#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61214	uniprotkb:P53805-2	intact:EBI-80344|ensembl:ENSMUSP00000023614|ensembl:ENSMUSP00000113660	intact:EBI-1541912|ensembl:ENSP00000370524	psi-mi:dyr1a_mouse(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:MP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)	psi-mi:p53805-2(display_long)|uniprotkb:RCAN1(gene name)|psi-mi:RCAN1(display_short)|uniprotkb:ADAPT78(gene name synonym)|uniprotkb:CSP1(gene name synonym)|uniprotkb:DSC1(gene name synonym)|uniprotkb:DSCR1(gene name synonym)|uniprotkb:Adapt78(gene name synonym)|uniprotkb:Down syndrome critical region protein 1(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 1(gene name synonym)|uniprotkb:Regulator of calcineurin 1(gene name synonym)|uniprotkb:CALP1-S(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Jung et al. (2011)	pubmed:21965663|imex:IM-21660	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8829863|imex:IM-21660-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022897(gene)|ensembl:ENSMUST00000023614(transcript)|ensembl:ENSMUST00000119878(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|reactome:R-MMU-1538133|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|refseq:XP_011244396.1|refseq:XP_011244397.1|refseq:NP_001106860.1|refseq:NP_031916.1	intact:EBI-1541887(isoform-parent)|uniprotkb:P53805-2(isoform-parent)|ensembl:ENSG00000159200(gene)|ensembl:ENST00000381132(transcript)	-	-	-	figure legend:1A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/10/25	2014/10/16	rogid:UK/KpVs/ghE0Oxjq8KGWBvxAt5s10090	rogid:OZrbrTBOMsbOsUCbRE1Nh6md0j09606	intact-crc:6103799E991CE80A|rigid:9z47QZRD2L0M1TDE/EI2MK/UJT4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61214	uniprotkb:P53805-2	intact:EBI-80344|ensembl:ENSMUSP00000023614|ensembl:ENSMUSP00000113660	intact:EBI-1541912|ensembl:ENSP00000370524	psi-mi:dyr1a_mouse(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:MP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)	psi-mi:p53805-2(display_long)|uniprotkb:RCAN1(gene name)|psi-mi:RCAN1(display_short)|uniprotkb:ADAPT78(gene name synonym)|uniprotkb:CSP1(gene name synonym)|uniprotkb:DSC1(gene name synonym)|uniprotkb:DSCR1(gene name synonym)|uniprotkb:Adapt78(gene name synonym)|uniprotkb:Down syndrome critical region protein 1(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 1(gene name synonym)|uniprotkb:Regulator of calcineurin 1(gene name synonym)|uniprotkb:CALP1-S(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Jung et al. (2011)	pubmed:21965663|imex:IM-21660	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8829873|imex:IM-21660-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022897(gene)|ensembl:ENSMUST00000023614(transcript)|ensembl:ENSMUST00000119878(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|reactome:R-MMU-1538133|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|refseq:XP_011244396.1|refseq:XP_011244397.1|refseq:NP_001106860.1|refseq:NP_031916.1	intact:EBI-1541887(isoform-parent)|uniprotkb:P53805-2(isoform-parent)|ensembl:ENSG00000159200(gene)|ensembl:ENST00000381132(transcript)	-	-	-	figure legend:1A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/10/25	2014/10/16	rogid:UK/KpVs/ghE0Oxjq8KGWBvxAt5s10090	rogid:OZrbrTBOMsbOsUCbRE1Nh6md0j09606	intact-crc:0456C0F9E7B56B01|rigid:9z47QZRD2L0M1TDE/EI2MK/UJT4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61214	uniprotkb:Q9JHG6	intact:EBI-80344|ensembl:ENSMUSP00000023614|ensembl:ENSMUSP00000113660	intact:EBI-644061|uniprotkb:Q91WQ4|uniprotkb:Q9JK50|uniprotkb:Q9JK51|uniprotkb:Q9JKK2|uniprotkb:Q9JKK3|ensembl:ENSMUSP00000060394|uniprotkb:Q7TNY3	psi-mi:dyr1a_mouse(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:MP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)	psi-mi:rcan1_mouse(display_long)|uniprotkb:Regulator of calcineurin 1(gene name synonym)|uniprotkb:Down syndrome critical region protein 1 homolog(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 1(gene name synonym)|uniprotkb:Rcan1(gene name)|psi-mi:Rcan1(display_short)|uniprotkb:Dscr1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Jung et al. (2011)	pubmed:21965663|imex:IM-21660	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8829892|imex:IM-21660-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022897(gene)|ensembl:ENSMUST00000023614(transcript)|ensembl:ENSMUST00000119878(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|reactome:R-MMU-1538133|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|refseq:XP_011244396.1|refseq:XP_011244397.1|refseq:NP_001106860.1|refseq:NP_031916.1	refseq:NP_062339.2|ensembl:ENSMUSG00000022951(gene)|ensembl:ENSMUST00000060005(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007614"(short-term memory)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR006931(Calcipressin)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR031271|interpro:IPR034906|interpro:IPR035979|rcsb pdb:1WEY|refseq:NP_001075018.1	-	-	-	figure legend:1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2013/10/25	2018/06/01	rogid:UK/KpVs/ghE0Oxjq8KGWBvxAt5s10090	rogid:JsU96N+kf20Ii4ZiIi0bTi0B/pw10090	intact-crc:80CBCCB7A7B5DFDB|rigid:9nWMfOBEE5awrnWv+ANUAo3Nur4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JHG6	uniprotkb:Q61214	intact:EBI-644061|uniprotkb:Q91WQ4|uniprotkb:Q9JK50|uniprotkb:Q9JK51|uniprotkb:Q9JKK2|uniprotkb:Q9JKK3|ensembl:ENSMUSP00000060394|uniprotkb:Q7TNY3	intact:EBI-80344|ensembl:ENSMUSP00000023614|ensembl:ENSMUSP00000113660	psi-mi:rcan1_mouse(display_long)|uniprotkb:Regulator of calcineurin 1(gene name synonym)|uniprotkb:Down syndrome critical region protein 1 homolog(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 1(gene name synonym)|uniprotkb:Rcan1(gene name)|psi-mi:Rcan1(display_short)|uniprotkb:Dscr1(gene name synonym)	psi-mi:dyr1a_mouse(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:MP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Jung et al. (2011)	pubmed:21965663|imex:IM-21660	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8829890|imex:IM-21660-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062339.2|ensembl:ENSMUSG00000022951(gene)|ensembl:ENSMUST00000060005(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007614"(short-term memory)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR006931(Calcipressin)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR031271|interpro:IPR034906|interpro:IPR035979|rcsb pdb:1WEY|refseq:NP_001075018.1	ensembl:ENSMUSG00000022897(gene)|ensembl:ENSMUST00000023614(transcript)|ensembl:ENSMUST00000119878(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|reactome:R-MMU-1538133|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|refseq:XP_011244396.1|refseq:XP_011244397.1|refseq:NP_001106860.1|refseq:NP_031916.1	-	-	-	figure legend:1B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2013/10/25	2018/06/01	rogid:JsU96N+kf20Ii4ZiIi0bTi0B/pw10090	rogid:UK/KpVs/ghE0Oxjq8KGWBvxAt5s10090	intact-crc:2DAB195033A6564D|rigid:9nWMfOBEE5awrnWv+ANUAo3Nur4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61214	uniprotkb:P53805-2	intact:EBI-80344|ensembl:ENSMUSP00000023614|ensembl:ENSMUSP00000113660	intact:EBI-1541912|ensembl:ENSP00000370524	psi-mi:dyr1a_mouse(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:MP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)	psi-mi:p53805-2(display_long)|uniprotkb:RCAN1(gene name)|psi-mi:RCAN1(display_short)|uniprotkb:ADAPT78(gene name synonym)|uniprotkb:CSP1(gene name synonym)|uniprotkb:DSC1(gene name synonym)|uniprotkb:DSCR1(gene name synonym)|uniprotkb:Adapt78(gene name synonym)|uniprotkb:Down syndrome critical region protein 1(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 1(gene name synonym)|uniprotkb:Regulator of calcineurin 1(gene name synonym)|uniprotkb:CALP1-S(isoform synonym)	psi-mi:"MI:0096"(pull down)	Jung et al. (2011)	pubmed:21965663|imex:IM-21660	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8829906|imex:IM-21660-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022897(gene)|ensembl:ENSMUST00000023614(transcript)|ensembl:ENSMUST00000119878(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|reactome:R-MMU-1538133|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|refseq:XP_011244396.1|refseq:XP_011244397.1|refseq:NP_001106860.1|refseq:NP_031916.1	intact:EBI-1541887(isoform-parent)|uniprotkb:P53805-2(isoform-parent)|ensembl:ENSG00000159200(gene)|ensembl:ENST00000381132(transcript)	-	-	-	figure legend:Fig. 1C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/25	2014/10/16	rogid:UK/KpVs/ghE0Oxjq8KGWBvxAt5s10090	rogid:OZrbrTBOMsbOsUCbRE1Nh6md0j09606	intact-crc:59779135BD2C1259|rigid:9z47QZRD2L0M1TDE/EI2MK/UJT4	false	his tag:c-c	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P53805-2	uniprotkb:Q61214	intact:EBI-1541912|ensembl:ENSP00000370524	intact:EBI-80344|ensembl:ENSMUSP00000023614|ensembl:ENSMUSP00000113660	psi-mi:p53805-2(display_long)|uniprotkb:RCAN1(gene name)|psi-mi:RCAN1(display_short)|uniprotkb:ADAPT78(gene name synonym)|uniprotkb:CSP1(gene name synonym)|uniprotkb:DSC1(gene name synonym)|uniprotkb:DSCR1(gene name synonym)|uniprotkb:Adapt78(gene name synonym)|uniprotkb:Down syndrome critical region protein 1(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 1(gene name synonym)|uniprotkb:Regulator of calcineurin 1(gene name synonym)|uniprotkb:CALP1-S(isoform synonym)	psi-mi:dyr1a_mouse(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:MP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Jung et al. (2011)	pubmed:21965663|imex:IM-21660	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8830015|imex:IM-21660-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1541887(isoform-parent)|uniprotkb:P53805-2(isoform-parent)|ensembl:ENSG00000159200(gene)|ensembl:ENST00000381132(transcript)	ensembl:ENSMUSG00000022897(gene)|ensembl:ENSMUST00000023614(transcript)|ensembl:ENSMUST00000119878(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|reactome:R-MMU-1538133|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|refseq:XP_011244396.1|refseq:XP_011244397.1|refseq:NP_001106860.1|refseq:NP_031916.1	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 3|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/25	2014/10/16	rogid:OZrbrTBOMsbOsUCbRE1Nh6md0j09606	rogid:UK/KpVs/ghE0Oxjq8KGWBvxAt5s10090	intact-crc:86B35AD1A892F140|rigid:9z47QZRD2L0M1TDE/EI2MK/UJT4	false	mutation decreasing interaction:112-112|mutation decreasing interaction:192-192|glutathione s tranferase tag:n-n	his tag:c-c	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P53805-2	uniprotkb:Q61214	intact:EBI-1541912|ensembl:ENSP00000370524	intact:EBI-80344|ensembl:ENSMUSP00000023614|ensembl:ENSMUSP00000113660	psi-mi:p53805-2(display_long)|uniprotkb:RCAN1(gene name)|psi-mi:RCAN1(display_short)|uniprotkb:ADAPT78(gene name synonym)|uniprotkb:CSP1(gene name synonym)|uniprotkb:DSC1(gene name synonym)|uniprotkb:DSCR1(gene name synonym)|uniprotkb:Adapt78(gene name synonym)|uniprotkb:Down syndrome critical region protein 1(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 1(gene name synonym)|uniprotkb:Regulator of calcineurin 1(gene name synonym)|uniprotkb:CALP1-S(isoform synonym)	psi-mi:dyr1a_mouse(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:MP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Jung et al. (2011)	pubmed:21965663|imex:IM-21660	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8829922|imex:IM-21660-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1541887(isoform-parent)|uniprotkb:P53805-2(isoform-parent)|ensembl:ENSG00000159200(gene)|ensembl:ENST00000381132(transcript)	ensembl:ENSMUSG00000022897(gene)|ensembl:ENSMUST00000023614(transcript)|ensembl:ENSMUST00000119878(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|reactome:R-MMU-1538133|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|refseq:XP_011244396.1|refseq:XP_011244397.1|refseq:NP_001106860.1|refseq:NP_031916.1	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 2A/B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/25	2014/10/16	rogid:OZrbrTBOMsbOsUCbRE1Nh6md0j09606	rogid:UK/KpVs/ghE0Oxjq8KGWBvxAt5s10090	intact-crc:7A0E130F5F20AA30|rigid:9z47QZRD2L0M1TDE/EI2MK/UJT4	false	mutation decreasing interaction:112-112|his tag:c-c|mutation decreasing interaction:192-192|mutation disrupting interaction:192-192,112-112|s tag:n-n	mutation disrupting interaction:321-321|his tag:c-c	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q61214	uniprotkb:Q61214	intact:EBI-80344|ensembl:ENSMUSP00000023614|ensembl:ENSMUSP00000113660	intact:EBI-80344|ensembl:ENSMUSP00000023614|ensembl:ENSMUSP00000113660	psi-mi:dyr1a_mouse(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:MP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)	psi-mi:dyr1a_mouse(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:MP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Jung et al. (2011)	pubmed:21965663|imex:IM-21660	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8829945|imex:IM-21660-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022897(gene)|ensembl:ENSMUST00000023614(transcript)|ensembl:ENSMUST00000119878(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|reactome:R-MMU-1538133|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|refseq:XP_011244396.1|refseq:XP_011244397.1|refseq:NP_001106860.1|refseq:NP_031916.1	ensembl:ENSMUSG00000022897(gene)|ensembl:ENSMUST00000023614(transcript)|ensembl:ENSMUST00000119878(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|reactome:R-MMU-1538133|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|refseq:XP_011244396.1|refseq:XP_011244397.1|refseq:NP_001106860.1|refseq:NP_031916.1	go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig. 2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/25	2014/10/16	rogid:UK/KpVs/ghE0Oxjq8KGWBvxAt5s10090	rogid:UK/KpVs/ghE0Oxjq8KGWBvxAt5s10090	intact-crc:9274F666622A1CA8|rigid:rf7egkEdqSWwIXrKqPMvKpUzbOc	false	mutation disrupting interaction:321-321|his tag:c-c	mutation disrupting interaction:321-321|his tag:c-c	-	0	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q63470	uniprotkb:Q6IN33	intact:EBI-7796229|ensembl:ENSRNOP00000042446|intact:MINT-2790195	intact:EBI-8830186|uniprotkb:Q8K4S2|ensembl:ENSRNOP00000002715	psi-mi:dyr1a_rat(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:RP86(gene name synonym)	psi-mi:rcan1_rat(display_long)|uniprotkb:Dscr1(gene name synonym)|uniprotkb:Down syndrome critical region protein 1 homolog(gene name synonym)|uniprotkb:Rcan1(gene name)|psi-mi:Rcan1(display_short)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 1(gene name synonym)|uniprotkb:Regulator of calcineurin 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Jung et al. (2011)	pubmed:21965663|imex:IM-21660	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8830184|imex:IM-21660-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008766785.1|refseq:XP_008766786.1|refseq:XP_008766787.1|ensembl:ENSRNOG00000001662(gene)|ensembl:ENSRNOT00000050342(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q63470|reactome:R-RNO-1538133|rgd:2528|refseq:NP_036923.1|refseq:XP_006248093.1	rgd:631338|refseq:NP_714946.2|ensembl:ENSRNOG00000001979(gene)|ensembl:ENSRNOT00000002715(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007614"(short-term memory)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR006931(Calcipressin)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR031271|interpro:IPR034906|interpro:IPR035979|go:"GO:0009612"(response to mechanical stimulus)	go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0043005"(neuron projection)	comment:mint|comment:homomint|function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates	-	figure legend:7A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2013/10/25	2014/10/16	rogid:A9JxUmJJEpow0xT2+Xp1A5hVGCQ10116	rogid:RHLrjp3qORYGc48h2oWkAUMSU2I10116	intact-crc:0B5FAD70C99859CC|rigid:vRHbDUrQFZS3AF3Q7/GzM2w54Rs	false	-	O-phospho-L-threonine:193-193	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q63470	uniprotkb:Q6IN33	intact:EBI-7796229|ensembl:ENSRNOP00000042446|intact:MINT-2790195	intact:EBI-8830186|uniprotkb:Q8K4S2|ensembl:ENSRNOP00000002715	psi-mi:dyr1a_rat(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:RP86(gene name synonym)	psi-mi:rcan1_rat(display_long)|uniprotkb:Dscr1(gene name synonym)|uniprotkb:Down syndrome critical region protein 1 homolog(gene name synonym)|uniprotkb:Rcan1(gene name)|psi-mi:Rcan1(display_short)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 1(gene name synonym)|uniprotkb:Regulator of calcineurin 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Jung et al. (2011)	pubmed:21965663|imex:IM-21660	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8830226|imex:IM-21660-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008766785.1|refseq:XP_008766786.1|refseq:XP_008766787.1|ensembl:ENSRNOG00000001662(gene)|ensembl:ENSRNOT00000050342(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q63470|reactome:R-RNO-1538133|rgd:2528|refseq:NP_036923.1|refseq:XP_006248093.1	rgd:631338|refseq:NP_714946.2|ensembl:ENSRNOG00000001979(gene)|ensembl:ENSRNOT00000002715(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007614"(short-term memory)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR006931(Calcipressin)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR031271|interpro:IPR034906|interpro:IPR035979|go:"GO:0009612"(response to mechanical stimulus)	go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0043195"(terminal bouton)	comment:mint|comment:homomint|function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates	-	figure legend:7B,  Supp fig 6.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons)	-	2013/10/25	2014/10/16	rogid:A9JxUmJJEpow0xT2+Xp1A5hVGCQ10116	rogid:RHLrjp3qORYGc48h2oWkAUMSU2I10116	intact-crc:FC593FF554734B5E|rigid:vRHbDUrQFZS3AF3Q7/GzM2w54Rs	false	-	O-phospho-L-threonine:193-193	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)