVAVwK01RvPxKbe3JEiBa6vI10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q91YT7	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-4286305|uniprotkb:Q3TWU3|uniprotkb:Q8BM70|uniprotkb:Q8K325|ensembl:ENSMUSP00000120414	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:ythd2_mouse(display_long)|uniprotkb:Ythdf2(gene name)|psi-mi:Ythdf2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_663368.3|ensembl:ENSMUSG00000040025(gene)|ensembl:ENSMUST00000152796(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045087"(innate immune response)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070925"(organelle assembly)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:2000232"(regulation of rRNA processing)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR007275(YT521-B-like protein)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:mMOth3TafazhsFBquXonvgj6Jz010090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q9EPU0-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-6877008|ensembl:ENSMUSP00000075089	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q9epu0-1(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)|uniprotkb:Rent1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUST00000075666(transcript)|ensembl:ENSMUSG00000058301(gene)|intact:EBI-6876715(isoform-parent)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:rwd4XXdf5Uqjtgao/zILckKP8AM10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q8BKI2-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030602|ensembl:ENSMUSP00000064336	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q8bki2-1(display_long)|uniprotkb:Tnrc6b(gene name)|psi-mi:Tnrc6b(display_short)|uniprotkb:Kiaa1093(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-9030490(isoform-parent)|ensembl:ENSMUSG00000047888(gene)|ensembl:ENSMUST00000067689(transcript)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:zFkNbprE9NdhNf4a/bcBU+nHcac10090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q99PU8-3	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030622|ensembl:ENSMUSP00000062622	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q99pu8-3(display_long)|uniprotkb:Dhx30(gene name)|psi-mi:Dhx30(display_short)|uniprotkb:Helg(gene name synonym)|uniprotkb:DEAH box protein 30(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-8329235(isoform-parent)|ensembl:ENSMUSG00000032480(gene)|ensembl:ENSMUST00000062368(transcript)	-	-	isoform-comment:Contains a phosphoserine at position 15.	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:ktfb3+MujvsVqfF/UktSoNqi+t810090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P70372	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-6877056|ensembl:ENSMUSP00000096549|ensembl:ENSMUSP00000146866|uniprotkb:Q60745|uniprotkb:Q78QY3	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:elav1_mouse(display_long)|uniprotkb:Elavl1(gene name)|psi-mi:Elavl1(display_short)|uniprotkb:Elra(gene name synonym)|uniprotkb:Hua(gene name synonym)|uniprotkb:Elav-like generic protein(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)|uniprotkb:MelG(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030750|imex:IM-21805-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000040028(gene)|ensembl:ENSMUST00000098950(transcript)|ensembl:ENSMUST00000209010(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:P70372|reactome:R-MMU-450520|reactome:R-MMU-72163|go:"GO:0019901"(protein kinase binding)|refseq:XP_006508761.1|refseq:NP_034615.2|dip:DIP-46480N	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264), Rps3a (P97351), Csda (Q9JKB3-1), Ddx9 (O70133-2), Elavl1 (P70372), FAM120A (Q6A0A9), Hnrnpc (Q3U6P5), Hnrnpul1 (Q8VDM6-1), Larp1 (Q6ZQ58-1), Matr3 (Q8K310), Pabp1 (P29341), Pabpc4 (Q99LF8), Rent1;Upf1 (Q9EPU0-1) and Ybx1 (P62960)."|comment:"Interaction of Apo2 with the following participants is weakly dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55), Ythdf2 (Q3TWU3) and Fxr1 (Q61584-1)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Dicer (Q8R418) and Tnrc6c (Q3UHC0)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:iKHrpZqi5b7EFLkfVJSRTpi9sj010090	intact-crc:7C8E442E702B056B|rigid:d7q5eAZwCLm5pVdVZs3mulWnenk	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q64378	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-492796|ensembl:ENSMUSP00000078382|ensembl:ENSMUSP00000110440|ensembl:ENSMUSP00000136245|ensembl:ENSMUSP00000156418	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:fkbp5_mouse(display_long)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Fkbp5(gene name)|psi-mi:Fkbp5(display_short)|uniprotkb:Fkbp51(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_034350.1|ensembl:ENSMUSG00000024222(gene)|ensembl:ENSMUST00000079413(transcript)|ensembl:ENSMUST00000114792(transcript)|ensembl:ENSMUST00000177939(transcript)|ensembl:ENSMUST00000233102(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q64378|reactome:R-MMU-3371497|reactome:R-MMU-8939211	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:ihh8rfBDWGjo3gceXNl406Y50pU10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P54823	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-3647041|ensembl:ENSMUSP00000128421|ensembl:ENSMUSP00000149620|uniprotkb:O54979|uniprotkb:Q3UFI3|uniprotkb:Q8BW68	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:ddx6_mouse(display_long)|uniprotkb:Ddx6(gene name)|psi-mi:Ddx6(display_short)|uniprotkb:Hlr2(gene name synonym)|uniprotkb:Rck(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:Oncogene RCK homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|mint:P54823|reactome:R-MMU-430039|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|ensembl:ENSMUSG00000032097(gene)|ensembl:ENSMUST00000170489(transcript)|ensembl:ENSMUST00000217034(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_001104296.1|refseq:NP_031867.1|refseq:NP_851841.2|refseq:XP_011240693.1|refseq:XP_011240694.1|refseq:XP_017168613.1	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:Q80hxmsbz9kQgOP9Gflto87Sp/M10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:O08848	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-8322484|intact:MINT-4132821|uniprotkb:Q9QYD8|ensembl:ENSMUSP00000125623	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:ro60_mouse(display_long)|uniprotkb:RO60(gene name)|psi-mi:RO60(display_short)|uniprotkb:Ssa2(gene name synonym)|uniprotkb:TROVE domain family member 2(gene name synonym)|uniprotkb:Trove2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_038863.1|refseq:XP_017174940.1|ensembl:ENSMUSG00000018199(gene)|ensembl:ENSMUST00000159879(transcript)|go:"GO:0002520"(immune system development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0009411"(response to UV)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0034336"(misfolded RNA binding)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0046872"(metal ion binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR008858(TROVE)|interpro:IPR036465|interpro:IPR037214|interpro:IPR040322|mint:O08848	-	-	comment:mint|function:RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:aWkAAnWO4Q8288vrhtKGEh3/ZcY10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q9CPN8	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-8419588|intact:MINT-1848725|uniprotkb:Q3UHZ6|uniprotkb:Q8C2J9|ensembl:ENSMUSP00000031838	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:if2b3_mouse(display_long)|uniprotkb:Igf2bp3(gene name)|psi-mi:Igf2bp3(display_short)|uniprotkb:Vickz3(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 3(gene name synonym)|uniprotkb:VICKZ family member 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_076159.3|ensembl:ENSMUSG00000029814(gene)|ensembl:ENSMUST00000031838(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034844|interpro:IPR035979|interpro:IPR036612|mint:Q9CPN8	-	-	comment:mint|function:"RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA"	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:sSSab2xJ+L+kO1qbiAbUU01YVxU10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:O88477	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-8419818|uniprotkb:Q8BRH1|intact:MINT-4112066|uniprotkb:Q80US9|ensembl:ENSMUSP00000013559	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:if2b1_mouse(display_long)|uniprotkb:Igf2bp1(gene name)|psi-mi:Igf2bp1(display_short)|uniprotkb:Vickz1(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 1(gene name synonym)|uniprotkb:Coding region determinant-binding protein(gene name synonym)|uniprotkb:VICKZ family member 1(gene name synonym)|uniprotkb:Zipcode-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_034081.1|dip:DIP-48578N|ensembl:ENSMUSG00000013415(gene)|ensembl:ENSMUST00000013559(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006403"(RNA localization)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010610"(regulation of mRNA stability involved in response to stress)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022013"(pallium cell proliferation in forebrain)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140059"(dendrite arborization)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034837|interpro:IPR034842|interpro:IPR035979|interpro:IPR036612|mint:O88477	-	-	comment:mint|function:"RNA-binding factor that affects mRNA nuclear export, localization, stability and translation. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulates its subcellular localization and translation. Binds both to the coding region mRNA stability determinant (CRD) and to AU-rich sequences in the 3'-UTR of the MYC mRNA. Protects the MYC and MDR-1 mRNAs from cleavage by a endoribonuclease, thus prolonging their stabilities. Binds to the 3'-UTR axonal localization signal (ALS) of TAU mRNA. Binds both to the coding region mRNA stability determinant (CRD) and to AU-rich sequences in the 3'-UTR of the CD44 mRNA (By similarity). Plays a role in regulating the stability of MYC and CD44 mRNAs (By similarity). Binds to the fourth and fifth exons of the oncofetal H19 and neuron-specific TAU mRNAs and regulates their localizations (By similarity). Binds to the adenine-rich autoregulatory sequence (ARS) 5'-UTR of the PABPC1 mRNA and is involved in its translational repression. The RNA-binding activity to ARS is stimulated by PABPC1 (By similarity). Binds to the coding sequence region of BTRC/FBW1A mRNA and mediates stabilization of BTRC/FBW1A and MYC mRNAs in response to beta-catenin signaling (By similarity). Binding to RNA employs a cooperative, sequential mechanism of homo- or heterodimerisation (By similarity). Also involved in growth or survival of lung-cancer cells (By similarity). Binds to a conserved 54-nucleotide element in the 3'-UTR of the beta actin mRNA known as the 'zipcode' (By similarity). Promotes translocation of the beta-actin mRNA to dendrites (By similarity). May act as a regulator of mRNA transport to activated synapses in response to synaptic activity"	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:TRF9+cyRXsAnqlscKWrtVgmgvmI10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q91V55	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-8328840|intact:MINT-4120755|ensembl:ENSMUSP00000004554|ensembl:ENSMUSP00000104179	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q91v55_mouse(display_long)|uniprotkb:Rps5(gene name)|psi-mi:Rps5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_033121.2|ensembl:ENSMUSG00000012848(gene)|ensembl:ENSMUST00000004554(transcript)|ensembl:ENSMUST00000108539(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006412"(translation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR000235(Ribosomal protein S7)|interpro:IPR005716(Ribosomal protein S7, eukaryotic/archaeal)|interpro:IPR020606|interpro:IPR023798|interpro:IPR036823|mint:Q91V55	-	-	comment:mint	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:lRrzLUZkgOWqBeFK1dXaNScYfWM10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:F2Z461	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030921|uniprotkb:Q3UEA7|uniprotkb:Q9CU70|ensembl:ENSMUSP00000031817	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:herc6_mouse(display_long)|uniprotkb:Herc6(gene name)|psi-mi:Herc6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_080268.1|ensembl:ENSMUSG00000029798(gene)|ensembl:ENSMUST00000031817(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045087"(innate immune response)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000569(HECT)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR035983|reactome:R-MMU-983168	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:rOqXxhlKMOSTGsbFiyHAvxhQw1Y10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q6KAS7-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030910|ensembl:ENSMUSP00000025288|ensembl:ENSMUSP00000157321	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q6kas7-1(display_long)|uniprotkb:Znf521(gene name)|psi-mi:Znf521(display_short)|uniprotkb:Evi3(gene name synonym)|uniprotkb:Zfp521(gene name synonym)|uniprotkb:Ecotropic viral integration site 3 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-9030836(isoform-parent)|ensembl:ENSMUSG00000024420(gene)|ensembl:ENSMUST00000025288(transcript)|ensembl:ENSMUST00000234410(transcript)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:LpLAA6DHGSfeGhVR5qYng3CFgZw10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q5SXR6	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-2308526|ensembl:ENSMUSP00000050220	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q5sxr6_mouse(display_long)|uniprotkb:Cltc(gene name)|psi-mi:Cltc(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000047126(gene)|ensembl:ENSMUST00000060766(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:zQkMlHHZuHQwJ3cU5pWAx/f6guc10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q8CJF9	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030886|uniprotkb:Q3TBP7|ensembl:ENSMUSP00000066633	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:ago3_mouse(display_long)|uniprotkb:Ago3(gene name)|psi-mi:Ago3(display_short)|uniprotkb:Eif2c3(gene name synonym)|uniprotkb:Argonaute RISC catalytic component 3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 3(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_700451.2|ensembl:ENSMUSG00000028842(gene)|ensembl:ENSMUST00000069097(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028603|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJF9|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:JBJer7uFfQamp+D9D7xPSd0iPuo10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q80U58-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030586|ensembl:ENSMUSP00000128292|ensembl:ENSMUSP00000131074	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q80u58-1(display_long)|uniprotkb:Pum2(gene name)|psi-mi:Pum2(display_short)|uniprotkb:Kiaa0235(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000020594(gene)|ensembl:ENSMUST00000163569(transcript)|ensembl:ENSMUST00000168361(transcript)|intact:EBI-998056(isoform-parent)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:e/dB62qP4f9FUwRvNvr21RYQh8Y10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P43274	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-913424|ensembl:ENSMUSP00000057308|uniprotkb:Q5EBH3	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:h14_mouse(display_long)|uniprotkb:H1-4(gene name)|psi-mi:H1-4(display_short)|uniprotkb:H1 VAR.2(gene name synonym)|uniprotkb:H1e(gene name synonym)|uniprotkb:H1f4(gene name synonym)|uniprotkb:Hist1h1e(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000051627(gene)|ensembl:ENSMUST00000062045(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016208"(AMP binding)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0032564"(dATP binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0098532"(histone H3-K27 trimethylation)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P43274|reactome:R-MMU-140342|reactome:R-MMU-2559584|refseq:NP_056602.1	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:RbnBt0O11C8PWtfWp8tJJxsn00A10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q3UJB9-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030678	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q3ujb9-1(display_long)|uniprotkb:Edc4(gene name)|psi-mi:Edc4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-2553526(isoform-parent)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:FVX5K/2axUrzI66j1QPmJsqpxec10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q8BKI2-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030602|ensembl:ENSMUSP00000064336	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q8bki2-1(display_long)|uniprotkb:Tnrc6b(gene name)|psi-mi:Tnrc6b(display_short)|uniprotkb:Kiaa1093(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-9030490(isoform-parent)|ensembl:ENSMUSG00000047888(gene)|ensembl:ENSMUST00000067689(transcript)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:zFkNbprE9NdhNf4a/bcBU+nHcac10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q3UHK8	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-6097131|ensembl:ENSMUSP00000091595|uniprotkb:F6ZMJ4	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:tnr6a_mouse(display_long)|uniprotkb:Tnrc6a(gene name)|psi-mi:Tnrc6a(display_short)|uniprotkb:Kiaa1460(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000052707(gene)|ensembl:ENSMUST00000094053(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|reactome:R-MMU-5578749|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016442"(RISC complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR019486|interpro:IPR032226|interpro:IPR033501|interpro:IPR034924|interpro:IPR035979|rcsb pdb:5UMZ|reactome:R-MMU-426496|refseq:NP_659174.3|dip:DIP-60538N	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:o+C/dW9qoYx9+jEuDMkIX8sSXZQ10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q9R0Q7	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-6913887|ensembl:ENSMUSP00000050292|uniprotkb:Q542V4|uniprotkb:Q9D7V0|uniprotkb:Q9WV83	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:tebp_mouse(display_long)|uniprotkb:Ptges3(gene name)|psi-mi:Ptges3(display_short)|uniprotkb:Sid3177(gene name synonym)|uniprotkb:Tebp(gene name synonym)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:Sid 3177(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000071072(gene)|ensembl:ENSMUST00000052798(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0002039"(p53 binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9R0Q7|reactome:R-MMU-2162123|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-8937144|reactome:R-MMU-8939211|reactome:R-MMU-9018519|refseq:NP_062740.1	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:YMwjVAVwK01RvPxKbe3JEiBa6vI10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q71LX8	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-2657945	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q71lx8_mouse(display_long)|uniprotkb:Hsp90ab1(gene name)|psi-mi:Hsp90ab1(display_short)|uniprotkb:Hsp84b(gene name synonym)|uniprotkb:Hspcb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_032328.2|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR020575|interpro:IPR020568|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019900"(kinase binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|interpro:IPR036890|interpro:IPR037196	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:5/MXDESVXdwuWna0s87Ap19aLMA10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P07901	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-78930|ensembl:ENSMUSP00000021698|ensembl:ENSMUSP00000091921	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:hs90a_mouse(display_long)|uniprotkb:Hsp90aa1(gene name)|psi-mi:Hsp90aa1(display_short)|uniprotkb:Hsp86(gene name synonym)|uniprotkb:Hsp86-1(gene name synonym)|uniprotkb:Hspca(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Tumor-specific transplantation 86 kDa antigen(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_034610.1|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045585"(positive regulation of cytotoxic T cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097226"(sperm mitochondrial sheath)|go:"GO:0097524"(sperm plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07901|rcsb pdb:5H22|reactome:R-MMU-1227986|reactome:R-MMU-1474151|reactome:R-MMU-168928|reactome:R-MMU-2029482|reactome:R-MMU-203615|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-399954|reactome:R-MMU-4420097|reactome:R-MMU-5218920|reactome:R-MMU-5620912|reactome:R-MMU-5675482|reactome:R-MMU-6798695|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8863795|reactome:R-MMU-8939211|reactome:R-MMU-9009391|reactome:R-MMU-9013418|reactome:R-MMU-9018519|reactome:R-MMU-9652282|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032564"(dATP binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|ensembl:ENSMUSG00000021270(gene)|ensembl:ENSMUST00000021698(transcript)|ensembl:ENSMUST00000094361(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042026"(protein refolding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|dip:DIP-30975N	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:t9XAeXdXezYOtJX0wp3IY9/ZMkQ10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P97351	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-773982|ensembl:ENSMUSP00000029722	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:rs3a_mouse(display_long)|uniprotkb:Rps3a(gene name)|psi-mi:Rps3a(display_short)|uniprotkb:Protein TU-11(gene name synonym)|uniprotkb:Rps3a1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_058655.3|ensembl:ENSMUSG00000028081(gene)|ensembl:ENSMUST00000029722(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|interpro:IPR027500|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:pi623FvaPjjNAiN44zPHjtep4gs10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P62264	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-2311514|uniprotkb:P06366|uniprotkb:Q544W4|ensembl:ENSMUSP00000025511|ensembl:ENSMUSP00000113081|ensembl:ENSMUSP00000113504|ensembl:ENSMUSP00000157948|ensembl:ENSMUSP00000158138	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:rs14_mouse(display_long)|uniprotkb:Rps14(gene name)|psi-mi:Rps14(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_065625.2|ensembl:ENSMUSG00000024608(gene)|ensembl:ENSMUST00000025511(transcript)|ensembl:ENSMUST00000118551(transcript)|ensembl:ENSMUST00000122279(transcript)|ensembl:ENSMUST00000235603(transcript)|ensembl:ENSMUST00000235966(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|interpro:IPR036967|mint:P62264|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:ee3bJ5JYFaZXyCCRG9Wooopyz2o10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q3TFC0	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030609	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q3tfc0_mouse(display_long)|uniprotkb:Mov10(gene name)|psi-mi:Mov10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	interpro:IPR027417|interpro:IPR041677|interpro:IPR026122|interpro:IPR041679|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0035194"(post-transcriptional gene silencing by RNA)|go:"GO:0140603"(obsolete ATP hydrolysis activity)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:8mRmAvsHhM3gvq5HHtMe0VxpGK010090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q5SF07-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030593|ensembl:ENSMUSP00000097629	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q5sf07-1(display_long)|uniprotkb:Igf2bp2(gene name)|psi-mi:Igf2bp2(display_short)|uniprotkb:Imp2(gene name synonym)|uniprotkb:Vickz2(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 2(gene name synonym)|uniprotkb:VICKZ family member 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-9030463(isoform-parent)|ensembl:ENSMUSG00000033581(gene)|ensembl:ENSMUST00000100052(transcript)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:BT6XeYD0XIbY+BcU76G2HkE9sx010090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q3TEA8-1	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030684|ensembl:ENSMUSP00000030541|ensembl:ENSMUSP00000132614	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q3tea8-1(display_long)|uniprotkb:Hp1bp3(gene name)|psi-mi:Hp1bp3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000028759(gene)|ensembl:ENSMUST00000030541(transcript)|ensembl:ENSMUST00000165861(transcript)|intact:EBI-6665967(isoform-parent)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:slrlB/B0DUfN8npc59xviu74mxs10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q8R081	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-647483|uniprotkb:O54789|uniprotkb:Q8K0S7|uniprotkb:Q499X2|ensembl:ENSMUSP00000049407|ensembl:ENSMUSP00000133728	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:hnrpl_mouse(display_long)|uniprotkb:Hnrpl(gene name synonym)|uniprotkb:Hnrnpl(gene name)|psi-mi:Hnrnpl(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_796275.3|refseq:XP_006539621.1|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034816|interpro:IPR034817|interpro:IPR035005|interpro:IPR035008|interpro:IPR035979|mint:Q8R081|rcsb pdb:3S01|rcsb pdb:3TYT|reactome:R-MMU-72163|reactome:R-MMU-72203|go:"GO:1990715"(mRNA CDS binding)|ensembl:ENSMUSG00000015165(gene)|ensembl:ENSMUST00000038572(transcript)|ensembl:ENSMUST00000174548(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045120"(pronucleus)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:1902416"(positive regulation of mRNA binding)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:BApt4fekoyJ285Ve13kxstcLbV010090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q99PU8-3	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030622|ensembl:ENSMUSP00000062622	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q99pu8-3(display_long)|uniprotkb:Dhx30(gene name)|psi-mi:Dhx30(display_short)|uniprotkb:Helg(gene name synonym)|uniprotkb:DEAH box protein 30(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	intact:EBI-8329235(isoform-parent)|ensembl:ENSMUSG00000032480(gene)|ensembl:ENSMUST00000062368(transcript)	-	-	isoform-comment:Contains a phosphoserine at position 15.	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:ktfb3+MujvsVqfF/UktSoNqi+t810090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q8VHK9	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030648|uniprotkb:G3X8Y4|uniprotkb:Q6ZPP7|uniprotkb:Q9CSE8|ensembl:ENSMUSP00000029336	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:dhx36_mouse(display_long)|uniprotkb:Dhx36(gene name)|psi-mi:Dhx36(display_short)|uniprotkb:Ddx36(gene name synonym)|uniprotkb:Kiaa1488(gene name synonym)|uniprotkb:Mlel1(gene name synonym)|uniprotkb:DEAH box protein 36(gene name synonym)|uniprotkb:MLE-like protein 1(gene name synonym)|uniprotkb:RNA helicase associated with AU-rich element ARE(gene name synonym)|uniprotkb:DEAD/H box polypeptide 36(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:XP_011238540.1|refseq:NP_082412.2|dip:DIP-48576N|ensembl:ENSMUSG00000027770(gene)|ensembl:ENSMUST00000029336(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001503"(ossification)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902064"(regulation of transcription from RNA polymerase II promoter involved in spermatogenesis)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904582"(positive regulation of intracellular mRNA localization)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|rcsb pdb:6UP2|rcsb pdb:6UP3|rcsb pdb:6UP4|reactome:R-MMU-3134963	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:P0657u4/yuv0IRfkUpvXuvlyzBE10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q91YT7	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-4286305|uniprotkb:Q3TWU3|uniprotkb:Q8BM70|uniprotkb:Q8K325|ensembl:ENSMUSP00000120414	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:ythd2_mouse(display_long)|uniprotkb:Ythdf2(gene name)|psi-mi:Ythdf2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_663368.3|ensembl:ENSMUSG00000040025(gene)|ensembl:ENSMUST00000152796(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045087"(innate immune response)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070925"(organelle assembly)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:2000232"(regulation of rRNA processing)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR007275(YT521-B-like protein)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:mMOth3TafazhsFBquXonvgj6Jz010090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:Q5M9P3	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030689	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:q5m9p3_mouse(display_long)|uniprotkb:Rps19(gene name)|psi-mi:Rps19(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	interpro:IPR036390|interpro:IPR036388|interpro:IPR001266(Ribosomal protein S19e)|interpro:IPR018277|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:J/Vs5J245BPWxC/K6DabugdADCc10090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P62270	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-352460|ensembl:ENSMUSP00000008812|uniprotkb:P25232	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:rs18_mouse(display_long)|uniprotkb:Rps18(gene name)|psi-mi:Rps18(display_short)|uniprotkb:Ke-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030815|imex:IM-21805-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_035426.1|ensembl:ENSMUSG00000008668(gene)|ensembl:ENSMUST00000008812(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0019843"(rRNA binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045202"(synapse)|interpro:IPR001892(Ribosomal protein S13)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR018269|interpro:IPR027437|mint:P62270|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:2, 3, tables 1 and 2|comment:"Interaction of Apo2 with the following participants is dependent on mRNA presence and was disrupted upon RNAse treatment: Ddx36 (Q8VHK9), Dhx30 (Q99PU8-3), Hnrnpl (Q8R081), Hp1bp3 (Q3TEA8-1), Igf2bp1 (O88477), Igf2bp2 (Q5SF07-1), Igf2bp3 (Q9CPN8), Mov10 (Q3TFC0), Rps14 (P62264) and Rps3a (P97351)."|comment:"Interaction of Apo2 with the following participants is partially dependent on mRNA presence and was decreased upon RNAse treatment: Rps18 (P62270), Rps19 (Q5M9P3), Rps5 (Q91V55) and Ythdf2 (Q3TWU3)."|comment:"Interaction of Apo2 with the following participants is independent on mRNA presence and was not affected by  RNAse treatment: Fkbp5 (Q64378), Hsp90 alpha (P07901), Hsp90 beta (Q71LX8), Ptges3 (Q9R0Q7), Tnrc6a (Q3UHK8), Tnrc6b (Q8BKI2-1), Ago3 (Q8CJF9), Cltc (Q5SXR6) and Zfp521 (Q6KAS7-1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2018/02/26	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:yOHgKM/BuvgGdqp1OEVPeuiABg810090	intact-crc:1ED4E6690E6B29D5|rigid:b4N+mzXzYXlKiFpM70SIKNLyym8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CJG0	uniprotkb:P62960	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-529779|uniprotkb:P22568|uniprotkb:P27817|uniprotkb:P43482|ensembl:ENSMUSP00000078589	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:ybox1_mouse(display_long)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Ybx1(gene name)|psi-mi:Ybx1(display_short)|uniprotkb:Msy1(gene name synonym)|uniprotkb:Msy-1(gene name synonym)|uniprotkb:Yb1(gene name synonym)|uniprotkb:Nsep1(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030831|imex:IM-21805-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_035862.2|dip:DIP-34256N|ensembl:ENSMUSG00000028639(gene)|ensembl:ENSMUST00000079644(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P62960|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-9017802|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:4|comment:Binding of Yb1 and UPF1 was dependent on mRNA presence, as evidenced by its disruption upon RNAse treatment. Binding of ZNF521 was unaffected by the treatment.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2014/10/16	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:imkViHICtFj/0wQ8IDprza1b43010090	intact-crc:7043836288D32090|rigid:+jERkPXWNjWVRA+zlOqHt8Balu8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CJG0	uniprotkb:Q9EPU0	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-6876715|ensembl:ENSMUSP00000075089|uniprotkb:Q3UG00|uniprotkb:Q6GYP5|uniprotkb:Q6PHQ5|uniprotkb:Q8K0N4|uniprotkb:Q99PR4	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:rent1_mouse(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)|uniprotkb:Rent1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030831|imex:IM-21805-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000058301(gene)|ensembl:ENSMUST00000075666(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q9EPU0|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0042162"(telomeric DNA binding)|refseq:XP_006509667.1|refseq:XP_006509668.1|refseq:NP_001116301.1|refseq:NP_109605.2|dip:DIP-60114N	-	-	-	figure legend:4|comment:Binding of Yb1 and UPF1 was dependent on mRNA presence, as evidenced by its disruption upon RNAse treatment. Binding of ZNF521 was unaffected by the treatment.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2014/10/16	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:rwd4XXdf5Uqjtgao/zILckKP8AM10090	intact-crc:7043836288D32090|rigid:+jERkPXWNjWVRA+zlOqHt8Balu8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CJG0	uniprotkb:Q6KAS7	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-9030836|uniprotkb:Q8BIF5|uniprotkb:Q8BV21|uniprotkb:Q8CIQ2|uniprotkb:Q8VDS6|ensembl:ENSMUSP00000025288|ensembl:ENSMUSP00000157321	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:zn521_mouse(display_long)|uniprotkb:Znf521(gene name)|psi-mi:Znf521(display_short)|uniprotkb:Evi3(gene name synonym)|uniprotkb:Zfp521(gene name synonym)|uniprotkb:Ecotropic viral integration site 3 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030831|imex:IM-21805-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_663467.1|ensembl:ENSMUSG00000024420(gene)|ensembl:ENSMUST00000025288(transcript)|ensembl:ENSMUST00000234410(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	figure legend:4|comment:Binding of Yb1 and UPF1 was dependent on mRNA presence, as evidenced by its disruption upon RNAse treatment. Binding of ZNF521 was unaffected by the treatment.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2014/10/16	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:LpLAA6DHGSfeGhVR5qYng3CFgZw10090	intact-crc:7043836288D32090|rigid:+jERkPXWNjWVRA+zlOqHt8Balu8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CJG0	uniprotkb:P62960	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-529779|uniprotkb:P22568|uniprotkb:P27817|uniprotkb:P43482|ensembl:ENSMUSP00000078589	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:ybox1_mouse(display_long)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Ybx1(gene name)|psi-mi:Ybx1(display_short)|uniprotkb:Msy1(gene name synonym)|uniprotkb:Msy-1(gene name synonym)|uniprotkb:Yb1(gene name synonym)|uniprotkb:Nsep1(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030960|imex:IM-21805-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	refseq:NP_035862.2|dip:DIP-34256N|ensembl:ENSMUSG00000028639(gene)|ensembl:ENSMUST00000079644(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P62960|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-9017802|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:4|comment:This interaction is disrupted upon lysate treatment with RNAse, so it is dependent on the presence of mRNA.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2014/10/16	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:imkViHICtFj/0wQ8IDprza1b43010090	intact-crc:7083DE2BBA297D07|rigid:XmIxPetCD1yRQx2uVbEWar8hZw8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CJG0	uniprotkb:Q9EPU0	intact:EBI-528299|uniprotkb:A1A563|uniprotkb:Q4VAB3|uniprotkb:Q571J6|ensembl:ENSMUSP00000042207	intact:EBI-6876715|ensembl:ENSMUSP00000075089|uniprotkb:Q3UG00|uniprotkb:Q6GYP5|uniprotkb:Q6PHQ5|uniprotkb:Q8K0N4|uniprotkb:Q99PR4	psi-mi:ago2_mouse(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Kiaa4215(gene name synonym)|uniprotkb:Piwi/argonaute family protein meIF2C2(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:rent1_mouse(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)|uniprotkb:Rent1(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frohn et al. (2012)	pubmed:22918229|imex:IM-21805	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9030960|imex:IM-21805-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694818.3|ensembl:ENSMUSG00000036698(gene)|ensembl:ENSMUST00000044113(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q8CJG0|reactome:R-MMU-203927|reactome:R-MMU-426486|reactome:R-MMU-426496|reactome:R-MMU-5578749|dip:DIP-35014N	ensembl:ENSMUSG00000058301(gene)|ensembl:ENSMUST00000075666(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q9EPU0|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0042162"(telomeric DNA binding)|refseq:XP_006509667.1|refseq:XP_006509668.1|refseq:NP_001116301.1|refseq:NP_109605.2|dip:DIP-60114N	-	-	-	figure legend:4|comment:This interaction is disrupted upon lysate treatment with RNAse, so it is dependent on the presence of mRNA.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/12/10	2014/10/16	rogid:1waGxV2TyNC9zsGyfTKHjUd1ENo10090	rogid:rwd4XXdf5Uqjtgao/zILckKP8AM10090	intact-crc:7083DE2BBA297D07|rigid:XmIxPetCD1yRQx2uVbEWar8hZw8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)