#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q80VW5-12	uniprotkb:Q9R0X5-5	intact:EBI-6915655	intact:EBI-6915646	psi-mi:q80vw5-12(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym)|uniprotkb:WhirlinNT1(isoform synonym)	psi-mi:q9r0x5-5(display_long)|uniprotkb:ORF15(isoform synonym)|uniprotkb:Rpgr(gene name)|psi-mi:Rpgr(display_short)	psi-mi:"MI:0018"(two hybrid)	Wright et al. (2012)	imex:IM-18119|pubmed:22323458	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6915645|imex:IM-18119-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7417603(isoform-parent)	intact:EBI-6915619(isoform-parent)	-	isoform-comment:May be due to intron retention.	isoform-comment:No experimental confirmation available.	caution:"The UniProt entry for Q9R0X5 isoform 5 (ORF15) differs in length from that given in the paper."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/08/05	2014/10/16	rogid:SiEw913dFmLEuyIRTMUtGwD9nxA10090	rogid:oVgOhlBYPCnFPSi8+cOA0q/+m+k10090	intact-crc:E629B7338EBDADC2|rigid:fFkxPR1I9DSpHXeOIsOmoO7jTwY	false	-	sufficient binding region:1203..1203-1305..1305	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R0X5-5	uniprotkb:Q80VW5-12	intact:EBI-6915646	intact:EBI-6915655	psi-mi:q9r0x5-5(display_long)|uniprotkb:ORF15(isoform synonym)|uniprotkb:Rpgr(gene name)|psi-mi:Rpgr(display_short)	psi-mi:q80vw5-12(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym)|uniprotkb:WhirlinNT1(isoform synonym)	psi-mi:"MI:0096"(pull down)	Wright et al. (2012)	imex:IM-18119|pubmed:22323458	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6915766|imex:IM-18119-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6915619(isoform-parent)	intact:EBI-7417603(isoform-parent)	-	isoform-comment:No experimental confirmation available.	isoform-comment:May be due to intron retention.	figure legend:Fig 3B|caution:"The UniProt entries for Q9R0X5 isoform 5 (ORF15) and Q80VW5 isoform 12 differ in length from those given in the paper."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/05	2014/10/16	rogid:oVgOhlBYPCnFPSi8+cOA0q/+m+k10090	rogid:SiEw913dFmLEuyIRTMUtGwD9nxA10090	intact-crc:9DBA5452D9F6613A|rigid:fFkxPR1I9DSpHXeOIsOmoO7jTwY	false	sufficient binding region:1241..1241-1305..1305|sufficient binding region:1241..1241-1305..1305	maltose binding protein tag:n-n|sufficient binding region:141-216(IPR001478)|sufficient binding region:270-322..322(IPR001478)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80VW5	uniprotkb:Q9R0X5-5	intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4	intact:EBI-6915646	psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym)	psi-mi:q9r0x5-5(display_long)|uniprotkb:ORF15(isoform synonym)|uniprotkb:Rpgr(gene name)|psi-mi:Rpgr(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Wright et al. (2012)	imex:IM-18119|pubmed:22323458	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9209900|imex:IM-18119-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N	intact:EBI-6915619(isoform-parent)	go:"GO:0032391"(photoreceptor connecting cilium)	function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"	isoform-comment:No experimental confirmation available.	figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2013/08/05	2014/10/16	rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090	rogid:oVgOhlBYPCnFPSi8+cOA0q/+m+k10090	intact-crc:EFA5F9C9C9C84C04|rigid:Lo++lASHIbGF1vAvq7Iv0Uumskw	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q80VW5	uniprotkb:Q9R0X5	intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4	intact:EBI-6915619|uniprotkb:A2ADP3|uniprotkb:G9BBQ2|uniprotkb:O88408|uniprotkb:Q9CU92	psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym)	psi-mi:rpgr_mouse(display_long)|uniprotkb:Rpgr(gene name)|psi-mi:Rpgr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wright et al. (2012)	imex:IM-18119|pubmed:22323458	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9209886|imex:IM-18119-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N	go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042995"(cell projection)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060271"(cilium assembly)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:0120206"(photoreceptor distal connecting cilium)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|refseq:NP_035415.1|dip:DIP-46319N	-	function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"	-	figure legend:Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-retina)|taxid:10090(Mus musculus retina)	-	2013/08/05	2014/10/16	rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090	rogid:d4RHxOTB6/KXJR/KJ8z32NJljsA10090	intact-crc:CFF419704681F448|rigid:QI1+kCL/5vQDpv3/17s8lvoOpiA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)