#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15873	uniprotkb:P12954	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:"MI:0071"(molecular sieving)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8753452|imex:IM-26728-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	-	crc64:9B56C5851621DDDC	crc64:AE8061B114C32120	figure legend:Suppl. Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2019/02/01	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	intact-crc:CA2B2F4E4F6D6706|rigid:+gwMbZTtwhthQ/g+IuKH4+Jh1ys	false	-	sufficient binding region:1107-1174	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q12306	uniprotkb:P12954	intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name)	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:"MI:0071"(molecular sieving)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8753458|imex:IM-26728-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	-	crc64:A2790DE7F315E1A7	crc64:AE8061B114C32120	figure legend:Suppl. Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2019/02/01	rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	intact-crc:4EF99D8CDAE322E4|rigid:TwjsZZkla1C4KDDdZ1XzXFDp9u0	false	mutation:19-19|sufficient binding region:19-98(IPR000626)	sufficient binding region:1107-1174	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P15873	uniprotkb:P15873	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:"MI:0071"(molecular sieving)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9029949|imex:IM-26728-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	-	crc64:9B56C5851621DDDC	crc64:9B56C5851621DDDC	figure legend:Suppl. Fig. 7a|inhibition:"N-ethylmaleimide (NEM) chemically modifies PCNA on Cys22 and Cys81, causing it to run on gel filtration at an apparent size 3 times smaller than the PCNA trimer."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	intact-crc:011F19CF048F96CE|rigid:Q/z9Dw33yu0Eq39tjXzyZl31oG0	false	-	-	3	0	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P12954	uniprotkb:P15873	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:"MI:0071"(molecular sieving)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9029954|imex:IM-26728-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	-	crc64:AE8061B114C32120	crc64:9B56C5851621DDDC	figure legend:Suppl. Fig. 7b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2014/10/16	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	intact-crc:7E0CE461E9F11B22|rigid:+gwMbZTtwhthQ/g+IuKH4+Jh1ys	false	sufficient binding region:1107-1174	mutation:127-127|sumoylated lysine:164-164	3	3	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P15873	uniprotkb:P12954	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:"MI:0071"(molecular sieving)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9029961|imex:IM-26728-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	-	crc64:9B56C5851621DDDC	crc64:AE8061B114C32120	figure legend:Suppl. Fig. 7b|comment:"N-ethylmaleimide (NEM) chemically modifies PCNA on Cys22 and Cys81, causing it to run on gel filtration at an apparent size 3 times smaller than the PCNA trimer."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	intact-crc:89BA844C8E03B8DC|rigid:+gwMbZTtwhthQ/g+IuKH4+Jh1ys	false	sumoylated lysine:164-164|mutation:127-127	sufficient binding region:1107-1174	1	1	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q12306	uniprotkb:P15873	intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name)	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8754288|wwpdb:3V60|imex:IM-26728-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	-	crc64:A2790DE7F315E1A7	crc64:9B56C5851621DDDC	figure legend:Suppl. Table 2|3d-r-factors:working 21.0%, free 24.9%|3d-resolution:2.60A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2014/10/16	rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	intact-crc:68F3D6F6F79FF9FD|rigid:zbH/LUhSAT0GIR2xfFt5DQ+OOnI	false	sufficient binding region:19-98(IPR000626)|mutation:19-19	mutation:127-127	3	3	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15873	uniprotkb:Q12306	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8786326|wwpdb:3V62|imex:IM-26728-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306	-	crc64:9B56C5851621DDDC	crc64:A2790DE7F315E1A7	figure legend:Suppl. Table 2|3d-r-factors:working 21.6%, free 26.1%|3d-resolution:2.90A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292	intact-crc:05DCA9E1CFD3802D|rigid:JzzeO93/aooHXG4RREqLFS3Yi2Y	false	mutation:127-127	sufficient binding region:19-98(IPR000626)|mutation:19-19	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15873	uniprotkb:P12954	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8786326|wwpdb:3V62|imex:IM-26728-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	-	crc64:9B56C5851621DDDC	crc64:AE8061B114C32120	figure legend:Suppl. Table 2|3d-r-factors:working 21.6%, free 26.1%|3d-resolution:2.90A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	intact-crc:05DCA9E1CFD3802D|rigid:JzzeO93/aooHXG4RREqLFS3Yi2Y	false	mutation:127-127	sufficient binding region:1107-1174	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15873	uniprotkb:Q12306	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9084547|wwpdb:3V61|imex:IM-26728-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306	-	crc64:9B56C5851621DDDC	crc64:A2790DE7F315E1A7	figure legend:Suppl. Table 2|3d-resolution:2.80A|3d-r-factors:working 21.4%, free 25.4%|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292	intact-crc:75FF6E68531CE2FB|rigid:zbH/LUhSAT0GIR2xfFt5DQ+OOnI	false	mutation:127-127	sufficient binding region:19-98(IPR000626)|mutation:19-19	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12954	uniprotkb:P15873	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8785759|imex:IM-26728-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	-	crc64:AE8061B114C32120	crc64:9B56C5851621DDDC	figure legend:Fig. 1, Fig. 4a, Fig. 4c, Suppl. Fig. 2 and 3, Suppl. Table 1|kinetics:"A weaker interaction is observed between Srs2 (1107-1174) and the PCNA quadruple (phe125ala_leu126ala_lys127ala_ile128ala) mutant with Kd = (11.4 +/- 2.9) x 10e-6 molar. Shorter Srs2 fragments, 1107-1167 and 1137-1174, bind with Kd = (60 +/- 18) x 10e-9 molar and Kd = (573 +/- 73) x 10e-9 molar, respectively. Mutations in Srs2 (1107-1174) also weaken the interaction: gln1149glu: Kd = (0.51 +/- 0.16) x 10e-6 molar; asp1151ala: Kd = (1.67 +/- 0.45) x 10e-6 molar; ile1152ala: Kd = (10.2 +/- 4.3) x 10e-6 molar; phe1153ala: Kd = (1.48 +/- 0.46) x 10e-6 molar; gln1155glu: Kd = (5.2 +/- 1.3) x 10e-6 molar; leu1156ala: Kd = (12.4 +/- 3.0) x 10e-6 molar; ile1152ala_leu1156ala: Kd = (18.5 +/- 6.7) x 10e-6 molar; gln1149ala_ile1152ala: Kd = (14.4 +/- 3.2) x 10e-6 molar. Similar effects were observed for the shorter Srs2 fragment (1107-1167): ile1152ala: Kd = (8.7 +/- 1.9) x 10e-6 molar; leu1156ala: Kd = (6.4 +/- 1.7) x 10e-6 molar; ile1152ala_leu1156ala: Kd = (10.0 +/- 3.3) x 10e-6 molar. Binding of the PCNA quadruple (phe125ala_leu126ala_lys127ala_ile128ala) mutant was also further reduced by mutations in Srs2 (1107-1174): leu1156ala: Kd = (61 +/- 20) x 10e-6 molar; gln1149ala_ile1152ala: Kd = (53 +/- 17) x 10e-6 molar. The PCNA lys127gly mutant and the PCNA lys164arg mutant interact with Srs2 (1107-1174) with similar affinities with (Kd = (0.169 +/- 0.026) x 10e-6 molar and Kd = (0.138 +/- 0.021) x 10e-6 molar, respectively). Srs2 (1107-1174) binds NEM-treated monomeric PCNA lys127gly mutant with Kd = (1.09 +/- 0.12) x 10e-6 molar."|comment:"Mutation of the Srs2 PIP-like motif or deletion of the SIM lessen interaction whereas mutations in both prevent interaction with SUMO–PCNA (Fig. 4c)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:169.0x10^-9 ~26.0(molar)	2013/09/02	2014/10/16	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	intact-crc:146EF47F9162BAE8|rigid:+gwMbZTtwhthQ/g+IuKH4+Jh1ys	false	mutation decreasing interaction:1149-1149,1152-1152|mutation decreasing interaction:1149-1149|sufficient binding region:1137-1167|mutation decreasing interaction:1151-1151|mutation decreasing interaction:1152-1152|mutation decreasing interaction:1153-1153|mutation decreasing interaction:1155-1155|mutation decreasing interaction:1156-1156|mutation decreasing interaction:1152-1152,1156-1156|bodipy label:n-n	mutation:127-127|mutation decreasing interaction:125-128|mutation:164-164	3	3	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12954	uniprotkb:Q12306	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8785770|imex:IM-26728-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306	-	crc64:AE8061B114C32120	crc64:A2790DE7F315E1A7	figure legend:Fig. 1, Fig. 4c, Suppl. Fig. 2 and 3, Suppl. Table 1|kinetics:"Shorter Srs2 fragments, 1107-1167 and 1137-1174, bind with Kd = (62 +/- 21) x 10e-6 molar and Kd = (3.40 +/- 0.76) x 10e-6 molar, respectively. Mutations in Srs2 (1107-1174) also weaken the interaction: leu1156ala: Kd = (1.09 +/- 0.21) x 10e-6 molar; ile1152ala_leu1156ala: Kd = (1.42 +/- 0.10) x 10e-6 molar; gln1149ala_ile1152ala: Kd = (1.27 +/- 0.17) x 10e-6 molar. Similar effects were observed for the shorter Srs2 fragment (1107-1167): ile1152ala: Kd = (85 +/- 15) x 10e-6 molar; leu1156ala: Kd = (85 +/- 61) x 10e-6 molar; ile1152ala_leu1156ala: Kd = (88 +/- 17) x 10e-6 molar."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:877.0x10^-9 ~59.0(molar)	2013/09/02	2014/10/16	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292	intact-crc:0C777A876EBCE4DB|rigid:TwjsZZkla1C4KDDdZ1XzXFDp9u0	false	mutation decreasing interaction:1152-1152,1156-1156|mutation decreasing interaction:1156-1156|mutation decreasing interaction:1152-1152,1149-1149|mutation decreasing interaction:1152-1152|sufficient binding region:1137-1174|bodipy label:n-n	glutathione s tranferase tag:?-?|mutation:19-19|sufficient binding region:19-98(IPR000626)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15873	uniprotkb:Q12306	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8785795|imex:IM-26728-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306	-	crc64:9B56C5851621DDDC	crc64:A2790DE7F315E1A7	figure legend:Fig. 1, Fig. 4a, Fig. 4c, Suppl. Fig. 2 and 3, Suppl. Table 1|kinetics:"In case of reductively methylated SUMO: Srs2 (1107-1174) interacts with PCNA sumoylated on lys164 (lys127gly mutant) with Kd = (26.3 +/- 3.1) x 10e-9 molar. Srs2 (1107-1174) interacts with PCNA sumoylated on lys127 (lys164arg mutant) with Kd = (25.1 +/- 4.9) x 10e-9 molar. Srs2 (1107-1174) interacts with PCNA quadruple (phe125ala_leu126ala_lys127ala_ile128ala) mutant sumoylated on lys164 (lys127gly mutant) with Kd = (45.7 +/- 9.7) x 10e-9 molar. Shorter Srs2 fragments, 1107-1167 and 1137-1174, bind to PCNA sumoylated on lys164 (lys127gly mutant) with Kd = (89 +/- 13) x 10e-9 molar and Kd = (3.50 +/- 1.0) x 10e-9 molar, respectively. Srs2 (1107-1174) binds to NEM-treated monomeric PCNA sumoylated on lys164 (Kd = (79 +/- 18) x 10e-9 molar) or on lys127 (Kd = (14 +/- 3.9) x 10e-9 molar). The val186ala_met188ala_glu189ala_his190ala mutations in PCNA sumoylated on lys164 have no effect on binding of Srs2 (1107-1174) (Kd = (29.7 +/- 6) x 10e-9 molar). In case of non-reduced SUMO: Srs2 (1107-1174) interacts with PCNA sumoylated on lys164 (lys127gly mutant) with Kd = (11.3 +/- 3.6) x 10e-9 molar."|comment:"Mutation of the Srs2 PIP-like motif or deletion of the SIM lessen interaction whereas mutations in both prevent interaction with SUMO–PCNA (Fig. 4c)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292	intact-crc:54FA4CF72758F697|rigid:JzzeO93/aooHXG4RREqLFS3Yi2Y	false	mutation decreasing interaction:125-128|mutation:127-127|mutation:164-164|mutation:186-186,188-190	mutation:19-19|sufficient binding region:19-98(IPR000626)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15873	uniprotkb:P12954	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8785795|imex:IM-26728-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	-	crc64:9B56C5851621DDDC	crc64:AE8061B114C32120	figure legend:Fig. 1, Fig. 4a, Fig. 4c, Suppl. Fig. 2 and 3, Suppl. Table 1|kinetics:"In case of reductively methylated SUMO: Srs2 (1107-1174) interacts with PCNA sumoylated on lys164 (lys127gly mutant) with Kd = (26.3 +/- 3.1) x 10e-9 molar. Srs2 (1107-1174) interacts with PCNA sumoylated on lys127 (lys164arg mutant) with Kd = (25.1 +/- 4.9) x 10e-9 molar. Srs2 (1107-1174) interacts with PCNA quadruple (phe125ala_leu126ala_lys127ala_ile128ala) mutant sumoylated on lys164 (lys127gly mutant) with Kd = (45.7 +/- 9.7) x 10e-9 molar. Shorter Srs2 fragments, 1107-1167 and 1137-1174, bind to PCNA sumoylated on lys164 (lys127gly mutant) with Kd = (89 +/- 13) x 10e-9 molar and Kd = (3.50 +/- 1.0) x 10e-9 molar, respectively. Srs2 (1107-1174) binds to NEM-treated monomeric PCNA sumoylated on lys164 (Kd = (79 +/- 18) x 10e-9 molar) or on lys127 (Kd = (14 +/- 3.9) x 10e-9 molar). The val186ala_met188ala_glu189ala_his190ala mutations in PCNA sumoylated on lys164 have no effect on binding of Srs2 (1107-1174) (Kd = (29.7 +/- 6) x 10e-9 molar). In case of non-reduced SUMO: Srs2 (1107-1174) interacts with PCNA sumoylated on lys164 (lys127gly mutant) with Kd = (11.3 +/- 3.6) x 10e-9 molar."|comment:"Mutation of the Srs2 PIP-like motif or deletion of the SIM lessen interaction whereas mutations in both prevent interaction with SUMO–PCNA (Fig. 4c)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	intact-crc:54FA4CF72758F697|rigid:JzzeO93/aooHXG4RREqLFS3Yi2Y	false	mutation decreasing interaction:125-128|mutation:127-127|mutation:164-164|mutation:186-186,188-190	mutation decreasing interaction:1151-1151|mutation decreasing interaction:1155-1155|mutation decreasing interaction:1152-1152,1156-1156|sufficient binding region:1107-1174|bodipy label:n-n|mutation decreasing interaction:1152-1152|mutation decreasing interaction:1156-1156|mutation decreasing interaction:1149-1149,1152-1152	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12306	uniprotkb:P12954	intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name)	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8785867|imex:IM-26728-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	-	crc64:A2790DE7F315E1A7	crc64:AE8061B114C32120	figure legend:Suppl. Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:3990.0x10^-9 ~670.0(molar)	2013/09/02	2014/10/16	rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	intact-crc:416EEA892E892F37|rigid:TwjsZZkla1C4KDDdZ1XzXFDp9u0	false	glutathione s tranferase tag:?-?|sufficient binding region:19-98(IPR000626)|mutation:19-19	sufficient binding region:1107-1174|bodipy label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12306	uniprotkb:P12954	intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name)	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8785867|imex:IM-26728-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	-	crc64:A2790DE7F315E1A7	crc64:AE8061B114C32120	figure legend:Suppl. Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:3990.0x10^-9 ~670.0(molar)	2013/09/02	2014/10/16	rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	intact-crc:416EEA892E892F37|rigid:TwjsZZkla1C4KDDdZ1XzXFDp9u0	false	glutathione s tranferase tag:?-?|sufficient binding region:19-98(IPR000626)|mutation:19-19	sufficient binding region:1107-1174	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15873	uniprotkb:P12954	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8785883|imex:IM-26728-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	-	crc64:9B56C5851621DDDC	crc64:AE8061B114C32120	figure legend:Suppl. Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:640.0x10^-9 ~180.0(molar)	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	intact-crc:F71A7802E7619B3B|rigid:+gwMbZTtwhthQ/g+IuKH4+Jh1ys	false	-	sufficient binding region:1107-1174|bodipy label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15873	uniprotkb:P12954	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8785883|imex:IM-26728-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	-	crc64:9B56C5851621DDDC	crc64:AE8061B114C32120	figure legend:Suppl. Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:640.0x10^-9 ~180.0(molar)	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	intact-crc:F71A7802E7619B3B|rigid:+gwMbZTtwhthQ/g+IuKH4+Jh1ys	false	-	sufficient binding region:1107-1174	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15873	uniprotkb:Q12306	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-17490|uniprotkb:D6VTD1|ensemblfungi:YDR510W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:smt3_yeast(display_long)|uniprotkb:SMT3(gene name)|psi-mi:SMT3(display_short)|uniprotkb:D9719.15(orf name)|uniprotkb:YDR510W(locus name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8785906|imex:IM-26728-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_010798.1|sgd:S000002918|ensemblfungi:YDR510W(gene)|ensemblfungi:YDR510W_mRNA(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005940"(septin ring)|go:"GO:0016925"(protein sumoylation)|go:"GO:0031386"(protein tag)|go:"GO:0042802"(identical protein binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|rcsb pdb:1EUV|rcsb pdb:1L2N|rcsb pdb:2EKE|rcsb pdb:3PGE|rcsb pdb:3QHT|rcsb pdb:3TIX|rcsb pdb:3UF8|rcsb pdb:3UQA|rcsb pdb:3UQB|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:3VAW|rcsb pdb:4FN2|rcsb pdb:4G50|rcsb pdb:4GGQ|rcsb pdb:4GIV|rcsb pdb:5D6J|rcsb pdb:5JNE|rcsb pdb:5KLX|rcsb pdb:5V8T|rcsb pdb:5YC2|rcsb pdb:5YCA|rcsb pdb:6CFP|rcsb pdb:6P81|rcsb pdb:6Q2S|rcsb pdb:6RPQ|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:6UKV|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6VEL|rcsb pdb:6VW2|rcsb pdb:7LTO|reactome:R-SCE-3065676|reactome:R-SCE-3065678|reactome:R-SCE-3065679|reactome:R-SCE-3108214|reactome:R-SCE-3108232|reactome:R-SCE-3232118|reactome:R-SCE-3899300|reactome:R-SCE-4085377|reactome:R-SCE-4551638|reactome:R-SCE-4570464|reactome:R-SCE-4615885|reactome:R-SCE-9615933|dip:DIP-1364N|mint:Q12306	-	crc64:9B56C5851621DDDC	crc64:A2790DE7F315E1A7	figure legend:Suppl. Fig. 2, Suppl. Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:101.0x10^-9 ~30.0(molar)	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:oFdVBxN9WlDXTM7oAnv+1vfcXFQ559292	intact-crc:FBA1A523E146748D|rigid:JzzeO93/aooHXG4RREqLFS3Yi2Y	false	mutation:127-127	mutation:19-19|sufficient binding region:19-98(IPR000626)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15873	uniprotkb:P12954	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8785906|imex:IM-26728-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	-	crc64:9B56C5851621DDDC	crc64:AE8061B114C32120	figure legend:Suppl. Fig. 2, Suppl. Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:101.0x10^-9 ~30.0(molar)	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	intact-crc:FBA1A523E146748D|rigid:JzzeO93/aooHXG4RREqLFS3Yi2Y	false	mutation:127-127	bodipy label:n-n|sufficient binding region:1107-1174	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15873	uniprotkb:P12954	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8785906|imex:IM-26728-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954	-	crc64:9B56C5851621DDDC	crc64:AE8061B114C32120	figure legend:Suppl. Fig. 2, Suppl. Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:101.0x10^-9 ~30.0(molar)	2013/09/02	2014/10/16	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292	intact-crc:FBA1A523E146748D|rigid:JzzeO93/aooHXG4RREqLFS3Yi2Y	false	mutation:127-127	sufficient binding region:1107-1174	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43605	uniprotkb:P15873	intact:EBI-22988|uniprotkb:D6VTQ7|ensemblfungi:YFR027W	intact:EBI-12993|uniprotkb:D6VQ89|ensemblfungi:YBR088C	psi-mi:eco1_yeast(display_long)|uniprotkb:ECO1(gene name)|psi-mi:ECO1(display_short)|uniprotkb:CTF7(gene name synonym)|uniprotkb:YFR027W(locus name)|uniprotkb:Establishment of cohesion protein 1(gene name synonym)|uniprotkb:Chromosome transmission fidelity protein 7(gene name synonym)	psi-mi:pcna_yeast(display_long)|uniprotkb:YBR0811(orf name)|uniprotkb:YBR088C(locus name)|uniprotkb:POL30(gene name)|psi-mi:POL30(display_short)	psi-mi:"MI:0096"(pull down)	Armstrong et al. (2012)	pubmed:22382979|imex:IM-26728	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9029782|imex:IM-26728-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116683.1|sgd:S000001923|dip:DIP-5602N|ensemblfungi:YFR027W(gene)|ensemblfungi:YFR027W_mRNA(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0032200"(telomere organization)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034421"(post-translational protein acetylation)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051276"(chromosome organization)|go:"GO:0070058"(tRNA gene clustering)|go:"GO:0140588"(chromatin looping)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR028005|interpro:IPR028009|interpro:IPR033257|reactome:R-SCE-2468052	refseq:NP_009645.1|sgd:S000000292|go:"GO:0043626"(PCNA complex)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:1902394"(positive regulation of exodeoxyribonuclease activity)|go:"GO:1903022"(positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands)|go:"GO:1905779"(positive regulation of exonuclease activity)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|rcsb pdb:1PLQ|rcsb pdb:1PLR|rcsb pdb:1SXJ|rcsb pdb:2OD8|rcsb pdb:3F1W|rcsb pdb:3GPM|rcsb pdb:3GPN|rcsb pdb:3L0W|rcsb pdb:4L6P|rcsb pdb:3L0X|rcsb pdb:3L10|rcsb pdb:4YHR|rcsb pdb:3PGE|rcsb pdb:3V60|rcsb pdb:3V61|rcsb pdb:3V62|rcsb pdb:5JNE|rcsb pdb:4L60|mint:P15873|dip:DIP-2417N|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|ensemblfungi:YBR088C(gene)|ensemblfungi:YBR088C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006348"|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0042802"(identical protein binding)|rcsb pdb:5T9D|rcsb pdb:5V7K|rcsb pdb:5V7M|rcsb pdb:5ZUT|rcsb pdb:6CX2|rcsb pdb:6CX3|rcsb pdb:6CX4|rcsb pdb:6D0Q|rcsb pdb:6D0R|rcsb pdb:6E49|rcsb pdb:6W9W|rcsb pdb:6WAC|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-4615885|reactome:R-SCE-5358565|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-69091|reactome:R-SCE-69166|reactome:R-SCE-69183|reactome:R-SCE-8866654|rcsb pdb:5V7L	-	crc64:0AF1B59BE9E71818	crc64:9B56C5851621DDDC	figure legend:Suppl. Fig. 14|comment:Neither the K164R or the K127G mutations, nor sumoylation of PCNA at K127 or K164 affected this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/02	2019/02/01	rogid:ub4jIV3f8qwGy0N1sEgvQ0/3ezQ559292	rogid:/+XSPV99OBBwBBC/nY0JiHaAeSI559292	intact-crc:17887D59848A4C5E|rigid:oH+tF7zt2bIuCX1i37COZwVTu9o	false	his tag:n-n	mutation decreasing interaction:125-128	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)