#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O88704	uniprotkb:O88704	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766345|imex:IM-21402-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	-	-	figure legend:3a, 3g, 5a, 5b, 5c|agonist:cAMP|comment:Tetramerization is enhanced by treatment with cAMP, but a small amount of HCN1 tetramerizes even without cAMP.  Increasing the salt concentration results in the disappearance of the tetrameric form of the protein.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:3380B0EF7C93160A|rigid:JbaO03YccEPdlGhOaVPuA41Z6As	false	sufficient binding region:390-592(IPR000595)|mutation disrupting interaction:538-538|necessary binding region:390-441..441	necessary binding region:390-441..441|sufficient binding region:390-592(IPR000595)|mutation disrupting interaction:538-538	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UL51	uniprotkb:Q9UL51	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766395|imex:IM-21402-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	-	-	figure legend:3b, 5b, 5c|agonist:cAMP|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:2B6483F1A6407082|rigid:uYWlW2sMNwZYqHp1yX9cdZVxvxE	false	necessary binding region:470-545..545|sufficient binding region:470-672(IPR000595)	necessary binding region:470-545..545|sufficient binding region:470-672(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y3Q4	uniprotkb:Q9Y3Q4	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0071"(molecular sieving)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766404|imex:IM-21402-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	-	-	figure legend:3c, 5b, 5c|agonist:cAMP|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:7946A008B48181AA|rigid:k5Gtz4LjT20jNSIf5ZPS48coujA	false	necessary binding region:521-597..597|sufficient binding region:521-723(IPR000595)	sufficient binding region:521-723(IPR000595)|necessary binding region:521-597..597	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88704	uniprotkb:O88704	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766423|imex:IM-21402-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	-	-	figure legend:3d, suppl. table 3b|agonist:cAMP|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:0E111CFF3EB767B5|rigid:GCQ9SZ+mVWz9KNluBnhpuQDO+KQ	false	sufficient binding region:390-592(IPR000595)	sufficient binding region:390-592(IPR000595)	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y3Q4	uniprotkb:Q9Y3Q4	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0028"(cosedimentation in solution)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766430|imex:IM-21402-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	-	-	figure legend:3f, suppl. table 3b|agonist:cAMP|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:0C8D7C7BC6875214|rigid:E2C1hyV9tum0SU9BpwbE9XC+Nrs	false	sufficient binding region:521-723(IPR000595)	sufficient binding region:521-723(IPR000595)	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UL51	uniprotkb:Q9UL51	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766427|imex:IM-21402-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	-	-	figure legend:3e, suppl. table 3b|agonist:cAMP|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:1E423BF0DF2DC122|rigid:+mb4d56xacjf3e84CBQ4hWVyexw	false	sufficient binding region:470-672(IPR000595)	sufficient binding region:470-672(IPR000595)	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:O88704	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793766|imex:IM-21402-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ec50:5.0x10^-6 ~1.0(molar)	2013/09/20	2014/10/16	-	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:F89FF68589EE9654	false	tag:?-?	sufficient binding region:441-592(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:O88704	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766521|imex:IM-21402-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ec50:5.0x10^-6 ~1.0(molar)	2013/09/20	2014/10/16	-	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:11EFC83ABCF59389	false	tag:?-?	sufficient binding region:441-592(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	chebi:"CHEBI:17489"	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:"MI:0107"(surface plasmon resonance)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766521|imex:IM-21402-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ec50:5.0x10^-6 ~1.0(molar)	2013/09/20	2014/10/16	-	-	intact-crc:11EFC83ABCF59389	false	tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9UL51	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766631|imex:IM-21402-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ec50:10.0x10^-6 ~4.0(molar)	2013/09/20	2014/10/16	-	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:D98412D0AD6BBA98	false	tag:?-?	sufficient binding region:470-672(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	chebi:"CHEBI:17489"	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:"MI:0107"(surface plasmon resonance)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766631|imex:IM-21402-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ec50:10.0x10^-6 ~4.0(molar)	2013/09/20	2014/10/16	-	-	intact-crc:D98412D0AD6BBA98	false	tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9UL51	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793776|imex:IM-21402-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ec50:10.0x10^-6 ~4.0(molar)	2013/09/20	2014/10/16	-	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:E850A96C1ED3DDE9	false	tag:?-?	sufficient binding region:470-672(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9Y3Q4	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793756|imex:IM-21402-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ec50:11.0x10^-6 ~2.0(molar)	2013/09/20	2014/10/16	-	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:6EDF16D3F9822B42	false	tag:?-?	sufficient binding region:521-723(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9Y3Q4	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766518|imex:IM-21402-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ec50:11.0x10^-6 ~2.0(molar)	2013/09/20	2014/10/16	-	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:5F0BAD6F4A3A4C33	false	tag:?-?	sufficient binding region:521-723(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	chebi:"CHEBI:17489"	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:"MI:0107"(surface plasmon resonance)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766518|imex:IM-21402-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ec50:11.0x10^-6 ~2.0(molar)	2013/09/20	2014/10/16	-	-	intact-crc:5F0BAD6F4A3A4C33	false	tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:O88704	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8767070|imex:IM-21402-30|pdbe:3u0z	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	-	-	figure legend:2, suppl. table 1|3d-r-factors:Rwork = 0.2  Rfree = 0.27|3d-resolution:2.9A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	-	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:DA6FD618F353B8DB	false	-	sufficient binding region:390-592(IPR000595)	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9UL51	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8767073|imex:IM-21402-31|pdbe:3u10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	-	-	figure legend:2d, suppl. table 1|3d-r-factors:Rwork = 0.2  Rfree = 0.27|3d-resolution:2.9A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	-	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:F4C1C36E5989D562	false	-	sufficient binding region:470-672(IPR000595)	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9Y3Q4	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8767067|imex:IM-21402-29|pdbe:3u11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	-	-	figure legend:Supp.  Table 1|3d-r-factors:Rwork = 0.19  Rfree = 0.28|3d-resolution:2.5A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	-	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:A81AC3B5F7D2DA17	false	-	sufficient binding region:521-723(IPR000595)	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9UL51	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0038"(dynamic light scattering)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8767120|imex:IM-21402-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	-	-	figure legend:3h, suppl. table 4|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	-	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:E37B7A3D0C484E65	false	-	sufficient binding region:470-672(IPR000595)	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88704	uniprotkb:O88704	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0038"(dynamic light scattering)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8767181|imex:IM-21402-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	-	-	figure legend:3h, suppl. table 4|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:937E4C44C5C10645|rigid:GCQ9SZ+mVWz9KNluBnhpuQDO+KQ	false	sufficient binding region:390-592(IPR000595)	sufficient binding region:390-592(IPR000595)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UL51	uniprotkb:Q9UL51	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0038"(dynamic light scattering)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8767202|imex:IM-21402-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	-	-	figure legend:3h, suppl. table 4|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:2BF0933B4A0F9256|rigid:+mb4d56xacjf3e84CBQ4hWVyexw	false	sufficient binding region:470-672(IPR000595)	sufficient binding region:470-672(IPR000595)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88704	uniprotkb:O88704	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0038"(dynamic light scattering)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8767175|imex:IM-21402-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	-	-	figure legend:3h, suppl. table 4|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:B65E4C4588BA1359|rigid:GCQ9SZ+mVWz9KNluBnhpuQDO+KQ	false	sufficient binding region:441-592(IPR000595)	sufficient binding region:441-592(IPR000595)	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:O88704	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0038"(dynamic light scattering)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8767114|imex:IM-21402-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	-	-	figure legend:3h, suppl. table 4|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	-	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:71114595F505B9BC	false	-	sufficient binding region:390-592(IPR000595)	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y3Q4	uniprotkb:Q9Y3Q4	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0038"(dynamic light scattering)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8767211|imex:IM-21402-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	-	-	figure legend:3h, suppl. table 4|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:E5EA0A7465EC0235|rigid:E2C1hyV9tum0SU9BpwbE9XC+Nrs	false	sufficient binding region:521-723(IPR000595)	sufficient binding region:521-723(IPR000595)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9Y3Q4	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0038"(dynamic light scattering)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8767125|imex:IM-21402-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	-	-	figure legend:3h, suppl. table 4|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/20	2014/10/16	-	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:2D61E37223ABDE06	false	-	sufficient binding region:521-723(IPR000595)	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:O88704	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766801|imex:IM-21402-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	-	-	figure legend:Table 1, 1a|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:116.0x10^-9 ~26.0(molar)	2013/09/20	2014/10/16	-	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:288A21F5F8CDCBC7	false	fluorescein label:?-?	sufficient binding region:390-592(IPR000595)|tandem tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:O88704	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766798|imex:IM-21402-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	-	-	figure legend:Table 1, 1a|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:382.0x10^-9 ~87.0(molar)	2013/09/20	2014/10/16	-	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:10112A5C85D8B605	false	fluorescein label:?-?	sufficient binding region:390-592(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16356"	uniprotkb:Q9UL51	intact:EBI-8766547|chebi:"CHEBI:488479"|chebi:"CHEBI:1327"|chebi:"CHEBI:11675"|chebi:"CHEBI:14377"|chebi:"CHEBI:19829"	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:3',5'-cyclic gmp(display_short)|psi-mi:"CHEBI:16356"(display_long)|intact:3',5'-Cyclic GMP(synonym)|intact:cGMP(synonym)|intact:Cyclic GMP(synonym)|intact:Guanosine 3',5'-cyclic monophosphate(synonym)|intact:Guanosine 3',5'-cyclic phosphate(synonym)|intact:Guanosine cyclic monophosphate(synonym)|intact:"guanosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766774|imex:IM-21402-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	inchi key:ZOOGRGPOEVQQDX-UUOKFMHZSA-N	-	figure legend:Table 1, 1b|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:286.0x10^-9 ~34.0(molar)	2013/09/20	2014/10/16	-	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:9495A33B28B2A1EF	false	fluorescein label:?-?	sufficient binding region:470-672(IPR000595)|tandem tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16356"	uniprotkb:O88704	intact:EBI-8766547|chebi:"CHEBI:488479"|chebi:"CHEBI:1327"|chebi:"CHEBI:11675"|chebi:"CHEBI:14377"|chebi:"CHEBI:19829"	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:3',5'-cyclic gmp(display_short)|psi-mi:"CHEBI:16356"(display_long)|intact:3',5'-Cyclic GMP(synonym)|intact:cGMP(synonym)|intact:Cyclic GMP(synonym)|intact:Guanosine 3',5'-cyclic monophosphate(synonym)|intact:Guanosine 3',5'-cyclic phosphate(synonym)|intact:Guanosine cyclic monophosphate(synonym)|intact:"guanosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766780|imex:IM-21402-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	inchi key:ZOOGRGPOEVQQDX-UUOKFMHZSA-N	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:386.0x10^-9 ~76.0(molar)	2013/09/20	2014/10/16	-	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:5BD9A7845CF5B6CD	false	fluorescein label:?-?	sufficient binding region:390-592(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9UL51	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766804|imex:IM-21402-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:752.0x10^-9 ~236.0(molar)	2013/09/20	2014/10/16	-	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:DADD618D51CB756A	false	fluorescein label:?-?	sufficient binding region:470-672(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16356"	uniprotkb:O88704	intact:EBI-8766547|chebi:"CHEBI:488479"|chebi:"CHEBI:1327"|chebi:"CHEBI:11675"|chebi:"CHEBI:14377"|chebi:"CHEBI:19829"	intact:EBI-8766347|ensembl:ENSMUSP00000006991|uniprotkb:O54899|uniprotkb:Q9D613	psi-mi:3',5'-cyclic gmp(display_short)|psi-mi:"CHEBI:16356"(display_long)|intact:3',5'-Cyclic GMP(synonym)|intact:cGMP(synonym)|intact:Cyclic GMP(synonym)|intact:Guanosine 3',5'-cyclic monophosphate(synonym)|intact:Guanosine 3',5'-cyclic phosphate(synonym)|intact:Guanosine cyclic monophosphate(synonym)|intact:"guanosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn1_mouse(display_long)|uniprotkb:Hcn1(gene name)|psi-mi:Hcn1(display_short)|uniprotkb:Bcng1(gene name synonym)|uniprotkb:Hac2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 1(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766771|imex:IM-21402-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0032590"(dendrite membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097440"(apical dendrite)|go:"GO:0098855"(HCN channel complex)|go:"GO:1902630"(regulation of membrane hyperpolarization)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR030169|rcsb pdb:3U0Z|ensembl:ENSMUSG00000021730(gene)|ensembl:ENSMUST00000006991(transcript)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|refseq:NP_034538.2|reactome:R-MMU-1296061	-	inchi key:ZOOGRGPOEVQQDX-UUOKFMHZSA-N	-	figure legend:Table 1, 1a|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:208.0x10^-9 ~51.0(molar)	2013/09/20	2014/10/16	-	rogid:aInIVeLLWkVFb1QVE42QVM4+mHU10090	intact-crc:5DAE8711D4723812	false	fluorescein label:?-?	sufficient binding region:390-592(IPR000595)|tandem tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9UL51	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766783|imex:IM-21402-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	-	-	figure legend:Table 1, 1b|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:115.0x10^-9 ~18.0(molar)	2013/09/20	2014/10/16	-	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:E1B105DF040D523A	false	fluorescein label:?-?	sufficient binding region:470-672(IPR000595)|tandem tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16356"	uniprotkb:Q9UL51	intact:EBI-8766547|chebi:"CHEBI:488479"|chebi:"CHEBI:1327"|chebi:"CHEBI:11675"|chebi:"CHEBI:14377"|chebi:"CHEBI:19829"	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:3',5'-cyclic gmp(display_short)|psi-mi:"CHEBI:16356"(display_long)|intact:3',5'-Cyclic GMP(synonym)|intact:cGMP(synonym)|intact:Cyclic GMP(synonym)|intact:Guanosine 3',5'-cyclic monophosphate(synonym)|intact:Guanosine 3',5'-cyclic phosphate(synonym)|intact:Guanosine cyclic monophosphate(synonym)|intact:"guanosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766786|imex:IM-21402-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	inchi key:ZOOGRGPOEVQQDX-UUOKFMHZSA-N	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:606.0x10^-9 ~219.0(molar)	2013/09/20	2014/10/16	-	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:DF5AB36B864782B0	false	fluorescein label:?-?	sufficient binding region:470-672(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9Y3Q4	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766777|imex:IM-21402-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:167.0x10^-9 ~36.0(molar)	2013/09/20	2014/10/16	-	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:84D6A427B0FD1B9A	false	fluorescein label:?-?	sufficient binding region:521-723(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16356"	uniprotkb:Q9Y3Q4	intact:EBI-8766547|chebi:"CHEBI:488479"|chebi:"CHEBI:1327"|chebi:"CHEBI:11675"|chebi:"CHEBI:14377"|chebi:"CHEBI:19829"	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:3',5'-cyclic gmp(display_short)|psi-mi:"CHEBI:16356"(display_long)|intact:3',5'-Cyclic GMP(synonym)|intact:cGMP(synonym)|intact:Cyclic GMP(synonym)|intact:Guanosine 3',5'-cyclic monophosphate(synonym)|intact:Guanosine 3',5'-cyclic phosphate(synonym)|intact:Guanosine cyclic monophosphate(synonym)|intact:"guanosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766789|imex:IM-21402-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	inchi key:ZOOGRGPOEVQQDX-UUOKFMHZSA-N	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:694.0x10^-9 ~121.0(molar)	2013/09/20	2014/10/16	-	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:815176C16771EC40	false	fluorescein label:?-?	sufficient binding region:521-723(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16356"	uniprotkb:Q9Y3Q4	intact:EBI-8766547|chebi:"CHEBI:488479"|chebi:"CHEBI:1327"|chebi:"CHEBI:11675"|chebi:"CHEBI:14377"|chebi:"CHEBI:19829"	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:3',5'-cyclic gmp(display_short)|psi-mi:"CHEBI:16356"(display_long)|intact:3',5'-Cyclic GMP(synonym)|intact:cGMP(synonym)|intact:Cyclic GMP(synonym)|intact:Guanosine 3',5'-cyclic monophosphate(synonym)|intact:Guanosine 3',5'-cyclic phosphate(synonym)|intact:Guanosine cyclic monophosphate(synonym)|intact:"guanosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766792|imex:IM-21402-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	inchi key:ZOOGRGPOEVQQDX-UUOKFMHZSA-N	-	figure legend:Table 1, 1c|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:414.0x10^-9 ~56.0(molar)	2013/09/20	2014/10/16	-	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:C3BBFD77540B8320	false	fluorescein label:?-?	sufficient binding region:521-723(IPR000595)|tandem tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9Y3Q4	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766795|imex:IM-21402-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	-	-	figure legend:Table 1, 1c|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:111.0x10^-9 ~36.0(molar)	2013/09/20	2014/10/16	-	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:B69F5B9378B470F5	false	fluorescein label:?-?	tandem tag:n-n|sufficient binding region:521-723(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9UL51	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766929|imex:IM-21402-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	-	-	figure legend:Table 1|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.6x10^-6 ~1.3(molar)	2013/09/20	2014/10/16	-	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:23F5C0DAC55D821C	false	-	sufficient binding region:470-672(IPR000595)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9UL51	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1751885|uniprotkb:O60742|uniprotkb:O60743|uniprotkb:O75267|uniprotkb:Q9UBS2|ensembl:ENSP00000251287	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn2_human(display_long)|uniprotkb:HCN2(gene name)|psi-mi:HCN2(display_short)|uniprotkb:BCNG2(gene name synonym)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766932|imex:IM-21402-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001185.3|dip:DIP-52285N|ensembl:ENSG00000099822(gene)|ensembl:ENST00000251287(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030552"(cAMP binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MPF|rcsb pdb:3U10|reactome:R-HSA-1296061	-	-	-	figure legend:Table 1, S2a, S2b|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.06x10^-6 ~0.7(molar)	2013/09/20	2014/10/16	-	rogid:hSwIUkY+NbKJ2a7/bYU7XGc9/l89606	intact-crc:2A0E746BD21424D8	false	-	tandem tag:n-n|sufficient binding region:470-672(IPR000595)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17489"	uniprotkb:Q9Y3Q4	intact:EBI-983884|chebi:"CHEBI:1325"|chebi:"CHEBI:41588"|chebi:"CHEBI:11673"|chebi:"CHEBI:19827"	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:3',5'-cyclic amp(display_short)|psi-mi:"CHEBI:17489"(display_long)|intact:3',5'-Cyclic AMP(synonym)|intact:adenosine 3',5'-cyclic monophosphate(synonym)|intact:Adenosine 3',5'-cyclic phosphate(synonym)|intact:Adenosine 3',5'-phosphate(synonym)|intact:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE(synonym)|intact:cAMP(synonym)|intact:Cyclic adenylic acid(synonym)|intact:Cyclic AMP(synonym)|intact:"adenosine 3',5'-(hydrogen phosphate)"(iupac name)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lolicato et al. (2011)	pubmed:22006928|imex:IM-21402	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8766956|imex:IM-21402-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	-	-	-	figure legend:Table 1, S2c, S2d|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.97x10^-6 ~0.7(molar)	2013/09/20	2014/10/16	-	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	intact-crc:A3761018702ADDEE	false	-	sufficient binding region:521-723(IPR000595)|tandem tag:n-n	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)