#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P17661 uniprotkb:Q13496 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0027"(cosedimentation) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-6861922 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:5C|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/06/14 2014/10/16 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:BA38E2867591B795|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P17661 uniprotkb:P17661 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:"MI:0027"(cosedimentation) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6867722 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 - - - figure legend:5D|comment:Polymerized form of desmin.|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/06/14 2014/10/16 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 intact-crc:1253D1EAA6EA0BEB|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P17661 uniprotkb:Q13496 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0027"(cosedimentation) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6867722 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:5D|comment:Polymerized form of desmin.|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/06/14 2014/10/16 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:1253D1EAA6EA0BEB|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q9Z2C5 uniprotkb:P31001 intact:EBI-6861578|ensembl:ENSMUSP00000033700|ensembl:ENSMUSP00000057182|ensembl:ENSMUSP00000110264|ensembl:ENSMUSP00000125798|uniprotkb:Q5BKQ5 intact:EBI-298565|ensembl:ENSMUSP00000027409 psi-mi:mtm1_mouse(display_long)|uniprotkb:Mtm1(gene name)|psi-mi:Mtm1(display_short)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:"MI:0663"(confocal microscopy) Hnia et al. (2011) pubmed:21135508 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6861642 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031337(gene)|ensembl:ENSMUST00000033700(transcript)|ensembl:ENSMUST00000061970(transcript)|ensembl:ENSMUST00000114617(transcript)|ensembl:ENSMUST00000171933(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031674"(I band)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|mint:Q9Z2C5|reactome:R-MMU-1660499|reactome:R-MMU-1660516|reactome:R-MMU-1660517|go:"GO:0030175"(filopodium)|refseq:NP_001157662.1|refseq:NP_001157663.1|refseq:NP_001157664.1|refseq:NP_064310.2 refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N go:"GO:0030018"(Z disc)|go:"GO:0042383"(sarcolemma) - - figure legend:1D and 4D|curation depth:mimix curation taxid:10090(mouse-skeletal-muscle)|taxid:10090(Mus musculus skeletal muscle.) - 2013/06/14 2014/10/16 rogid:3hn4I4iyQmlS8LHEnXenJxG0aUc10090 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 intact-crc:DC8D75A0B93E04E6|rigid:zbMY+bdWR/4vpm/LKINL8LO78zs false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q13496 uniprotkb:P17661 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:"MI:0049"(filter binding) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-6861690 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 - - - figure legend:S3D|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/06/14 2014/10/16 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 intact-crc:07492EFB0F24C0D7|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P17661 uniprotkb:Q13496 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0049"(filter binding) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-6861694 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:S3F and 2D|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/06/14 2014/10/16 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:B63EDF4C4EDE9716|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P17661 uniprotkb:Q13496 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0047"(far western blotting) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-6861551 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:1B and 3G|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/06/14 2014/10/16 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:4EB4BEAD381B3616|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false mutation disrupting interaction:342-342|mutation disrupting interaction:357-357|mutation disrupting interaction:360-360|mutation:370-370 - 1 - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13496 uniprotkb:P17661 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:"MI:0047"(far western blotting) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-6867700 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 - - - figure legend:1B|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/06/14 2014/10/16 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 intact-crc:26A2CE5C9B7658BC|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - 4 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P17661 uniprotkb:Q13496 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6861565 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:1C, 3F and Supp 3B.|curation depth:mimix curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2013/06/14 2014/10/16 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:DE9CD9361ED81FD2|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - mutation disrupting interaction:184-184|mutation disrupting interaction:205-205|mutation disrupting interaction:241-241|mutation disrupting interaction:278-278 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Z2C5 uniprotkb:P31001 intact:EBI-6861578|ensembl:ENSMUSP00000033700|ensembl:ENSMUSP00000057182|ensembl:ENSMUSP00000110264|ensembl:ENSMUSP00000125798|uniprotkb:Q5BKQ5 intact:EBI-298565|ensembl:ENSMUSP00000027409 psi-mi:mtm1_mouse(display_long)|uniprotkb:Mtm1(gene name)|psi-mi:Mtm1(display_short)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hnia et al. (2011) pubmed:21135508 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6861576 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031337(gene)|ensembl:ENSMUST00000033700(transcript)|ensembl:ENSMUST00000061970(transcript)|ensembl:ENSMUST00000114617(transcript)|ensembl:ENSMUST00000171933(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031674"(I band)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|mint:Q9Z2C5|reactome:R-MMU-1660499|reactome:R-MMU-1660516|reactome:R-MMU-1660517|go:"GO:0030175"(filopodium)|refseq:NP_001157662.1|refseq:NP_001157663.1|refseq:NP_001157664.1|refseq:NP_064310.2 refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N - - - figure legend:1C|curation depth:mimix curation taxid:10090(mouse-myotubes)|taxid:10090(Mus musculus) - 2013/06/14 2014/10/16 rogid:3hn4I4iyQmlS8LHEnXenJxG0aUc10090 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 intact-crc:9B511DB28BEF2CBF|rigid:zbMY+bdWR/4vpm/LKINL8LO78zs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P31001 uniprotkb:Q9Z2C5 intact:EBI-298565|ensembl:ENSMUSP00000027409 intact:EBI-6861578|ensembl:ENSMUSP00000033700|ensembl:ENSMUSP00000057182|ensembl:ENSMUSP00000110264|ensembl:ENSMUSP00000125798|uniprotkb:Q5BKQ5 psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:mtm1_mouse(display_long)|uniprotkb:Mtm1(gene name)|psi-mi:Mtm1(display_short)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hnia et al. (2011) pubmed:21135508 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6861631 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N ensembl:ENSMUSG00000031337(gene)|ensembl:ENSMUST00000033700(transcript)|ensembl:ENSMUST00000061970(transcript)|ensembl:ENSMUST00000114617(transcript)|ensembl:ENSMUST00000171933(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031674"(I band)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|mint:Q9Z2C5|reactome:R-MMU-1660499|reactome:R-MMU-1660516|reactome:R-MMU-1660517|go:"GO:0030175"(filopodium)|refseq:NP_001157662.1|refseq:NP_001157663.1|refseq:NP_001157664.1|refseq:NP_064310.2 - - - figure legend:1C|curation depth:mimix curation taxid:10090(mouse-skeletal-muscle)|taxid:10090(Mus musculus skeletal muscle.) - 2013/06/14 2014/10/16 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 rogid:3hn4I4iyQmlS8LHEnXenJxG0aUc10090 intact-crc:1053AC10A55FE0CD|rigid:zbMY+bdWR/4vpm/LKINL8LO78zs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Z2C5 uniprotkb:P31001 intact:EBI-6861578|ensembl:ENSMUSP00000033700|ensembl:ENSMUSP00000057182|ensembl:ENSMUSP00000110264|ensembl:ENSMUSP00000125798|uniprotkb:Q5BKQ5 intact:EBI-298565|ensembl:ENSMUSP00000027409 psi-mi:mtm1_mouse(display_long)|uniprotkb:Mtm1(gene name)|psi-mi:Mtm1(display_short)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hnia et al. (2011) pubmed:21135508 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6861627 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031337(gene)|ensembl:ENSMUST00000033700(transcript)|ensembl:ENSMUST00000061970(transcript)|ensembl:ENSMUST00000114617(transcript)|ensembl:ENSMUST00000171933(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0031674"(I band)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|mint:Q9Z2C5|reactome:R-MMU-1660499|reactome:R-MMU-1660516|reactome:R-MMU-1660517|go:"GO:0030175"(filopodium)|refseq:NP_001157662.1|refseq:NP_001157663.1|refseq:NP_001157664.1|refseq:NP_064310.2 refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N - - - figure legend:1C|curation depth:mimix curation taxid:10090(mouse-skeletal-muscle)|taxid:10090(Mus musculus skeletal muscle.) - 2013/06/14 2014/10/16 rogid:3hn4I4iyQmlS8LHEnXenJxG0aUc10090 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 intact-crc:30BB021203D8A37F|rigid:zbMY+bdWR/4vpm/LKINL8LO78zs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9QXS1 uniprotkb:P31001 intact:EBI-774583|uniprotkb:Q9QXR8|uniprotkb:Q9QXR9|uniprotkb:Q6S384|uniprotkb:Q6S389|uniprotkb:Q6S394|uniprotkb:Q9CS65|uniprotkb:Q9QUT2|uniprotkb:Q9QXQ8|uniprotkb:Q9QXQ9|uniprotkb:Q9QXR0|uniprotkb:Q9QXR1|uniprotkb:Q9QXR2|uniprotkb:Q9QXR3|uniprotkb:Q9QXR4|uniprotkb:Q9QXR5|uniprotkb:Q9QXR6|uniprotkb:Q9QXR7|uniprotkb:Q9QXS0|uniprotkb:Q9QXS2|uniprotkb:Q9QXS3|uniprotkb:E9QN87|ensembl:ENSMUSP00000073124 intact:EBI-298565|ensembl:ENSMUSP00000027409 psi-mi:plec_mouse(display_long)|uniprotkb:Plectin-6(gene name synonym)|uniprotkb:Plec(gene name)|psi-mi:Plec(display_short)|uniprotkb:Plec1(gene name synonym)|uniprotkb:Plectin-1(gene name synonym) psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Hnia et al. (2011) pubmed:21135508 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6862440 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001157012.1|refseq:NP_001157014.1|refseq:NP_001157021.1|refseq:NP_001157675.1|refseq:NP_035247.2|refseq:NP_958791.2|refseq:NP_958796.2|dip:DIP-32004N|ensembl:ENSMUSG00000022565(gene)|ensembl:ENSMUST00000073418(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006997"(nucleus organization)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010467"(gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016569"(obsolete covalent chromatin modification)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032094"(response to food)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043209"(myelin sheath)|go:"GO:0043292"(contractile fiber)|go:"GO:0043588"(skin development)|go:"GO:0043621"(protein self-association)|go:"GO:0043933"(protein-containing complex organization)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048870"(cell motility)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071944"(cell periphery)|go:"GO:0120193"(tight junction organization)|go:"GO:2000689"(actomyosin contractile ring assembly actin filament organization)|go:"GO:2000983"(regulation of ATP citrate synthase activity)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR005326(Plectin/S10, N-terminal)|interpro:IPR018159|interpro:IPR030269|interpro:IPR035915|interpro:IPR036388|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:Q9QXS1|rcsb pdb:1SH5|rcsb pdb:1SH6|rcsb pdb:4Q57|reactome:R-MMU-264870|reactome:R-MMU-446107 refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N go:"GO:0005739"(mitochondrion)|go:"GO:0005792"(obsolete microsome) - - figure legend:8F|curation depth:mimix curation taxid:10090(mouse-skeletal-muscle)|taxid:10090(Mus musculus skeletal muscle.) - 2013/06/14 2014/10/16 rogid:9cGCRGhjImLIGd9shNPJRdSpdoY10090 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 intact-crc:B097AD0AF5A0A0FA|rigid:SuXmIBFVF54UqX/1z0mOazLEbjM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13496 uniprotkb:P17661 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:"MI:0018"(two hybrid) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6861519 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 - - - figure legend:no figure|curation depth:mimix curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2013/06/14 2014/10/16 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 intact-crc:DE85C5121D50427D|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P17661 uniprotkb:Q13496 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6862451 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:S3C and 2B|curation depth:mimix curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2013/06/14 2014/10/16 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:475CA99ECC43C402|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P31001 uniprotkb:Q13496 intact:EBI-298565|ensembl:ENSMUSP00000027409 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Hnia et al. (2011) pubmed:21135508 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6867736 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) go:"GO:0005882"(intermediate filament) - - figure legend:S7A and 8A|curation depth:mimix curation taxid:10090(mouse-myoblast)|taxid:10090(Mus musculus myoblasts) - 2013/06/14 2014/10/16 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:B6E1EA7AF97615CC|rigid:X7nFUBrK9eC2GERGjQaV6YKcTOE false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P31001 uniprotkb:Q13496 intact:EBI-298565|ensembl:ENSMUSP00000027409 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Hnia et al. (2011) pubmed:21135508 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6867760 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) go:"GO:0005882"(intermediate filament) - - figure legend:S8B|curation depth:mimix curation taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast) - 2013/06/14 2014/10/16 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:2472CF3435CE62F3|rigid:X7nFUBrK9eC2GERGjQaV6YKcTOE false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P17661 uniprotkb:P17661 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:"MI:0982"(electrophoretic mobility-based method) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-6868180 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 - - - figure legend:1B|curation depth:mimix curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2013/06/14 2014/10/16 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 intact-crc:5AC003A2D3F6BA86|rigid:T19suC9XbLda2wXP0mff0g0/pFo false - - 4 0 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13496 uniprotkb:P17661 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:"MI:0663"(confocal microscopy) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6861663 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 go:"GO:0030018"(Z disc)|go:"GO:0042383"(sarcolemma) - - figure legend:S1|curation depth:mimix curation taxid:9606(human-skeletal-muscle)|taxid:9606(Homo sapiens skeletal muscle.) - 2013/06/14 2014/10/16 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 intact-crc:4F6959C6A9F6A5CA|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P31001 uniprotkb:Q13496 intact:EBI-298565|ensembl:ENSMUSP00000027409 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0096"(pull down) Hnia et al. (2011) pubmed:21135508 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6861539 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:1A|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/06/14 2014/10/16 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:EEFEE651B931BCE2|rigid:X7nFUBrK9eC2GERGjQaV6YKcTOE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13496 uniprotkb:P17661 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:"MI:0096"(pull down) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6861652 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 - - - figure legend:2A|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/06/14 2014/10/16 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 intact-crc:D452E211B24DC8B5|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13496 uniprotkb:P17661 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:"MI:0096"(pull down) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6862467 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 - - - figure legend:S3E|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/06/14 2014/10/16 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 intact-crc:62351B1BF7517246|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P31001 uniprotkb:Q13496 intact:EBI-298565|ensembl:ENSMUSP00000027409 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 psi-mi:desm_mouse(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short) psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:"MI:0096"(pull down) Hnia et al. (2011) pubmed:21135508 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6861530 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034173.1|go:"GO:0005916"(fascia adherens)|ensembl:ENSMUSG00000026208(gene)|ensembl:ENSMUST00000027409(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P31001|reactome:R-MMU-390522|go:"GO:0005921"(gap junction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|dip:DIP-256N refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) - - - figure legend:1A|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/06/14 2014/10/16 rogid:00+9If1SeTNgGlloChCKgqWMtFo10090 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 intact-crc:EAD98F4F193553E6|rigid:X7nFUBrK9eC2GERGjQaV6YKcTOE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13496 uniprotkb:P17661 intact:EBI-2864109|uniprotkb:Q8NEL1|uniprotkb:A6NDB1|uniprotkb:B7Z491|uniprotkb:F2Z330|ensembl:ENSP00000359423 intact:EBI-1055572|uniprotkb:Q15787|uniprotkb:Q8IZR1|uniprotkb:Q8IZR6|uniprotkb:Q8NES2|uniprotkb:Q8NEU6|uniprotkb:Q8TAC4|uniprotkb:Q8TCX2|uniprotkb:Q8TD99|uniprotkb:Q9UHN5|uniprotkb:Q9UJ80|uniprotkb:Q549R7|uniprotkb:Q549R8|uniprotkb:Q549R9|ensembl:ENSP00000363071 psi-mi:mtm1_human(display_long)|uniprotkb:MTM1(gene name)|psi-mi:MTM1(display_short)|uniprotkb:CG2(gene name synonym)|uniprotkb:Phosphatidylinositol-3,5-bisphosphate 3-phosphatase(gene name synonym)|uniprotkb:Phosphatidylinositol-3-phosphate phosphatase(gene name synonym) psi-mi:desm_human(display_long)|uniprotkb:DES(gene name)|psi-mi:DES(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Hnia et al. (2011) pubmed:21135508 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6862031 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011529475.1|refseq:NP_000243.1|refseq:XP_016885039.1|refseq:XP_005274744.1|dip:DIP-61934N|go:"GO:0052629"(phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR004182(GRAM)|interpro:IPR010569(Myotubularin-related)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR030561|interpro:IPR030564|reactome:R-HSA-1660499|reactome:R-HSA-1660516|reactome:R-HSA-1660517|ensembl:ENSG00000171100(gene)|ensembl:ENST00000370396(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030175"(filopodium)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0044088"(regulation of vacuole organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048311"(mitochondrion distribution) refseq:NP_001918.3|ensembl:ENSG00000175084(gene)|ensembl:ENST00000373960(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005916"(fascia adherens)|go:"GO:0006936"(muscle contraction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR039008|mint:P17661|reactome:R-HSA-390522 - - - figure legend:6B|curation depth:mimix curation taxid:9606(human-sw13vim-)|taxid:9606(Homo sapiens SW13 vim- cells lacking endogenous cytoplasmic intermediate filaments) - 2013/06/14 2014/10/16 rogid:M4w0bu6vAz5ALjDZDpmAr+lILJI9606 rogid:htjPzLKLLbRXxfKz9NUgMYMuIaY9606 intact-crc:44179E9D1A6E4A6E|rigid:Y7jgxpS5IthNb3IdN5+FDzLQ7kE false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)