#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9V3I2	uniprotkb:Q9VDJ9	intact:EBI-150687|ensemblmetazoa:FBpp0077470|ensemblmetazoa:FBpp0077471|ensemblmetazoa:FBpp0077472|ensemblmetazoa:FBpp0077473|ensemblmetazoa:FBpp0077474|ensemblmetazoa:FBpp0077475|ensemblmetazoa:FBpp0303518|ensemblmetazoa:FBpp0303519|ensemblmetazoa:FBpp0303520	intact:EBI-3404137|ensemblmetazoa:FBpp0111700|uniprotkb:Q0Q7G2	psi-mi:q9v3i2_drome(display_long)|uniprotkb:Rab5(gene name)|psi-mi:Rab5(display_short)|uniprotkb:Drab5(gene name synonym)|uniprotkb:AAF51265(gene name synonym)|uniprotkb:BAA88244(gene name synonym)|uniprotkb:DRab5(gene name synonym)|uniprotkb:Dm Rab5(gene name synonym)|uniprotkb:DmRab5(gene name synonym)|uniprotkb:Dmel\CG3664(gene name synonym)|uniprotkb:RAB5(gene name synonym)|uniprotkb:RAB5a(gene name synonym)|uniprotkb:Rab(gene name synonym)|uniprotkb:Rab-5(gene name synonym)|uniprotkb:dRab5(gene name synonym)|uniprotkb:drab5(gene name synonym)|uniprotkb:"l(2)k08232"(gene name synonym)|uniprotkb:rab5(gene name synonym)|uniprotkb:Dmel_CG3664(orf name)|uniprotkb:CG3664(orf name)	psi-mi:q9vdj9_drome(display_long)|uniprotkb:Lrrk(gene name)|psi-mi:Lrrk(display_short)|uniprotkb:lrrk(gene name synonym)|uniprotkb:Dmel_CG5483(orf name)|uniprotkb:dLRRK2(gene name synonym)|uniprotkb:dLrrk(gene name synonym)|uniprotkb:CG5483(orf name)|uniprotkb:CT17358(gene name synonym)|uniprotkb:Dmel\CG5483(gene name synonym)|uniprotkb:LRRK(gene name synonym)|uniprotkb:LRRK2(gene name synonym)|uniprotkb:dLRRK(gene name synonym)|uniprotkb:Lrrk2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dodson et al. (2012)	imex:IM-18668|pubmed:22171073	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6513659|imex:IM-18668-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523457.1|refseq:NP_722795.1|refseq:NP_722796.1|refseq:NP_722797.1|refseq:NP_722798.1|refseq:NP_722799.1|flybase:FBgn0014010|refseq:NP_001259925.1|refseq:NP_001259926.1|refseq:NP_001259927.1|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035220"(wing disc development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048477"(oogenesis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0048803"(imaginal disc-derived male genitalia morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0061883"(clathrin-dependent endocytosis involved in vitellogenesis)|go:"GO:0098793"(presynapse)|go:"GO:0099532"(synaptic vesicle endosomal processing)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DME-432722|reactome:R-DME-6798695|reactome:R-DME-8854214|reactome:R-DME-8856828|reactome:R-DME-8873719|reactome:R-DME-8876198|reactome:R-DME-983231|go:"GO:0007349"(cellularization)|ensemblmetazoa:FBgn0014010(gene)|ensemblmetazoa:FBtr0077793(transcript)|ensemblmetazoa:FBtr0077794(transcript)|ensemblmetazoa:FBtr0077795(transcript)|ensemblmetazoa:FBtr0077796(transcript)|ensemblmetazoa:FBtr0077797(transcript)|ensemblmetazoa:FBtr0077798(transcript)|ensemblmetazoa:FBtr0330668(transcript)|ensemblmetazoa:FBtr0330669(transcript)|ensemblmetazoa:FBtr0330670(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007298"(border follicle cell migration)	ensemblmetazoa:FBgn0038816(gene)|ensemblmetazoa:FBtr0112788(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0040011"(locomotion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044297"(cell body)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990033"(dendritic branch point)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036770|go:"GO:0050808"(synapse organization)|flybase:FBgn0038816|refseq:NP_001097847.1	-	-	-	figure legend:7A|comment:The G2014S mutation reduces LRRK binding to Rab7 but not Rab5.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/02/14	2014/10/16	rogid:wTcCiL+f9QaG1AiHXhGX8PXHwr47227	rogid:dT7/hjObXsBKNuTaRP/TTseVzUY7227	intact-crc:E0D8E9FFCED31701|rigid:zLddlP69SgD2kdnyQjTbehRmPxM	false	green fluorescent protein tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O76742	uniprotkb:Q9VDJ9	intact:EBI-183175|ensemblmetazoa:FBpp0083891|ensemblmetazoa:FBpp0300835|ensemblmetazoa:FBpp0300836	intact:EBI-3404137|ensemblmetazoa:FBpp0111700|uniprotkb:Q0Q7G2	psi-mi:o76742_drome(display_long)|uniprotkb:Rab7(gene name)|psi-mi:Rab7(display_short)|uniprotkb:rab7(gene name synonym)|uniprotkb:AAF56218(gene name synonym)|uniprotkb:Dmel_CG5915(orf name)|uniprotkb:DRAB7(gene name synonym)|uniprotkb:DRab7(gene name synonym)|uniprotkb:Dm Rab7(gene name synonym)|uniprotkb:DmRab7(gene name synonym)|uniprotkb:Dmel\CG5915(gene name synonym)|uniprotkb:Drab7(gene name synonym)|uniprotkb:O76742(gene name synonym)|uniprotkb:RAB7(gene name synonym)|uniprotkb:Rab-7(gene name synonym)|uniprotkb:Rab-r7(gene name synonym)|uniprotkb:Rab7A(gene name synonym)|uniprotkb:dRab7(gene name synonym)|uniprotkb:drab7(gene name synonym)|uniprotkb:CG5915(orf name)	psi-mi:q9vdj9_drome(display_long)|uniprotkb:Lrrk(gene name)|psi-mi:Lrrk(display_short)|uniprotkb:lrrk(gene name synonym)|uniprotkb:Dmel_CG5483(orf name)|uniprotkb:dLRRK2(gene name synonym)|uniprotkb:dLrrk(gene name synonym)|uniprotkb:CG5483(orf name)|uniprotkb:CT17358(gene name synonym)|uniprotkb:Dmel\CG5483(gene name synonym)|uniprotkb:LRRK(gene name synonym)|uniprotkb:LRRK2(gene name synonym)|uniprotkb:dLRRK(gene name synonym)|uniprotkb:Lrrk2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dodson et al. (2012)	imex:IM-18668|pubmed:22171073	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6513667|imex:IM-18668-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524472.1|flybase:FBgn0015795|refseq:NP_001247276.1|refseq:NP_001247277.1|ensemblmetazoa:FBgn0015795(gene)|ensemblmetazoa:FBtr0084503(transcript)|ensemblmetazoa:FBtr0308611(transcript)|ensemblmetazoa:FBtr0308612(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0061883"(clathrin-dependent endocytosis involved in vitellogenesis)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:O76742|reactome:R-DME-6798695|reactome:R-DME-8854214|reactome:R-DME-8873719|reactome:R-DME-8876198|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013405|reactome:R-DME-9013406|reactome:R-DME-9013407|reactome:R-DME-9035034	ensemblmetazoa:FBgn0038816(gene)|ensemblmetazoa:FBtr0112788(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0040011"(locomotion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044297"(cell body)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990033"(dendritic branch point)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036770|go:"GO:0050808"(synapse organization)|flybase:FBgn0038816|refseq:NP_001097847.1	-	-	-	figure legend:7A-2/B|comment:"The G2014S mutation reduces LRRK binding to Rab7 but not Rab5.  Lrrk-WT shows a markedly stronger binding with the GTP-binding deficient dominant-negative form of Rab7 (T22N) compared with the constitutively active form of Rab7 (Q67L) that is deficient in GTP hydrolysis. Lrrk-GS appears to bind equally well with both mutant forms of Rab7."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/02/14	2014/10/16	rogid:/Ix06yHcSboew5dwj0Qh5lILbt87227	rogid:dT7/hjObXsBKNuTaRP/TTseVzUY7227	intact-crc:B185D785AB8C45FD|rigid:xv6VkNgCQpwpe5SXze0nRfp9O3s	false	green fluorescent protein tag:?-?|mutation increasing interaction:22-22|mutation increasing interaction:67-67	myc tag:c-c|mutation decreasing interaction:1914-1914	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)