#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99IB8-PRO_0000045596 uniprotkb:Q99IB8-PRO_0000045598 intact:EBI-6901449|intact:EBI-6927909 intact:EBI-6901421|intact:EBI-6928831 psi-mi:q99ib8-pro_0000045596(display_long) psi-mi:q99ib8-pro_0000045598(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Popescu et al. (2011) pubmed:21347350|imex:IM-25873 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8771739|imex:IM-25873-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-6674379(chain-parent) - chain-seq-start:384|chain-seq-end:750 chain-seq-start:814|chain-seq-end:1030 figure legend:Fig. 2C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/24 2017/09/02 rogid:d8l1EuWXqUdXoYmKoeOf+YKqJ4w356411 rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411 intact-crc:10B9CC56B9758447|rigid:bajBlqUsxnOAlCNeeoZ+2LUOr/4 false - necessary binding region:32-96|ha tag:?-?|mutation decreasing interaction:41-41 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q99IB8-PRO_0000045596 uniprotkb:Q99IB8-PRO_0000045598 intact:EBI-6901449|intact:EBI-6927909 intact:EBI-6901421|intact:EBI-6928831 psi-mi:q99ib8-pro_0000045596(display_long) psi-mi:q99ib8-pro_0000045598(display_long) psi-mi:"MI:0663"(confocal microscopy) Popescu et al. (2011) pubmed:21347350|imex:IM-25873 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-8771759|imex:IM-25873-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-6674379(chain-parent) - chain-seq-start:384|chain-seq-end:750 chain-seq-start:814|chain-seq-end:1030 figure legend:Fig. 3B and 5B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/24 2017/09/02 rogid:d8l1EuWXqUdXoYmKoeOf+YKqJ4w356411 rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411 intact-crc:EB74C8B78388AA30|rigid:bajBlqUsxnOAlCNeeoZ+2LUOr/4 false - mutation decreasing interaction:41-41|necessary binding region:32-96|ha tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q99IB8-PRO_0000045592 uniprotkb:Q99IB8-PRO_0000045598 intact:EBI-6858513|intact:EBI-6929338 intact:EBI-6901421|intact:EBI-6928831 psi-mi:q99ib8-pro_0000045592(display_long) psi-mi:q99ib8-pro_0000045598(display_long) psi-mi:"MI:0663"(confocal microscopy) Popescu et al. (2011) pubmed:21347350|imex:IM-25873 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-8771797|imex:IM-25873-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-6674379(chain-parent) go:"GO:0005811"(lipid droplet) chain-seq-start:2|chain-seq-end:191 chain-seq-start:814|chain-seq-end:1030 figure legend:Fig. 4B, S2, 5A and 5C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/24 2017/09/02 rogid:IvCIliS0Wa+ryvS2l1H9PDAun94356411 rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411 intact-crc:EE5A19CC7411020C|rigid:F1pRqdQHO8xhMd+6cofo8aesdKk false - necessary binding region:32-96|ha tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q99IB8-PRO_0000045599 uniprotkb:Q99IB8-PRO_0000045598 intact:EBI-6858501|intact:EBI-6927943 intact:EBI-6901421|intact:EBI-6928831 psi-mi:q99ib8-pro_0000045599(display_long) psi-mi:q99ib8-pro_0000045598(display_long) psi-mi:"MI:0663"(confocal microscopy) Popescu et al. (2011) pubmed:21347350|imex:IM-25873 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-8771809|imex:IM-25873-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-6674379(chain-parent) - chain-seq-start:1031|chain-seq-end:1661 chain-seq-start:814|chain-seq-end:1030 figure legend:Fig. S2 and 3B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/24 2014/10/16 rogid:a8wPpxzwQPs8clBzhGspZO2pi4c356411 rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411 intact-crc:4109558A6BD83BEF|rigid:ENno5T5eyV1/WHhjPi7lUmhUxKY false - ha tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q99IB8-PRO_0000045598 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-6901421|intact:EBI-6928831 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:q99ib8-pro_0000045598(display_long) psi-mi:"MI:0663"(confocal microscopy) Popescu et al. (2011) pubmed:21347350|imex:IM-25873 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-8771783|imex:IM-25873-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-6674379(chain-parent) go:"GO:0005811"(lipid droplet) chain-seq-start:1977|chain-seq-end:2442 chain-seq-start:814|chain-seq-end:1030 figure legend:Fig. 4A, S2, 5A, 5C, 6 and 9D|comment:"Deletion of p7 and a RR/QQ mutation believed to abolish the ion channel activity of p7 and NS5A mutations (JFH-S/A-HA and JFH-3BS/A-HA) decreased NS2-NS5A interaction."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/24 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411 intact-crc:338933E1CD0AE6EC|rigid:AdhZOTm7q53ph8nE5A5KSiHjkkc false mutation decreasing interaction:452-452|mutation decreasing interaction:454-454|mutation decreasing interaction:457-457 ha tag:?-?|necessary binding region:32-96 - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q99IB8-PRO_0000045598 uniprotkb:Q99IB8-PRO_0000045595 intact:EBI-6901421|intact:EBI-6928831 intact:EBI-6901441 psi-mi:q99ib8-pro_0000045598(display_long) psi-mi:q99ib8-pro_0000045595(display_long) psi-mi:"MI:0663"(confocal microscopy) Popescu et al. (2011) pubmed:21347350|imex:IM-25873 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-8771771|imex:IM-25873-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-6674379(chain-parent) - chain-seq-start:814|chain-seq-end:1030 chain-seq-start:192|chain-seq-end:383 figure legend:Fig. S2|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/24 2014/10/16 rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411 rogid:2jztNkYW0DUTz6ygVMOZp/7Xn8E356411 intact-crc:BCED878D0142586C|rigid:muSiN23Oqjgjx0DyHXfaKtJcQdY false ha tag:?-? - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q99IB8-PRO_0000045597 uniprotkb:Q99IB8-PRO_0000045598 intact:EBI-8772829 intact:EBI-6901421|intact:EBI-6928831 psi-mi:q99ib8-pro_0000045597(display_long) psi-mi:q99ib8-pro_0000045598(display_long) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Popescu et al. (2011) pubmed:21347350|imex:IM-25873 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:1335"(HPIDb) intact:EBI-8772877|imex:IM-25873-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-6674379(chain-parent) - chain-seq-start:751|chain-seq-end:813 chain-seq-start:814|chain-seq-end:1030 figure legend:Fig. 8C and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2013/09/24 2017/09/02 rogid:g1N1nFD9PcDZYobytpfV14YG0no356411 rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411 intact-crc:2EF99FE63F3562F3|rigid:3DifIGlYUK6kvIcaGNrmGh2M+3Y false cyan fluorescent protein tag:?-? yellow fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q99IB8-PRO_0000045596 uniprotkb:Q99IB8-PRO_0000045595 intact:EBI-6901449|intact:EBI-6927909 intact:EBI-6901441 psi-mi:q99ib8-pro_0000045596(display_long) psi-mi:q99ib8-pro_0000045595(display_long) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Popescu et al. (2011) pubmed:21347350|imex:IM-25873 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:1335"(HPIDb) intact:EBI-8772888|imex:IM-25873-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-6674379(chain-parent) - chain-seq-start:384|chain-seq-end:750 chain-seq-start:192|chain-seq-end:383 figure legend:Fig. S5 and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2013/09/24 2017/09/02 rogid:d8l1EuWXqUdXoYmKoeOf+YKqJ4w356411 rogid:2jztNkYW0DUTz6ygVMOZp/7Xn8E356411 intact-crc:7B47BC40704519E6|rigid:fUMQbu5tOhnSnsIk6AqE50oDYrY false cyan fluorescent protein tag:?-? yellow fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q99IB8-PRO_0000045598 uniprotkb:Q99IB8-PRO_0000045597 intact:EBI-6901421|intact:EBI-6928831 intact:EBI-8772829 psi-mi:q99ib8-pro_0000045598(display_long) psi-mi:q99ib8-pro_0000045597(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Popescu et al. (2011) pubmed:21347350|imex:IM-25873 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8772823|imex:IM-25873-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-6674379(chain-parent) - chain-seq-start:814|chain-seq-end:1030 chain-seq-start:751|chain-seq-end:813 figure legend:Fig. 7B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/24 2014/10/16 rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411 rogid:g1N1nFD9PcDZYobytpfV14YG0no356411 intact-crc:2C3E700D5CF78D81|rigid:3DifIGlYUK6kvIcaGNrmGh2M+3Y false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99IB8-PRO_0000045597 uniprotkb:Q99IB8-PRO_0000045598 intact:EBI-8772829 intact:EBI-6901421|intact:EBI-6928831 psi-mi:q99ib8-pro_0000045597(display_long) psi-mi:q99ib8-pro_0000045598(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Popescu et al. (2011) pubmed:21347350|imex:IM-25873 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8772839|imex:IM-25873-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-6674379(chain-parent) - chain-seq-start:751|chain-seq-end:813 chain-seq-start:814|chain-seq-end:1030 figure legend:Fig. 7B|comment:Replacment of the transmembrane domain of NS2 by the transmembrane domain of glycoprotein G of VSV abolishes NS2-P7 interaction.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/24 2014/10/16 rogid:g1N1nFD9PcDZYobytpfV14YG0no356411 rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411 intact-crc:D401AC2B73EE5C44|rigid:3DifIGlYUK6kvIcaGNrmGh2M+3Y false flag tag:?-? green fluorescent protein tag:c-c|binding-associated region:74..74-94..94|ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99IB8-PRO_0000045597 uniprotkb:Q99IB8-PRO_0000045598 intact:EBI-8772829 intact:EBI-6901421|intact:EBI-6928831 psi-mi:q99ib8-pro_0000045597(display_long) psi-mi:q99ib8-pro_0000045598(display_long) psi-mi:"MI:0663"(confocal microscopy) Popescu et al. (2011) pubmed:21347350|imex:IM-25873 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-8772858|imex:IM-25873-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-6674379(chain-parent) go:"GO:0044165"(host cell endoplasmic reticulum) chain-seq-start:751|chain-seq-end:813 chain-seq-start:814|chain-seq-end:1030 figure legend:Fig. 8B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2013/09/24 2017/09/02 rogid:g1N1nFD9PcDZYobytpfV14YG0no356411 rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411 intact-crc:B80B1B5780A6CEA0|rigid:3DifIGlYUK6kvIcaGNrmGh2M+3Y false cyan fluorescent protein tag:?-? yellow fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)