#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96BD6	uniprotkb:Q96IZ0	intact:EBI-2659201|uniprotkb:Q9BRY9|uniprotkb:Q59FA1|uniprotkb:Q5TIH9|uniprotkb:A2A275|uniprotkb:Q9H6C5|intact:EBI-28985495|ensembl:ENSP00000330221|ensembl:ENSP00000350573|ensembl:ENSP00000366616	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	psi-mi:spsb1_human(display_long)|uniprotkb:SSB1(gene name synonym)|uniprotkb:SPSB1(gene name)|psi-mi:SPSB1(display_short)	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8820324|wwpdb:2JK9|imex:IM-21737-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079382.2|ensembl:ENSP00000330221|ensembl:ENSP00000350573|ensembl:ENSP00000366616|ensembl:ENSG00000171621(gene)|ensembl:ENST00000328089(transcript)|ensembl:ENST00000357898(transcript)|ensembl:ENST00000377399(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR043136|mint:Q96BD6|rcsb pdb:2JK9|rcsb pdb:3F2O|reactome:R-HSA-8951664|reactome:R-HSA-983168	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	-	-	-	figure legend:Table 3|3d-resolution:1.79A|3d-r-factors:working 19.2%, free 23.9%|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/23	2014/10/16	rogid:oILuoZD3/R7RwvYVRHWDTXMHctE9606	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	intact-crc:32543183316ECDE0|rigid:lKzsR30JRFrHNcDdt6M/4FNFyjE	false	sufficient binding region:24-233(IPR001870)	sufficient binding region:67-81(LIG_SPRY_1)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96BD6	uniprotkb:P09052	intact:EBI-2659201|uniprotkb:Q9BRY9|uniprotkb:Q59FA1|uniprotkb:Q5TIH9|uniprotkb:A2A275|uniprotkb:Q9H6C5|intact:EBI-28985495|ensembl:ENSP00000330221|ensembl:ENSP00000350573|ensembl:ENSP00000366616	intact:EBI-134067|uniprotkb:Q24582|uniprotkb:Q8SXU8|uniprotkb:Q9V3Q8|ensemblmetazoa:FBpp0401445|ensemblmetazoa:FBpp0401446|ensemblmetazoa:FBpp0401447	psi-mi:spsb1_human(display_long)|uniprotkb:SSB1(gene name synonym)|uniprotkb:SPSB1(gene name)|psi-mi:SPSB1(display_short)	psi-mi:vasa1_drome(display_long)|uniprotkb:vas(gene name)|psi-mi:vas(display_short)|uniprotkb:Antigen Mab46F11(gene name synonym)|uniprotkb:vasa(gene name synonym)|uniprotkb:CG46283(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8820338|rcsb pdb:3F2O|imex:IM-21737-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079382.2|ensembl:ENSP00000330221|ensembl:ENSP00000350573|ensembl:ENSP00000366616|ensembl:ENSG00000171621(gene)|ensembl:ENST00000328089(transcript)|ensembl:ENST00000357898(transcript)|ensembl:ENST00000377399(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR043136|mint:Q96BD6|rcsb pdb:2JK9|rcsb pdb:3F2O|reactome:R-HSA-8951664|reactome:R-HSA-983168	flybase:FBgn0283442|refseq:NP_723899.1|refseq:NP_001303322.1|refseq:NP_001260458.1|ensemblmetazoa:FBgn0283442(gene)|rcsb pdb:2IHS|rcsb pdb:3EMW|rcsb pdb:3F2O|rcsb pdb:5NT7|ensemblmetazoa:FBtr0445185(transcript)|ensemblmetazoa:FBtr0445186(transcript)|ensemblmetazoa:FBtr0445187(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007276"(gamete generation)|go:"GO:0008104"(protein localization)|go:"GO:0030154"(cell differentiation)|go:"GO:0043073"(germ cell nucleus)|go:"GO:0043186"(P granule)|go:"GO:0048477"(oogenesis)|go:"GO:0061803"(posterior cell cortex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044763|mint:P09052|rcsb pdb:2DB3|dip:DIP-20604N	-	-	-	figure legend:Table 3|3d-resolution:2.05A|3d-r-factors:working 18.0%, free 23.2%|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/23	2014/10/16	rogid:oILuoZD3/R7RwvYVRHWDTXMHctE9606	rogid:MPzIr/Dex98V189t6FOs8l0nQnM7227	intact-crc:8AF814A2072AC21D|rigid:RP7IYGBFTIxne0ScJoJN3FnFpGo	false	sufficient binding region:24-233(IPR001870)	sufficient binding region:184-203(LIG_SPRY_1)	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99619	uniprotkb:P09052	intact:EBI-2323209|uniprotkb:D3DUT0|uniprotkb:B7Z4W1|ensembl:ENSP00000428338|ensembl:ENSP00000430872	intact:EBI-134067|uniprotkb:Q24582|uniprotkb:Q8SXU8|uniprotkb:Q9V3Q8|ensemblmetazoa:FBpp0401445|ensemblmetazoa:FBpp0401446|ensemblmetazoa:FBpp0401447	psi-mi:spsb2_human(display_long)|uniprotkb:SPSB2(gene name)|psi-mi:SPSB2(display_short)|uniprotkb:GRCC9(gene name synonym)|uniprotkb:SSB2(gene name synonym)|uniprotkb:Gene-rich cluster protein C9(gene name synonym)	psi-mi:vasa1_drome(display_long)|uniprotkb:vas(gene name)|psi-mi:vas(display_short)|uniprotkb:Antigen Mab46F11(gene name synonym)|uniprotkb:vasa(gene name synonym)|uniprotkb:CG46283(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8820351|rcsb pdb:3EMW|imex:IM-21737-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139788.1|refseq:NP_116030.1|refseq:NP_001306599.1|ensembl:ENSG00000111671(gene)|ensembl:ENST00000523102(transcript)|ensembl:ENST00000524270(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR037340|interpro:IPR043136|mint:Q99619|rcsb pdb:3EMW|rcsb pdb:5XN3|rcsb pdb:6DN5|rcsb pdb:6DN6|rcsb pdb:6JKJ|rcsb pdb:6JWM|rcsb pdb:6JWN|rcsb pdb:6KEY|reactome:R-HSA-8951664|reactome:R-HSA-983168	flybase:FBgn0283442|refseq:NP_723899.1|refseq:NP_001303322.1|refseq:NP_001260458.1|ensemblmetazoa:FBgn0283442(gene)|rcsb pdb:2IHS|rcsb pdb:3EMW|rcsb pdb:3F2O|rcsb pdb:5NT7|ensemblmetazoa:FBtr0445185(transcript)|ensemblmetazoa:FBtr0445186(transcript)|ensemblmetazoa:FBtr0445187(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007276"(gamete generation)|go:"GO:0008104"(protein localization)|go:"GO:0030154"(cell differentiation)|go:"GO:0043073"(germ cell nucleus)|go:"GO:0043186"(P granule)|go:"GO:0048477"(oogenesis)|go:"GO:0061803"(posterior cell cortex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044763|mint:P09052|rcsb pdb:2DB3|dip:DIP-20604N	-	-	-	figure legend:Table 3|3d-resolution:1.80A|3d-r-factors:working 17.8%, free 21.6%|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/23	2014/10/16	rogid:d9ATBVBuRYT4OE5DV+pjGasS9qs9606	rogid:MPzIr/Dex98V189t6FOs8l0nQnM7227	intact-crc:8F27337503A02296|rigid:SNJJvjhh1yfoGLRMDRrDoIm3brM	false	his tag:n-n|sufficient binding region:26-219(IPR001870)	sufficient binding region:184-203(LIG_SPRY_1)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IZ0	uniprotkb:Q96BD6	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	intact:EBI-2659201|uniprotkb:Q9BRY9|uniprotkb:Q59FA1|uniprotkb:Q5TIH9|uniprotkb:A2A275|uniprotkb:Q9H6C5|intact:EBI-28985495|ensembl:ENSP00000330221|ensembl:ENSP00000350573|ensembl:ENSP00000366616	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:spsb1_human(display_long)|uniprotkb:SSB1(gene name synonym)|uniprotkb:SPSB1(gene name)|psi-mi:SPSB1(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8821631|imex:IM-21737-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	refseq:NP_079382.2|ensembl:ENSP00000330221|ensembl:ENSP00000350573|ensembl:ENSP00000366616|ensembl:ENSG00000171621(gene)|ensembl:ENST00000328089(transcript)|ensembl:ENST00000357898(transcript)|ensembl:ENST00000377399(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR043136|mint:Q96BD6|rcsb pdb:2JK9|rcsb pdb:3F2O|reactome:R-HSA-8951664|reactome:R-HSA-983168	-	-	-	figure legend:Table 2|kinetic_conditions:Temp = 20C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:150.0x10^-9 ~12.0(molar)	2013/10/23	2014/10/16	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	rogid:oILuoZD3/R7RwvYVRHWDTXMHctE9606	intact-crc:2BDB307040AE95BA|rigid:lKzsR30JRFrHNcDdt6M/4FNFyjE	false	sufficient binding region:67-81(LIG_SPRY_1)	sufficient binding region:24-233(IPR001870)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09052	uniprotkb:Q96BD6	intact:EBI-134067|uniprotkb:Q24582|uniprotkb:Q8SXU8|uniprotkb:Q9V3Q8|ensemblmetazoa:FBpp0401445|ensemblmetazoa:FBpp0401446|ensemblmetazoa:FBpp0401447	intact:EBI-2659201|uniprotkb:Q9BRY9|uniprotkb:Q59FA1|uniprotkb:Q5TIH9|uniprotkb:A2A275|uniprotkb:Q9H6C5|intact:EBI-28985495|ensembl:ENSP00000330221|ensembl:ENSP00000350573|ensembl:ENSP00000366616	psi-mi:vasa1_drome(display_long)|uniprotkb:vas(gene name)|psi-mi:vas(display_short)|uniprotkb:Antigen Mab46F11(gene name synonym)|uniprotkb:vasa(gene name synonym)|uniprotkb:CG46283(orf name)	psi-mi:spsb1_human(display_long)|uniprotkb:SSB1(gene name synonym)|uniprotkb:SPSB1(gene name)|psi-mi:SPSB1(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8821654|imex:IM-21737-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0283442|refseq:NP_723899.1|refseq:NP_001303322.1|refseq:NP_001260458.1|ensemblmetazoa:FBgn0283442(gene)|rcsb pdb:2IHS|rcsb pdb:3EMW|rcsb pdb:3F2O|rcsb pdb:5NT7|ensemblmetazoa:FBtr0445185(transcript)|ensemblmetazoa:FBtr0445186(transcript)|ensemblmetazoa:FBtr0445187(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007276"(gamete generation)|go:"GO:0008104"(protein localization)|go:"GO:0030154"(cell differentiation)|go:"GO:0043073"(germ cell nucleus)|go:"GO:0043186"(P granule)|go:"GO:0048477"(oogenesis)|go:"GO:0061803"(posterior cell cortex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044763|mint:P09052|rcsb pdb:2DB3|dip:DIP-20604N	refseq:NP_079382.2|ensembl:ENSP00000330221|ensembl:ENSP00000350573|ensembl:ENSP00000366616|ensembl:ENSG00000171621(gene)|ensembl:ENST00000328089(transcript)|ensembl:ENST00000357898(transcript)|ensembl:ENST00000377399(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR043136|mint:Q96BD6|rcsb pdb:2JK9|rcsb pdb:3F2O|reactome:R-HSA-8951664|reactome:R-HSA-983168	-	-	-	figure legend:Table 2|kinetic_conditions:Temp = 20C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:40.0x10^-9 ~5.0(molar)	2013/10/23	2014/10/16	rogid:MPzIr/Dex98V189t6FOs8l0nQnM7227	rogid:oILuoZD3/R7RwvYVRHWDTXMHctE9606	intact-crc:8B8C98E5F3B51C88|rigid:RP7IYGBFTIxne0ScJoJN3FnFpGo	false	sufficient binding region:184-203(LIG_SPRY_1)	sufficient binding region:24-233(IPR001870)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IZ0	uniprotkb:Q99619	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	intact:EBI-2323209|uniprotkb:D3DUT0|uniprotkb:B7Z4W1|ensembl:ENSP00000428338|ensembl:ENSP00000430872	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:spsb2_human(display_long)|uniprotkb:SPSB2(gene name)|psi-mi:SPSB2(display_short)|uniprotkb:GRCC9(gene name synonym)|uniprotkb:SSB2(gene name synonym)|uniprotkb:Gene-rich cluster protein C9(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8821666|imex:IM-21737-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	refseq:NP_001139788.1|refseq:NP_116030.1|refseq:NP_001306599.1|ensembl:ENSG00000111671(gene)|ensembl:ENST00000523102(transcript)|ensembl:ENST00000524270(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR037340|interpro:IPR043136|mint:Q99619|rcsb pdb:3EMW|rcsb pdb:5XN3|rcsb pdb:6DN5|rcsb pdb:6DN6|rcsb pdb:6JKJ|rcsb pdb:6JWM|rcsb pdb:6JWN|rcsb pdb:6KEY|reactome:R-HSA-8951664|reactome:R-HSA-983168	-	-	-	figure legend:Table 2|kinetic_conditions:Temp = 20C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1520.0x10^-9 ~50.0(molar)	2013/10/23	2014/10/16	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	rogid:d9ATBVBuRYT4OE5DV+pjGasS9qs9606	intact-crc:164CB6635DDCA27E|rigid:2icx0YvoxCUVwI0rVJhLdgqDoio	false	sufficient binding region:67-81(LIG_SPRY_1)	sufficient binding region:26-219(IPR001870)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99619	uniprotkb:P09052	intact:EBI-2323209|uniprotkb:D3DUT0|uniprotkb:B7Z4W1|ensembl:ENSP00000428338|ensembl:ENSP00000430872	intact:EBI-134067|uniprotkb:Q24582|uniprotkb:Q8SXU8|uniprotkb:Q9V3Q8|ensemblmetazoa:FBpp0401445|ensemblmetazoa:FBpp0401446|ensemblmetazoa:FBpp0401447	psi-mi:spsb2_human(display_long)|uniprotkb:SPSB2(gene name)|psi-mi:SPSB2(display_short)|uniprotkb:GRCC9(gene name synonym)|uniprotkb:SSB2(gene name synonym)|uniprotkb:Gene-rich cluster protein C9(gene name synonym)	psi-mi:vasa1_drome(display_long)|uniprotkb:vas(gene name)|psi-mi:vas(display_short)|uniprotkb:Antigen Mab46F11(gene name synonym)|uniprotkb:vasa(gene name synonym)|uniprotkb:CG46283(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8821685|imex:IM-21737-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139788.1|refseq:NP_116030.1|refseq:NP_001306599.1|ensembl:ENSG00000111671(gene)|ensembl:ENST00000523102(transcript)|ensembl:ENST00000524270(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR037340|interpro:IPR043136|mint:Q99619|rcsb pdb:3EMW|rcsb pdb:5XN3|rcsb pdb:6DN5|rcsb pdb:6DN6|rcsb pdb:6JKJ|rcsb pdb:6JWM|rcsb pdb:6JWN|rcsb pdb:6KEY|reactome:R-HSA-8951664|reactome:R-HSA-983168	flybase:FBgn0283442|refseq:NP_723899.1|refseq:NP_001303322.1|refseq:NP_001260458.1|ensemblmetazoa:FBgn0283442(gene)|rcsb pdb:2IHS|rcsb pdb:3EMW|rcsb pdb:3F2O|rcsb pdb:5NT7|ensemblmetazoa:FBtr0445185(transcript)|ensemblmetazoa:FBtr0445186(transcript)|ensemblmetazoa:FBtr0445187(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007276"(gamete generation)|go:"GO:0008104"(protein localization)|go:"GO:0030154"(cell differentiation)|go:"GO:0043073"(germ cell nucleus)|go:"GO:0043186"(P granule)|go:"GO:0048477"(oogenesis)|go:"GO:0061803"(posterior cell cortex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044763|mint:P09052|rcsb pdb:2DB3|dip:DIP-20604N	-	-	-	figure legend:Table 2|kinetic_conditions:Temp = 20C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:147.0x10^-9 ~7.0(molar)	2013/10/23	2014/10/16	rogid:d9ATBVBuRYT4OE5DV+pjGasS9qs9606	rogid:MPzIr/Dex98V189t6FOs8l0nQnM7227	intact-crc:AD404D8922811A71|rigid:SNJJvjhh1yfoGLRMDRrDoIm3brM	false	sufficient binding region:26-219(IPR001870)	sufficient binding region:184-203(LIG_SPRY_1)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96A44	uniprotkb:Q96IZ0	intact:EBI-2323233|ensembl:ENSP00000311609	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	psi-mi:spsb4_human(display_long)|uniprotkb:SPSB4(gene name)|psi-mi:SPSB4(display_short)|uniprotkb:SSB4(gene name synonym)	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8821697|imex:IM-21737-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_543138.1|ensembl:ENSG00000175093(gene)|ensembl:ENST00000310546(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR043136|rcsb pdb:2V24|rcsb pdb:6DN7|rcsb pdb:6DN8|reactome:R-HSA-8951664|reactome:R-HSA-983168	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	-	-	-	figure legend:Table 2|kinetic_conditions:Temp = 20C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:65.0x10^-9 ~4.0	2013/10/23	2014/10/16	rogid:cFUMMr7QQ5DPJPs1FUEFnmsua8w9606	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	intact-crc:A997BF43F8E84395|rigid:GmGVK5NNv4jn8nO7g2J9IJMaiEM	false	sufficient binding region:28-233(IPR001870)	sufficient binding region:67-81(LIG_SPRY_1)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09052	uniprotkb:Q96A44	intact:EBI-134067|uniprotkb:Q24582|uniprotkb:Q8SXU8|uniprotkb:Q9V3Q8|ensemblmetazoa:FBpp0401445|ensemblmetazoa:FBpp0401446|ensemblmetazoa:FBpp0401447	intact:EBI-2323233|ensembl:ENSP00000311609	psi-mi:vasa1_drome(display_long)|uniprotkb:vas(gene name)|psi-mi:vas(display_short)|uniprotkb:Antigen Mab46F11(gene name synonym)|uniprotkb:vasa(gene name synonym)|uniprotkb:CG46283(orf name)	psi-mi:spsb4_human(display_long)|uniprotkb:SPSB4(gene name)|psi-mi:SPSB4(display_short)|uniprotkb:SSB4(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8821709|imex:IM-21737-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0283442|refseq:NP_723899.1|refseq:NP_001303322.1|refseq:NP_001260458.1|ensemblmetazoa:FBgn0283442(gene)|rcsb pdb:2IHS|rcsb pdb:3EMW|rcsb pdb:3F2O|rcsb pdb:5NT7|ensemblmetazoa:FBtr0445185(transcript)|ensemblmetazoa:FBtr0445186(transcript)|ensemblmetazoa:FBtr0445187(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007276"(gamete generation)|go:"GO:0008104"(protein localization)|go:"GO:0030154"(cell differentiation)|go:"GO:0043073"(germ cell nucleus)|go:"GO:0043186"(P granule)|go:"GO:0048477"(oogenesis)|go:"GO:0061803"(posterior cell cortex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044763|mint:P09052|rcsb pdb:2DB3|dip:DIP-20604N	refseq:NP_543138.1|ensembl:ENSG00000175093(gene)|ensembl:ENST00000310546(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR043136|rcsb pdb:2V24|rcsb pdb:6DN7|rcsb pdb:6DN8|reactome:R-HSA-8951664|reactome:R-HSA-983168	-	-	-	figure legend:Table 2|kinetic_conditions:Temp = 20C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.0x10^-9 ~0.7(molar)	2013/10/23	2014/10/16	rogid:MPzIr/Dex98V189t6FOs8l0nQnM7227	rogid:cFUMMr7QQ5DPJPs1FUEFnmsua8w9606	intact-crc:112A383467587351|rigid:Wnl1rE9uP1eV/OB12jvpQ9ArX7w	false	sufficient binding region:184-203(LIG_SPRY_1)	sufficient binding region:28-233(IPR001870)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88838	uniprotkb:Q96IZ0	intact:EBI-8820410|ensembl:ENSMUSP00000041585|ensembl:ENSMUSP00000060124|uniprotkb:Q8CBA5|uniprotkb:Q91Z15	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	psi-mi:spsb2_mouse(display_long)|uniprotkb:Spsb2(gene name)|psi-mi:Spsb2(display_short)|uniprotkb:Grcc9(gene name synonym)|uniprotkb:Ssb2(gene name synonym)|uniprotkb:Gene-rich cluster protein C9(gene name synonym)	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8869160|imex:IM-21737-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038451(gene)|ensembl:ENSMUST00000047760(transcript)|ensembl:ENSMUST00000052727(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR037340|interpro:IPR043136|rcsb pdb:2AFJ|rcsb pdb:3EK9|reactome:R-MMU-8951664|reactome:R-MMU-983168|interpro:IPR001870("B302 (SPRY)-like")|refseq:NP_038567.1|refseq:NP_001292979.1|refseq:NP_001292980.1|refseq:NP_001292981.1|refseq:NP_001292982.1|refseq:XP_006505630.1|dip:DIP-29001N	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	-	-	-	figure legend:Table 1|kinetic_conditions:Temp = 22C|kinetics:"The glu68asp and leu69ile mutations increase the affinity of this peptide to Kd = 106 +/- 30 x 10E-9 molar (for glu68asp-leu69ile); Kd = 208 +/- 13 x 10E-9 molar (for glu68asp); and Kd = 1.6 +/- 0.4 x 10E-6 molar (for leu69ile)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.2x10^-6 ~0.002(molar)	2013/10/23	2014/10/16	rogid:5KQI8W6od4+c9c0xQNS/XfLk5O010090	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	intact-crc:0598978B2782ACF1|rigid:d2wsr96RX7xC0VeNrp5tPN7vRBM	false	sufficient binding region:12-224(IPR001870)	mutation disrupting interaction:71-71|sufficient binding region:64-77(LIG_SPRY_1)|mutation increasing interaction:68-68|mutation increasing interaction:69-69|mutation disrupting interaction:70-70|mutation increasing interaction:68-69	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88838	uniprotkb:Q96IZ0	intact:EBI-8820410|ensembl:ENSMUSP00000041585|ensembl:ENSMUSP00000060124|uniprotkb:Q8CBA5|uniprotkb:Q91Z15	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	psi-mi:spsb2_mouse(display_long)|uniprotkb:Spsb2(gene name)|psi-mi:Spsb2(display_short)|uniprotkb:Grcc9(gene name synonym)|uniprotkb:Ssb2(gene name synonym)|uniprotkb:Gene-rich cluster protein C9(gene name synonym)	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8821738|imex:IM-21737-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038451(gene)|ensembl:ENSMUST00000047760(transcript)|ensembl:ENSMUST00000052727(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR037340|interpro:IPR043136|rcsb pdb:2AFJ|rcsb pdb:3EK9|reactome:R-MMU-8951664|reactome:R-MMU-983168|interpro:IPR001870("B302 (SPRY)-like")|refseq:NP_038567.1|refseq:NP_001292979.1|refseq:NP_001292980.1|refseq:NP_001292981.1|refseq:NP_001292982.1|refseq:XP_006505630.1|dip:DIP-29001N	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	-	-	-	figure legend:Table 1|kinetic_conditions:Temp = 22C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.6x10^-6 ~0.1(molar)	2013/10/23	2014/10/16	rogid:5KQI8W6od4+c9c0xQNS/XfLk5O010090	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	intact-crc:2DDA5C5F0107C1E3|rigid:d2wsr96RX7xC0VeNrp5tPN7vRBM	false	mutation disrupting interaction:206-206|sufficient binding region:12-224(IPR001870)|mutation disrupting interaction:120-120|mutation disrupting interaction:123-125|mutation disrupting interaction:126-128	sufficient binding region:59-77(LIG_SPRY_1)|mutation disrupting interaction:72-72	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9D5L7	uniprotkb:Q96IZ0	intact:EBI-8821912|uniprotkb:Q5FWI0|uniprotkb:Q8BJA4|ensembl:ENSMUSP00000048969|ensembl:ENSMUSP00000101309|ensembl:ENSMUSP00000101310	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	psi-mi:spsb1_mouse(display_long)|uniprotkb:Spsb1(gene name)|psi-mi:Spsb1(display_short)|uniprotkb:Ssb1(gene name synonym)	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8821933|imex:IM-21737-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011248646.1|refseq:XP_011248647.1|refseq:NP_083311.1|refseq:XP_006539297.1|dip:DIP-29000N|ensembl:ENSMUSG00000039911(gene)|ensembl:ENSMUST00000038562(transcript)|ensembl:ENSMUST00000105684(transcript)|ensembl:ENSMUST00000105685(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR043136|reactome:R-MMU-8951664|reactome:R-MMU-983168	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	-	-	-	figure legend:Table 1|kinetic_conditions:Temp = 22C|kinetics:The glu68asp-leu69ile mutation increases the affinity to Kd = 40 +/- 5 x 10E-9 molar.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:210.0x10^-9 ~19.0(molar)	2013/10/23	2014/10/16	rogid:NRrKtop5djTSXHLb1P963RtEByQ10090	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	intact-crc:401BAD2F531B5EE3|rigid:3BqkUxmg8e3MDdt1+BE4qA/kZDQ	false	sufficient binding region:1..1-231..231(IPR001870)	sufficient binding region:64-77(LIG_SPRY_1)|mutation disrupting interaction:70-70|mutation disrupting interaction:71-71|mutation increasing interaction:68-69	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R5B6	uniprotkb:Q96IZ0	intact:EBI-8821982|uniprotkb:Q8BJI9|uniprotkb:Q8VHS8|ensembl:ENSMUSP00000057849	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	psi-mi:spsb4_mouse(display_long)|uniprotkb:Spsb4(gene name)|psi-mi:Spsb4(display_short)|uniprotkb:Ssb4(gene name synonym)	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8869205|imex:IM-21737-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660116.1|dip:DIP-29002N|ensembl:ENSMUSG00000046997(gene)|ensembl:ENSMUST00000055433(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR043136|reactome:R-MMU-8951664|reactome:R-MMU-983168	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	-	-	-	figure legend:Table 1|kinetic_conditions:Temp = 22C|kinetics:"The glu68asp and leu69ile mutations increase the affinity of this peptide to Kd = 33 +/- 23 x 10E-9 molar (for glu68asp-leu69ile); Kd = 47 +/- 22 x 10E-9 molar (for glu68asp); and Kd = 55 +/- 8 x 10E-9 molar (for leu69ile)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:213.0x10^-9 ~7.0(molar)	2013/10/23	2014/10/16	rogid:VrTqYvksfTqUeIpoowkxGXQ4MXM10090	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	intact-crc:193FDA6FC6D627ED|rigid:z6pjA27XHULoLEJniOwLuQSSbvw	false	sufficient binding region:1..1-233..233(IPR001870)	mutation increasing interaction:68-69|mutation disrupting interaction:70-70|sufficient binding region:64-77(LIG_SPRY_1)|mutation disrupting interaction:71-71|mutation increasing interaction:68-68|mutation increasing interaction:69-69	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IZ0	uniprotkb:Q8R5B6	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	intact:EBI-8821982|uniprotkb:Q8BJI9|uniprotkb:Q8VHS8|ensembl:ENSMUSP00000057849	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:spsb4_mouse(display_long)|uniprotkb:Spsb4(gene name)|psi-mi:Spsb4(display_short)|uniprotkb:Ssb4(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8822001|imex:IM-21737-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	refseq:NP_660116.1|dip:DIP-29002N|ensembl:ENSMUSG00000046997(gene)|ensembl:ENSMUST00000055433(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR043136|reactome:R-MMU-8951664|reactome:R-MMU-983168	-	-	-	figure legend:Table 1|kinetic_conditions:Temp = 22C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:189.0x10^-9 ~1.0(molar)	2013/10/23	2014/10/16	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	rogid:VrTqYvksfTqUeIpoowkxGXQ4MXM10090	intact-crc:77F5F8CA9625B36A|rigid:z6pjA27XHULoLEJniOwLuQSSbvw	false	mutation disrupting interaction:72-72|sufficient binding region:59-77(LIG_SPRY_1)	sufficient binding region:1..1-233..233(IPR001870)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88838	uniprotkb:Q96IZ0	intact:EBI-8820410|ensembl:ENSMUSP00000041585|ensembl:ENSMUSP00000060124|uniprotkb:Q8CBA5|uniprotkb:Q91Z15	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	psi-mi:spsb2_mouse(display_long)|uniprotkb:Spsb2(gene name)|psi-mi:Spsb2(display_short)|uniprotkb:Grcc9(gene name synonym)|uniprotkb:Ssb2(gene name synonym)|uniprotkb:Gene-rich cluster protein C9(gene name synonym)	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8820435|imex:IM-21737-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038451(gene)|ensembl:ENSMUST00000047760(transcript)|ensembl:ENSMUST00000052727(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR037340|interpro:IPR043136|rcsb pdb:2AFJ|rcsb pdb:3EK9|reactome:R-MMU-8951664|reactome:R-MMU-983168|interpro:IPR001870("B302 (SPRY)-like")|refseq:NP_038567.1|refseq:NP_001292979.1|refseq:NP_001292980.1|refseq:NP_001292981.1|refseq:NP_001292982.1|refseq:XP_006505630.1|dip:DIP-29001N	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	-	-	-	figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/23	2014/10/16	rogid:5KQI8W6od4+c9c0xQNS/XfLk5O010090	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	intact-crc:64C100B81ABBD393|rigid:d2wsr96RX7xC0VeNrp5tPN7vRBM	false	sufficient binding region:12-224(IPR001870)	15n label:?-?|sufficient binding region:59-77(LIG_SPRY_1)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88838	uniprotkb:Q96IZ0	intact:EBI-8820410|ensembl:ENSMUSP00000041585|ensembl:ENSMUSP00000060124|uniprotkb:Q8CBA5|uniprotkb:Q91Z15	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	psi-mi:spsb2_mouse(display_long)|uniprotkb:Spsb2(gene name)|psi-mi:Spsb2(display_short)|uniprotkb:Grcc9(gene name synonym)|uniprotkb:Ssb2(gene name synonym)|uniprotkb:Gene-rich cluster protein C9(gene name synonym)	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Filippakopoulos et al. (2010)	pubmed:20561531|imex:IM-21737	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8820447|imex:IM-21737-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038451(gene)|ensembl:ENSMUST00000047760(transcript)|ensembl:ENSMUST00000052727(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR036036|interpro:IPR037340|interpro:IPR043136|rcsb pdb:2AFJ|rcsb pdb:3EK9|reactome:R-MMU-8951664|reactome:R-MMU-983168|interpro:IPR001870("B302 (SPRY)-like")|refseq:NP_038567.1|refseq:NP_001292979.1|refseq:NP_001292980.1|refseq:NP_001292981.1|refseq:NP_001292982.1|refseq:XP_006505630.1|dip:DIP-29001N	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	-	-	-	figure legend:Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/23	2014/10/16	rogid:5KQI8W6od4+c9c0xQNS/XfLk5O010090	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	intact-crc:6D12E75C83D99807|rigid:d2wsr96RX7xC0VeNrp5tPN7vRBM	false	sufficient binding region:12-224(IPR001870)|15n label:?-?	sufficient binding region:59-77(LIG_SPRY_1)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)