#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62151	uniprotkb:P63158	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-6665811|ensembl:ENSMUSP00000082682|ensembl:ENSMUSP00000106131|ensembl:ENSMUSP00000106132|uniprotkb:P07155|uniprotkb:P27109|uniprotkb:P27428	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:hmgb1_mouse(display_long)|uniprotkb:Hmgb1(gene name)|psi-mi:Hmgb1(display_short)|uniprotkb:Hmg-1(gene name synonym)|uniprotkb:Hmg1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chiba et al. (2012)	pubmed:22842346|imex:IM-21400	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6665080|imex:IM-21400-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_001300823.1|ensembl:ENSMUSG00000066551(gene)|ensembl:ENSMUST00000085546(transcript)|ensembl:ENSMUST00000093196(transcript)|ensembl:ENSMUST00000110505(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000401"(open form four-way junction DNA binding)|go:"GO:0000402"(crossed form four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003681"(bent DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006284"(base-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008201"(heparin binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0005576"(extracellular region)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|interpro:IPR036910|mint:P63158|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|reactome:R-MMU-140342|reactome:R-MMU-445989|reactome:R-MMU-5620971|reactome:R-MMU-5686938|reactome:R-MMU-6798695|reactome:R-MMU-933542|reactome:R-MMU-879415|refseq:NP_034569.1|refseq:XP_003945388.1	-	-	-	figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/07	2016/03/16	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:Ujrs2BBefbmNxZj+S9H8lhWjnNc10090	intact-crc:232E4382588D42F7|rigid:xf660dtSFCjxh6lGYKqzQO4UMQQ	false	fc-igg tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P63158	uniprotkb:Q8VIM0	intact:EBI-6665811|ensembl:ENSMUSP00000082682|ensembl:ENSMUSP00000106131|ensembl:ENSMUSP00000106132|uniprotkb:P07155|uniprotkb:P27109|uniprotkb:P27428	intact:EBI-6665112|ensembl:ENSMUSP00000020668	psi-mi:hmgb1_mouse(display_long)|uniprotkb:Hmgb1(gene name)|psi-mi:Hmgb1(display_short)|uniprotkb:Hmg-1(gene name synonym)|uniprotkb:Hmg1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chiba et al. (2012)	pubmed:22842346|imex:IM-21400	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6665130|imex:IM-21400-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300823.1|ensembl:ENSMUSG00000066551(gene)|ensembl:ENSMUST00000085546(transcript)|ensembl:ENSMUST00000093196(transcript)|ensembl:ENSMUST00000110505(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000401"(open form four-way junction DNA binding)|go:"GO:0000402"(crossed form four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003681"(bent DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006284"(base-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008201"(heparin binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0005576"(extracellular region)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|interpro:IPR036910|mint:P63158|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|reactome:R-MMU-140342|reactome:R-MMU-445989|reactome:R-MMU-5620971|reactome:R-MMU-5686938|reactome:R-MMU-6798695|reactome:R-MMU-933542|reactome:R-MMU-879415|refseq:NP_034569.1|refseq:XP_003945388.1	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	-	-	-	figure legend:Fig. 6A, 6B, 6D, S5A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/07	2014/10/16	rogid:Ujrs2BBefbmNxZj+S9H8lhWjnNc10090	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	intact-crc:260A0B9293FF994B|rigid:2hzNcpvdjLEl5fOCxxFUAIZSxxs	false	mutation decreasing interaction:62-62|biotin tag:?-?	fc-igg tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8VIM0	uniprotkb:P63158	intact:EBI-6665112|ensembl:ENSMUSP00000020668	intact:EBI-6665811|ensembl:ENSMUSP00000082682|ensembl:ENSMUSP00000106131|ensembl:ENSMUSP00000106132|uniprotkb:P07155|uniprotkb:P27109|uniprotkb:P27428	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:hmgb1_mouse(display_long)|uniprotkb:Hmgb1(gene name)|psi-mi:Hmgb1(display_short)|uniprotkb:Hmg-1(gene name synonym)|uniprotkb:Hmg1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chiba et al. (2012)	pubmed:22842346|imex:IM-21400	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6666580|imex:IM-21400-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	refseq:NP_001300823.1|ensembl:ENSMUSG00000066551(gene)|ensembl:ENSMUST00000085546(transcript)|ensembl:ENSMUST00000093196(transcript)|ensembl:ENSMUST00000110505(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000401"(open form four-way junction DNA binding)|go:"GO:0000402"(crossed form four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003681"(bent DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006284"(base-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008201"(heparin binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0005576"(extracellular region)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|interpro:IPR036910|mint:P63158|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|reactome:R-MMU-140342|reactome:R-MMU-445989|reactome:R-MMU-5620971|reactome:R-MMU-5686938|reactome:R-MMU-6798695|reactome:R-MMU-933542|reactome:R-MMU-879415|refseq:NP_034569.1|refseq:XP_003945388.1	-	-	-	figure legend:Fig. S5D.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/07	2014/10/16	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rogid:Ujrs2BBefbmNxZj+S9H8lhWjnNc10090	intact-crc:B9424E847D8446B6|rigid:2hzNcpvdjLEl5fOCxxFUAIZSxxs	false	biotin tag:?-?|fc-igg tag:?-?	necessary binding region:1..1-84..84	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P63158	uniprotkb:Q8VIM0	intact:EBI-6665811|ensembl:ENSMUSP00000082682|ensembl:ENSMUSP00000106131|ensembl:ENSMUSP00000106132|uniprotkb:P07155|uniprotkb:P27109|uniprotkb:P27428	intact:EBI-6665112|ensembl:ENSMUSP00000020668	psi-mi:hmgb1_mouse(display_long)|uniprotkb:Hmgb1(gene name)|psi-mi:Hmgb1(display_short)|uniprotkb:Hmg-1(gene name synonym)|uniprotkb:Hmg1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Chiba et al. (2012)	pubmed:22842346|imex:IM-21400	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6666598|imex:IM-21400-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300823.1|ensembl:ENSMUSG00000066551(gene)|ensembl:ENSMUST00000085546(transcript)|ensembl:ENSMUST00000093196(transcript)|ensembl:ENSMUST00000110505(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000401"(open form four-way junction DNA binding)|go:"GO:0000402"(crossed form four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003681"(bent DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006284"(base-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008201"(heparin binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0005576"(extracellular region)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|interpro:IPR036910|mint:P63158|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|reactome:R-MMU-140342|reactome:R-MMU-445989|reactome:R-MMU-5620971|reactome:R-MMU-5686938|reactome:R-MMU-6798695|reactome:R-MMU-933542|reactome:R-MMU-879415|refseq:NP_034569.1|refseq:XP_003945388.1	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	go:"GO:0005768"(endosome)	-	-	figure legend:Fig. 6E, 7D|comment:EEA1 used as an endosomal marker|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmdc)|taxid:10090(Mus musculus bone marrow-derived dendritic cells)	-	2013/05/07	2014/10/16	rogid:Ujrs2BBefbmNxZj+S9H8lhWjnNc10090	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	intact-crc:BA5FB5B57429D2A5|rigid:2hzNcpvdjLEl5fOCxxFUAIZSxxs	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P63158	uniprotkb:Q8VIM0	intact:EBI-6665811|ensembl:ENSMUSP00000082682|ensembl:ENSMUSP00000106131|ensembl:ENSMUSP00000106132|uniprotkb:P07155|uniprotkb:P27109|uniprotkb:P27428	intact:EBI-6665112|ensembl:ENSMUSP00000020668	psi-mi:hmgb1_mouse(display_long)|uniprotkb:Hmgb1(gene name)|psi-mi:Hmgb1(display_short)|uniprotkb:Hmg-1(gene name synonym)|uniprotkb:Hmg1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chiba et al. (2012)	pubmed:22842346|imex:IM-21400	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6666612|imex:IM-21400-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300823.1|ensembl:ENSMUSG00000066551(gene)|ensembl:ENSMUST00000085546(transcript)|ensembl:ENSMUST00000093196(transcript)|ensembl:ENSMUST00000110505(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000401"(open form four-way junction DNA binding)|go:"GO:0000402"(crossed form four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003681"(bent DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006284"(base-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008201"(heparin binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0005576"(extracellular region)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|interpro:IPR036910|mint:P63158|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|reactome:R-MMU-140342|reactome:R-MMU-445989|reactome:R-MMU-5620971|reactome:R-MMU-5686938|reactome:R-MMU-6798695|reactome:R-MMU-933542|reactome:R-MMU-879415|refseq:NP_034569.1|refseq:XP_003945388.1	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	-	-	-	figure legend:Fig. 6F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/05/07	2014/10/16	rogid:Ujrs2BBefbmNxZj+S9H8lhWjnNc10090	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	intact-crc:23C784EC749E0E24|rigid:2hzNcpvdjLEl5fOCxxFUAIZSxxs	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)