#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P25205	uniprotkb:P53355	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	intact:EBI-358616|uniprotkb:Q6ZRZ3|uniprotkb:Q68CP8|uniprotkb:B7ZLD2|uniprotkb:Q1W5W0|ensembl:ENSP00000350785|ensembl:ENSP00000386135|ensembl:ENSP00000417076|ensembl:ENSP00000484267|uniprotkb:Q9BTL8|uniprotkb:Q14CQ7|uniprotkb:B7ZLE7	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:dapk1_human(display_long)|uniprotkb:DAPK1(gene name)|psi-mi:DAPK1(display_short)|uniprotkb:DAPK(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Mor et al. (2012)	imex:IM-18624|pubmed:21725354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-6694393|imex:IM-18624-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	ensembl:ENST00000358077(transcript)|ensembl:ENST00000408954(transcript)|ensembl:ENST00000472284(transcript)|ensembl:ENST00000622514(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|ensembl:ENSG00000196730(gene)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020676|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR036770|mint:P53355|rcsb pdb:1IG1|rcsb pdb:1JKK|refseq:NP_004929.2|rcsb pdb:1JKL|rcsb pdb:1JKS|rcsb pdb:1JKT|rcsb pdb:1P4F|rcsb pdb:1WVW|rcsb pdb:1WVY|rcsb pdb:1YR5|rcsb pdb:2W4J|rcsb pdb:2W4K|rcsb pdb:2X0G|rcsb pdb:2XUU|rcsb pdb:2XZS|rcsb pdb:1WVX|rcsb pdb:2Y0A|rcsb pdb:2Y4P|rcsb pdb:2Y4V|rcsb pdb:2YAK|rcsb pdb:3DFC|rcsb pdb:3DGK|rcsb pdb:3EH9|rcsb pdb:3EHA|rcsb pdb:3F5G|rcsb pdb:3F5U|rcsb pdb:3GU4|rcsb pdb:3GU5|rcsb pdb:3GU6|rcsb pdb:3GU7|rcsb pdb:3GU8|rcsb pdb:3GUB|rcsb pdb:3ZXT|rcsb pdb:4B4L|rcsb pdb:4PF4|rcsb pdb:4TL0|rcsb pdb:4TXC|rcsb pdb:4UV0|rcsb pdb:4YO4|rcsb pdb:4YPD|rcsb pdb:5AUT|rcsb pdb:5AUU|rcsb pdb:5AUV|rcsb pdb:5AUW|rcsb pdb:5AUX|rcsb pdb:5AUY|rcsb pdb:5AUZ|rcsb pdb:5AV0|rcsb pdb:5AV1|rcsb pdb:5AV2|rcsb pdb:5AV3|rcsb pdb:5AV4|rcsb pdb:6AAR|rcsb pdb:6FHA|rcsb pdb:6FHB|rcsb pdb:6QN4|rcsb pdb:6GY5|rcsb pdb:6IN4|rcsb pdb:6QMO|refseq:NP_001275658.1|refseq:NP_001275659.1|refseq:NP_001275660.1|rcsb pdb:7CCW|rcsb pdb:7CCV|rcsb pdb:7CCU|reactome:R-HSA-418889	-	-	-	figure legend:supp fig 4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/10	2014/10/16	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	rogid:GCxGiQSqtI+M2uqNXe9F4AN1x909606	intact-crc:6967C4E167DC6392|rigid:snATGMIkIoDrstosC6ELooqsEp4	false	flag tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P14618-1	uniprotkb:P53355	intact:EBI-4304679|ensembl:ENSP00000334983	intact:EBI-358616|uniprotkb:Q6ZRZ3|uniprotkb:Q68CP8|uniprotkb:B7ZLD2|uniprotkb:Q1W5W0|ensembl:ENSP00000350785|ensembl:ENSP00000386135|ensembl:ENSP00000417076|ensembl:ENSP00000484267|uniprotkb:Q9BTL8|uniprotkb:Q14CQ7|uniprotkb:B7ZLE7	psi-mi:p14618-1(display_long)|uniprotkb:M2-PK(isoform synonym)|uniprotkb:PKM2(isoform synonym)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:dapk1_human(display_long)|uniprotkb:DAPK1(gene name)|psi-mi:DAPK1(display_short)|uniprotkb:DAPK(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mor et al. (2012)	imex:IM-18624|pubmed:21725354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-6694352|imex:IM-18624-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-353408(isoform-parent)|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)	ensembl:ENST00000358077(transcript)|ensembl:ENST00000408954(transcript)|ensembl:ENST00000472284(transcript)|ensembl:ENST00000622514(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|ensembl:ENSG00000196730(gene)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020676|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR036770|mint:P53355|rcsb pdb:1IG1|rcsb pdb:1JKK|refseq:NP_004929.2|rcsb pdb:1JKL|rcsb pdb:1JKS|rcsb pdb:1JKT|rcsb pdb:1P4F|rcsb pdb:1WVW|rcsb pdb:1WVY|rcsb pdb:1YR5|rcsb pdb:2W4J|rcsb pdb:2W4K|rcsb pdb:2X0G|rcsb pdb:2XUU|rcsb pdb:2XZS|rcsb pdb:1WVX|rcsb pdb:2Y0A|rcsb pdb:2Y4P|rcsb pdb:2Y4V|rcsb pdb:2YAK|rcsb pdb:3DFC|rcsb pdb:3DGK|rcsb pdb:3EH9|rcsb pdb:3EHA|rcsb pdb:3F5G|rcsb pdb:3F5U|rcsb pdb:3GU4|rcsb pdb:3GU5|rcsb pdb:3GU6|rcsb pdb:3GU7|rcsb pdb:3GU8|rcsb pdb:3GUB|rcsb pdb:3ZXT|rcsb pdb:4B4L|rcsb pdb:4PF4|rcsb pdb:4TL0|rcsb pdb:4TXC|rcsb pdb:4UV0|rcsb pdb:4YO4|rcsb pdb:4YPD|rcsb pdb:5AUT|rcsb pdb:5AUU|rcsb pdb:5AUV|rcsb pdb:5AUW|rcsb pdb:5AUX|rcsb pdb:5AUY|rcsb pdb:5AUZ|rcsb pdb:5AV0|rcsb pdb:5AV1|rcsb pdb:5AV2|rcsb pdb:5AV3|rcsb pdb:5AV4|rcsb pdb:6AAR|rcsb pdb:6FHA|rcsb pdb:6FHB|rcsb pdb:6QN4|rcsb pdb:6GY5|rcsb pdb:6IN4|rcsb pdb:6QMO|refseq:NP_001275658.1|refseq:NP_001275659.1|refseq:NP_001275660.1|rcsb pdb:7CCW|rcsb pdb:7CCV|rcsb pdb:7CCU|reactome:R-HSA-418889	-	-	-	figure legend:no figure|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/01/10	2014/10/16	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	rogid:GCxGiQSqtI+M2uqNXe9F4AN1x909606	intact-crc:39066FA41780A7AE|rigid:GBnd+kvuZMgPVe2vOPRhi+XS+z0	false	necessary binding region:354-531	sufficient binding region:1308-1396(IPR000488)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P14618-2	uniprotkb:P53355	intact:EBI-6694361|uniprotkb:P14786-1|ensembl:ENSP00000320171|ensembl:ENSP00000456970	intact:EBI-358616|uniprotkb:Q6ZRZ3|uniprotkb:Q68CP8|uniprotkb:B7ZLD2|uniprotkb:Q1W5W0|ensembl:ENSP00000350785|ensembl:ENSP00000386135|ensembl:ENSP00000417076|ensembl:ENSP00000484267|uniprotkb:Q9BTL8|uniprotkb:Q14CQ7|uniprotkb:B7ZLE7	psi-mi:p14618-2(display_long)|uniprotkb:M1-PK(isoform synonym)|uniprotkb:PKM1(isoform synonym)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:OIP3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:dapk1_human(display_long)|uniprotkb:DAPK1(gene name)|psi-mi:DAPK1(display_short)|uniprotkb:DAPK(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mor et al. (2012)	imex:IM-18624|pubmed:21725354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-6694343|imex:IM-18624-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-353408(isoform-parent)|ensembl:ENSG00000067225(gene)|ensembl:ENST00000319622(transcript)|ensembl:ENST00000568459(transcript)|uniprotkb:P14618-2(isoform-parent)	ensembl:ENST00000358077(transcript)|ensembl:ENST00000408954(transcript)|ensembl:ENST00000472284(transcript)|ensembl:ENST00000622514(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|ensembl:ENSG00000196730(gene)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020676|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR036770|mint:P53355|rcsb pdb:1IG1|rcsb pdb:1JKK|refseq:NP_004929.2|rcsb pdb:1JKL|rcsb pdb:1JKS|rcsb pdb:1JKT|rcsb pdb:1P4F|rcsb pdb:1WVW|rcsb pdb:1WVY|rcsb pdb:1YR5|rcsb pdb:2W4J|rcsb pdb:2W4K|rcsb pdb:2X0G|rcsb pdb:2XUU|rcsb pdb:2XZS|rcsb pdb:1WVX|rcsb pdb:2Y0A|rcsb pdb:2Y4P|rcsb pdb:2Y4V|rcsb pdb:2YAK|rcsb pdb:3DFC|rcsb pdb:3DGK|rcsb pdb:3EH9|rcsb pdb:3EHA|rcsb pdb:3F5G|rcsb pdb:3F5U|rcsb pdb:3GU4|rcsb pdb:3GU5|rcsb pdb:3GU6|rcsb pdb:3GU7|rcsb pdb:3GU8|rcsb pdb:3GUB|rcsb pdb:3ZXT|rcsb pdb:4B4L|rcsb pdb:4PF4|rcsb pdb:4TL0|rcsb pdb:4TXC|rcsb pdb:4UV0|rcsb pdb:4YO4|rcsb pdb:4YPD|rcsb pdb:5AUT|rcsb pdb:5AUU|rcsb pdb:5AUV|rcsb pdb:5AUW|rcsb pdb:5AUX|rcsb pdb:5AUY|rcsb pdb:5AUZ|rcsb pdb:5AV0|rcsb pdb:5AV1|rcsb pdb:5AV2|rcsb pdb:5AV3|rcsb pdb:5AV4|rcsb pdb:6AAR|rcsb pdb:6FHA|rcsb pdb:6FHB|rcsb pdb:6QN4|rcsb pdb:6GY5|rcsb pdb:6IN4|rcsb pdb:6QMO|refseq:NP_001275658.1|refseq:NP_001275659.1|refseq:NP_001275660.1|rcsb pdb:7CCW|rcsb pdb:7CCV|rcsb pdb:7CCU|reactome:R-HSA-418889	-	-	-	figure legend:no figure|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/01/10	2014/10/16	rogid:Y4GmK6T2kMgo7CZg0FDlWbO3Pok9606	rogid:GCxGiQSqtI+M2uqNXe9F4AN1x909606	intact-crc:14FE887BB7EF82EA|rigid:7QfD3QPDsMV99Mo0syF+v/oVG/Q	false	necessary binding region:354-531	sufficient binding region:1308-1396(IPR000488)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P53355	uniprotkb:P14618	intact:EBI-358616|uniprotkb:Q6ZRZ3|uniprotkb:Q68CP8|uniprotkb:B7ZLD2|uniprotkb:Q1W5W0|ensembl:ENSP00000350785|ensembl:ENSP00000386135|ensembl:ENSP00000417076|ensembl:ENSP00000484267|uniprotkb:Q9BTL8|uniprotkb:Q14CQ7|uniprotkb:B7ZLE7	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:dapk1_human(display_long)|uniprotkb:DAPK1(gene name)|psi-mi:DAPK1(display_short)|uniprotkb:DAPK(gene name synonym)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mor et al. (2012)	imex:IM-18624|pubmed:21725354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-6476136|imex:IM-18624-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000358077(transcript)|ensembl:ENST00000408954(transcript)|ensembl:ENST00000472284(transcript)|ensembl:ENST00000622514(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|ensembl:ENSG00000196730(gene)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020676|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR036770|mint:P53355|rcsb pdb:1IG1|rcsb pdb:1JKK|refseq:NP_004929.2|rcsb pdb:1JKL|rcsb pdb:1JKS|rcsb pdb:1JKT|rcsb pdb:1P4F|rcsb pdb:1WVW|rcsb pdb:1WVY|rcsb pdb:1YR5|rcsb pdb:2W4J|rcsb pdb:2W4K|rcsb pdb:2X0G|rcsb pdb:2XUU|rcsb pdb:2XZS|rcsb pdb:1WVX|rcsb pdb:2Y0A|rcsb pdb:2Y4P|rcsb pdb:2Y4V|rcsb pdb:2YAK|rcsb pdb:3DFC|rcsb pdb:3DGK|rcsb pdb:3EH9|rcsb pdb:3EHA|rcsb pdb:3F5G|rcsb pdb:3F5U|rcsb pdb:3GU4|rcsb pdb:3GU5|rcsb pdb:3GU6|rcsb pdb:3GU7|rcsb pdb:3GU8|rcsb pdb:3GUB|rcsb pdb:3ZXT|rcsb pdb:4B4L|rcsb pdb:4PF4|rcsb pdb:4TL0|rcsb pdb:4TXC|rcsb pdb:4UV0|rcsb pdb:4YO4|rcsb pdb:4YPD|rcsb pdb:5AUT|rcsb pdb:5AUU|rcsb pdb:5AUV|rcsb pdb:5AUW|rcsb pdb:5AUX|rcsb pdb:5AUY|rcsb pdb:5AUZ|rcsb pdb:5AV0|rcsb pdb:5AV1|rcsb pdb:5AV2|rcsb pdb:5AV3|rcsb pdb:5AV4|rcsb pdb:6AAR|rcsb pdb:6FHA|rcsb pdb:6FHB|rcsb pdb:6QN4|rcsb pdb:6GY5|rcsb pdb:6IN4|rcsb pdb:6QMO|refseq:NP_001275658.1|refseq:NP_001275659.1|refseq:NP_001275660.1|rcsb pdb:7CCW|rcsb pdb:7CCV|rcsb pdb:7CCU|reactome:R-HSA-418889	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	figure legend:1b|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/01/10	2014/10/16	rogid:GCxGiQSqtI+M2uqNXe9F4AN1x909606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	intact-crc:2B3D794E8E7127E4|rigid:GBnd+kvuZMgPVe2vOPRhi+XS+z0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P53355	uniprotkb:P14618-1	intact:EBI-358616|uniprotkb:Q6ZRZ3|uniprotkb:Q68CP8|uniprotkb:B7ZLD2|uniprotkb:Q1W5W0|ensembl:ENSP00000350785|ensembl:ENSP00000386135|ensembl:ENSP00000417076|ensembl:ENSP00000484267|uniprotkb:Q9BTL8|uniprotkb:Q14CQ7|uniprotkb:B7ZLE7	intact:EBI-4304679|ensembl:ENSP00000334983	psi-mi:dapk1_human(display_long)|uniprotkb:DAPK1(gene name)|psi-mi:DAPK1(display_short)|uniprotkb:DAPK(gene name synonym)	psi-mi:p14618-1(display_long)|uniprotkb:M2-PK(isoform synonym)|uniprotkb:PKM2(isoform synonym)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Mor et al. (2012)	imex:IM-18624|pubmed:21725354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-6476149|imex:IM-18624-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000358077(transcript)|ensembl:ENST00000408954(transcript)|ensembl:ENST00000472284(transcript)|ensembl:ENST00000622514(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|ensembl:ENSG00000196730(gene)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020676|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR036770|mint:P53355|rcsb pdb:1IG1|rcsb pdb:1JKK|refseq:NP_004929.2|rcsb pdb:1JKL|rcsb pdb:1JKS|rcsb pdb:1JKT|rcsb pdb:1P4F|rcsb pdb:1WVW|rcsb pdb:1WVY|rcsb pdb:1YR5|rcsb pdb:2W4J|rcsb pdb:2W4K|rcsb pdb:2X0G|rcsb pdb:2XUU|rcsb pdb:2XZS|rcsb pdb:1WVX|rcsb pdb:2Y0A|rcsb pdb:2Y4P|rcsb pdb:2Y4V|rcsb pdb:2YAK|rcsb pdb:3DFC|rcsb pdb:3DGK|rcsb pdb:3EH9|rcsb pdb:3EHA|rcsb pdb:3F5G|rcsb pdb:3F5U|rcsb pdb:3GU4|rcsb pdb:3GU5|rcsb pdb:3GU6|rcsb pdb:3GU7|rcsb pdb:3GU8|rcsb pdb:3GUB|rcsb pdb:3ZXT|rcsb pdb:4B4L|rcsb pdb:4PF4|rcsb pdb:4TL0|rcsb pdb:4TXC|rcsb pdb:4UV0|rcsb pdb:4YO4|rcsb pdb:4YPD|rcsb pdb:5AUT|rcsb pdb:5AUU|rcsb pdb:5AUV|rcsb pdb:5AUW|rcsb pdb:5AUX|rcsb pdb:5AUY|rcsb pdb:5AUZ|rcsb pdb:5AV0|rcsb pdb:5AV1|rcsb pdb:5AV2|rcsb pdb:5AV3|rcsb pdb:5AV4|rcsb pdb:6AAR|rcsb pdb:6FHA|rcsb pdb:6FHB|rcsb pdb:6QN4|rcsb pdb:6GY5|rcsb pdb:6IN4|rcsb pdb:6QMO|refseq:NP_001275658.1|refseq:NP_001275659.1|refseq:NP_001275660.1|rcsb pdb:7CCW|rcsb pdb:7CCV|rcsb pdb:7CCU|reactome:R-HSA-418889	intact:EBI-353408(isoform-parent)|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)	-	-	-	figure legend:1c and suppl fig 2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/10	2014/10/16	rogid:GCxGiQSqtI+M2uqNXe9F4AN1x909606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	intact-crc:287184EB04AC2F57|rigid:GBnd+kvuZMgPVe2vOPRhi+XS+z0	false	flag tag:n-n|sufficient binding region:1-1271	flag tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P14618	uniprotkb:P53355	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	intact:EBI-358616|uniprotkb:Q6ZRZ3|uniprotkb:Q68CP8|uniprotkb:B7ZLD2|uniprotkb:Q1W5W0|ensembl:ENSP00000350785|ensembl:ENSP00000386135|ensembl:ENSP00000417076|ensembl:ENSP00000484267|uniprotkb:Q9BTL8|uniprotkb:Q14CQ7|uniprotkb:B7ZLE7	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:dapk1_human(display_long)|uniprotkb:DAPK1(gene name)|psi-mi:DAPK1(display_short)|uniprotkb:DAPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mor et al. (2012)	imex:IM-18624|pubmed:21725354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-6476185|imex:IM-18624-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	ensembl:ENST00000358077(transcript)|ensembl:ENST00000408954(transcript)|ensembl:ENST00000472284(transcript)|ensembl:ENST00000622514(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|ensembl:ENSG00000196730(gene)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020676|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR036770|mint:P53355|rcsb pdb:1IG1|rcsb pdb:1JKK|refseq:NP_004929.2|rcsb pdb:1JKL|rcsb pdb:1JKS|rcsb pdb:1JKT|rcsb pdb:1P4F|rcsb pdb:1WVW|rcsb pdb:1WVY|rcsb pdb:1YR5|rcsb pdb:2W4J|rcsb pdb:2W4K|rcsb pdb:2X0G|rcsb pdb:2XUU|rcsb pdb:2XZS|rcsb pdb:1WVX|rcsb pdb:2Y0A|rcsb pdb:2Y4P|rcsb pdb:2Y4V|rcsb pdb:2YAK|rcsb pdb:3DFC|rcsb pdb:3DGK|rcsb pdb:3EH9|rcsb pdb:3EHA|rcsb pdb:3F5G|rcsb pdb:3F5U|rcsb pdb:3GU4|rcsb pdb:3GU5|rcsb pdb:3GU6|rcsb pdb:3GU7|rcsb pdb:3GU8|rcsb pdb:3GUB|rcsb pdb:3ZXT|rcsb pdb:4B4L|rcsb pdb:4PF4|rcsb pdb:4TL0|rcsb pdb:4TXC|rcsb pdb:4UV0|rcsb pdb:4YO4|rcsb pdb:4YPD|rcsb pdb:5AUT|rcsb pdb:5AUU|rcsb pdb:5AUV|rcsb pdb:5AUW|rcsb pdb:5AUX|rcsb pdb:5AUY|rcsb pdb:5AUZ|rcsb pdb:5AV0|rcsb pdb:5AV1|rcsb pdb:5AV2|rcsb pdb:5AV3|rcsb pdb:5AV4|rcsb pdb:6AAR|rcsb pdb:6FHA|rcsb pdb:6FHB|rcsb pdb:6QN4|rcsb pdb:6GY5|rcsb pdb:6IN4|rcsb pdb:6QMO|refseq:NP_001275658.1|refseq:NP_001275659.1|refseq:NP_001275660.1|rcsb pdb:7CCW|rcsb pdb:7CCV|rcsb pdb:7CCU|reactome:R-HSA-418889	-	-	-	figure legend:1d|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/01/10	2014/10/16	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	rogid:GCxGiQSqtI+M2uqNXe9F4AN1x909606	intact-crc:92FB29BDA54FEC7F|rigid:GBnd+kvuZMgPVe2vOPRhi+XS+z0	false	green fluorescent protein tag:n-n	flag tag:n-n|necessary binding region:306-1271	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14618	uniprotkb:P53355	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	intact:EBI-358616|uniprotkb:Q6ZRZ3|uniprotkb:Q68CP8|uniprotkb:B7ZLD2|uniprotkb:Q1W5W0|ensembl:ENSP00000350785|ensembl:ENSP00000386135|ensembl:ENSP00000417076|ensembl:ENSP00000484267|uniprotkb:Q9BTL8|uniprotkb:Q14CQ7|uniprotkb:B7ZLE7	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:dapk1_human(display_long)|uniprotkb:DAPK1(gene name)|psi-mi:DAPK1(display_short)|uniprotkb:DAPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mor et al. (2012)	imex:IM-18624|pubmed:21725354	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-6476257|imex:IM-18624-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	ensembl:ENST00000358077(transcript)|ensembl:ENST00000408954(transcript)|ensembl:ENST00000472284(transcript)|ensembl:ENST00000622514(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|ensembl:ENSG00000196730(gene)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020676|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR036770|mint:P53355|rcsb pdb:1IG1|rcsb pdb:1JKK|refseq:NP_004929.2|rcsb pdb:1JKL|rcsb pdb:1JKS|rcsb pdb:1JKT|rcsb pdb:1P4F|rcsb pdb:1WVW|rcsb pdb:1WVY|rcsb pdb:1YR5|rcsb pdb:2W4J|rcsb pdb:2W4K|rcsb pdb:2X0G|rcsb pdb:2XUU|rcsb pdb:2XZS|rcsb pdb:1WVX|rcsb pdb:2Y0A|rcsb pdb:2Y4P|rcsb pdb:2Y4V|rcsb pdb:2YAK|rcsb pdb:3DFC|rcsb pdb:3DGK|rcsb pdb:3EH9|rcsb pdb:3EHA|rcsb pdb:3F5G|rcsb pdb:3F5U|rcsb pdb:3GU4|rcsb pdb:3GU5|rcsb pdb:3GU6|rcsb pdb:3GU7|rcsb pdb:3GU8|rcsb pdb:3GUB|rcsb pdb:3ZXT|rcsb pdb:4B4L|rcsb pdb:4PF4|rcsb pdb:4TL0|rcsb pdb:4TXC|rcsb pdb:4UV0|rcsb pdb:4YO4|rcsb pdb:4YPD|rcsb pdb:5AUT|rcsb pdb:5AUU|rcsb pdb:5AUV|rcsb pdb:5AUW|rcsb pdb:5AUX|rcsb pdb:5AUY|rcsb pdb:5AUZ|rcsb pdb:5AV0|rcsb pdb:5AV1|rcsb pdb:5AV2|rcsb pdb:5AV3|rcsb pdb:5AV4|rcsb pdb:6AAR|rcsb pdb:6FHA|rcsb pdb:6FHB|rcsb pdb:6QN4|rcsb pdb:6GY5|rcsb pdb:6IN4|rcsb pdb:6QMO|refseq:NP_001275658.1|refseq:NP_001275659.1|refseq:NP_001275660.1|rcsb pdb:7CCW|rcsb pdb:7CCV|rcsb pdb:7CCU|reactome:R-HSA-418889	-	-	-	figure legend:3c|comment:Interaction between DAPk and PKM2 is increased upon treatment of cells with latrunculin-B pre-lysis.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/01/10	2014/10/16	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	rogid:GCxGiQSqtI+M2uqNXe9F4AN1x909606	intact-crc:F48824D755AEB801|rigid:GBnd+kvuZMgPVe2vOPRhi+XS+z0	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)