#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0AEX9 uniprotkb:P02916 intact:EBI-369910|uniprotkb:P02928|uniprotkb:Q2M6S0|ensemblbacteria:AAC77004|ensemblbacteria:BAE78036 intact:EBI-1118919|uniprotkb:Q2M6S1|ensemblbacteria:AAC77003|ensemblbacteria:BAE78035 psi-mi:male_ecoli(display_long)|uniprotkb:malE(gene name)|psi-mi:malE(display_short)|uniprotkb:MMBP(gene name synonym)|uniprotkb:Maltodextrin-binding protein(gene name synonym)|uniprotkb:Maltose-binding protein(gene name synonym)|uniprotkb:JW3994(locus name)|uniprotkb:b4034(locus name) psi-mi:malf_ecoli(display_long)|uniprotkb:malF(gene name)|psi-mi:malF(display_short)|uniprotkb:b4033(locus name)|uniprotkb:JW3993(locus name) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477542|imex:IM-18621-3|rcsb pdb:3puz - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC77004(transcript)|ensemblbacteria:b4034(gene)|ensemblbacteria:BAE78036(gene)|ensemblbacteria:BAE78036(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:NP_418458.1|rcsb pdb:2N45|rcsb pdb:2NVU|rcsb pdb:2OBG|rcsb pdb:2OK2|rcsb pdb:2R6G|rcsb pdb:2V93|rcsb pdb:2VGQ|rcsb pdb:2XZ3|rcsb pdb:2ZXT|rcsb pdb:3A3C|rcsb pdb:3C4M|rcsb pdb:3CSB|rcsb pdb:3CSG|rcsb pdb:3D4C|rcsb pdb:3D4G|rcsb pdb:3DM0|rcsb pdb:3EF7|rcsb pdb:3EHS|rcsb pdb:3EHT|rcsb pdb:3EHU|rcsb pdb:3F5F|go:"GO:0034289"(detection of maltose stimulus)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|go:"GO:0060326"(cell chemotaxis)|go:"GO:1901982"(maltose binding)|interpro:IPR006059(Bacterial extracellular solute-binding, family 1)|interpro:IPR006060(Maltose binding protein)|interpro:IPR006061(Bacterial extracellular solute-binding family 1, conserved site)|rcsb pdb:1A7L|rcsb pdb:1ANF|rcsb pdb:1DMB|rcsb pdb:1EZ9|rcsb pdb:1EZO|rcsb pdb:1EZP|rcsb pdb:1FQA|rcsb pdb:1FQB|rcsb pdb:1FQC|rcsb pdb:1FQD|rcsb pdb:1HSJ|rcsb pdb:1IUD|rcsb pdb:1JVX|rcsb pdb:1JVY|rcsb pdb:1JW4|go:"GO:0042597"(periplasmic space)|go:"GO:0042956"(maltodextrin transport)|rcsb pdb:1JW5|rcsb pdb:1LAX|rcsb pdb:1LLS|rcsb pdb:1MDP|rcsb pdb:1MDQ|rcsb pdb:1MG1|rcsb pdb:1MH3|rcsb pdb:1MH4|rcsb pdb:1MPB|rcsb pdb:1MPC|rcsb pdb:1MPD|rcsb pdb:1N3W|rcsb pdb:1N3X|rcsb pdb:1NL5|rcsb pdb:1NMU|rcsb pdb:1OMP|rcsb pdb:1PEB|rcsb pdb:1R6Z|rcsb pdb:1SVX|rcsb pdb:1T0K|rcsb pdb:1Y4C|rcsb pdb:1YTV|rcsb pdb:1ZIU|rcsb pdb:1ZJL|rcsb pdb:1ZKB|rcsb pdb:1ZMG|rcsb pdb:2D21|rcsb pdb:2H25|rcsb pdb:2KLF|rcsb pdb:2MV0|rcsb pdb:2N44|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3H3G|rcsb pdb:3H4Z|rcsb pdb:3HPI|rcsb pdb:3HST|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3J9P|rcsb pdb:3KJT|rcsb pdb:3L2J|rcsb pdb:3LBS|rcsb pdb:3LC8|rcsb pdb:3MBP|rcsb pdb:3MP1|rcsb pdb:3IO4|rcsb pdb:3MP6|rcsb pdb:3MP8|rcsb pdb:3MQ9|rcsb pdb:3N93|rcsb pdb:3N94|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4GIZ|rcsb pdb:4GLI|rcsb pdb:4IFP|rcsb pdb:4FEB|rcsb pdb:4IKM|rcsb pdb:4IRL|rcsb pdb:4JBZ|rcsb pdb:4JKM|rcsb pdb:4KEG|rcsb pdb:4KHZ|rcsb pdb:4KI0|rcsb pdb:4KV3|rcsb pdb:4KYC|rcsb pdb:4KYD|rcsb pdb:4KYE|rcsb pdb:4LOG|rcsb pdb:4MBP|rcsb pdb:4N4X|rcsb pdb:4NDZ|rcsb pdb:4NUF|rcsb pdb:4O2X|rcsb pdb:4OGM|rcsb pdb:4PE2|rcsb pdb:4PQK|rcsb pdb:4QSZ|rcsb pdb:4QVH|rcsb pdb:3N95|rcsb pdb:3N96|rcsb pdb:3O3U|rcsb pdb:3OAI|rcsb pdb:3OB4|rcsb pdb:3OSQ|rcsb pdb:3OSR|rcsb pdb:3PGF|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3PY7|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:3RLF|rcsb pdb:3RUM|rcsb pdb:3SER|rcsb pdb:3SES|rcsb pdb:3SET|rcsb pdb:3SEU|rcsb pdb:3SEV|rcsb pdb:3SEW|rcsb pdb:3SEX|rcsb pdb:3SEY|rcsb pdb:3VFJ|rcsb pdb:3W15|rcsb pdb:3WAI|rcsb pdb:3WOA|rcsb pdb:4B3N|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4DXB|rcsb pdb:4DXC|rcsb pdb:4EDQ|rcsb pdb:4EGC|rcsb pdb:4EXK|rcsb pdb:4FE8|refseq:WP_000695387.1|rcsb pdb:4R0Y|rcsb pdb:4RG5|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:4TSM|rcsb pdb:4WJV|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4WRN|rcsb pdb:4WTH|rcsb pdb:4WVH|rcsb pdb:4XA2|rcsb pdb:4XAJ|rcsb pdb:4XHS|rcsb pdb:4XR8|rcsb pdb:4XZS|rcsb pdb:4XZV|rcsb pdb:5AQ9|rcsb pdb:5AZ6|rcsb pdb:5AZ7|rcsb pdb:5AZ8|rcsb pdb:5AZ9|rcsb pdb:5AZA|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BK1|rcsb pdb:5BK2|rcsb pdb:5C7R|rcsb pdb:5CBN|rcsb pdb:5CFV|rcsb pdb:5DFM|rcsb pdb:5DIS|rcsb pdb:5E24|rcsb pdb:5E7U|rcsb pdb:5EDU|rcsb pdb:5FIO|rcsb pdb:5FSG|rcsb pdb:5GRU|rcsb pdb:5GS2|rcsb pdb:5GXT|rcsb pdb:5GXV|rcsb pdb:5H7N|rcsb pdb:5H7Q|rcsb pdb:5HZ7|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|rcsb pdb:5I69|rcsb pdb:5IHJ|rcsb pdb:5II5|rcsb pdb:5IIC|rcsb pdb:5IQZ|rcsb pdb:5JJ4|rcsb pdb:5JST|rcsb pdb:5JTQ|rcsb pdb:5JTR|rcsb pdb:5LDF|rcsb pdb:5M13|rcsb pdb:5M14|rcsb pdb:5M15|rcsb pdb:5MM3|rcsb pdb:5OSQ|rcsb pdb:5T03|rcsb pdb:5T05|rcsb pdb:5T0A|rcsb pdb:5TTD|rcsb pdb:5VAW|rcsb pdb:5WPZ|rcsb pdb:5WQ6|rcsb pdb:5Y2G|rcsb pdb:5YGP|rcsb pdb:5YGS|rcsb pdb:5Z0R|rcsb pdb:5Z0V|rcsb pdb:5ZCA|rcsb pdb:5ZNY|rcsb pdb:5ZNZ|rcsb pdb:5ZR0|rcsb pdb:6APX|rcsb pdb:6CXS|rcsb pdb:6D65|rcsb pdb:6D66|rcsb pdb:6D67|rcsb pdb:6DM8|rcsb pdb:6EQZ|rcsb pdb:6HD8|rcsb pdb:6HD9|rcsb pdb:6HDA|rcsb pdb:6HDB|rcsb pdb:6HDC|rcsb pdb:6I4Y|rcsb pdb:6K7D|rcsb pdb:6K7E|rcsb pdb:6K7F|rcsb pdb:6KEA|rcsb pdb:6KI0|rcsb pdb:6KXG|rcsb pdb:6LES|rcsb pdb:6LF3|rcsb pdb:6M4V|rcsb pdb:6M4W|rcsb pdb:6N84|rcsb pdb:6NDJ|rcsb pdb:6OB5|rcsb pdb:6P6W|rcsb pdb:6QUG|rcsb pdb:6QYK|rcsb pdb:6QYL|rcsb pdb:6QYN|rcsb pdb:6QYO|rcsb pdb:6QZ7|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6SLM|rcsb pdb:6SMV|rcsb pdb:6SWR|rcsb pdb:6TZC|rcsb pdb:6V2E|rcsb pdb:6VLS|rcsb pdb:6WBH|rcsb pdb:6WBJ|rcsb pdb:6XDS|rcsb pdb:6XRX|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6YSN|rcsb pdb:6ZHO|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7JTR|rcsb pdb:7K48|dip:DIP-31871N ensemblbacteria:AAC77003(transcript)|ensemblbacteria:b4033(gene)|ensemblbacteria:BAE78035(gene)|ensemblbacteria:BAE78035(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0015423"(ABC-type maltose transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0016020"(membrane)|go:"GO:0042956"(maltodextrin transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:1990060"(maltose transport complex)|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR029345|interpro:IPR030156|interpro:IPR035277|interpro:IPR035906|rcsb pdb:2R6G|rcsb pdb:3FH6|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3RLF|rcsb pdb:4JBW|rcsb pdb:4KHZ|rcsb pdb:4KI0|refseq:NP_418457.1|refseq:WP_001297290.1|dip:DIP-10142N go:"GO:0043234"|go:"GO:0005886"(plasma membrane)|go:"GO:0005363"(maltose transmembrane transporter activity) - - figure legend:Fig.s 2b, 3a, S1, S2, S4, S5|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains malE mutant.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 rogid:eRW6SNukWqn5RNc2mgN4yOfxK3k83333 rogid:wYFw3rvr0kQXggDify4+jU6Lsfs83333 intact-crc:47856883ECBFD2EB false sufficient binding region:27-396|mutation:363-363|mutation:95-95 - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0AEX9 uniprotkb:P68183 intact:EBI-369910|uniprotkb:P02928|uniprotkb:Q2M6S0|ensemblbacteria:AAC77004|ensemblbacteria:BAE78036 intact:EBI-6400985|ensemblbacteria:AAC77002|ensemblbacteria:BAE78034|uniprotkb:P07622|uniprotkb:Q2M6S2 psi-mi:male_ecoli(display_long)|uniprotkb:malE(gene name)|psi-mi:malE(display_short)|uniprotkb:MMBP(gene name synonym)|uniprotkb:Maltodextrin-binding protein(gene name synonym)|uniprotkb:Maltose-binding protein(gene name synonym)|uniprotkb:JW3994(locus name)|uniprotkb:b4034(locus name) psi-mi:malg_ecoli(display_long)|uniprotkb:JW3992(locus name)|uniprotkb:b4032(locus name)|uniprotkb:malG(gene name)|psi-mi:malG(display_short) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477542|imex:IM-18621-3|rcsb pdb:3puz - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC77004(transcript)|ensemblbacteria:b4034(gene)|ensemblbacteria:BAE78036(gene)|ensemblbacteria:BAE78036(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:NP_418458.1|rcsb pdb:2N45|rcsb pdb:2NVU|rcsb pdb:2OBG|rcsb pdb:2OK2|rcsb pdb:2R6G|rcsb pdb:2V93|rcsb pdb:2VGQ|rcsb pdb:2XZ3|rcsb pdb:2ZXT|rcsb pdb:3A3C|rcsb pdb:3C4M|rcsb pdb:3CSB|rcsb pdb:3CSG|rcsb pdb:3D4C|rcsb pdb:3D4G|rcsb pdb:3DM0|rcsb pdb:3EF7|rcsb pdb:3EHS|rcsb pdb:3EHT|rcsb pdb:3EHU|rcsb pdb:3F5F|go:"GO:0034289"(detection of maltose stimulus)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|go:"GO:0060326"(cell chemotaxis)|go:"GO:1901982"(maltose binding)|interpro:IPR006059(Bacterial extracellular solute-binding, family 1)|interpro:IPR006060(Maltose binding protein)|interpro:IPR006061(Bacterial extracellular solute-binding family 1, conserved site)|rcsb pdb:1A7L|rcsb pdb:1ANF|rcsb pdb:1DMB|rcsb pdb:1EZ9|rcsb pdb:1EZO|rcsb pdb:1EZP|rcsb pdb:1FQA|rcsb pdb:1FQB|rcsb pdb:1FQC|rcsb pdb:1FQD|rcsb pdb:1HSJ|rcsb pdb:1IUD|rcsb pdb:1JVX|rcsb pdb:1JVY|rcsb pdb:1JW4|go:"GO:0042597"(periplasmic space)|go:"GO:0042956"(maltodextrin transport)|rcsb pdb:1JW5|rcsb pdb:1LAX|rcsb pdb:1LLS|rcsb pdb:1MDP|rcsb pdb:1MDQ|rcsb pdb:1MG1|rcsb pdb:1MH3|rcsb pdb:1MH4|rcsb pdb:1MPB|rcsb pdb:1MPC|rcsb pdb:1MPD|rcsb pdb:1N3W|rcsb pdb:1N3X|rcsb pdb:1NL5|rcsb pdb:1NMU|rcsb pdb:1OMP|rcsb pdb:1PEB|rcsb pdb:1R6Z|rcsb pdb:1SVX|rcsb pdb:1T0K|rcsb pdb:1Y4C|rcsb pdb:1YTV|rcsb pdb:1ZIU|rcsb pdb:1ZJL|rcsb pdb:1ZKB|rcsb pdb:1ZMG|rcsb pdb:2D21|rcsb pdb:2H25|rcsb pdb:2KLF|rcsb pdb:2MV0|rcsb pdb:2N44|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3H3G|rcsb pdb:3H4Z|rcsb pdb:3HPI|rcsb pdb:3HST|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3J9P|rcsb pdb:3KJT|rcsb pdb:3L2J|rcsb pdb:3LBS|rcsb pdb:3LC8|rcsb pdb:3MBP|rcsb pdb:3MP1|rcsb pdb:3IO4|rcsb pdb:3MP6|rcsb pdb:3MP8|rcsb pdb:3MQ9|rcsb pdb:3N93|rcsb pdb:3N94|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4GIZ|rcsb pdb:4GLI|rcsb pdb:4IFP|rcsb pdb:4FEB|rcsb pdb:4IKM|rcsb pdb:4IRL|rcsb pdb:4JBZ|rcsb pdb:4JKM|rcsb pdb:4KEG|rcsb pdb:4KHZ|rcsb pdb:4KI0|rcsb pdb:4KV3|rcsb pdb:4KYC|rcsb pdb:4KYD|rcsb pdb:4KYE|rcsb pdb:4LOG|rcsb pdb:4MBP|rcsb pdb:4N4X|rcsb pdb:4NDZ|rcsb pdb:4NUF|rcsb pdb:4O2X|rcsb pdb:4OGM|rcsb pdb:4PE2|rcsb pdb:4PQK|rcsb pdb:4QSZ|rcsb pdb:4QVH|rcsb pdb:3N95|rcsb pdb:3N96|rcsb pdb:3O3U|rcsb pdb:3OAI|rcsb pdb:3OB4|rcsb pdb:3OSQ|rcsb pdb:3OSR|rcsb pdb:3PGF|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3PY7|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:3RLF|rcsb pdb:3RUM|rcsb pdb:3SER|rcsb pdb:3SES|rcsb pdb:3SET|rcsb pdb:3SEU|rcsb pdb:3SEV|rcsb pdb:3SEW|rcsb pdb:3SEX|rcsb pdb:3SEY|rcsb pdb:3VFJ|rcsb pdb:3W15|rcsb pdb:3WAI|rcsb pdb:3WOA|rcsb pdb:4B3N|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4DXB|rcsb pdb:4DXC|rcsb pdb:4EDQ|rcsb pdb:4EGC|rcsb pdb:4EXK|rcsb pdb:4FE8|refseq:WP_000695387.1|rcsb pdb:4R0Y|rcsb pdb:4RG5|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:4TSM|rcsb pdb:4WJV|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4WRN|rcsb pdb:4WTH|rcsb pdb:4WVH|rcsb pdb:4XA2|rcsb pdb:4XAJ|rcsb pdb:4XHS|rcsb pdb:4XR8|rcsb pdb:4XZS|rcsb pdb:4XZV|rcsb pdb:5AQ9|rcsb pdb:5AZ6|rcsb pdb:5AZ7|rcsb pdb:5AZ8|rcsb pdb:5AZ9|rcsb pdb:5AZA|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BK1|rcsb pdb:5BK2|rcsb pdb:5C7R|rcsb pdb:5CBN|rcsb pdb:5CFV|rcsb pdb:5DFM|rcsb pdb:5DIS|rcsb pdb:5E24|rcsb pdb:5E7U|rcsb pdb:5EDU|rcsb pdb:5FIO|rcsb pdb:5FSG|rcsb pdb:5GRU|rcsb pdb:5GS2|rcsb pdb:5GXT|rcsb pdb:5GXV|rcsb pdb:5H7N|rcsb pdb:5H7Q|rcsb pdb:5HZ7|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|rcsb pdb:5I69|rcsb pdb:5IHJ|rcsb pdb:5II5|rcsb pdb:5IIC|rcsb pdb:5IQZ|rcsb pdb:5JJ4|rcsb pdb:5JST|rcsb pdb:5JTQ|rcsb pdb:5JTR|rcsb pdb:5LDF|rcsb pdb:5M13|rcsb pdb:5M14|rcsb pdb:5M15|rcsb pdb:5MM3|rcsb pdb:5OSQ|rcsb pdb:5T03|rcsb pdb:5T05|rcsb pdb:5T0A|rcsb pdb:5TTD|rcsb pdb:5VAW|rcsb pdb:5WPZ|rcsb pdb:5WQ6|rcsb pdb:5Y2G|rcsb pdb:5YGP|rcsb pdb:5YGS|rcsb pdb:5Z0R|rcsb pdb:5Z0V|rcsb pdb:5ZCA|rcsb pdb:5ZNY|rcsb pdb:5ZNZ|rcsb pdb:5ZR0|rcsb pdb:6APX|rcsb pdb:6CXS|rcsb pdb:6D65|rcsb pdb:6D66|rcsb pdb:6D67|rcsb pdb:6DM8|rcsb pdb:6EQZ|rcsb pdb:6HD8|rcsb pdb:6HD9|rcsb pdb:6HDA|rcsb pdb:6HDB|rcsb pdb:6HDC|rcsb pdb:6I4Y|rcsb pdb:6K7D|rcsb pdb:6K7E|rcsb pdb:6K7F|rcsb pdb:6KEA|rcsb pdb:6KI0|rcsb pdb:6KXG|rcsb pdb:6LES|rcsb pdb:6LF3|rcsb pdb:6M4V|rcsb pdb:6M4W|rcsb pdb:6N84|rcsb pdb:6NDJ|rcsb pdb:6OB5|rcsb pdb:6P6W|rcsb pdb:6QUG|rcsb pdb:6QYK|rcsb pdb:6QYL|rcsb pdb:6QYN|rcsb pdb:6QYO|rcsb pdb:6QZ7|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6SLM|rcsb pdb:6SMV|rcsb pdb:6SWR|rcsb pdb:6TZC|rcsb pdb:6V2E|rcsb pdb:6VLS|rcsb pdb:6WBH|rcsb pdb:6WBJ|rcsb pdb:6XDS|rcsb pdb:6XRX|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6YSN|rcsb pdb:6ZHO|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7JTR|rcsb pdb:7K48|dip:DIP-31871N refseq:WP_001252058.1|ensemblbacteria:AAC77002(transcript)|ensemblbacteria:b4032(gene)|ensemblbacteria:BAE78034(gene)|ensemblbacteria:BAE78034(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015423"(ABC-type maltose transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0016020"(membrane)|go:"GO:0042956"(maltodextrin transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:1990060"(maltose transport complex)|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR035906|rcsb pdb:2R6G|rcsb pdb:3FH6|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3RLF|rcsb pdb:4JBW|rcsb pdb:4KI0|refseq:NP_418456.1|dip:DIP-59709N go:"GO:0043234"|go:"GO:0005886"(plasma membrane)|go:"GO:0005363"(maltose transmembrane transporter activity) - - figure legend:Fig.s 2b, 3a, S1, S2, S4, S5|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains malE mutant.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 rogid:eRW6SNukWqn5RNc2mgN4yOfxK3k83333 rogid:JslgyRfgqSfHJ0QTLpej9DnSoUw83333 intact-crc:47856883ECBFD2EB false sufficient binding region:27-396|mutation:363-363|mutation:95-95 - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0AEX9 uniprotkb:P68187 intact:EBI-369910|uniprotkb:P02928|uniprotkb:Q2M6S0|ensemblbacteria:AAC77004|ensemblbacteria:BAE78036 intact:EBI-550803|uniprotkb:P02914|uniprotkb:Q2M6R9|uniprotkb:Q47348|ensemblbacteria:AAC77005|ensemblbacteria:BAE78037 psi-mi:male_ecoli(display_long)|uniprotkb:malE(gene name)|psi-mi:malE(display_short)|uniprotkb:MMBP(gene name synonym)|uniprotkb:Maltodextrin-binding protein(gene name synonym)|uniprotkb:Maltose-binding protein(gene name synonym)|uniprotkb:JW3994(locus name)|uniprotkb:b4034(locus name) psi-mi:malk_ecoli(display_long)|uniprotkb:malK(gene name)|psi-mi:malK(display_short)|uniprotkb:b4035(locus name)|uniprotkb:JW3995(locus name) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477542|imex:IM-18621-3|rcsb pdb:3puz - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC77004(transcript)|ensemblbacteria:b4034(gene)|ensemblbacteria:BAE78036(gene)|ensemblbacteria:BAE78036(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:NP_418458.1|rcsb pdb:2N45|rcsb pdb:2NVU|rcsb pdb:2OBG|rcsb pdb:2OK2|rcsb pdb:2R6G|rcsb pdb:2V93|rcsb pdb:2VGQ|rcsb pdb:2XZ3|rcsb pdb:2ZXT|rcsb pdb:3A3C|rcsb pdb:3C4M|rcsb pdb:3CSB|rcsb pdb:3CSG|rcsb pdb:3D4C|rcsb pdb:3D4G|rcsb pdb:3DM0|rcsb pdb:3EF7|rcsb pdb:3EHS|rcsb pdb:3EHT|rcsb pdb:3EHU|rcsb pdb:3F5F|go:"GO:0034289"(detection of maltose stimulus)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|go:"GO:0060326"(cell chemotaxis)|go:"GO:1901982"(maltose binding)|interpro:IPR006059(Bacterial extracellular solute-binding, family 1)|interpro:IPR006060(Maltose binding protein)|interpro:IPR006061(Bacterial extracellular solute-binding family 1, conserved site)|rcsb pdb:1A7L|rcsb pdb:1ANF|rcsb pdb:1DMB|rcsb pdb:1EZ9|rcsb pdb:1EZO|rcsb pdb:1EZP|rcsb pdb:1FQA|rcsb pdb:1FQB|rcsb pdb:1FQC|rcsb pdb:1FQD|rcsb pdb:1HSJ|rcsb pdb:1IUD|rcsb pdb:1JVX|rcsb pdb:1JVY|rcsb pdb:1JW4|go:"GO:0042597"(periplasmic space)|go:"GO:0042956"(maltodextrin transport)|rcsb pdb:1JW5|rcsb pdb:1LAX|rcsb pdb:1LLS|rcsb pdb:1MDP|rcsb pdb:1MDQ|rcsb pdb:1MG1|rcsb pdb:1MH3|rcsb pdb:1MH4|rcsb pdb:1MPB|rcsb pdb:1MPC|rcsb pdb:1MPD|rcsb pdb:1N3W|rcsb pdb:1N3X|rcsb pdb:1NL5|rcsb pdb:1NMU|rcsb pdb:1OMP|rcsb pdb:1PEB|rcsb pdb:1R6Z|rcsb pdb:1SVX|rcsb pdb:1T0K|rcsb pdb:1Y4C|rcsb pdb:1YTV|rcsb pdb:1ZIU|rcsb pdb:1ZJL|rcsb pdb:1ZKB|rcsb pdb:1ZMG|rcsb pdb:2D21|rcsb pdb:2H25|rcsb pdb:2KLF|rcsb pdb:2MV0|rcsb pdb:2N44|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3H3G|rcsb pdb:3H4Z|rcsb pdb:3HPI|rcsb pdb:3HST|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3J9P|rcsb pdb:3KJT|rcsb pdb:3L2J|rcsb pdb:3LBS|rcsb pdb:3LC8|rcsb pdb:3MBP|rcsb pdb:3MP1|rcsb pdb:3IO4|rcsb pdb:3MP6|rcsb pdb:3MP8|rcsb pdb:3MQ9|rcsb pdb:3N93|rcsb pdb:3N94|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4GIZ|rcsb pdb:4GLI|rcsb pdb:4IFP|rcsb pdb:4FEB|rcsb pdb:4IKM|rcsb pdb:4IRL|rcsb pdb:4JBZ|rcsb pdb:4JKM|rcsb pdb:4KEG|rcsb pdb:4KHZ|rcsb pdb:4KI0|rcsb pdb:4KV3|rcsb pdb:4KYC|rcsb pdb:4KYD|rcsb pdb:4KYE|rcsb pdb:4LOG|rcsb pdb:4MBP|rcsb pdb:4N4X|rcsb pdb:4NDZ|rcsb pdb:4NUF|rcsb pdb:4O2X|rcsb pdb:4OGM|rcsb pdb:4PE2|rcsb pdb:4PQK|rcsb pdb:4QSZ|rcsb pdb:4QVH|rcsb pdb:3N95|rcsb pdb:3N96|rcsb pdb:3O3U|rcsb pdb:3OAI|rcsb pdb:3OB4|rcsb pdb:3OSQ|rcsb pdb:3OSR|rcsb pdb:3PGF|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3PY7|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:3RLF|rcsb pdb:3RUM|rcsb pdb:3SER|rcsb pdb:3SES|rcsb pdb:3SET|rcsb pdb:3SEU|rcsb pdb:3SEV|rcsb pdb:3SEW|rcsb pdb:3SEX|rcsb pdb:3SEY|rcsb pdb:3VFJ|rcsb pdb:3W15|rcsb pdb:3WAI|rcsb pdb:3WOA|rcsb pdb:4B3N|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4DXB|rcsb pdb:4DXC|rcsb pdb:4EDQ|rcsb pdb:4EGC|rcsb pdb:4EXK|rcsb pdb:4FE8|refseq:WP_000695387.1|rcsb pdb:4R0Y|rcsb pdb:4RG5|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:4TSM|rcsb pdb:4WJV|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4WRN|rcsb pdb:4WTH|rcsb pdb:4WVH|rcsb pdb:4XA2|rcsb pdb:4XAJ|rcsb pdb:4XHS|rcsb pdb:4XR8|rcsb pdb:4XZS|rcsb pdb:4XZV|rcsb pdb:5AQ9|rcsb pdb:5AZ6|rcsb pdb:5AZ7|rcsb pdb:5AZ8|rcsb pdb:5AZ9|rcsb pdb:5AZA|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BK1|rcsb pdb:5BK2|rcsb pdb:5C7R|rcsb pdb:5CBN|rcsb pdb:5CFV|rcsb pdb:5DFM|rcsb pdb:5DIS|rcsb pdb:5E24|rcsb pdb:5E7U|rcsb pdb:5EDU|rcsb pdb:5FIO|rcsb pdb:5FSG|rcsb pdb:5GRU|rcsb pdb:5GS2|rcsb pdb:5GXT|rcsb pdb:5GXV|rcsb pdb:5H7N|rcsb pdb:5H7Q|rcsb pdb:5HZ7|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|rcsb pdb:5I69|rcsb pdb:5IHJ|rcsb pdb:5II5|rcsb pdb:5IIC|rcsb pdb:5IQZ|rcsb pdb:5JJ4|rcsb pdb:5JST|rcsb pdb:5JTQ|rcsb pdb:5JTR|rcsb pdb:5LDF|rcsb pdb:5M13|rcsb pdb:5M14|rcsb pdb:5M15|rcsb pdb:5MM3|rcsb pdb:5OSQ|rcsb pdb:5T03|rcsb pdb:5T05|rcsb pdb:5T0A|rcsb pdb:5TTD|rcsb pdb:5VAW|rcsb pdb:5WPZ|rcsb pdb:5WQ6|rcsb pdb:5Y2G|rcsb pdb:5YGP|rcsb pdb:5YGS|rcsb pdb:5Z0R|rcsb pdb:5Z0V|rcsb pdb:5ZCA|rcsb pdb:5ZNY|rcsb pdb:5ZNZ|rcsb pdb:5ZR0|rcsb pdb:6APX|rcsb pdb:6CXS|rcsb pdb:6D65|rcsb pdb:6D66|rcsb pdb:6D67|rcsb pdb:6DM8|rcsb pdb:6EQZ|rcsb pdb:6HD8|rcsb pdb:6HD9|rcsb pdb:6HDA|rcsb pdb:6HDB|rcsb pdb:6HDC|rcsb pdb:6I4Y|rcsb pdb:6K7D|rcsb pdb:6K7E|rcsb pdb:6K7F|rcsb pdb:6KEA|rcsb pdb:6KI0|rcsb pdb:6KXG|rcsb pdb:6LES|rcsb pdb:6LF3|rcsb pdb:6M4V|rcsb pdb:6M4W|rcsb pdb:6N84|rcsb pdb:6NDJ|rcsb pdb:6OB5|rcsb pdb:6P6W|rcsb pdb:6QUG|rcsb pdb:6QYK|rcsb pdb:6QYL|rcsb pdb:6QYN|rcsb pdb:6QYO|rcsb pdb:6QZ7|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6SLM|rcsb pdb:6SMV|rcsb pdb:6SWR|rcsb pdb:6TZC|rcsb pdb:6V2E|rcsb pdb:6VLS|rcsb pdb:6WBH|rcsb pdb:6WBJ|rcsb pdb:6XDS|rcsb pdb:6XRX|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6YSN|rcsb pdb:6ZHO|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7JTR|rcsb pdb:7K48|dip:DIP-31871N refseq:NP_418459.1|refseq:WP_000179165.1|dip:DIP-47850N|ensemblbacteria:AAC77005(transcript)|ensemblbacteria:b4035(gene)|ensemblbacteria:BAE78037(gene)|ensemblbacteria:BAE78037(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0015423"(ABC-type maltose transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0016020"(membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0042956"(maltodextrin transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|go:"GO:1990060"(maltose transport complex)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008995(Molybdate/tungstate binding)|interpro:IPR015855(ABC transporter, maltose/maltodextrin import, MalK)|interpro:IPR017871|interpro:IPR027417|interpro:IPR040582|rcsb pdb:1Q12|rcsb pdb:1Q1B|rcsb pdb:1Q1E|rcsb pdb:2AWN|rcsb pdb:2AWO|rcsb pdb:2R6G|rcsb pdb:3FH6|rcsb pdb:3GD7|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3RLF|rcsb pdb:4JBW|rcsb pdb:4KI0 go:"GO:0043234"|go:"GO:0005886"(plasma membrane)|go:"GO:0005363"(maltose transmembrane transporter activity) - - figure legend:Fig.s 2b, 3a, S1, S2, S4, S5|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains malE mutant.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 rogid:eRW6SNukWqn5RNc2mgN4yOfxK3k83333 rogid:Z2VXSeO5q36t6IR4Sisvp78Ubu083333 intact-crc:47856883ECBFD2EB false sufficient binding region:27-396|mutation:363-363|mutation:95-95 his tag:c-c 1 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:17306" uniprotkb:P0AEX9 intact:EBI-1774952 intact:EBI-369910|uniprotkb:P02928|uniprotkb:Q2M6S0|ensemblbacteria:AAC77004|ensemblbacteria:BAE78036 psi-mi:maltose(display_short)|psi-mi:"CHEBI:17306"(display_long) psi-mi:male_ecoli(display_long)|uniprotkb:malE(gene name)|psi-mi:malE(display_short)|uniprotkb:MMBP(gene name synonym)|uniprotkb:Maltodextrin-binding protein(gene name synonym)|uniprotkb:Maltose-binding protein(gene name synonym)|uniprotkb:JW3994(locus name)|uniprotkb:b4034(locus name) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477542|imex:IM-18621-3|rcsb pdb:3puz - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensemblbacteria:AAC77004(transcript)|ensemblbacteria:b4034(gene)|ensemblbacteria:BAE78036(gene)|ensemblbacteria:BAE78036(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:NP_418458.1|rcsb pdb:2N45|rcsb pdb:2NVU|rcsb pdb:2OBG|rcsb pdb:2OK2|rcsb pdb:2R6G|rcsb pdb:2V93|rcsb pdb:2VGQ|rcsb pdb:2XZ3|rcsb pdb:2ZXT|rcsb pdb:3A3C|rcsb pdb:3C4M|rcsb pdb:3CSB|rcsb pdb:3CSG|rcsb pdb:3D4C|rcsb pdb:3D4G|rcsb pdb:3DM0|rcsb pdb:3EF7|rcsb pdb:3EHS|rcsb pdb:3EHT|rcsb pdb:3EHU|rcsb pdb:3F5F|go:"GO:0034289"(detection of maltose stimulus)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|go:"GO:0060326"(cell chemotaxis)|go:"GO:1901982"(maltose binding)|interpro:IPR006059(Bacterial extracellular solute-binding, family 1)|interpro:IPR006060(Maltose binding protein)|interpro:IPR006061(Bacterial extracellular solute-binding family 1, conserved site)|rcsb pdb:1A7L|rcsb pdb:1ANF|rcsb pdb:1DMB|rcsb pdb:1EZ9|rcsb pdb:1EZO|rcsb pdb:1EZP|rcsb pdb:1FQA|rcsb pdb:1FQB|rcsb pdb:1FQC|rcsb pdb:1FQD|rcsb pdb:1HSJ|rcsb pdb:1IUD|rcsb pdb:1JVX|rcsb pdb:1JVY|rcsb pdb:1JW4|go:"GO:0042597"(periplasmic space)|go:"GO:0042956"(maltodextrin transport)|rcsb pdb:1JW5|rcsb pdb:1LAX|rcsb pdb:1LLS|rcsb pdb:1MDP|rcsb pdb:1MDQ|rcsb pdb:1MG1|rcsb pdb:1MH3|rcsb pdb:1MH4|rcsb pdb:1MPB|rcsb pdb:1MPC|rcsb pdb:1MPD|rcsb pdb:1N3W|rcsb pdb:1N3X|rcsb pdb:1NL5|rcsb pdb:1NMU|rcsb pdb:1OMP|rcsb pdb:1PEB|rcsb pdb:1R6Z|rcsb pdb:1SVX|rcsb pdb:1T0K|rcsb pdb:1Y4C|rcsb pdb:1YTV|rcsb pdb:1ZIU|rcsb pdb:1ZJL|rcsb pdb:1ZKB|rcsb pdb:1ZMG|rcsb pdb:2D21|rcsb pdb:2H25|rcsb pdb:2KLF|rcsb pdb:2MV0|rcsb pdb:2N44|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3H3G|rcsb pdb:3H4Z|rcsb pdb:3HPI|rcsb pdb:3HST|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3J9P|rcsb pdb:3KJT|rcsb pdb:3L2J|rcsb pdb:3LBS|rcsb pdb:3LC8|rcsb pdb:3MBP|rcsb pdb:3MP1|rcsb pdb:3IO4|rcsb pdb:3MP6|rcsb pdb:3MP8|rcsb pdb:3MQ9|rcsb pdb:3N93|rcsb pdb:3N94|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4GIZ|rcsb pdb:4GLI|rcsb pdb:4IFP|rcsb pdb:4FEB|rcsb pdb:4IKM|rcsb pdb:4IRL|rcsb pdb:4JBZ|rcsb pdb:4JKM|rcsb pdb:4KEG|rcsb pdb:4KHZ|rcsb pdb:4KI0|rcsb pdb:4KV3|rcsb pdb:4KYC|rcsb pdb:4KYD|rcsb pdb:4KYE|rcsb pdb:4LOG|rcsb pdb:4MBP|rcsb pdb:4N4X|rcsb pdb:4NDZ|rcsb pdb:4NUF|rcsb pdb:4O2X|rcsb pdb:4OGM|rcsb pdb:4PE2|rcsb pdb:4PQK|rcsb pdb:4QSZ|rcsb pdb:4QVH|rcsb pdb:3N95|rcsb pdb:3N96|rcsb pdb:3O3U|rcsb pdb:3OAI|rcsb pdb:3OB4|rcsb pdb:3OSQ|rcsb pdb:3OSR|rcsb pdb:3PGF|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3PY7|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:3RLF|rcsb pdb:3RUM|rcsb pdb:3SER|rcsb pdb:3SES|rcsb pdb:3SET|rcsb pdb:3SEU|rcsb pdb:3SEV|rcsb pdb:3SEW|rcsb pdb:3SEX|rcsb pdb:3SEY|rcsb pdb:3VFJ|rcsb pdb:3W15|rcsb pdb:3WAI|rcsb pdb:3WOA|rcsb pdb:4B3N|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4DXB|rcsb pdb:4DXC|rcsb pdb:4EDQ|rcsb pdb:4EGC|rcsb pdb:4EXK|rcsb pdb:4FE8|refseq:WP_000695387.1|rcsb pdb:4R0Y|rcsb pdb:4RG5|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:4TSM|rcsb pdb:4WJV|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4WRN|rcsb pdb:4WTH|rcsb pdb:4WVH|rcsb pdb:4XA2|rcsb pdb:4XAJ|rcsb pdb:4XHS|rcsb pdb:4XR8|rcsb pdb:4XZS|rcsb pdb:4XZV|rcsb pdb:5AQ9|rcsb pdb:5AZ6|rcsb pdb:5AZ7|rcsb pdb:5AZ8|rcsb pdb:5AZ9|rcsb pdb:5AZA|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BK1|rcsb pdb:5BK2|rcsb pdb:5C7R|rcsb pdb:5CBN|rcsb pdb:5CFV|rcsb pdb:5DFM|rcsb pdb:5DIS|rcsb pdb:5E24|rcsb pdb:5E7U|rcsb pdb:5EDU|rcsb pdb:5FIO|rcsb pdb:5FSG|rcsb pdb:5GRU|rcsb pdb:5GS2|rcsb pdb:5GXT|rcsb pdb:5GXV|rcsb pdb:5H7N|rcsb pdb:5H7Q|rcsb pdb:5HZ7|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|rcsb pdb:5I69|rcsb pdb:5IHJ|rcsb pdb:5II5|rcsb pdb:5IIC|rcsb pdb:5IQZ|rcsb pdb:5JJ4|rcsb pdb:5JST|rcsb pdb:5JTQ|rcsb pdb:5JTR|rcsb pdb:5LDF|rcsb pdb:5M13|rcsb pdb:5M14|rcsb pdb:5M15|rcsb pdb:5MM3|rcsb pdb:5OSQ|rcsb pdb:5T03|rcsb pdb:5T05|rcsb pdb:5T0A|rcsb pdb:5TTD|rcsb pdb:5VAW|rcsb pdb:5WPZ|rcsb pdb:5WQ6|rcsb pdb:5Y2G|rcsb pdb:5YGP|rcsb pdb:5YGS|rcsb pdb:5Z0R|rcsb pdb:5Z0V|rcsb pdb:5ZCA|rcsb pdb:5ZNY|rcsb pdb:5ZNZ|rcsb pdb:5ZR0|rcsb pdb:6APX|rcsb pdb:6CXS|rcsb pdb:6D65|rcsb pdb:6D66|rcsb pdb:6D67|rcsb pdb:6DM8|rcsb pdb:6EQZ|rcsb pdb:6HD8|rcsb pdb:6HD9|rcsb pdb:6HDA|rcsb pdb:6HDB|rcsb pdb:6HDC|rcsb pdb:6I4Y|rcsb pdb:6K7D|rcsb pdb:6K7E|rcsb pdb:6K7F|rcsb pdb:6KEA|rcsb pdb:6KI0|rcsb pdb:6KXG|rcsb pdb:6LES|rcsb pdb:6LF3|rcsb pdb:6M4V|rcsb pdb:6M4W|rcsb pdb:6N84|rcsb pdb:6NDJ|rcsb pdb:6OB5|rcsb pdb:6P6W|rcsb pdb:6QUG|rcsb pdb:6QYK|rcsb pdb:6QYL|rcsb pdb:6QYN|rcsb pdb:6QYO|rcsb pdb:6QZ7|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6SLM|rcsb pdb:6SMV|rcsb pdb:6SWR|rcsb pdb:6TZC|rcsb pdb:6V2E|rcsb pdb:6VLS|rcsb pdb:6WBH|rcsb pdb:6WBJ|rcsb pdb:6XDS|rcsb pdb:6XRX|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6YSN|rcsb pdb:6ZHO|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7JTR|rcsb pdb:7K48|dip:DIP-31871N go:"GO:0043234"|go:"GO:0005886"(plasma membrane)|go:"GO:0005363"(maltose transmembrane transporter activity) - - figure legend:Fig.s 2b, 3a, S1, S2, S4, S5|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains malE mutant.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 - rogid:eRW6SNukWqn5RNc2mgN4yOfxK3k83333 intact-crc:47856883ECBFD2EB false - sufficient binding region:27-396|mutation:363-363|mutation:95-95 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" uniprotkb:P0AEX9 intact:EBI-1554642 intact:EBI-369910|uniprotkb:P02928|uniprotkb:Q2M6S0|ensemblbacteria:AAC77004|ensemblbacteria:BAE78036 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:male_ecoli(display_long)|uniprotkb:malE(gene name)|psi-mi:malE(display_short)|uniprotkb:MMBP(gene name synonym)|uniprotkb:Maltodextrin-binding protein(gene name synonym)|uniprotkb:Maltose-binding protein(gene name synonym)|uniprotkb:JW3994(locus name)|uniprotkb:b4034(locus name) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477522|rcsb pdb:3puz|imex:IM-18621-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensemblbacteria:AAC77004(transcript)|ensemblbacteria:b4034(gene)|ensemblbacteria:BAE78036(gene)|ensemblbacteria:BAE78036(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:NP_418458.1|rcsb pdb:2N45|rcsb pdb:2NVU|rcsb pdb:2OBG|rcsb pdb:2OK2|rcsb pdb:2R6G|rcsb pdb:2V93|rcsb pdb:2VGQ|rcsb pdb:2XZ3|rcsb pdb:2ZXT|rcsb pdb:3A3C|rcsb pdb:3C4M|rcsb pdb:3CSB|rcsb pdb:3CSG|rcsb pdb:3D4C|rcsb pdb:3D4G|rcsb pdb:3DM0|rcsb pdb:3EF7|rcsb pdb:3EHS|rcsb pdb:3EHT|rcsb pdb:3EHU|rcsb pdb:3F5F|go:"GO:0034289"(detection of maltose stimulus)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|go:"GO:0060326"(cell chemotaxis)|go:"GO:1901982"(maltose binding)|interpro:IPR006059(Bacterial extracellular solute-binding, family 1)|interpro:IPR006060(Maltose binding protein)|interpro:IPR006061(Bacterial extracellular solute-binding family 1, conserved site)|rcsb pdb:1A7L|rcsb pdb:1ANF|rcsb pdb:1DMB|rcsb pdb:1EZ9|rcsb pdb:1EZO|rcsb pdb:1EZP|rcsb pdb:1FQA|rcsb pdb:1FQB|rcsb pdb:1FQC|rcsb pdb:1FQD|rcsb pdb:1HSJ|rcsb pdb:1IUD|rcsb pdb:1JVX|rcsb pdb:1JVY|rcsb pdb:1JW4|go:"GO:0042597"(periplasmic space)|go:"GO:0042956"(maltodextrin transport)|rcsb pdb:1JW5|rcsb pdb:1LAX|rcsb pdb:1LLS|rcsb pdb:1MDP|rcsb pdb:1MDQ|rcsb pdb:1MG1|rcsb pdb:1MH3|rcsb pdb:1MH4|rcsb pdb:1MPB|rcsb pdb:1MPC|rcsb pdb:1MPD|rcsb pdb:1N3W|rcsb pdb:1N3X|rcsb pdb:1NL5|rcsb pdb:1NMU|rcsb pdb:1OMP|rcsb pdb:1PEB|rcsb pdb:1R6Z|rcsb pdb:1SVX|rcsb pdb:1T0K|rcsb pdb:1Y4C|rcsb pdb:1YTV|rcsb pdb:1ZIU|rcsb pdb:1ZJL|rcsb pdb:1ZKB|rcsb pdb:1ZMG|rcsb pdb:2D21|rcsb pdb:2H25|rcsb pdb:2KLF|rcsb pdb:2MV0|rcsb pdb:2N44|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3H3G|rcsb pdb:3H4Z|rcsb pdb:3HPI|rcsb pdb:3HST|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3J9P|rcsb pdb:3KJT|rcsb pdb:3L2J|rcsb pdb:3LBS|rcsb pdb:3LC8|rcsb pdb:3MBP|rcsb pdb:3MP1|rcsb pdb:3IO4|rcsb pdb:3MP6|rcsb pdb:3MP8|rcsb pdb:3MQ9|rcsb pdb:3N93|rcsb pdb:3N94|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4GIZ|rcsb pdb:4GLI|rcsb pdb:4IFP|rcsb pdb:4FEB|rcsb pdb:4IKM|rcsb pdb:4IRL|rcsb pdb:4JBZ|rcsb pdb:4JKM|rcsb pdb:4KEG|rcsb pdb:4KHZ|rcsb pdb:4KI0|rcsb pdb:4KV3|rcsb pdb:4KYC|rcsb pdb:4KYD|rcsb pdb:4KYE|rcsb pdb:4LOG|rcsb pdb:4MBP|rcsb pdb:4N4X|rcsb pdb:4NDZ|rcsb pdb:4NUF|rcsb pdb:4O2X|rcsb pdb:4OGM|rcsb pdb:4PE2|rcsb pdb:4PQK|rcsb pdb:4QSZ|rcsb pdb:4QVH|rcsb pdb:3N95|rcsb pdb:3N96|rcsb pdb:3O3U|rcsb pdb:3OAI|rcsb pdb:3OB4|rcsb pdb:3OSQ|rcsb pdb:3OSR|rcsb pdb:3PGF|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3PY7|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:3RLF|rcsb pdb:3RUM|rcsb pdb:3SER|rcsb pdb:3SES|rcsb pdb:3SET|rcsb pdb:3SEU|rcsb pdb:3SEV|rcsb pdb:3SEW|rcsb pdb:3SEX|rcsb pdb:3SEY|rcsb pdb:3VFJ|rcsb pdb:3W15|rcsb pdb:3WAI|rcsb pdb:3WOA|rcsb pdb:4B3N|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4DXB|rcsb pdb:4DXC|rcsb pdb:4EDQ|rcsb pdb:4EGC|rcsb pdb:4EXK|rcsb pdb:4FE8|refseq:WP_000695387.1|rcsb pdb:4R0Y|rcsb pdb:4RG5|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:4TSM|rcsb pdb:4WJV|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4WRN|rcsb pdb:4WTH|rcsb pdb:4WVH|rcsb pdb:4XA2|rcsb pdb:4XAJ|rcsb pdb:4XHS|rcsb pdb:4XR8|rcsb pdb:4XZS|rcsb pdb:4XZV|rcsb pdb:5AQ9|rcsb pdb:5AZ6|rcsb pdb:5AZ7|rcsb pdb:5AZ8|rcsb pdb:5AZ9|rcsb pdb:5AZA|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BK1|rcsb pdb:5BK2|rcsb pdb:5C7R|rcsb pdb:5CBN|rcsb pdb:5CFV|rcsb pdb:5DFM|rcsb pdb:5DIS|rcsb pdb:5E24|rcsb pdb:5E7U|rcsb pdb:5EDU|rcsb pdb:5FIO|rcsb pdb:5FSG|rcsb pdb:5GRU|rcsb pdb:5GS2|rcsb pdb:5GXT|rcsb pdb:5GXV|rcsb pdb:5H7N|rcsb pdb:5H7Q|rcsb pdb:5HZ7|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|rcsb pdb:5I69|rcsb pdb:5IHJ|rcsb pdb:5II5|rcsb pdb:5IIC|rcsb pdb:5IQZ|rcsb pdb:5JJ4|rcsb pdb:5JST|rcsb pdb:5JTQ|rcsb pdb:5JTR|rcsb pdb:5LDF|rcsb pdb:5M13|rcsb pdb:5M14|rcsb pdb:5M15|rcsb pdb:5MM3|rcsb pdb:5OSQ|rcsb pdb:5T03|rcsb pdb:5T05|rcsb pdb:5T0A|rcsb pdb:5TTD|rcsb pdb:5VAW|rcsb pdb:5WPZ|rcsb pdb:5WQ6|rcsb pdb:5Y2G|rcsb pdb:5YGP|rcsb pdb:5YGS|rcsb pdb:5Z0R|rcsb pdb:5Z0V|rcsb pdb:5ZCA|rcsb pdb:5ZNY|rcsb pdb:5ZNZ|rcsb pdb:5ZR0|rcsb pdb:6APX|rcsb pdb:6CXS|rcsb pdb:6D65|rcsb pdb:6D66|rcsb pdb:6D67|rcsb pdb:6DM8|rcsb pdb:6EQZ|rcsb pdb:6HD8|rcsb pdb:6HD9|rcsb pdb:6HDA|rcsb pdb:6HDB|rcsb pdb:6HDC|rcsb pdb:6I4Y|rcsb pdb:6K7D|rcsb pdb:6K7E|rcsb pdb:6K7F|rcsb pdb:6KEA|rcsb pdb:6KI0|rcsb pdb:6KXG|rcsb pdb:6LES|rcsb pdb:6LF3|rcsb pdb:6M4V|rcsb pdb:6M4W|rcsb pdb:6N84|rcsb pdb:6NDJ|rcsb pdb:6OB5|rcsb pdb:6P6W|rcsb pdb:6QUG|rcsb pdb:6QYK|rcsb pdb:6QYL|rcsb pdb:6QYN|rcsb pdb:6QYO|rcsb pdb:6QZ7|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6SLM|rcsb pdb:6SMV|rcsb pdb:6SWR|rcsb pdb:6TZC|rcsb pdb:6V2E|rcsb pdb:6VLS|rcsb pdb:6WBH|rcsb pdb:6WBJ|rcsb pdb:6XDS|rcsb pdb:6XRX|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6YSN|rcsb pdb:6ZHO|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7JTR|rcsb pdb:7K48|dip:DIP-31871N go:"GO:0043234"|go:"GO:0005886"(plasma membrane)|go:"GO:0005363"(maltose transmembrane transporter activity) - - figure legend:Fig.s 2b, 3b, S6, S8|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains malE mutant and the nonhydrolysable ATP analog, AMP-PNP.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 - rogid:eRW6SNukWqn5RNc2mgN4yOfxK3k83333 intact-crc:F5DBB1F734B0FEEF false - mutation:363-363|mutation:95-95|sufficient binding region:27-396 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" uniprotkb:P02916 intact:EBI-1554642 intact:EBI-1118919|uniprotkb:Q2M6S1|ensemblbacteria:AAC77003|ensemblbacteria:BAE78035 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:malf_ecoli(display_long)|uniprotkb:malF(gene name)|psi-mi:malF(display_short)|uniprotkb:b4033(locus name)|uniprotkb:JW3993(locus name) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477522|rcsb pdb:3puz|imex:IM-18621-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensemblbacteria:AAC77003(transcript)|ensemblbacteria:b4033(gene)|ensemblbacteria:BAE78035(gene)|ensemblbacteria:BAE78035(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0015423"(ABC-type maltose transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0016020"(membrane)|go:"GO:0042956"(maltodextrin transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:1990060"(maltose transport complex)|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR029345|interpro:IPR030156|interpro:IPR035277|interpro:IPR035906|rcsb pdb:2R6G|rcsb pdb:3FH6|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3RLF|rcsb pdb:4JBW|rcsb pdb:4KHZ|rcsb pdb:4KI0|refseq:NP_418457.1|refseq:WP_001297290.1|dip:DIP-10142N go:"GO:0043234"|go:"GO:0005886"(plasma membrane)|go:"GO:0005363"(maltose transmembrane transporter activity) - - figure legend:Fig.s 2b, 3b, S6, S8|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains malE mutant and the nonhydrolysable ATP analog, AMP-PNP.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 - rogid:wYFw3rvr0kQXggDify4+jU6Lsfs83333 intact-crc:F5DBB1F734B0FEEF false - - - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" uniprotkb:P68183 intact:EBI-1554642 intact:EBI-6400985|ensemblbacteria:AAC77002|ensemblbacteria:BAE78034|uniprotkb:P07622|uniprotkb:Q2M6S2 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:malg_ecoli(display_long)|uniprotkb:JW3992(locus name)|uniprotkb:b4032(locus name)|uniprotkb:malG(gene name)|psi-mi:malG(display_short) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477522|rcsb pdb:3puz|imex:IM-18621-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_001252058.1|ensemblbacteria:AAC77002(transcript)|ensemblbacteria:b4032(gene)|ensemblbacteria:BAE78034(gene)|ensemblbacteria:BAE78034(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015423"(ABC-type maltose transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0016020"(membrane)|go:"GO:0042956"(maltodextrin transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:1990060"(maltose transport complex)|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR035906|rcsb pdb:2R6G|rcsb pdb:3FH6|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3RLF|rcsb pdb:4JBW|rcsb pdb:4KI0|refseq:NP_418456.1|dip:DIP-59709N go:"GO:0043234"|go:"GO:0005886"(plasma membrane)|go:"GO:0005363"(maltose transmembrane transporter activity) - - figure legend:Fig.s 2b, 3b, S6, S8|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains malE mutant and the nonhydrolysable ATP analog, AMP-PNP.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 - rogid:JslgyRfgqSfHJ0QTLpej9DnSoUw83333 intact-crc:F5DBB1F734B0FEEF false - - - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" uniprotkb:P68187 intact:EBI-1554642 intact:EBI-550803|uniprotkb:P02914|uniprotkb:Q2M6R9|uniprotkb:Q47348|ensemblbacteria:AAC77005|ensemblbacteria:BAE78037 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:malk_ecoli(display_long)|uniprotkb:malK(gene name)|psi-mi:malK(display_short)|uniprotkb:b4035(locus name)|uniprotkb:JW3995(locus name) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477522|rcsb pdb:3puz|imex:IM-18621-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_418459.1|refseq:WP_000179165.1|dip:DIP-47850N|ensemblbacteria:AAC77005(transcript)|ensemblbacteria:b4035(gene)|ensemblbacteria:BAE78037(gene)|ensemblbacteria:BAE78037(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0015423"(ABC-type maltose transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0016020"(membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0042956"(maltodextrin transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|go:"GO:1990060"(maltose transport complex)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008995(Molybdate/tungstate binding)|interpro:IPR015855(ABC transporter, maltose/maltodextrin import, MalK)|interpro:IPR017871|interpro:IPR027417|interpro:IPR040582|rcsb pdb:1Q12|rcsb pdb:1Q1B|rcsb pdb:1Q1E|rcsb pdb:2AWN|rcsb pdb:2AWO|rcsb pdb:2R6G|rcsb pdb:3FH6|rcsb pdb:3GD7|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3RLF|rcsb pdb:4JBW|rcsb pdb:4KI0 go:"GO:0043234"|go:"GO:0005886"(plasma membrane)|go:"GO:0005363"(maltose transmembrane transporter activity) - - figure legend:Fig.s 2b, 3b, S6, S8|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains malE mutant and the nonhydrolysable ATP analog, AMP-PNP.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 - rogid:Z2VXSeO5q36t6IR4Sisvp78Ubu083333 intact-crc:F5DBB1F734B0FEEF false - his tag:c-c - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" chebi:"CHEBI:17306" intact:EBI-1554642 intact:EBI-1774952 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:maltose(display_short)|psi-mi:"CHEBI:17306"(display_long) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477522|rcsb pdb:3puz|imex:IM-18621-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - go:"GO:0043234"|go:"GO:0005886"(plasma membrane)|go:"GO:0005363"(maltose transmembrane transporter activity) - - figure legend:Fig.s 2b, 3b, S6, S8|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains malE mutant and the nonhydrolysable ATP analog, AMP-PNP.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 - - intact-crc:F5DBB1F734B0FEEF false - - - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" uniprotkb:P0AEX9 intact:EBI-1554642 intact:EBI-369910|uniprotkb:P02928|uniprotkb:Q2M6S0|ensemblbacteria:AAC77004|ensemblbacteria:BAE78036 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:male_ecoli(display_long)|uniprotkb:malE(gene name)|psi-mi:malE(display_short)|uniprotkb:MMBP(gene name synonym)|uniprotkb:Maltodextrin-binding protein(gene name synonym)|uniprotkb:Maltose-binding protein(gene name synonym)|uniprotkb:JW3994(locus name)|uniprotkb:b4034(locus name) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477279|rcsb pdb:3puy|imex:IM-18621-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensemblbacteria:AAC77004(transcript)|ensemblbacteria:b4034(gene)|ensemblbacteria:BAE78036(gene)|ensemblbacteria:BAE78036(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:NP_418458.1|rcsb pdb:2N45|rcsb pdb:2NVU|rcsb pdb:2OBG|rcsb pdb:2OK2|rcsb pdb:2R6G|rcsb pdb:2V93|rcsb pdb:2VGQ|rcsb pdb:2XZ3|rcsb pdb:2ZXT|rcsb pdb:3A3C|rcsb pdb:3C4M|rcsb pdb:3CSB|rcsb pdb:3CSG|rcsb pdb:3D4C|rcsb pdb:3D4G|rcsb pdb:3DM0|rcsb pdb:3EF7|rcsb pdb:3EHS|rcsb pdb:3EHT|rcsb pdb:3EHU|rcsb pdb:3F5F|go:"GO:0034289"(detection of maltose stimulus)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|go:"GO:0060326"(cell chemotaxis)|go:"GO:1901982"(maltose binding)|interpro:IPR006059(Bacterial extracellular solute-binding, family 1)|interpro:IPR006060(Maltose binding protein)|interpro:IPR006061(Bacterial extracellular solute-binding family 1, conserved site)|rcsb pdb:1A7L|rcsb pdb:1ANF|rcsb pdb:1DMB|rcsb pdb:1EZ9|rcsb pdb:1EZO|rcsb pdb:1EZP|rcsb pdb:1FQA|rcsb pdb:1FQB|rcsb pdb:1FQC|rcsb pdb:1FQD|rcsb pdb:1HSJ|rcsb pdb:1IUD|rcsb pdb:1JVX|rcsb pdb:1JVY|rcsb pdb:1JW4|go:"GO:0042597"(periplasmic space)|go:"GO:0042956"(maltodextrin transport)|rcsb pdb:1JW5|rcsb pdb:1LAX|rcsb pdb:1LLS|rcsb pdb:1MDP|rcsb pdb:1MDQ|rcsb pdb:1MG1|rcsb pdb:1MH3|rcsb pdb:1MH4|rcsb pdb:1MPB|rcsb pdb:1MPC|rcsb pdb:1MPD|rcsb pdb:1N3W|rcsb pdb:1N3X|rcsb pdb:1NL5|rcsb pdb:1NMU|rcsb pdb:1OMP|rcsb pdb:1PEB|rcsb pdb:1R6Z|rcsb pdb:1SVX|rcsb pdb:1T0K|rcsb pdb:1Y4C|rcsb pdb:1YTV|rcsb pdb:1ZIU|rcsb pdb:1ZJL|rcsb pdb:1ZKB|rcsb pdb:1ZMG|rcsb pdb:2D21|rcsb pdb:2H25|rcsb pdb:2KLF|rcsb pdb:2MV0|rcsb pdb:2N44|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3H3G|rcsb pdb:3H4Z|rcsb pdb:3HPI|rcsb pdb:3HST|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3J9P|rcsb pdb:3KJT|rcsb pdb:3L2J|rcsb pdb:3LBS|rcsb pdb:3LC8|rcsb pdb:3MBP|rcsb pdb:3MP1|rcsb pdb:3IO4|rcsb pdb:3MP6|rcsb pdb:3MP8|rcsb pdb:3MQ9|rcsb pdb:3N93|rcsb pdb:3N94|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4GIZ|rcsb pdb:4GLI|rcsb pdb:4IFP|rcsb pdb:4FEB|rcsb pdb:4IKM|rcsb pdb:4IRL|rcsb pdb:4JBZ|rcsb pdb:4JKM|rcsb pdb:4KEG|rcsb pdb:4KHZ|rcsb pdb:4KI0|rcsb pdb:4KV3|rcsb pdb:4KYC|rcsb pdb:4KYD|rcsb pdb:4KYE|rcsb pdb:4LOG|rcsb pdb:4MBP|rcsb pdb:4N4X|rcsb pdb:4NDZ|rcsb pdb:4NUF|rcsb pdb:4O2X|rcsb pdb:4OGM|rcsb pdb:4PE2|rcsb pdb:4PQK|rcsb pdb:4QSZ|rcsb pdb:4QVH|rcsb pdb:3N95|rcsb pdb:3N96|rcsb pdb:3O3U|rcsb pdb:3OAI|rcsb pdb:3OB4|rcsb pdb:3OSQ|rcsb pdb:3OSR|rcsb pdb:3PGF|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3PY7|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:3RLF|rcsb pdb:3RUM|rcsb pdb:3SER|rcsb pdb:3SES|rcsb pdb:3SET|rcsb pdb:3SEU|rcsb pdb:3SEV|rcsb pdb:3SEW|rcsb pdb:3SEX|rcsb pdb:3SEY|rcsb pdb:3VFJ|rcsb pdb:3W15|rcsb pdb:3WAI|rcsb pdb:3WOA|rcsb pdb:4B3N|rcsb pdb:4BL8|rcsb pdb:4BL9|rcsb pdb:4BLA|rcsb pdb:4BLB|rcsb pdb:4BLD|rcsb pdb:4DXB|rcsb pdb:4DXC|rcsb pdb:4EDQ|rcsb pdb:4EGC|rcsb pdb:4EXK|rcsb pdb:4FE8|refseq:WP_000695387.1|rcsb pdb:4R0Y|rcsb pdb:4RG5|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:4TSM|rcsb pdb:4WJV|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4WRN|rcsb pdb:4WTH|rcsb pdb:4WVH|rcsb pdb:4XA2|rcsb pdb:4XAJ|rcsb pdb:4XHS|rcsb pdb:4XR8|rcsb pdb:4XZS|rcsb pdb:4XZV|rcsb pdb:5AQ9|rcsb pdb:5AZ6|rcsb pdb:5AZ7|rcsb pdb:5AZ8|rcsb pdb:5AZ9|rcsb pdb:5AZA|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BK1|rcsb pdb:5BK2|rcsb pdb:5C7R|rcsb pdb:5CBN|rcsb pdb:5CFV|rcsb pdb:5DFM|rcsb pdb:5DIS|rcsb pdb:5E24|rcsb pdb:5E7U|rcsb pdb:5EDU|rcsb pdb:5FIO|rcsb pdb:5FSG|rcsb pdb:5GRU|rcsb pdb:5GS2|rcsb pdb:5GXT|rcsb pdb:5GXV|rcsb pdb:5H7N|rcsb pdb:5H7Q|rcsb pdb:5HZ7|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|rcsb pdb:5I69|rcsb pdb:5IHJ|rcsb pdb:5II5|rcsb pdb:5IIC|rcsb pdb:5IQZ|rcsb pdb:5JJ4|rcsb pdb:5JST|rcsb pdb:5JTQ|rcsb pdb:5JTR|rcsb pdb:5LDF|rcsb pdb:5M13|rcsb pdb:5M14|rcsb pdb:5M15|rcsb pdb:5MM3|rcsb pdb:5OSQ|rcsb pdb:5T03|rcsb pdb:5T05|rcsb pdb:5T0A|rcsb pdb:5TTD|rcsb pdb:5VAW|rcsb pdb:5WPZ|rcsb pdb:5WQ6|rcsb pdb:5Y2G|rcsb pdb:5YGP|rcsb pdb:5YGS|rcsb pdb:5Z0R|rcsb pdb:5Z0V|rcsb pdb:5ZCA|rcsb pdb:5ZNY|rcsb pdb:5ZNZ|rcsb pdb:5ZR0|rcsb pdb:6APX|rcsb pdb:6CXS|rcsb pdb:6D65|rcsb pdb:6D66|rcsb pdb:6D67|rcsb pdb:6DM8|rcsb pdb:6EQZ|rcsb pdb:6HD8|rcsb pdb:6HD9|rcsb pdb:6HDA|rcsb pdb:6HDB|rcsb pdb:6HDC|rcsb pdb:6I4Y|rcsb pdb:6K7D|rcsb pdb:6K7E|rcsb pdb:6K7F|rcsb pdb:6KEA|rcsb pdb:6KI0|rcsb pdb:6KXG|rcsb pdb:6LES|rcsb pdb:6LF3|rcsb pdb:6M4V|rcsb pdb:6M4W|rcsb pdb:6N84|rcsb pdb:6NDJ|rcsb pdb:6OB5|rcsb pdb:6P6W|rcsb pdb:6QUG|rcsb pdb:6QYK|rcsb pdb:6QYL|rcsb pdb:6QYN|rcsb pdb:6QYO|rcsb pdb:6QZ7|rcsb pdb:6SIV|rcsb pdb:6SJA|rcsb pdb:6SLM|rcsb pdb:6SMV|rcsb pdb:6SWR|rcsb pdb:6TZC|rcsb pdb:6V2E|rcsb pdb:6VLS|rcsb pdb:6WBH|rcsb pdb:6WBJ|rcsb pdb:6XDS|rcsb pdb:6XRX|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6YSN|rcsb pdb:6ZHO|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7JTR|rcsb pdb:7K48|dip:DIP-31871N go:"GO:0043234"|go:"GO:0005363"(maltose transmembrane transporter activity)|go:"GO:0005886"(plasma membrane) - - figure legend:Fig.s 2c, 3, S1, S2, S4-S6, S8|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains wild-type malE and the nonhydrolysable ATP analog, AMP-PNP.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 - rogid:eRW6SNukWqn5RNc2mgN4yOfxK3k83333 intact-crc:030D09A456BCFC69 false - his tag:c-c|sufficient binding region:27-396 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" uniprotkb:P02916 intact:EBI-1554642 intact:EBI-1118919|uniprotkb:Q2M6S1|ensemblbacteria:AAC77003|ensemblbacteria:BAE78035 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:malf_ecoli(display_long)|uniprotkb:malF(gene name)|psi-mi:malF(display_short)|uniprotkb:b4033(locus name)|uniprotkb:JW3993(locus name) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477279|rcsb pdb:3puy|imex:IM-18621-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensemblbacteria:AAC77003(transcript)|ensemblbacteria:b4033(gene)|ensemblbacteria:BAE78035(gene)|ensemblbacteria:BAE78035(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0015423"(ABC-type maltose transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0016020"(membrane)|go:"GO:0042956"(maltodextrin transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:1990060"(maltose transport complex)|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR029345|interpro:IPR030156|interpro:IPR035277|interpro:IPR035906|rcsb pdb:2R6G|rcsb pdb:3FH6|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3RLF|rcsb pdb:4JBW|rcsb pdb:4KHZ|rcsb pdb:4KI0|refseq:NP_418457.1|refseq:WP_001297290.1|dip:DIP-10142N go:"GO:0043234"|go:"GO:0005363"(maltose transmembrane transporter activity)|go:"GO:0005886"(plasma membrane) - - figure legend:Fig.s 2c, 3, S1, S2, S4-S6, S8|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains wild-type malE and the nonhydrolysable ATP analog, AMP-PNP.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 - rogid:wYFw3rvr0kQXggDify4+jU6Lsfs83333 intact-crc:030D09A456BCFC69 false - - - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" uniprotkb:P68183 intact:EBI-1554642 intact:EBI-6400985|ensemblbacteria:AAC77002|ensemblbacteria:BAE78034|uniprotkb:P07622|uniprotkb:Q2M6S2 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:malg_ecoli(display_long)|uniprotkb:JW3992(locus name)|uniprotkb:b4032(locus name)|uniprotkb:malG(gene name)|psi-mi:malG(display_short) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477279|rcsb pdb:3puy|imex:IM-18621-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_001252058.1|ensemblbacteria:AAC77002(transcript)|ensemblbacteria:b4032(gene)|ensemblbacteria:BAE78034(gene)|ensemblbacteria:BAE78034(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015423"(ABC-type maltose transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0016020"(membrane)|go:"GO:0042956"(maltodextrin transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:1990060"(maltose transport complex)|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR035906|rcsb pdb:2R6G|rcsb pdb:3FH6|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3RLF|rcsb pdb:4JBW|rcsb pdb:4KI0|refseq:NP_418456.1|dip:DIP-59709N go:"GO:0043234"|go:"GO:0005363"(maltose transmembrane transporter activity)|go:"GO:0005886"(plasma membrane) - - figure legend:Fig.s 2c, 3, S1, S2, S4-S6, S8|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains wild-type malE and the nonhydrolysable ATP analog, AMP-PNP.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 - rogid:JslgyRfgqSfHJ0QTLpej9DnSoUw83333 intact-crc:030D09A456BCFC69 false - - - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" uniprotkb:P68187 intact:EBI-1554642 intact:EBI-550803|uniprotkb:P02914|uniprotkb:Q2M6R9|uniprotkb:Q47348|ensemblbacteria:AAC77005|ensemblbacteria:BAE78037 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:malk_ecoli(display_long)|uniprotkb:malK(gene name)|psi-mi:malK(display_short)|uniprotkb:b4035(locus name)|uniprotkb:JW3995(locus name) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477279|rcsb pdb:3puy|imex:IM-18621-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_418459.1|refseq:WP_000179165.1|dip:DIP-47850N|ensemblbacteria:AAC77005(transcript)|ensemblbacteria:b4035(gene)|ensemblbacteria:BAE78037(gene)|ensemblbacteria:BAE78037(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0015423"(ABC-type maltose transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0016020"(membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0042956"(maltodextrin transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055052"("ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing")|go:"GO:1990060"(maltose transport complex)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008995(Molybdate/tungstate binding)|interpro:IPR015855(ABC transporter, maltose/maltodextrin import, MalK)|interpro:IPR017871|interpro:IPR027417|interpro:IPR040582|rcsb pdb:1Q12|rcsb pdb:1Q1B|rcsb pdb:1Q1E|rcsb pdb:2AWN|rcsb pdb:2AWO|rcsb pdb:2R6G|rcsb pdb:3FH6|rcsb pdb:3GD7|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3RLF|rcsb pdb:4JBW|rcsb pdb:4KI0 go:"GO:0043234"|go:"GO:0005363"(maltose transmembrane transporter activity)|go:"GO:0005886"(plasma membrane) - - figure legend:Fig.s 2c, 3, S1, S2, S4-S6, S8|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains wild-type malE and the nonhydrolysable ATP analog, AMP-PNP.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 - rogid:Z2VXSeO5q36t6IR4Sisvp78Ubu083333 intact-crc:030D09A456BCFC69 false - his tag:c-c - 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:47785" chebi:"CHEBI:17306" intact:EBI-1554642 intact:EBI-1774952 psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long) psi-mi:maltose(display_short)|psi-mi:"CHEBI:17306"(display_long) psi-mi:"MI:0114"(x-ray crystallography) Oldham et al. (2011) pubmed:21566157|imex:IM-18621 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6477279|rcsb pdb:3puy|imex:IM-18621-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - go:"GO:0043234"|go:"GO:0005363"(maltose transmembrane transporter activity)|go:"GO:0005886"(plasma membrane) - - figure legend:Fig.s 2c, 3, S1, S2, S4-S6, S8|3d-r-factors:R = 0.22 Rworking = 0.21, Rfree = 0.25|3d-resolution:3.1 A|assembly:"pentamer consisting of 3 monomers (malF, malG, malE) and one dimer (malK2)."|complex-synonym:maltose transporter MalFGK2; maltose transporter; maltose transporter MalFGK2 complex; maltose transporter complex|complex-properties:"The maltose transporter channels maltose from the periplasmic space into the cytoplasm through an ATP-dependent transmembrane channel. It consists of a transmembrane (TM) heterodimer (malFG) and a cytoplasmic ATPase (malK2). Maltose binds to malE, the maltose binding protein (MBP), which attaches to the malFG dimer. Upon release of the maltose into the TM channel the malK2 dimer acquires ATP whose hydrolysis triggers the release of maltose into the cytoplasm."|comment:This crystal contains wild-type malE and the nonhydrolysable ATP analog, AMP-PNP.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/11 2014/10/16 - - intact-crc:030D09A456BCFC69 false - - - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)