#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8K2X3 intact:EBI-8792879 intact:EBI-2553883|uniprotkb:Q8C6I6|uniprotkb:Q3TPH0|ensembl:ENSMUSP00000040944 - psi-mi:stn1_mouse(display_long)|uniprotkb:Stn1(gene name)|psi-mi:Stn1(display_short)|uniprotkb:Alpha-accessory factor of 44 kDa(gene name synonym)|uniprotkb:Obfc1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:telomeric_dna_human_c-strand(display_short)|psi-mi:EBI-8792879(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8792847|imex:IM-22162-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) refseq:NP_780569.1|ensembl:ENSMUSG00000042694(gene)|ensembl:ENSMUST00000049369(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|rcsb pdb:1WJ5|go:"GO:0043047"(single-stranded telomeric DNA binding)|reactome:R-MMU-174411|reactome:R-MMU-174430|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082 - - - - figure legend:Figure 1 G left|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2013/10/10 2014/10/16 rogid:N2QA+Bs0g8hsUHFMHX+eGDr8H1o10090 - intact-crc:C822920A0298DAA8 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P70371 intact:EBI-8792879 intact:EBI-6919183|ensembl:ENSMUSP00000140744|uniprotkb:Q9CY71 - psi-mi:terf1_mouse(display_long)|uniprotkb:Terf1(gene name)|psi-mi:Terf1(display_short)|uniprotkb:Trf1(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym) psi-mi:telomeric_dna_human_c-strand(display_short)|psi-mi:EBI-8792879(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8792862|imex:IM-22162-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) ensembl:ENSMUSG00000025925(gene)|ensembl:ENSMUST00000188371(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0051301"(cell division)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P70371|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|reactome:R-MMU-9670095|refseq:NP_033378.1|dip:DIP-44231N - - - - figure legend:Figure 1 G left|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2013/10/10 2014/10/16 rogid:jpK0DXdrNcuBqR96dkp45t/W5+M10090 - intact-crc:93753F34B61B1DF8 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q91WC1 intact:EBI-8792879 intact:EBI-7051001|ensembl:ENSMUSP00000110986|ensembl:ENSMUSP00000131928|uniprotkb:Q8BUH9|intact:MINT-3379580 - psi-mi:pote1_mouse(display_long)|uniprotkb:Pot1(gene name)|psi-mi:Pot1(display_short)|uniprotkb:Pot1a(gene name synonym)|uniprotkb:POT1-like telomere end-binding protein(gene name synonym) psi-mi:telomeric_dna_human_c-strand(display_short)|psi-mi:EBI-8792879(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8792865|imex:IM-22162-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) ensembl:ENSMUSG00000029676(gene)|ensembl:ENSMUST00000115330(transcript)|ensembl:ENSMUST00000166445(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0032202"(telomere assembly)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051276"(chromosome organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060383"(positive regulation of DNA strand elongation)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1905774"(regulation of DNA helicase activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:1905776"(positive regulation of DNA helicase activity)|go:"GO:1990955"(G-rich single-stranded DNA binding)|go:"GO:2001032"(regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|mint:Q91WC1|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:NP_598692.1|dip:DIP-29608N - - comment:mint|function:"Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity" - figure legend:Figure 1 G left|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2013/10/10 2014/10/16 rogid:eWtXiaGr1uIBoKk4po2tJ+EwGRc10090 - intact-crc:5EA272ADE0F19512 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q86WV5 intact:EBI-8792879 intact:EBI-2562799|ensembl:ENSP00000380762|uniprotkb:I3L0C7 - psi-mi:ten1l_human(display_long)|uniprotkb:TEN1(gene name)|psi-mi:TEN1(display_short)|uniprotkb:C17orf106(gene name synonym)|uniprotkb:Telomere length regulation protein TEN1 homolog(gene name synonym)|uniprotkb:Protein telomeric pathways with STN1 homolog(gene name synonym) psi-mi:telomeric_dna_human_c-strand(display_short)|psi-mi:EBI-8792879(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793377|imex:IM-22162-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) refseq:NP_001106795.2|ensembl:ENSG00000257949(gene)|ensembl:ENST00000397640(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029146|rcsb pdb:4JOI|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56901N - - - - figure legend:Figures 3 J bottom and 3 K|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/10/10 2014/10/16 rogid:BTchMyEKu9ZhBDMU/R3ZkrCSiGk9606 - intact-crc:2319EB3D46769F9D false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P54274 intact:EBI-8792879 intact:EBI-710997|uniprotkb:A7XP29|uniprotkb:Q15553|uniprotkb:Q93029|ensembl:ENSP00000276603|uniprotkb:Q8NHT6 - psi-mi:terf1_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)|uniprotkb:NIMA-interacting protein 2(gene name synonym)|uniprotkb:Telomeric protein Pin2/TRF1(gene name synonym)|uniprotkb:TERF1(gene name)|psi-mi:TERF1(display_short)|uniprotkb:PIN2(gene name synonym)|uniprotkb:TRF(gene name synonym)|uniprotkb:TRF1(gene name synonym)|uniprotkb:TRBF1(gene name synonym) psi-mi:telomeric_dna_human_c-strand(display_short)|psi-mi:EBI-8792879(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8792886|imex:IM-22162-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) refseq:NP_003209.2|refseq:NP_059523.2|ensembl:ENSG00000147601(gene)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|ensembl:ENST00000276603(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P54274|rcsb pdb:1BA5|rcsb pdb:1H6O|rcsb pdb:1ITY|rcsb pdb:1IV6|rcsb pdb:1W0T|rcsb pdb:3BQO|rcsb pdb:3L82|rcsb pdb:5HKP|rcsb pdb:5WIR|rcsb pdb:5XUP|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0090656"(t-circle formation)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1904914"(negative regulation of establishment of protein-containing complex localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|dip:DIP-29412N - - - - figure legend:Figures 1 G right and 3 J|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/10/10 2014/10/16 rogid:3Tjmp8hqEhLBIQqxxWHntpL4hz49606 - intact-crc:E8AA0E954C4D7BBD false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q2NKJ3 intact:EBI-8792879 intact:EBI-2562802|uniprotkb:Q9H6L0|uniprotkb:Q8N3S6|uniprotkb:Q2TBE3|uniprotkb:Q1PCD1|uniprotkb:B3KR66|uniprotkb:C9JEX5|ensembl:ENSP00000498499 - psi-mi:ctc1_human(display_long)|uniprotkb:HBV DNAPTP1-transactivated protein B(gene name synonym)|uniprotkb:C17orf68(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym)|uniprotkb:CTC1(gene name)|psi-mi:CTC1(display_short) psi-mi:telomeric_dna_human_c-strand(display_short)|psi-mi:EBI-8792879(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8792890|imex:IM-22162-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) refseq:NP_079375.3|ensembl:ENSG00000178971(gene)|ensembl:ENST00000651323(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|rcsb pdb:5W2L|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56900N - - - - figure legend:Figures 3 J Top and 3 K|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/10/10 2014/10/16 rogid:aavdKljLwgWaWRSJvHNomox6+Yw9606 - intact-crc:3FA74C169B2F5619 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15554 intact:EBI-8792879 intact:EBI-706637|ensembl:ENSP00000254942|intact:EBI-706651 - psi-mi:terf2_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)|uniprotkb:TERF2(gene name)|psi-mi:TERF2(display_short)|uniprotkb:TRF2(gene name synonym)|uniprotkb:TRBF2(gene name synonym) psi-mi:telomeric_dna_human_c-strand(display_short)|psi-mi:EBI-8792879(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8792858|imex:IM-22162-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0090398"(cellular senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1903824"(negative regulation of telomere single strand break repair)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0032205"(negative regulation of telomere maintenance)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|ensembl:ENSG00000132604(gene)|ensembl:ENST00000254942(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:Q15554|rcsb pdb:1H6P|rcsb pdb:1VF9|rcsb pdb:1VFC|rcsb pdb:1W0U|rcsb pdb:1XG1|rcsb pdb:3BU8|rcsb pdb:3BUA|rcsb pdb:3K6G|rcsb pdb:3SJM|rcsb pdb:4M7C|rcsb pdb:4RQI|rcsb pdb:5WQD|rcsb pdb:5XYF|rcsb pdb:6J67|rcsb pdb:7C5D|reactome:R-HSA-110328|reactome:R-HSA-110329|go:"GO:1904354"(negative regulation of telomere capping)|refseq:NP_005643.2|dip:DIP-34052N - - - - figure legend:Figures 1 G right, 3 J and 3 K|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/10/10 2014/10/16 rogid:MzPf3uCpzJzkIKvgaP0Xro7xnHo9606 - intact-crc:D02DE1ABCD2D5BE2 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q9H668 intact:EBI-8792879 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 - psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:telomeric_dna_human_c-strand(display_short)|psi-mi:EBI-8792879(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793642|imex:IM-22162-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N - - - - figure legend:Figures 1 G right and 3 K|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/10/10 2014/10/16 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 - intact-crc:0BAE8F45F98B2E39 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q8K2X3 uniprotkb:Q9D7K2 intact:EBI-2553883|uniprotkb:Q8C6I6|uniprotkb:Q3TPH0|ensembl:ENSMUSP00000040944 intact:EBI-6258509|ensembl:ENSMUSP00000021130 psi-mi:stn1_mouse(display_long)|uniprotkb:Stn1(gene name)|psi-mi:Stn1(display_short)|uniprotkb:Alpha-accessory factor of 44 kDa(gene name synonym)|uniprotkb:Obfc1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:ten1l_mouse(display_long)|uniprotkb:Ten1(gene name)|psi-mi:Ten1(display_short)|uniprotkb:Protein telomeric pathways with STN1 homolog(gene name synonym)|uniprotkb:Telomere length regulation protein TEN1 homolog(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793120|imex:IM-22162-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_780569.1|ensembl:ENSMUSG00000042694(gene)|ensembl:ENSMUST00000049369(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|rcsb pdb:1WJ5|go:"GO:0043047"(single-stranded telomeric DNA binding)|reactome:R-MMU-174411|reactome:R-MMU-174430|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082 ensembl:ENSMUSG00000020778(gene)|ensembl:ENSMUST00000021130(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029146|reactome:R-MMU-174411|reactome:R-MMU-174430|refseq:NP_081383.1 - - - figure legend:Figure 2 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2013/10/10 2014/10/16 rogid:N2QA+Bs0g8hsUHFMHX+eGDr8H1o10090 rogid:JLgYwRVgilaEBFfee/oClj0bfzI10090 intact-crc:9B3D4719438A9122|rigid:Zp0ZlEzuxeuiQErGmtO1qartmMQ false ha tag:?-?|flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8K2X3 uniprotkb:Q5SUQ9 intact:EBI-2553883|uniprotkb:Q8C6I6|uniprotkb:Q3TPH0|ensembl:ENSMUSP00000040944 intact:EBI-6258382|ensembl:ENSMUSP00000112063|uniprotkb:B2RW14|uniprotkb:Q3UKQ1|uniprotkb:Q6P9S2|uniprotkb:Q8BRK2|uniprotkb:Q91WN0|uniprotkb:Q9CW32 psi-mi:stn1_mouse(display_long)|uniprotkb:Stn1(gene name)|psi-mi:Stn1(display_short)|uniprotkb:Alpha-accessory factor of 44 kDa(gene name synonym)|uniprotkb:Obfc1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:ctc1_mouse(display_long)|uniprotkb:Ctc1(gene name)|psi-mi:Ctc1(display_short)|uniprotkb:Alpha-accessory factor of 132 kDa(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793120|imex:IM-22162-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_780569.1|ensembl:ENSMUSG00000042694(gene)|ensembl:ENSMUST00000049369(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|rcsb pdb:1WJ5|go:"GO:0043047"(single-stranded telomeric DNA binding)|reactome:R-MMU-174411|reactome:R-MMU-174430|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082 ensembl:ENSMUSG00000020898(gene)|ensembl:ENSMUST00000116359(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0051276"(chromosome organization)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|reactome:R-MMU-174411|reactome:R-MMU-174430|refseq:NP_001268394.1|refseq:NP_001013274.2|refseq:NP_001137262.1 - - - figure legend:Figure 2 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells) - 2013/10/10 2014/10/16 rogid:N2QA+Bs0g8hsUHFMHX+eGDr8H1o10090 rogid:pAT2ffnxDHBCElcRDNqgUsY0YR810090 intact-crc:9B3D4719438A9122|rigid:Zp0ZlEzuxeuiQErGmtO1qartmMQ false ha tag:?-?|flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q2NKJ3 uniprotkb:Q9H668 intact:EBI-2562802|uniprotkb:Q9H6L0|uniprotkb:Q8N3S6|uniprotkb:Q2TBE3|uniprotkb:Q1PCD1|uniprotkb:B3KR66|uniprotkb:C9JEX5|ensembl:ENSP00000498499 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 psi-mi:ctc1_human(display_long)|uniprotkb:HBV DNAPTP1-transactivated protein B(gene name synonym)|uniprotkb:C17orf68(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym)|uniprotkb:CTC1(gene name)|psi-mi:CTC1(display_short) psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793146|imex:IM-22162-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079375.3|ensembl:ENSG00000178971(gene)|ensembl:ENST00000651323(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|rcsb pdb:5W2L|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56900N refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N - - - figure legend:Figure 2 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/10/10 2014/10/16 rogid:aavdKljLwgWaWRSJvHNomox6+Yw9606 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 intact-crc:02E80FC1A66275D7|rigid:Du/FdWjjhaBVwuTgEKCGxkdmkOA false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q2NKJ3 uniprotkb:Q86WV5 intact:EBI-2562802|uniprotkb:Q9H6L0|uniprotkb:Q8N3S6|uniprotkb:Q2TBE3|uniprotkb:Q1PCD1|uniprotkb:B3KR66|uniprotkb:C9JEX5|ensembl:ENSP00000498499 intact:EBI-2562799|ensembl:ENSP00000380762|uniprotkb:I3L0C7 psi-mi:ctc1_human(display_long)|uniprotkb:HBV DNAPTP1-transactivated protein B(gene name synonym)|uniprotkb:C17orf68(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym)|uniprotkb:CTC1(gene name)|psi-mi:CTC1(display_short) psi-mi:ten1l_human(display_long)|uniprotkb:TEN1(gene name)|psi-mi:TEN1(display_short)|uniprotkb:C17orf106(gene name synonym)|uniprotkb:Telomere length regulation protein TEN1 homolog(gene name synonym)|uniprotkb:Protein telomeric pathways with STN1 homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793146|imex:IM-22162-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079375.3|ensembl:ENSG00000178971(gene)|ensembl:ENST00000651323(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|rcsb pdb:5W2L|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56900N refseq:NP_001106795.2|ensembl:ENSG00000257949(gene)|ensembl:ENST00000397640(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029146|rcsb pdb:4JOI|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56901N - - - figure legend:Figure 2 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/10/10 2014/10/16 rogid:aavdKljLwgWaWRSJvHNomox6+Yw9606 rogid:BTchMyEKu9ZhBDMU/R3ZkrCSiGk9606 intact-crc:02E80FC1A66275D7|rigid:Du/FdWjjhaBVwuTgEKCGxkdmkOA false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q2NKJ3 uniprotkb:Q9H668 intact:EBI-2562802|uniprotkb:Q9H6L0|uniprotkb:Q8N3S6|uniprotkb:Q2TBE3|uniprotkb:Q1PCD1|uniprotkb:B3KR66|uniprotkb:C9JEX5|ensembl:ENSP00000498499 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 psi-mi:ctc1_human(display_long)|uniprotkb:HBV DNAPTP1-transactivated protein B(gene name synonym)|uniprotkb:C17orf68(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym)|uniprotkb:CTC1(gene name)|psi-mi:CTC1(display_short) psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793459|imex:IM-22162-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079375.3|ensembl:ENSG00000178971(gene)|ensembl:ENST00000651323(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|rcsb pdb:5W2L|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56900N refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N - - - figure legend:Figure 5 A lanes 3 and 8, and figure 5 D|comment:"Author states that HA-hStn1 and HA-hTen1 were coimmunoprecipitated with Flag-hCtc1 from 293T extracts expressing these proteins, indicating that hCtc1-hStn1 and hCtc1-hStn1-hTen1 complexes were formed (Figure 5A, lanes 3, 7, and 8). Interestingly, the amount of immunoprecipitated hStn1 was significantly smaller in hCtc1-hStn1-expressing cells than in the three-component-expressing cells, suggesting that the hCtc1-hStn1 subcomplex is relatively unstable."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/10/10 2014/10/16 rogid:aavdKljLwgWaWRSJvHNomox6+Yw9606 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 intact-crc:F7C1D7AC49F99492|rigid:Du/FdWjjhaBVwuTgEKCGxkdmkOA false sufficient binding region:700-1217|flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q2NKJ3 uniprotkb:Q86WV5 intact:EBI-2562802|uniprotkb:Q9H6L0|uniprotkb:Q8N3S6|uniprotkb:Q2TBE3|uniprotkb:Q1PCD1|uniprotkb:B3KR66|uniprotkb:C9JEX5|ensembl:ENSP00000498499 intact:EBI-2562799|ensembl:ENSP00000380762|uniprotkb:I3L0C7 psi-mi:ctc1_human(display_long)|uniprotkb:HBV DNAPTP1-transactivated protein B(gene name synonym)|uniprotkb:C17orf68(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym)|uniprotkb:CTC1(gene name)|psi-mi:CTC1(display_short) psi-mi:ten1l_human(display_long)|uniprotkb:TEN1(gene name)|psi-mi:TEN1(display_short)|uniprotkb:C17orf106(gene name synonym)|uniprotkb:Telomere length regulation protein TEN1 homolog(gene name synonym)|uniprotkb:Protein telomeric pathways with STN1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793459|imex:IM-22162-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079375.3|ensembl:ENSG00000178971(gene)|ensembl:ENST00000651323(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|rcsb pdb:5W2L|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56900N refseq:NP_001106795.2|ensembl:ENSG00000257949(gene)|ensembl:ENST00000397640(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029146|rcsb pdb:4JOI|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56901N - - - figure legend:Figure 5 A lanes 3 and 8, and figure 5 D|comment:"Author states that HA-hStn1 and HA-hTen1 were coimmunoprecipitated with Flag-hCtc1 from 293T extracts expressing these proteins, indicating that hCtc1-hStn1 and hCtc1-hStn1-hTen1 complexes were formed (Figure 5A, lanes 3, 7, and 8). Interestingly, the amount of immunoprecipitated hStn1 was significantly smaller in hCtc1-hStn1-expressing cells than in the three-component-expressing cells, suggesting that the hCtc1-hStn1 subcomplex is relatively unstable."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/10/10 2014/10/16 rogid:aavdKljLwgWaWRSJvHNomox6+Yw9606 rogid:BTchMyEKu9ZhBDMU/R3ZkrCSiGk9606 intact-crc:F7C1D7AC49F99492|rigid:Du/FdWjjhaBVwuTgEKCGxkdmkOA false sufficient binding region:700-1217|flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9H668 uniprotkb:Q2NKJ3 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 intact:EBI-2562802|uniprotkb:Q9H6L0|uniprotkb:Q8N3S6|uniprotkb:Q2TBE3|uniprotkb:Q1PCD1|uniprotkb:B3KR66|uniprotkb:C9JEX5|ensembl:ENSP00000498499 psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:ctc1_human(display_long)|uniprotkb:HBV DNAPTP1-transactivated protein B(gene name synonym)|uniprotkb:C17orf68(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym)|uniprotkb:CTC1(gene name)|psi-mi:CTC1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793201|imex:IM-22162-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N refseq:NP_079375.3|ensembl:ENSG00000178971(gene)|ensembl:ENST00000651323(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|rcsb pdb:5W2L|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56900N - - - figure legend:Figure 3 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/10/10 2014/10/16 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 rogid:aavdKljLwgWaWRSJvHNomox6+Yw9606 intact-crc:D8A81D31181D0CEA|rigid:am1BKSpQV4Xwo2Wt90mtY8gs6NY false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9H668 uniprotkb:Q86WV5 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 intact:EBI-2562799|ensembl:ENSP00000380762|uniprotkb:I3L0C7 psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:ten1l_human(display_long)|uniprotkb:TEN1(gene name)|psi-mi:TEN1(display_short)|uniprotkb:C17orf106(gene name synonym)|uniprotkb:Telomere length regulation protein TEN1 homolog(gene name synonym)|uniprotkb:Protein telomeric pathways with STN1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793223|imex:IM-22162-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N refseq:NP_001106795.2|ensembl:ENSG00000257949(gene)|ensembl:ENST00000397640(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029146|rcsb pdb:4JOI|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56901N - - - figure legend:Figure 3 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/10/10 2014/10/16 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 rogid:BTchMyEKu9ZhBDMU/R3ZkrCSiGk9606 intact-crc:E34601B4CBFCABDA|rigid:qlBiee53iqlvsWYpMix0nfgE7yQ false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q2NKJ3 uniprotkb:Q9H668 intact:EBI-2562802|uniprotkb:Q9H6L0|uniprotkb:Q8N3S6|uniprotkb:Q2TBE3|uniprotkb:Q1PCD1|uniprotkb:B3KR66|uniprotkb:C9JEX5|ensembl:ENSP00000498499 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 psi-mi:ctc1_human(display_long)|uniprotkb:HBV DNAPTP1-transactivated protein B(gene name synonym)|uniprotkb:C17orf68(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym)|uniprotkb:CTC1(gene name)|psi-mi:CTC1(display_short) psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793190|imex:IM-22162-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079375.3|ensembl:ENSG00000178971(gene)|ensembl:ENST00000651323(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|rcsb pdb:5W2L|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56900N refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N - - - figure legend:Figure 3 A and figure 5 A lane 7|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/10/10 2014/10/16 rogid:aavdKljLwgWaWRSJvHNomox6+Yw9606 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 intact-crc:FD8FE3723E01516E|rigid:am1BKSpQV4Xwo2Wt90mtY8gs6NY false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9H668 uniprotkb:Q86WV5 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 intact:EBI-2562799|ensembl:ENSP00000380762|uniprotkb:I3L0C7 psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:ten1l_human(display_long)|uniprotkb:TEN1(gene name)|psi-mi:TEN1(display_short)|uniprotkb:C17orf106(gene name synonym)|uniprotkb:Telomere length regulation protein TEN1 homolog(gene name synonym)|uniprotkb:Protein telomeric pathways with STN1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793212|imex:IM-22162-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N refseq:NP_001106795.2|ensembl:ENSG00000257949(gene)|ensembl:ENST00000397640(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029146|rcsb pdb:4JOI|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56901N - - - figure legend:Figure 3 C and figure 5 A lane 10|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/10/10 2014/10/16 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 rogid:BTchMyEKu9ZhBDMU/R3ZkrCSiGk9606 intact-crc:50DAE9922526D7D9|rigid:qlBiee53iqlvsWYpMix0nfgE7yQ false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9H668 uniprotkb:P54274 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 intact:EBI-710997|uniprotkb:A7XP29|uniprotkb:Q15553|uniprotkb:Q93029|ensembl:ENSP00000276603|uniprotkb:Q8NHT6 psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:terf1_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)|uniprotkb:NIMA-interacting protein 2(gene name synonym)|uniprotkb:Telomeric protein Pin2/TRF1(gene name synonym)|uniprotkb:TERF1(gene name)|psi-mi:TERF1(display_short)|uniprotkb:PIN2(gene name synonym)|uniprotkb:TRF(gene name synonym)|uniprotkb:TRF1(gene name synonym)|uniprotkb:TRBF1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793550|imex:IM-22162-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N refseq:NP_003209.2|refseq:NP_059523.2|ensembl:ENSG00000147601(gene)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|ensembl:ENST00000276603(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P54274|rcsb pdb:1BA5|rcsb pdb:1H6O|rcsb pdb:1ITY|rcsb pdb:1IV6|rcsb pdb:1W0T|rcsb pdb:3BQO|rcsb pdb:3L82|rcsb pdb:5HKP|rcsb pdb:5WIR|rcsb pdb:5XUP|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0090656"(t-circle formation)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1904914"(negative regulation of establishment of protein-containing complex localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|dip:DIP-29412N go:"GO:0005634"(nucleus) - - figure legend:Figure 6 C|comment:This experiment was conducted in Pot1 knock-down cells by using an shRNA toward Pot1. Author states that the frequencies of colocalized HA-hStn1 signals among total TRF1 IF signals did not significantly change. These results indicate that CST is localized at telomeres independently of Pot1.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-143b)|taxid:9606(Human bone osteosarcoma 143B) - 2013/10/10 2014/10/16 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 rogid:3Tjmp8hqEhLBIQqxxWHntpL4hz49606 intact-crc:E08A13D74BFCA7EF|rigid:3XvsE+hYO1bV3IFOys56lt1Bj/E false ha tag:?-? - - - psi-mi:"MI:1201"(anti-tag immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9H668 uniprotkb:Q2NKJ3 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 intact:EBI-2562802|uniprotkb:Q9H6L0|uniprotkb:Q8N3S6|uniprotkb:Q2TBE3|uniprotkb:Q1PCD1|uniprotkb:B3KR66|uniprotkb:C9JEX5|ensembl:ENSP00000498499 psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:ctc1_human(display_long)|uniprotkb:HBV DNAPTP1-transactivated protein B(gene name synonym)|uniprotkb:C17orf68(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym)|uniprotkb:CTC1(gene name)|psi-mi:CTC1(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793354|imex:IM-22162-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N refseq:NP_079375.3|ensembl:ENSG00000178971(gene)|ensembl:ENST00000651323(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|rcsb pdb:5W2L|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56900N - - - figure legend:Figure 3 H|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/10/10 2014/10/16 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 rogid:aavdKljLwgWaWRSJvHNomox6+Yw9606 intact-crc:65EBE36CF64B0924|rigid:am1BKSpQV4Xwo2Wt90mtY8gs6NY false ha tag:?-? flag tag:?-? - - psi-mi:"MI:1201"(anti-tag immunocytochemistry) psi-mi:"MI:1201"(anti-tag immunocytochemistry) uniprotkb:Q86WV5 uniprotkb:Q9H668 intact:EBI-2562799|ensembl:ENSP00000380762|uniprotkb:I3L0C7 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 psi-mi:ten1l_human(display_long)|uniprotkb:TEN1(gene name)|psi-mi:TEN1(display_short)|uniprotkb:C17orf106(gene name synonym)|uniprotkb:Telomere length regulation protein TEN1 homolog(gene name synonym)|uniprotkb:Protein telomeric pathways with STN1 homolog(gene name synonym) psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0018"(two hybrid) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793294|imex:IM-22162-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001106795.2|ensembl:ENSG00000257949(gene)|ensembl:ENST00000397640(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029146|rcsb pdb:4JOI|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56901N refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N - - - figure legend:Figure 3 G|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2013/10/10 2014/10/16 rogid:BTchMyEKu9ZhBDMU/R3ZkrCSiGk9606 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 intact-crc:AA3228F6DB58BF62|rigid:qlBiee53iqlvsWYpMix0nfgE7yQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2NKJ3 uniprotkb:Q9H668 intact:EBI-2562802|uniprotkb:Q9H6L0|uniprotkb:Q8N3S6|uniprotkb:Q2TBE3|uniprotkb:Q1PCD1|uniprotkb:B3KR66|uniprotkb:C9JEX5|ensembl:ENSP00000498499 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 psi-mi:ctc1_human(display_long)|uniprotkb:HBV DNAPTP1-transactivated protein B(gene name synonym)|uniprotkb:C17orf68(gene name synonym)|uniprotkb:Conserved telomere maintenance component 1(gene name synonym)|uniprotkb:CTC1(gene name)|psi-mi:CTC1(display_short) psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0018"(two hybrid) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8793324|imex:IM-22162-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079375.3|ensembl:ENSG00000178971(gene)|ensembl:ENST00000651323(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0090399"(replicative senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR029156|interpro:IPR042617|rcsb pdb:5W2L|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|dip:DIP-56900N refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N - - - figure legend:Figure 3 G|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2013/10/10 2014/10/16 rogid:aavdKljLwgWaWRSJvHNomox6+Yw9606 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 intact-crc:D2AF17B159A67942|rigid:am1BKSpQV4Xwo2Wt90mtY8gs6NY false necessary binding region:700-1217 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O13852 uniprotkb:O14246 intact:EBI-8802034|ensemblfungi:"SPAC19G12.13c.1:pep"|uniprotkb:B3A005 intact:EBI-8802014|ensemblfungi:"SPAC6F6.16c.1:pep"|uniprotkb:B3A004 psi-mi:poz1_schpo(display_long)|uniprotkb:poz1(gene name)|psi-mi:poz1(display_short)|uniprotkb:Pot1-associated protein poz1(gene name synonym)|uniprotkb:SPAC19G12.13c(orf name) psi-mi:tpz1_schpo(display_long)|uniprotkb:tpz1(gene name)|psi-mi:tpz1(display_short)|uniprotkb:mug169(gene name synonym)|uniprotkb:Meiotically up-regulated gene 169 protein(gene name synonym)|uniprotkb:SPAC6F6.16c(orf name)|uniprotkb:SPAC6F6.18c(orf name) psi-mi:"MI:0018"(two hybrid) Miyake et al. (2009) pubmed:19854130|imex:IM-22162 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8802032|imex:IM-22162-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0070187"(shelterin complex)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|ensemblfungi:SPAC19G12.13c(gene)|ensemblfungi:SPAC19G12.13c.1(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016233"(telomere capping)|go:"GO:0032200"(telomere organization)|rcsb pdb:5WE0|rcsb pdb:5WE1|rcsb pdb:5WE2|rcsb pdb:5XXE|rcsb pdb:5XXF|refseq:NP_594428.1 ensemblfungi:SPAC6F6.16c(gene)|ensemblfungi:SPAC6F6.16c.1(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000782"(telomere cap complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|go:"GO:1905324"(telomere-telomerase complex assembly)|interpro:IPR028631|rcsb pdb:5WE0|rcsb pdb:5WE1|rcsb pdb:5WE2|rcsb pdb:5XXE|rcsb pdb:5XXF|reactome:R-SPO-174437|refseq:NP_593908.2|dip:DIP-59445N - - crc64:A1A2F59238DACBF7 figure legend:Figure 3G|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2013/10/10 2014/10/16 rogid:36K5s8ygDkcoHQahYmElc6NfOaM284812 rogid:rMyjAulmp7bk7WOGQ3J52ZVaNfI284812 intact-crc:D8092FA4803E13EC|rigid:viftlO5qdGodjU8WSS81di7PhEg false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)