#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6PE92	uniprotkb:P51637	intact:EBI-6918775	intact:EBI-298576|ensembl:ENSMUSP00000074922	psi-mi:q6pe92_mouse(display_long)|uniprotkb:Cacna1h(gene name)|psi-mi:Cacna1h(display_short)	psi-mi:cav3_mouse(display_long)|uniprotkb:Cav3(gene name)|psi-mi:Cav3(display_short)|uniprotkb:M-caveolin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Markandeya et al. (2011)	pubmed:21084288|imex:IM-22130	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6918862|imex:IM-22130-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|interpro:IPR005821(Ion transport)|interpro:IPR005445(Voltage-dependent calcium channel, T-type, alpha-1 subunit)|interpro:IPR027359	go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070836"(caveola assembly)|go:"GO:0071253"(connexin binding)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|ensembl:ENSMUSG00000062694(gene)|ensembl:ENSMUST00000075477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014704"(intercalated disc)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|interpro:IPR001612(Caveolin)|interpro:IPR018361|interpro:IPR031091|mint:P51637|reactome:R-MMU-445355|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|refseq:NP_031643.1|dip:DIP-31069N	-	-	-	figure legend:Fig. 1c|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/08/05	2014/10/16	rogid:ACNBch+O0zvqQRJLaxN5Othlp5c10090	rogid:K9freRN6XcY4lMheGDyaDgx/ZT010090	intact-crc:13C2E453717C8415|rigid:ovY9Ick9YhVFM9HXeZNksPPpSXI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5SUG4	uniprotkb:P51637	intact:EBI-6918583|ensembl:ENSMUSP00000098127	intact:EBI-298576|ensembl:ENSMUSP00000074922	psi-mi:q5sug4_mouse(display_long)|uniprotkb:Cacna1g(gene name)|psi-mi:Cacna1g(display_short)	psi-mi:cav3_mouse(display_long)|uniprotkb:Cav3(gene name)|psi-mi:Cav3(display_short)|uniprotkb:M-caveolin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Markandeya et al. (2011)	pubmed:21084288|imex:IM-22130	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6918866|imex:IM-22130-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020866(gene)|ensembl:ENSMUST00000100561(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008332"(low voltage-gated calcium channel activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010045"(response to nickel cation)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030425"(dendrite)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086016"(AV node cell action potential)|go:"GO:0086018"(SA node cell to atrial cardiac muscle cell signaling)|go:"GO:0086027"(AV node cell to bundle of His cell signaling)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005445(Voltage-dependent calcium channel, T-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR030154|interpro:IPR043203|refseq:NP_033913.2	go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070836"(caveola assembly)|go:"GO:0071253"(connexin binding)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|ensembl:ENSMUSG00000062694(gene)|ensembl:ENSMUST00000075477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014704"(intercalated disc)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|interpro:IPR001612(Caveolin)|interpro:IPR018361|interpro:IPR031091|mint:P51637|reactome:R-MMU-445355|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|refseq:NP_031643.1|dip:DIP-31069N	-	-	-	figure legend:Fig. 1c|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/08/05	2014/10/16	rogid:Ka3Oe2CBpNmlZAXsbFN++JNZsyk10090	rogid:K9freRN6XcY4lMheGDyaDgx/ZT010090	intact-crc:CD728E898843D5F7|rigid:TdPiXyjjOCpdVvxwuAMRB1SChRE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PE92	uniprotkb:P51637	intact:EBI-6918775	intact:EBI-298576|ensembl:ENSMUSP00000074922	psi-mi:q6pe92_mouse(display_long)|uniprotkb:Cacna1h(gene name)|psi-mi:Cacna1h(display_short)	psi-mi:cav3_mouse(display_long)|uniprotkb:Cav3(gene name)|psi-mi:Cav3(display_short)|uniprotkb:M-caveolin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Markandeya et al. (2011)	pubmed:21084288|imex:IM-22130	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6917709|imex:IM-22130-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|interpro:IPR005821(Ion transport)|interpro:IPR005445(Voltage-dependent calcium channel, T-type, alpha-1 subunit)|interpro:IPR027359	go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070836"(caveola assembly)|go:"GO:0071253"(connexin binding)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|ensembl:ENSMUSG00000062694(gene)|ensembl:ENSMUST00000075477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014704"(intercalated disc)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|interpro:IPR001612(Caveolin)|interpro:IPR018361|interpro:IPR031091|mint:P51637|reactome:R-MMU-445355|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|refseq:NP_031643.1|dip:DIP-31069N	-	-	-	figure legend:Fig. 1B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ventricular myocyte_neo)|taxid:10090(Mus musculus)	-	2013/08/05	2014/10/16	rogid:ACNBch+O0zvqQRJLaxN5Othlp5c10090	rogid:K9freRN6XcY4lMheGDyaDgx/ZT010090	intact-crc:228D65026ABB2C4C|rigid:ovY9Ick9YhVFM9HXeZNksPPpSXI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5SUG4	uniprotkb:P51637	intact:EBI-6918583|ensembl:ENSMUSP00000098127	intact:EBI-298576|ensembl:ENSMUSP00000074922	psi-mi:q5sug4_mouse(display_long)|uniprotkb:Cacna1g(gene name)|psi-mi:Cacna1g(display_short)	psi-mi:cav3_mouse(display_long)|uniprotkb:Cav3(gene name)|psi-mi:Cav3(display_short)|uniprotkb:M-caveolin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Markandeya et al. (2011)	pubmed:21084288|imex:IM-22130	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6918581|imex:IM-22130-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020866(gene)|ensembl:ENSMUST00000100561(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008332"(low voltage-gated calcium channel activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010045"(response to nickel cation)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030425"(dendrite)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086016"(AV node cell action potential)|go:"GO:0086018"(SA node cell to atrial cardiac muscle cell signaling)|go:"GO:0086027"(AV node cell to bundle of His cell signaling)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005445(Voltage-dependent calcium channel, T-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR030154|interpro:IPR043203|refseq:NP_033913.2	go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070836"(caveola assembly)|go:"GO:0071253"(connexin binding)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|ensembl:ENSMUSG00000062694(gene)|ensembl:ENSMUST00000075477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014704"(intercalated disc)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|interpro:IPR001612(Caveolin)|interpro:IPR018361|interpro:IPR031091|mint:P51637|reactome:R-MMU-445355|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|refseq:NP_031643.1|dip:DIP-31069N	-	-	-	figure legend:Fig. 1A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ventricular myocyte_neo)|taxid:10090(Mus musculus)	-	2013/08/05	2014/10/16	rogid:Ka3Oe2CBpNmlZAXsbFN++JNZsyk10090	rogid:K9freRN6XcY4lMheGDyaDgx/ZT010090	intact-crc:12ABFEDB4170096D|rigid:TdPiXyjjOCpdVvxwuAMRB1SChRE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5SUG4	uniprotkb:P51637	intact:EBI-6918583|ensembl:ENSMUSP00000098127	intact:EBI-298576|ensembl:ENSMUSP00000074922	psi-mi:q5sug4_mouse(display_long)|uniprotkb:Cacna1g(gene name)|psi-mi:Cacna1g(display_short)	psi-mi:cav3_mouse(display_long)|uniprotkb:Cav3(gene name)|psi-mi:Cav3(display_short)|uniprotkb:M-caveolin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Markandeya et al. (2011)	pubmed:21084288|imex:IM-22130	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6918611|imex:IM-22130-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020866(gene)|ensembl:ENSMUST00000100561(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008332"(low voltage-gated calcium channel activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010045"(response to nickel cation)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030425"(dendrite)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086016"(AV node cell action potential)|go:"GO:0086018"(SA node cell to atrial cardiac muscle cell signaling)|go:"GO:0086027"(AV node cell to bundle of His cell signaling)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005445(Voltage-dependent calcium channel, T-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR030154|interpro:IPR043203|refseq:NP_033913.2	go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070836"(caveola assembly)|go:"GO:0071253"(connexin binding)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|ensembl:ENSMUSG00000062694(gene)|ensembl:ENSMUST00000075477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014704"(intercalated disc)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|interpro:IPR001612(Caveolin)|interpro:IPR018361|interpro:IPR031091|mint:P51637|reactome:R-MMU-445355|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|refseq:NP_031643.1|dip:DIP-31069N	-	-	-	figure legend:Fig. 1A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ventricular myocyte_neo)|taxid:10090(Mus musculus)	-	2013/08/05	2014/10/16	rogid:Ka3Oe2CBpNmlZAXsbFN++JNZsyk10090	rogid:K9freRN6XcY4lMheGDyaDgx/ZT010090	intact-crc:ECCC72CA7CB12776|rigid:TdPiXyjjOCpdVvxwuAMRB1SChRE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51637	uniprotkb:Q6PE92	intact:EBI-298576|ensembl:ENSMUSP00000074922	intact:EBI-6918775	psi-mi:cav3_mouse(display_long)|uniprotkb:Cav3(gene name)|psi-mi:Cav3(display_short)|uniprotkb:M-caveolin(gene name synonym)	psi-mi:q6pe92_mouse(display_long)|uniprotkb:Cacna1h(gene name)|psi-mi:Cacna1h(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Markandeya et al. (2011)	pubmed:21084288|imex:IM-22130	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6917780|imex:IM-22130-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070836"(caveola assembly)|go:"GO:0071253"(connexin binding)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|ensembl:ENSMUSG00000062694(gene)|ensembl:ENSMUST00000075477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014704"(intercalated disc)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|interpro:IPR001612(Caveolin)|interpro:IPR018361|interpro:IPR031091|mint:P51637|reactome:R-MMU-445355|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|refseq:NP_031643.1|dip:DIP-31069N	go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|interpro:IPR005821(Ion transport)|interpro:IPR005445(Voltage-dependent calcium channel, T-type, alpha-1 subunit)|interpro:IPR027359	-	-	-	figure legend:Fig. 1B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ventricular myocyte_neo)|taxid:10090(Mus musculus)	-	2013/08/05	2014/10/16	rogid:K9freRN6XcY4lMheGDyaDgx/ZT010090	rogid:ACNBch+O0zvqQRJLaxN5Othlp5c10090	intact-crc:6D7012A0A6481827|rigid:ovY9Ick9YhVFM9HXeZNksPPpSXI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PE92	uniprotkb:P51637	intact:EBI-6918775	intact:EBI-298576|ensembl:ENSMUSP00000074922	psi-mi:q6pe92_mouse(display_long)|uniprotkb:Cacna1h(gene name)|psi-mi:Cacna1h(display_short)	psi-mi:cav3_mouse(display_long)|uniprotkb:Cav3(gene name)|psi-mi:Cav3(display_short)|uniprotkb:M-caveolin(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Markandeya et al. (2011)	pubmed:21084288|imex:IM-22130	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6919018|imex:IM-22130-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|interpro:IPR005821(Ion transport)|interpro:IPR005445(Voltage-dependent calcium channel, T-type, alpha-1 subunit)|interpro:IPR027359	go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070836"(caveola assembly)|go:"GO:0071253"(connexin binding)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|ensembl:ENSMUSG00000062694(gene)|ensembl:ENSMUST00000075477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014704"(intercalated disc)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|interpro:IPR001612(Caveolin)|interpro:IPR018361|interpro:IPR031091|mint:P51637|reactome:R-MMU-445355|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|refseq:NP_031643.1|dip:DIP-31069N	go:"GO:0042383"(sarcolemma)|go:"GO:0005901"(caveola)	-	-	figure legend:Fig. 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ventricular myocyte_neo)|taxid:10090(Mus musculus)	-	2013/08/05	2014/10/16	rogid:ACNBch+O0zvqQRJLaxN5Othlp5c10090	rogid:K9freRN6XcY4lMheGDyaDgx/ZT010090	intact-crc:AA198E1B5EE0CBD6|rigid:ovY9Ick9YhVFM9HXeZNksPPpSXI	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6PE92	uniprotkb:P51637	intact:EBI-6918775	intact:EBI-298576|ensembl:ENSMUSP00000074922	psi-mi:q6pe92_mouse(display_long)|uniprotkb:Cacna1h(gene name)|psi-mi:Cacna1h(display_short)	psi-mi:cav3_mouse(display_long)|uniprotkb:Cav3(gene name)|psi-mi:Cav3(display_short)|uniprotkb:M-caveolin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Markandeya et al. (2011)	pubmed:21084288|imex:IM-22130	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6919418|imex:IM-22130-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|interpro:IPR005821(Ion transport)|interpro:IPR005445(Voltage-dependent calcium channel, T-type, alpha-1 subunit)|interpro:IPR027359	go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070836"(caveola assembly)|go:"GO:0071253"(connexin binding)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|ensembl:ENSMUSG00000062694(gene)|ensembl:ENSMUST00000075477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014704"(intercalated disc)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|interpro:IPR001612(Caveolin)|interpro:IPR018361|interpro:IPR031091|mint:P51637|reactome:R-MMU-445355|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|refseq:NP_031643.1|dip:DIP-31069N	-	-	-	figure legend:"Fig. 4B (and A)"|comment:"The authors discuss that: although it is clear from our GST-Cav-3 pulldown experiments that the N terminus region of Cav-3 interacts with the Cav3.2 channel and modulates the ICav3.2, there exists a likely possibility of direct interaction between the Cav3.2 channel and Cav-3. The intracellular linker region between domains II and III for the Cav3.2 channel contains clusters of serine and threonine residues and has been identified as an important region for interaction and regulation of the channel by serine/threonine kinases and G-protein signaling pathway proteins (3). In this context, it may not be unreasonable to hypothesize an interaction between the N terminus region of Cav-3 and the intracellular loop between domains II and III of the Cav3.2 channel. Further studies are needed to identify the site of Cav3.2 channel involved in the interaction with Cav-3, which may also help us understand dynamic regulation of the Cav3.2 channels."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/05	2014/10/16	rogid:ACNBch+O0zvqQRJLaxN5Othlp5c10090	rogid:K9freRN6XcY4lMheGDyaDgx/ZT010090	intact-crc:0BF2FFF2D0959975|rigid:ovY9Ick9YhVFM9HXeZNksPPpSXI	false	-	glutathione s tranferase tag:n-n|necessary binding region:1-50	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)