#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04631	uniprotkb:Q63495	intact:EBI-2696631|ensembl:ENSRNOP00000001743	intact:EBI-6479195	psi-mi:s100b_rat(display_long)|uniprotkb:S100b(gene name)|psi-mi:S100b(display_short)|uniprotkb:S100 calcium-binding protein B(gene name synonym)|uniprotkb:S-100 protein subunit beta(gene name synonym)|uniprotkb:S-100 protein beta chain(gene name synonym)	psi-mi:rage_rat(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Tsoporis et al. (2010)	pubmed:19910580|imex:IM-21719	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6479229|imex:IM-21719-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3615|refseq:NP_037323.1|refseq:XP_008771090.1|ensembl:ENSRNOG00000001295(gene)|ensembl:ENSRNOT00000001743(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044548"(S100 protein binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051597"(response to methylmercury)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:2001015"(negative regulation of skeletal muscle cell differentiation)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028481|rcsb pdb:1B4C|rcsb pdb:1DT7|rcsb pdb:1MWN|rcsb pdb:1QLK|rcsb pdb:1SYM|rcsb pdb:1XYD|rcsb pdb:2K7O|reactome:R-RNO-445989|reactome:R-RNO-879415|reactome:R-RNO-933542|go:"GO:0005654"(nucleoplasm)|refseq:XP_017457057.1	go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0009100"(glycoprotein metabolic process)|go:"GO:0009750"(response to fructose)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014823"(response to activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033595"(response to genistein)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051595"(response to methylglyoxal)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0072714"(response to selenite ion)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:0072657"(protein localization to membrane)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|rgd:69258|interpro:IPR036179|reactome:R-RNO-445989|reactome:R-RNO-879415|reactome:R-RNO-933542	-	-	-	figure legend:3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2013/01/16	2014/10/16	rogid:BN/sXFZ+oymAQz/00q9FApIbwbw10116	rogid:6M9IQBuLlVwCESsGOM1mZ1T8fnM10116	intact-crc:A4DA29896369EA85|rigid:RvAfhXzSq/pRyhnbJgF1OCBW79E	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q63495	uniprotkb:P04631	intact:EBI-6479195	intact:EBI-2696631|ensembl:ENSRNOP00000001743	psi-mi:rage_rat(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:s100b_rat(display_long)|uniprotkb:S100b(gene name)|psi-mi:S100b(display_short)|uniprotkb:S100 calcium-binding protein B(gene name synonym)|uniprotkb:S-100 protein subunit beta(gene name synonym)|uniprotkb:S-100 protein beta chain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tsoporis et al. (2010)	pubmed:19910580|imex:IM-21719	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6479240|imex:IM-21719-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0009100"(glycoprotein metabolic process)|go:"GO:0009750"(response to fructose)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014823"(response to activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033595"(response to genistein)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051595"(response to methylglyoxal)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0072714"(response to selenite ion)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:0072657"(protein localization to membrane)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|rgd:69258|interpro:IPR036179|reactome:R-RNO-445989|reactome:R-RNO-879415|reactome:R-RNO-933542	rgd:3615|refseq:NP_037323.1|refseq:XP_008771090.1|ensembl:ENSRNOG00000001295(gene)|ensembl:ENSRNOT00000001743(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044548"(S100 protein binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051597"(response to methylmercury)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:2001015"(negative regulation of skeletal muscle cell differentiation)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028481|rcsb pdb:1B4C|rcsb pdb:1DT7|rcsb pdb:1MWN|rcsb pdb:1QLK|rcsb pdb:1SYM|rcsb pdb:1XYD|rcsb pdb:2K7O|reactome:R-RNO-445989|reactome:R-RNO-879415|reactome:R-RNO-933542|go:"GO:0005654"(nucleoplasm)|refseq:XP_017457057.1	-	-	-	figure legend:3Bi|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2013/01/16	2014/10/16	rogid:6M9IQBuLlVwCESsGOM1mZ1T8fnM10116	rogid:BN/sXFZ+oymAQz/00q9FApIbwbw10116	intact-crc:D0D1C070970265A8|rigid:RvAfhXzSq/pRyhnbJgF1OCBW79E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63495	uniprotkb:P04631	intact:EBI-6479195	intact:EBI-2696631|ensembl:ENSRNOP00000001743	psi-mi:rage_rat(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:s100b_rat(display_long)|uniprotkb:S100b(gene name)|psi-mi:S100b(display_short)|uniprotkb:S100 calcium-binding protein B(gene name synonym)|uniprotkb:S-100 protein subunit beta(gene name synonym)|uniprotkb:S-100 protein beta chain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tsoporis et al. (2010)	pubmed:19910580|imex:IM-21719	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6479244|imex:IM-21719-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0009100"(glycoprotein metabolic process)|go:"GO:0009750"(response to fructose)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014823"(response to activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033595"(response to genistein)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051595"(response to methylglyoxal)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0072714"(response to selenite ion)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:0072657"(protein localization to membrane)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|rgd:69258|interpro:IPR036179|reactome:R-RNO-445989|reactome:R-RNO-879415|reactome:R-RNO-933542	rgd:3615|refseq:NP_037323.1|refseq:XP_008771090.1|ensembl:ENSRNOG00000001295(gene)|ensembl:ENSRNOT00000001743(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044548"(S100 protein binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051597"(response to methylmercury)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:2001015"(negative regulation of skeletal muscle cell differentiation)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028481|rcsb pdb:1B4C|rcsb pdb:1DT7|rcsb pdb:1MWN|rcsb pdb:1QLK|rcsb pdb:1SYM|rcsb pdb:1XYD|rcsb pdb:2K7O|reactome:R-RNO-445989|reactome:R-RNO-879415|reactome:R-RNO-933542|go:"GO:0005654"(nucleoplasm)|refseq:XP_017457057.1	-	-	-	figure legend:3Bii|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2013/01/16	2014/10/16	rogid:6M9IQBuLlVwCESsGOM1mZ1T8fnM10116	rogid:BN/sXFZ+oymAQz/00q9FApIbwbw10116	intact-crc:7B813DC5BFA9D4C6|rigid:RvAfhXzSq/pRyhnbJgF1OCBW79E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)