#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O95786	uniprotkb:P04487	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-6150681	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879592|imex:IM-20938-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	-	-	-	figure legend:4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:7EDB036FAE8EFF5B|rigid:bkHjI6SnGAT0f/yGhpXC6gFDf34	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BYX4	uniprotkb:P04487	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	intact:EBI-6150681	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879589|imex:IM-20938-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	-	-	-	figure legend:4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:E799D46B6A6CDEE0|rigid:ltIu0oxoVHKaXjQTCN/0Z1Lcx4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04487	uniprotkb:Q9BYX4	intact:EBI-6150681	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879645|imex:IM-20938-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	-	-	-	figure legend:5F|comment:Also observed upon RNAse treatment|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	intact-crc:37AB0AF2A40C4E68|rigid:ltIu0oxoVHKaXjQTCN/0Z1Lcx4I	false	enhanced yellow fluorescent protein tag:?-?|sufficient binding region:84-152	sufficient binding region:287-1025|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95786	uniprotkb:P04487	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-6150681	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879564|imex:IM-20938-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	-	-	-	figure legend:4A and C, 5A|comment:Also observed upon RNAse treatment|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:F3E9FDC0845445C6|rigid:bkHjI6SnGAT0f/yGhpXC6gFDf34	false	flag tag:?-?|necessary binding region:218-925	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95786	uniprotkb:P04487	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-6150681	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879627|imex:IM-20938-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	-	-	-	figure legend:5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:32D5E36F038B6444|rigid:bkHjI6SnGAT0f/yGhpXC6gFDf34	false	flag tag:?-?|sufficient binding region:218-925	enhanced yellow fluorescent protein tag:?-?|sufficient binding region:84-152	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P04487	uniprotkb:Q9BYX4	intact:EBI-6150681	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879573|imex:IM-20938-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	-	-	-	figure legend:4B and D, 5C.|comment:Also observed upon RNAse treatment|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	intact-crc:6E576ECB5DBA59BE|rigid:ltIu0oxoVHKaXjQTCN/0Z1Lcx4I	false	ha tag:?-?	flag tag:?-?|necessary binding region:288-1025	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:O95786	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879664|imex:IM-20938-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	-	-	-	figure legend:6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	intact-crc:2D80F647A1EED12C|rigid:gUUJMu56Lb35moxPA008sSn290M	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:P04487	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-6150681	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879664|imex:IM-20938-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	-	-	-	figure legend:6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:2D80F647A1EED12C|rigid:gUUJMu56Lb35moxPA008sSn290M	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:Q9BYX4	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879698|imex:IM-20938-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	-	-	-	figure legend:6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	intact-crc:A2454D5EBC1BB48C|rigid:/KLy92wUwYOHgLzmzLUH1RmNlMU	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:P04487	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-6150681	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879698|imex:IM-20938-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	-	-	-	figure legend:6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:A2454D5EBC1BB48C|rigid:/KLy92wUwYOHgLzmzLUH1RmNlMU	false	myc tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:Q9BYX4	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6894134|imex:IM-20938-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	-	-	-	figure legend:6B and D|comment:Association also observed in cotransfected HEK293T cells that have been infected with HSV-1 mutant strain defective in US11 expression.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	intact-crc:228F44F553E25BE6|rigid:mvrvInV5DTTax/FEAaVdcya/PAQ	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:Q9BYX4	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879687|imex:IM-20938-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	-	-	-	figure legend:6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	intact-crc:0859370AEFA55A97|rigid:/KLy92wUwYOHgLzmzLUH1RmNlMU	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:P04487	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-6150681	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879687|imex:IM-20938-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	-	-	-	figure legend:6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:0859370AEFA55A97|rigid:/KLy92wUwYOHgLzmzLUH1RmNlMU	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:O95786	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879676|imex:IM-20938-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	-	-	-	figure legend:6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	intact-crc:A6DF40B503705BA0|rigid:gUUJMu56Lb35moxPA008sSn290M	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:P04487	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-6150681	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879676|imex:IM-20938-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	-	-	-	figure legend:6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:A6DF40B503705BA0|rigid:gUUJMu56Lb35moxPA008sSn290M	false	myc tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:O95786	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6894125|imex:IM-20938-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	-	-	-	figure legend:6A and C|comment:Association also observed in cotransfected HEK293T cells that have been infected with HSV-1 mutant strain defective in US11 expression.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	intact-crc:4F40DCF47807B423|rigid:obR2EHoHumN9pPBg9pR31HUKako	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95786	uniprotkb:P04487	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-6150681	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879614|imex:IM-20938-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	-	-	-	figure legend:4G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:01D21304F0BBD140|rigid:bkHjI6SnGAT0f/yGhpXC6gFDf34	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04487	uniprotkb:Q9BYX4	intact:EBI-6150681	intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xing et al. (2012)	pubmed:22301138|imex:IM-20938	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6879616|imex:IM-20938-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	-	-	-	figure legend:4H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/07/05	2014/10/16	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606	intact-crc:989B84003459F0FB|rigid:ltIu0oxoVHKaXjQTCN/0Z1Lcx4I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)