#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17302	uniprotkb:Q02487-1	intact:EBI-1103439|uniprotkb:Q6FHU1|uniprotkb:Q9Y5I8|uniprotkb:B2R5U9|ensembl:ENSP00000282561|ensembl:ENSP00000497283|ensembl:ENSP00000497367|ensembl:ENSP00000497565	intact:EBI-6900677|ensembl:ENSP00000280904	psi-mi:cxa1_human(display_long)|uniprotkb:GJAL(gene name synonym)|uniprotkb:Connexin-43(gene name synonym)|uniprotkb:Gap junction 43 kDa heart protein(gene name synonym)|uniprotkb:GJA1(gene name)|psi-mi:GJA1(display_short)	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6901776|imex:IM-20978-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0005921"(gap junction)|go:"GO:0005922"(connexin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009268"(response to pH)|go:"GO:0009749"(response to glucose)|go:"GO:0010232"(vascular transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010652"(positive regulation of cell communication by chemical coupling)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014704"(intercalated disc)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0015631"(tubulin binding)|go:"GO:0015867"(ATP transport)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032277"(negative regulation of gonadotropin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034634"(glutathione transmembrane transporter activity)|ensembl:ENSG00000152661(gene)|ensembl:ENST00000282561(transcript)|ensembl:ENST00000647564(transcript)|ensembl:ENST00000649003(transcript)|ensembl:ENST00000650427(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002931"(response to ischemia)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0003158"(endothelium development)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005634"(nucleus)|interpro:IPR017990|interpro:IPR019570|interpro:IPR034634|interpro:IPR035091|interpro:IPR038359|mint:P17302|rcsb pdb:2LL2|reactome:R-HSA-190704|reactome:R-HSA-190827|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-190873|reactome:R-HSA-191650|reactome:R-HSA-196025|reactome:R-HSA-9013406|reactome:R-HSA-9013409|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042311"(vasodilation)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046697"(decidualization)|go:"GO:0046849"(bone remodeling)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070160"(tight junction)|go:"GO:0071253"(connexin binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086075"(gap junction channel activity involved in cardiac conduction electrical coupling)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140115"(export across plasma membrane)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1903763"(gap junction channel activity involved in cell communication by electrical coupling)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905332"(positive regulation of morphogenesis of an epithelium)|go:"GO:1905772"(positive regulation of mesodermal cell differentiation)|go:"GO:1905867"(epididymis development)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000500(Connexins)|interpro:IPR002261("Gap junction alpha-1 protein (Cx43)")|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR013124("Gap junction alpha-1 protein (Cx43), C-terminal")|refseq:NP_000156.1	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	intact:EBI-6901881(see-also)	-	-	figure legend:6C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/24	2014/10/16	rogid:ri2cG7YGyM1rVOXreP305UK1h4U9606	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	intact-crc:FD13E383CADB0B26|rigid:+gQpqYFNEmWuTgjXd7xv65Eqx+s	false	sufficient binding region:228-382|enhanced green fluorescent protein tag:n-n	necessary binding region:852-901|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6P0K8	uniprotkb:Q02487-1	intact:EBI-918926|ensembl:ENSRNOP00000043950|ensembl:ENSRNOP00000070840	intact:EBI-6900677|ensembl:ENSP00000280904	psi-mi:plak_rat(display_long)|uniprotkb:Jup(gene name)|psi-mi:Jup(display_short)	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900581|imex:IM-20978-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620412|refseq:NP_112309.2|refseq:XP_006247491.1|refseq:XP_006247492.1|refseq:XP_017453037.1|ensembl:ENSRNOG00000015380(gene)|ensembl:ENSRNOT00000040845(transcript)|ensembl:ENSRNOT00000089933(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002159"(desmosome assembly)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030057"(desmosome)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0071665"(gamma-catenin-TCF7L2 complex)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR030461|reactome:R-RNO-418990|reactome:R-RNO-5218920|reactome:R-RNO-6798695|reactome:R-RNO-6805567|reactome:R-RNO-6809371|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013406|reactome:R-RNO-9013407	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	go:"GO:0014704"(intercalated disc)	-	-	figure legend:4B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes_neo)|taxid:10116(rat cardiac myocytes neo)	-	2013/07/24	2014/10/16	rogid:yWbzwtNtLlRBegMUJ6YQyJzQpXE10116	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	intact-crc:BCBE2C513791B0D0|rigid:3ukRiWeElwMnFQMdIber04UxIGE	false	-	mutation:852-854|sufficient binding region:1-854	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q02487-1	uniprotkb:Q6P0K8	intact:EBI-6900677|ensembl:ENSP00000280904	intact:EBI-918926|ensembl:ENSRNOP00000043950|ensembl:ENSRNOP00000070840	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:plak_rat(display_long)|uniprotkb:Jup(gene name)|psi-mi:Jup(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8753386|imex:IM-20978-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	rgd:620412|refseq:NP_112309.2|refseq:XP_006247491.1|refseq:XP_006247492.1|refseq:XP_017453037.1|ensembl:ENSRNOG00000015380(gene)|ensembl:ENSRNOT00000040845(transcript)|ensembl:ENSRNOT00000089933(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002159"(desmosome assembly)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030057"(desmosome)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0071665"(gamma-catenin-TCF7L2 complex)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR030461|reactome:R-RNO-418990|reactome:R-RNO-5218920|reactome:R-RNO-6798695|reactome:R-RNO-6805567|reactome:R-RNO-6809371|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013406|reactome:R-RNO-9013407	go:"GO:0014704"(intercalated disc)	-	-	figure legend:4Bi|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes_neo)|taxid:10116(rat cardiac myocytes neo)	-	2013/07/24	2014/10/16	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	rogid:yWbzwtNtLlRBegMUJ6YQyJzQpXE10116	intact-crc:076A79F40A0BB875|rigid:3ukRiWeElwMnFQMdIber04UxIGE	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q02487-2	uniprotkb:F1M7L9	intact:EBI-6900918|ensembl:ENSP00000251081	intact:EBI-6900770|ensembl:ENSRNOP00000002498	psi-mi:q02487-2(display_long)|uniprotkb:DGIII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:f1m7l9_rat(display_long)	psi-mi:"MI:0096"(pull down)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900908|imex:IM-20978-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134755(gene)|ensembl:ENST00000251081(transcript)|intact:EBI-3048545(isoform-parent)	ensembl:ENSRNOG00000001825(gene)|ensembl:ENSRNOT00000002498(transcript)|go:"GO:0002159"(desmosome assembly)|go:"GO:0002934"(desmosome organization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007507"(heart development)|go:"GO:0014704"(intercalated disc)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086019"(cell-cell signaling involved in cardiac conduction)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|reactome:R-RNO-6805567|reactome:R-RNO-6809371	-	-	-	figure legend:5B-2b|comment:"DSC2b (and the mutant)  bound only to PKP2 (Figure 5B)."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/24	2015/07/27	rogid:cD7qy9ZJ5k6qj0jf5E9zzKdQ7ME9606	rogid:mJktQiuGcLQBsaYxTMTkLRm5XTg10116	intact-crc:654B115D444D95F7|rigid:lv/RKyIZALiX5JRAZ4GULoI/NsM	false	glutathione s tranferase tag:n-n|sufficient binding region:716-847	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02487-1	uniprotkb:F1M7L9	intact:EBI-6900677|ensembl:ENSP00000280904	intact:EBI-6900770|ensembl:ENSRNOP00000002498	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:f1m7l9_rat(display_long)	psi-mi:"MI:0096"(pull down)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900752|imex:IM-20978-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	ensembl:ENSRNOG00000001825(gene)|ensembl:ENSRNOT00000002498(transcript)|go:"GO:0002159"(desmosome assembly)|go:"GO:0002934"(desmosome organization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007507"(heart development)|go:"GO:0014704"(intercalated disc)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086019"(cell-cell signaling involved in cardiac conduction)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|reactome:R-RNO-6805567|reactome:R-RNO-6809371	intact:EBI-6901829(see-also)	-	-	figure legend:5B -wt|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/24	2015/07/27	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	rogid:mJktQiuGcLQBsaYxTMTkLRm5XTg10116	intact-crc:484ADA225A5FF86B|rigid:91ron5EXYSHTK6cKq3jcUvx7Y9A	false	sufficient binding region:716-901|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02487-1	uniprotkb:Q6P0K8	intact:EBI-6900677|ensembl:ENSP00000280904	intact:EBI-918926|ensembl:ENSRNOP00000043950|ensembl:ENSRNOP00000070840	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:plak_rat(display_long)|uniprotkb:Jup(gene name)|psi-mi:Jup(display_short)	psi-mi:"MI:0096"(pull down)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900752|imex:IM-20978-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	rgd:620412|refseq:NP_112309.2|refseq:XP_006247491.1|refseq:XP_006247492.1|refseq:XP_017453037.1|ensembl:ENSRNOG00000015380(gene)|ensembl:ENSRNOT00000040845(transcript)|ensembl:ENSRNOT00000089933(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002159"(desmosome assembly)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030057"(desmosome)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0071665"(gamma-catenin-TCF7L2 complex)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR030461|reactome:R-RNO-418990|reactome:R-RNO-5218920|reactome:R-RNO-6798695|reactome:R-RNO-6805567|reactome:R-RNO-6809371|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013406|reactome:R-RNO-9013407	intact:EBI-6901829(see-also)	-	-	figure legend:5B -wt|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/24	2015/07/27	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	rogid:yWbzwtNtLlRBegMUJ6YQyJzQpXE10116	intact-crc:484ADA225A5FF86B|rigid:91ron5EXYSHTK6cKq3jcUvx7Y9A	false	sufficient binding region:716-901|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:F1M7L9	uniprotkb:Q02487-1	intact:EBI-6900770|ensembl:ENSRNOP00000002498	intact:EBI-6900677|ensembl:ENSP00000280904	psi-mi:f1m7l9_rat(display_long)	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900859|imex:IM-20978-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000001825(gene)|ensembl:ENSRNOT00000002498(transcript)|go:"GO:0002159"(desmosome assembly)|go:"GO:0002934"(desmosome organization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007507"(heart development)|go:"GO:0014704"(intercalated disc)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086019"(cell-cell signaling involved in cardiac conduction)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|reactome:R-RNO-6805567|reactome:R-RNO-6809371	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	-	-	-	figure legend:5 B -mut|comment:"DSC2b (and the mutant)  bound only to PKP2 (Figure 5B)."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/24	2015/07/27	rogid:mJktQiuGcLQBsaYxTMTkLRm5XTg10116	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	intact-crc:B27D3EA1CFC3248F|rigid:dVnIG5LeJdQuXChciryAHeMo4bo	false	-	sufficient binding region:716-855|mutation:852-854|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6TYA9	uniprotkb:Q02487-2	intact:EBI-6901331	intact:EBI-6900918|ensembl:ENSP00000251081	psi-mi:cxa1_chlae(display_long)|uniprotkb:GJA1(gene name)|psi-mi:GJA1(display_short)|uniprotkb:Connexin-43(gene name synonym)	psi-mi:q02487-2(display_long)|uniprotkb:DGIII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6901406|imex:IM-20978-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035091|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015631"(tubulin binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:0060348"(bone development)|go:"GO:0099111"(microtubule-based transport)|interpro:IPR034634|interpro:IPR038359|interpro:IPR000500(Connexins)|interpro:IPR002261("Gap junction alpha-1 protein (Cx43)")|interpro:IPR013124("Gap junction alpha-1 protein (Cx43), C-terminal")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)	ensembl:ENSG00000134755(gene)|ensembl:ENST00000251081(transcript)|intact:EBI-3048545(isoform-parent)	-	-	-	figure legend:6B -wt|caution:"The text states that:-  \"DSC2a WT bound to endogenous Cx43, and again the mutant DSC2a protein and DSC2b did not bind (Figure 6B).\"  However a weak  band is clearly visible for Dsc2b."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/07/24	2014/10/16	rogid:3d64/4bhU8qI6R6LMnWLURtuA+U9534	rogid:cD7qy9ZJ5k6qj0jf5E9zzKdQ7ME9606	intact-crc:8D74A3DB91FAF0F9|rigid:iQ0apcPtbfkaSM4NDq5sj88Ym1U	false	-	glutathione s tranferase tag:n-n|sufficient binding region:716-847	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02487-1	uniprotkb:Q6TYA9	intact:EBI-6900677|ensembl:ENSP00000280904	intact:EBI-6901331	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:cxa1_chlae(display_long)|uniprotkb:GJA1(gene name)|psi-mi:GJA1(display_short)|uniprotkb:Connexin-43(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6901292|imex:IM-20978-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	interpro:IPR035091|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015631"(tubulin binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:0060348"(bone development)|go:"GO:0099111"(microtubule-based transport)|interpro:IPR034634|interpro:IPR038359|interpro:IPR000500(Connexins)|interpro:IPR002261("Gap junction alpha-1 protein (Cx43)")|interpro:IPR013124("Gap junction alpha-1 protein (Cx43), C-terminal")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)	-	-	-	figure legend:6B|comment:"DSC2a WT bound to endogenous Cx43, and again the mutant DSC2a protein  did not bind (Figure 6B)"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/07/24	2014/10/16	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	rogid:3d64/4bhU8qI6R6LMnWLURtuA+U9534	intact-crc:DED79B351826F89D|rigid:wu1J0RtEzMmxBZCGYDyM3wZzJ5E	false	necessary binding region:852-896|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02487-1	uniprotkb:P17302	intact:EBI-6900677|ensembl:ENSP00000280904	intact:EBI-1103439|uniprotkb:Q6FHU1|uniprotkb:Q9Y5I8|uniprotkb:B2R5U9|ensembl:ENSP00000282561|ensembl:ENSP00000497283|ensembl:ENSP00000497367|ensembl:ENSP00000497565	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:cxa1_human(display_long)|uniprotkb:GJAL(gene name synonym)|uniprotkb:Connexin-43(gene name synonym)|uniprotkb:Gap junction 43 kDa heart protein(gene name synonym)|uniprotkb:GJA1(gene name)|psi-mi:GJA1(display_short)	psi-mi:"MI:0096"(pull down)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6901142|imex:IM-20978-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005916"(fascia adherens)|go:"GO:0005921"(gap junction)|go:"GO:0005922"(connexin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009268"(response to pH)|go:"GO:0009749"(response to glucose)|go:"GO:0010232"(vascular transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010652"(positive regulation of cell communication by chemical coupling)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014704"(intercalated disc)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0015631"(tubulin binding)|go:"GO:0015867"(ATP transport)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032277"(negative regulation of gonadotropin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034634"(glutathione transmembrane transporter activity)|ensembl:ENSG00000152661(gene)|ensembl:ENST00000282561(transcript)|ensembl:ENST00000647564(transcript)|ensembl:ENST00000649003(transcript)|ensembl:ENST00000650427(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002931"(response to ischemia)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0003158"(endothelium development)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005634"(nucleus)|interpro:IPR017990|interpro:IPR019570|interpro:IPR034634|interpro:IPR035091|interpro:IPR038359|mint:P17302|rcsb pdb:2LL2|reactome:R-HSA-190704|reactome:R-HSA-190827|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-190873|reactome:R-HSA-191650|reactome:R-HSA-196025|reactome:R-HSA-9013406|reactome:R-HSA-9013409|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042311"(vasodilation)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046697"(decidualization)|go:"GO:0046849"(bone remodeling)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070160"(tight junction)|go:"GO:0071253"(connexin binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086075"(gap junction channel activity involved in cardiac conduction electrical coupling)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140115"(export across plasma membrane)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1903763"(gap junction channel activity involved in cell communication by electrical coupling)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905332"(positive regulation of morphogenesis of an epithelium)|go:"GO:1905772"(positive regulation of mesodermal cell differentiation)|go:"GO:1905867"(epididymis development)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000500(Connexins)|interpro:IPR002261("Gap junction alpha-1 protein (Cx43)")|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR013124("Gap junction alpha-1 protein (Cx43), C-terminal")|refseq:NP_000156.1	intact:EBI-6901218(see-also)	-	-	figure legend:6A -wt|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/07/24	2014/10/16	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	rogid:ri2cG7YGyM1rVOXreP305UK1h4U9606	intact-crc:E85CAEEBD77493D6|rigid:+gQpqYFNEmWuTgjXd7xv65Eqx+s	false	sufficient binding region:716-901|glutathione s tranferase tag:n-n	yellow fluorescent protein tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P15924	uniprotkb:Q02487-1	intact:EBI-355041|uniprotkb:O75993|uniprotkb:Q14189|uniprotkb:Q9UHN4|uniprotkb:B2RTT2|uniprotkb:D7RX09|ensembl:ENSP00000369129	intact:EBI-6900677|ensembl:ENSP00000280904	psi-mi:desp_human(display_long)|uniprotkb:DSP(gene name)|psi-mi:DSP(display_short)|uniprotkb:250/210 kDa paraneoplastic pemphigus antigen(gene name synonym)	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6902060|imex:IM-20978-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001305963.1|refseq:NP_001008844.1|refseq:NP_004406.2|go:"GO:0014704"(intercalated disc)|go:"GO:0005916"(fascia adherens)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086083"(cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|ensembl:ENSG00000096696(gene)|ensembl:ENST00000379802(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:P15924|rcsb pdb:1LM5|rcsb pdb:1LM7|rcsb pdb:3R6N|rcsb pdb:5DZZ|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696273|dip:DIP-109N	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	intact:EBI-6901218(see-also)	-	-	figure legend:Supp 5A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/07/24	2014/10/16	rogid:enapEqSoyTSLfPEQUAopkGpdxbo9606	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	intact-crc:C5AB299E5F3BFC7C|rigid:FCyGIqYwP0pAiIVorfQSAH0rOvk	false	sufficient binding region:1-584|enhanced green fluorescent protein tag:c-c	glutathione s tranferase tag:n-n|necessary binding region:852-901	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02487-1	intact:EBI-6900983	intact:EBI-6900677|ensembl:ENSP00000280904	-	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:jup_chlae_protein(display_short)|psi-mi:EBI-6900983(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900961|imex:IM-20978-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	-	-	-	-	figure legend:5C -wt|comment:There was impaired binding of the DSC2a mutant full-length protein to plakoglobin.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/07/24	2014/10/16	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	-	intact-crc:45DDBF6D4B558495	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02487-1	uniprotkb:Q6TYA9	intact:EBI-6900677|ensembl:ENSP00000280904	intact:EBI-6901331	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:cxa1_chlae(display_long)|uniprotkb:GJA1(gene name)|psi-mi:GJA1(display_short)|uniprotkb:Connexin-43(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6900971|imex:IM-20978-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	interpro:IPR035091|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015631"(tubulin binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:0060348"(bone development)|go:"GO:0099111"(microtubule-based transport)|interpro:IPR034634|interpro:IPR038359|interpro:IPR000500(Connexins)|interpro:IPR002261("Gap junction alpha-1 protein (Cx43)")|interpro:IPR013124("Gap junction alpha-1 protein (Cx43), C-terminal")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)	-	-	-	figure legend:6d mut|comment:There was impaired binding of the DSC2a mutant full-length protein.|caution:There appears to be weak binding between Cx43 and mutant DSC2a, in spite of the text stating there is no binding.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/07/24	2014/10/16	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	rogid:3d64/4bhU8qI6R6LMnWLURtuA+U9534	intact-crc:01CE2B1B2074ADFE|rigid:wu1J0RtEzMmxBZCGYDyM3wZzJ5E	false	mutation:852-854|sufficient binding region:1-854	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-6900983	uniprotkb:Q02487-1	-	intact:EBI-6900677|ensembl:ENSP00000280904	psi-mi:jup_chlae_protein(display_short)|psi-mi:EBI-6900983(display_long)	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6901937|imex:IM-20978-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	-	-	-	figure legend:5C mut|comment:There was impaired binding of the DSC2a mutant full-length protein.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/07/24	2014/10/16	-	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	intact-crc:1447307E509780E7	false	-	sufficient binding region:1-854|mutation:852-854	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02487-1	uniprotkb:Q6TYA9	intact:EBI-6900677|ensembl:ENSP00000280904	intact:EBI-6901331	psi-mi:q02487-1(display_long)|uniprotkb:DGII(isoform synonym)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:cxa1_chlae(display_long)|uniprotkb:GJA1(gene name)|psi-mi:GJA1(display_short)|uniprotkb:Connexin-43(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6901923|imex:IM-20978-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|intact:EBI-3048545(isoform-parent)	interpro:IPR035091|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015631"(tubulin binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:0060348"(bone development)|go:"GO:0099111"(microtubule-based transport)|interpro:IPR034634|interpro:IPR038359|interpro:IPR000500(Connexins)|interpro:IPR002261("Gap junction alpha-1 protein (Cx43)")|interpro:IPR013124("Gap junction alpha-1 protein (Cx43), C-terminal")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)	-	-	-	figure legend:6D|comment:There was impaired binding of the DSC2a mutant full-length protein.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/07/24	2014/10/16	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	rogid:3d64/4bhU8qI6R6LMnWLURtuA+U9534	intact-crc:B7CBD2826BE5EA8D|rigid:wu1J0RtEzMmxBZCGYDyM3wZzJ5E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02487	uniprotkb:Q14126	intact:EBI-3048545|ensembl:ENSP00000280904	intact:EBI-2556545|uniprotkb:Q4KKU6|ensembl:ENSP00000261590	psi-mi:dsc2_human(display_long)|uniprotkb:DSC2(gene name)|psi-mi:DSC2(display_short)|uniprotkb:CDHF2(gene name synonym)|uniprotkb:DSC3(gene name synonym)|uniprotkb:Cadherin family member 2(gene name synonym)|uniprotkb:Desmocollin-3(gene name synonym)|uniprotkb:Desmosomal glycoprotein II(gene name synonym)|uniprotkb:Desmosomal glycoprotein III(gene name synonym)	psi-mi:dsg2_human(display_long)|uniprotkb:CDHF5(gene name synonym)|uniprotkb:HDGC(gene name synonym)|uniprotkb:Cadherin family member 5(gene name synonym)|uniprotkb:DSG2(gene name)|psi-mi:DSG2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Gehmlich et al. (2011)	imex:IM-20978|pubmed:21220045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6901957|imex:IM-20978-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134755(gene)|ensembl:ENST00000280904(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0014704"(intercalated disc)|go:"GO:0030057"(desmosome)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086042"(cardiac muscle cell-cardiac muscle cell adhesion)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086083"(cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|go:"GO:0016021"(integral component of membrane)|rcsb pdb:5ERP|interpro:IPR027397|rcsb pdb:5J5J|rcsb pdb:7A7D|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_004940.1|refseq:NP_077740.1	refseq:NP_001934.2|reactome:R-HSA-9013423|ensembl:ENSG00000046604(gene)|ensembl:ENST00000261590(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003165"(Purkinje myocyte development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0014704"(intercalated disc)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086083"(cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|interpro:IPR002126(Cadherin)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR009123(Desmoglein)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|rcsb pdb:2YQG|rcsb pdb:5ERD|rcsb pdb:5J5J|rcsb pdb:6QNT|rcsb pdb:6QNU|rcsb pdb:6SIT|rcsb pdb:7A7D|rcsb pdb:7AGF|rcsb pdb:7AGG|reactome:R-HSA-351906|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9013404|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|reactome:R-HSA-9013408|dip:DIP-46250N	-	-	-	figure legend:Supp 4B, Supp 5B.|comment:"The A517V mutant shows normal binding to DSC2.  Binding to DSG2 by mutant DSC2a (mediated by the extracellular portion) was preserved (Figure S5B)."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/07/24	2014/10/16	rogid:EUXe5KbkWaO5wRalhRX+pf7jkOQ9606	rogid:LCSf84WRgh5lTrze5IEzFaBeuEc9606	intact-crc:C85CD3964F8107E4|rigid:s1wf6tU1/vTxreiuelAO2v8xcao	false	sufficient binding region:1-851..851	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)