#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:74858"	uniprotkb:P49768-PRO_0000025591	intact:EBI-6899434	intact:EBI-2606326	psi-mi:gcb(display_short)|psi-mi:"CHEBI:74858"(display_long)	psi-mi:p49768-pro_0000025591(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:"MI:0096"(pull down)	Teranishi et al. (2012)	imex:IM-20964|pubmed:22771797	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6899599|imex:IM-20964-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-297277(chain-parent)	go:"GO:0005792"(obsolete microsome)	-	chain-seq-start:1|chain-seq-end:298	figure legend:1B|antagonist:L-685,458 -a gamma secretase inhibitor|comment:The N-terminal domain of Presenilin-1 is identified by a combination of molecular weight and western blot.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain-cortex)|taxid:9606(Homo sapiens brain cortex)	-	2013/07/23	2014/10/16	-	rogid:LkOs+b4Ke5mtyCo4IXRVHUf25/M9606	intact-crc:370222D5094738B3	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:74858"	uniprotkb:Q92542	intact:EBI-6899434	intact:EBI-998440|uniprotkb:Q86VV5|uniprotkb:Q5T207|ensembl:ENSP00000294785|uniprotkb:Q5T208	psi-mi:gcb(display_short)|psi-mi:"CHEBI:74858"(display_long)	psi-mi:nica_human(display_long)|uniprotkb:NCSTN(gene name)|psi-mi:NCSTN(display_short)|uniprotkb:KIAA0253(gene name synonym)|uniprotkb:UNQ1874/PRO4317(orf name)	psi-mi:"MI:0096"(pull down)	Teranishi et al. (2012)	imex:IM-20964|pubmed:22771797	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6899599|imex:IM-20964-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|rcsb pdb:6LQG|reactome:R-HSA-977225|ensembl:ENSG00000162736(gene)|ensembl:ENST00000294785(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|mint:Q92542|rcsb pdb:2N7Q|rcsb pdb:2N7R|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|refseq:NP_056146.1|refseq:NP_001277113.1|refseq:NP_001277115.1|dip:DIP-36336N	go:"GO:0005792"(obsolete microsome)	-	-	figure legend:1B|antagonist:L-685,458 -a gamma secretase inhibitor|comment:The N-terminal domain of Presenilin-1 is identified by a combination of molecular weight and western blot.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain-cortex)|taxid:9606(Homo sapiens brain cortex)	-	2013/07/23	2014/10/16	-	rogid:Lf6xGDVDkOQXMUuG3Yn0tayAjF89606	intact-crc:370222D5094738B3	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:74858"	uniprotkb:O94905	intact:EBI-6899434	intact:EBI-4400770|uniprotkb:A0JLQ1|uniprotkb:A8K5S9|uniprotkb:B4DM38|uniprotkb:D3DSW0|uniprotkb:Q6NW21|uniprotkb:Q86VS6|uniprotkb:Q86W49|ensembl:ENSP00000428112	psi-mi:gcb(display_short)|psi-mi:"CHEBI:74858"(display_long)	psi-mi:erln2_human(display_long)|uniprotkb:ERLIN2(gene name)|psi-mi:ERLIN2(display_short)|uniprotkb:C8orf2(gene name synonym)|uniprotkb:SPFH2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)|uniprotkb:UNQ2441/PRO5003/PRO9924(orf name)	psi-mi:"MI:0096"(pull down)	Teranishi et al. (2012)	imex:IM-20964|pubmed:22771797	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6899599|imex:IM-20964-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001003790.1|refseq:NP_001003791.1|refseq:NP_009106.1|refseq:XP_016868489.1|refseq:XP_005273449.1|ensembl:ENSG00000147475(gene)|ensembl:ENST00000519638(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O94905|reactome:R-HSA-382556|reactome:R-HSA-5655302|reactome:R-HSA-5678895|reactome:R-HSA-8853336	go:"GO:0005792"(obsolete microsome)	-	-	figure legend:1B|antagonist:L-685,458 -a gamma secretase inhibitor|comment:The N-terminal domain of Presenilin-1 is identified by a combination of molecular weight and western blot.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain-cortex)|taxid:9606(Homo sapiens brain cortex)	-	2013/07/23	2014/10/16	-	rogid:Evjg3G0FFeQ499BNlJxpK6t8to89606	intact-crc:370222D5094738B3	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:B5DEH2	uniprotkb:P97887-PRO_0000025600	intact:EBI-6899638|ensembl:ENSRNOP00000018973	intact:EBI-2606447	psi-mi:erln2_rat(display_long)|uniprotkb:Erlin2(gene name)|psi-mi:Erlin2(display_short)|uniprotkb:Spfh2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)	psi-mi:p97887-pro_0000025600(display_long)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Psnl1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Teranishi et al. (2012)	imex:IM-20964|pubmed:22771797	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900028|imex:IM-20964-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008769545.1|refseq:XP_008769546.1|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:B5DEH2|reactome:R-RNO-382556|ensembl:ENSRNOG00000013763(gene)|ensembl:ENSRNOT00000018973(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|refseq:NP_001099558.1|rgd:1309010	intact:EBI-2878956(chain-parent)	go:"GO:0045121"(membrane raft)|go:"GO:0005792"(obsolete microsome)	-	chain-seq-start:299|chain-seq-end:468	figure legend:1D/E|comment:There was a higher degree of interaction between erlin-2 and gamma-secretase in DRMs.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2013/07/23	2014/10/16	rogid:kM+VJSUenZBMGic+n66k8LHXWdo10116	rogid:EprRK8FVKmA6/nJupLX6InAf0jc10116	intact-crc:570C80088E95D340|rigid:G5Rde5bzLzTTfGdFdooM2D/IysU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:B5DEH2	uniprotkb:Q8CGU6	intact:EBI-6899638|ensembl:ENSRNOP00000018973	intact:EBI-919483|uniprotkb:Q8CH12|ensembl:ENSRNOP00000008150	psi-mi:erln2_rat(display_long)|uniprotkb:Erlin2(gene name)|psi-mi:Erlin2(display_short)|uniprotkb:Spfh2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)	psi-mi:nica_rat(display_long)|uniprotkb:Ncstn(gene name)|psi-mi:Ncstn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Teranishi et al. (2012)	imex:IM-20964|pubmed:22771797	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900028|imex:IM-20964-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008769545.1|refseq:XP_008769546.1|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:B5DEH2|reactome:R-RNO-382556|ensembl:ENSRNOG00000013763(gene)|ensembl:ENSRNOT00000018973(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|refseq:NP_001099558.1|rgd:1309010	rgd:631418|refseq:NP_777353.1|refseq:XP_008767955.1|ensembl:ENSRNOG00000005355(gene)|ensembl:ENSRNOT00000008150(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0045202"(synapse)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0070997"(neuron death)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|reactome:R-RNO-1251985|reactome:R-RNO-193692|reactome:R-RNO-205043|reactome:R-RNO-3928665|reactome:R-RNO-6798695|reactome:R-RNO-9013507|reactome:R-RNO-9017802	go:"GO:0045121"(membrane raft)|go:"GO:0005792"(obsolete microsome)	-	-	figure legend:1D/E|comment:There was a higher degree of interaction between erlin-2 and gamma-secretase in DRMs.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2013/07/23	2014/10/16	rogid:kM+VJSUenZBMGic+n66k8LHXWdo10116	rogid:i7mLB/dG+pTidsJNUywhbvAzjDs10116	intact-crc:570C80088E95D340|rigid:G5Rde5bzLzTTfGdFdooM2D/IysU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:74858"	uniprotkb:Q8CGU6	intact:EBI-6899434	intact:EBI-919483|uniprotkb:Q8CH12|ensembl:ENSRNOP00000008150	psi-mi:gcb(display_short)|psi-mi:"CHEBI:74858"(display_long)	psi-mi:nica_rat(display_long)|uniprotkb:Ncstn(gene name)|psi-mi:Ncstn(display_short)	psi-mi:"MI:0096"(pull down)	Teranishi et al. (2012)	imex:IM-20964|pubmed:22771797	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6899628|imex:IM-20964-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rgd:631418|refseq:NP_777353.1|refseq:XP_008767955.1|ensembl:ENSRNOG00000005355(gene)|ensembl:ENSRNOT00000008150(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0045202"(synapse)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0070997"(neuron death)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|reactome:R-RNO-1251985|reactome:R-RNO-193692|reactome:R-RNO-205043|reactome:R-RNO-3928665|reactome:R-RNO-6798695|reactome:R-RNO-9013507|reactome:R-RNO-9017802	go:"GO:0045121"(membrane raft)|go:"GO:0005792"(obsolete microsome)	-	-	figure legend:1B/C|antagonist:L-685,458 -a gamma secretase inhibitor|comment:The N-terminal domain of Presenilin-1 was identified by a combination of molecular weight and western blot.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2013/07/23	2014/10/16	-	rogid:i7mLB/dG+pTidsJNUywhbvAzjDs10116	intact-crc:41561110F3345C3C	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:74858"	uniprotkb:P97887-PRO_0000025599	intact:EBI-6899434	intact:EBI-2606464	psi-mi:gcb(display_short)|psi-mi:"CHEBI:74858"(display_long)	psi-mi:p97887-pro_0000025599(display_long)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Psnl1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:"MI:0096"(pull down)	Teranishi et al. (2012)	imex:IM-20964|pubmed:22771797	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6899628|imex:IM-20964-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-2878956(chain-parent)	go:"GO:0045121"(membrane raft)|go:"GO:0005792"(obsolete microsome)	-	chain-seq-start:1|chain-seq-end:298	figure legend:1B/C|antagonist:L-685,458 -a gamma secretase inhibitor|comment:The N-terminal domain of Presenilin-1 was identified by a combination of molecular weight and western blot.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2013/07/23	2014/10/16	-	rogid:S8wSdbFAa+PNwz9XFt3qf34BN4810116	intact-crc:41561110F3345C3C	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:74858"	uniprotkb:B5DEH2	intact:EBI-6899434	intact:EBI-6899638|ensembl:ENSRNOP00000018973	psi-mi:gcb(display_short)|psi-mi:"CHEBI:74858"(display_long)	psi-mi:erln2_rat(display_long)|uniprotkb:Erlin2(gene name)|psi-mi:Erlin2(display_short)|uniprotkb:Spfh2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Teranishi et al. (2012)	imex:IM-20964|pubmed:22771797	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6899628|imex:IM-20964-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_008769545.1|refseq:XP_008769546.1|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:B5DEH2|reactome:R-RNO-382556|ensembl:ENSRNOG00000013763(gene)|ensembl:ENSRNOT00000018973(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|refseq:NP_001099558.1|rgd:1309010	go:"GO:0045121"(membrane raft)|go:"GO:0005792"(obsolete microsome)	-	-	figure legend:1B/C|antagonist:L-685,458 -a gamma secretase inhibitor|comment:The N-terminal domain of Presenilin-1 was identified by a combination of molecular weight and western blot.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2013/07/23	2014/10/16	-	rogid:kM+VJSUenZBMGic+n66k8LHXWdo10116	intact-crc:41561110F3345C3C	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8BFZ9	uniprotkb:P49769	intact:EBI-1635049|uniprotkb:Q8BML8|ensembl:ENSMUSP00000033873	intact:EBI-990067|uniprotkb:Q91WK6|uniprotkb:Q9JLP9|ensembl:ENSMUSP00000048363|ensembl:ENSMUSP00000098786	psi-mi:erln2_mouse(display_long)|uniprotkb:Erlin2(gene name)|psi-mi:Erlin2(display_short)|uniprotkb:Spfh2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)	psi-mi:psn1_mouse(display_long)|uniprotkb:Protein S182(gene name synonym)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Ad3h(gene name synonym)|uniprotkb:Psnl1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Teranishi et al. (2012)	imex:IM-20964|pubmed:22771797	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900321|imex:IM-20964-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_705820.1|refseq:XP_006509179.1|refseq:XP_006509180.1|ensembl:ENSMUSG00000031483(gene)|ensembl:ENSMUST00000033873(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:Q8BFZ9|reactome:R-MMU-382556	go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49769|reactome:R-MMU-1251985|reactome:R-MMU-193692|reactome:R-MMU-205043|reactome:R-MMU-3928665|reactome:R-MMU-6798695|reactome:R-MMU-9013507|reactome:R-MMU-9017802|ensembl:ENSMUSG00000019969(gene)|ensembl:ENSMUST00000041806(transcript)|ensembl:ENSMUST00000101225(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010467"(gene expression)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0015031"(protein transport)|go:"GO:0015871"(choline transport)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030900"(forebrain development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040011"(locomotion)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0016485"(protein processing)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051604"(protein maturation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:0048143"(astrocyte activation)|refseq:NP_032969.1|refseq:XP_006515668.1|dip:DIP-36237N	-	-	-	figure legend:2A|comment:weak interaction - BD8 cells are deficient in PS1 and 2.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bd8)|taxid:10090(Mouse BD8 cell line - Blastocyst derived ES cells lacking PS1 +2)	-	2013/07/23	2014/10/16	rogid:/OxFugzl4zprvnZbqOGcXmUe3ao10090	rogid:o/Am8u42WLTycj02WRXHancU9Ek10090	intact-crc:CF769BC81A6ACA6E|rigid:2W0CUzJSC3uIUZLEDlB2BDVzmQI	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8BFZ9	uniprotkb:P49769	intact:EBI-1635049|uniprotkb:Q8BML8|ensembl:ENSMUSP00000033873	intact:EBI-990067|uniprotkb:Q91WK6|uniprotkb:Q9JLP9|ensembl:ENSMUSP00000048363|ensembl:ENSMUSP00000098786	psi-mi:erln2_mouse(display_long)|uniprotkb:Erlin2(gene name)|psi-mi:Erlin2(display_short)|uniprotkb:Spfh2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)	psi-mi:psn1_mouse(display_long)|uniprotkb:Protein S182(gene name synonym)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Ad3h(gene name synonym)|uniprotkb:Psnl1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Teranishi et al. (2012)	imex:IM-20964|pubmed:22771797	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900418|imex:IM-20964-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_705820.1|refseq:XP_006509179.1|refseq:XP_006509180.1|ensembl:ENSMUSG00000031483(gene)|ensembl:ENSMUST00000033873(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:Q8BFZ9|reactome:R-MMU-382556	go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49769|reactome:R-MMU-1251985|reactome:R-MMU-193692|reactome:R-MMU-205043|reactome:R-MMU-3928665|reactome:R-MMU-6798695|reactome:R-MMU-9013507|reactome:R-MMU-9017802|ensembl:ENSMUSG00000019969(gene)|ensembl:ENSMUST00000041806(transcript)|ensembl:ENSMUST00000101225(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010467"(gene expression)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0015031"(protein transport)|go:"GO:0015871"(choline transport)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030900"(forebrain development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040011"(locomotion)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0016485"(protein processing)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051604"(protein maturation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:0048143"(astrocyte activation)|refseq:NP_032969.1|refseq:XP_006515668.1|dip:DIP-36237N	-	-	-	figure legend:2C|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bd3)|taxid:10090(Mouse BD3 ES cell line- deficient in PS2)	-	2013/07/23	2014/10/16	rogid:/OxFugzl4zprvnZbqOGcXmUe3ao10090	rogid:o/Am8u42WLTycj02WRXHancU9Ek10090	intact-crc:5EAD9AA018F9278F|rigid:2W0CUzJSC3uIUZLEDlB2BDVzmQI	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:74858"	uniprotkb:Q8BFZ9	intact:EBI-6899434	intact:EBI-1635049|uniprotkb:Q8BML8|ensembl:ENSMUSP00000033873	psi-mi:gcb(display_short)|psi-mi:"CHEBI:74858"(display_long)	psi-mi:erln2_mouse(display_long)|uniprotkb:Erlin2(gene name)|psi-mi:Erlin2(display_short)|uniprotkb:Spfh2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Teranishi et al. (2012)	imex:IM-20964|pubmed:22771797	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900478|imex:IM-20964-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_705820.1|refseq:XP_006509179.1|refseq:XP_006509180.1|ensembl:ENSMUSG00000031483(gene)|ensembl:ENSMUST00000033873(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:Q8BFZ9|reactome:R-MMU-382556	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:2 E-G|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuron)|taxid:10090(Mus musculus neuronal cell)	-	2013/07/23	2014/10/16	-	rogid:/OxFugzl4zprvnZbqOGcXmUe3ao10090	intact-crc:468AD2B43836F35C	false	biotin tag:?-?	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)