#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P45592	uniprotkb:Q66HL2	intact:EBI-917556|ensembl:ENSRNOP00000059624	intact:EBI-6273816|ensembl:ENSRNOP00000028283|ensembl:ENSRNOP00000072540|ensembl:ENSRNOP00000075952|uniprotkb:D3ZRB0	psi-mi:cof1_rat(display_long)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)	psi-mi:src8_rat(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Oser et al. (2009)	imex:IM-18856|pubmed:19704022	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6555216|imex:IM-18856-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69285|refseq:NP_058843.1|ensembl:ENSRNOG00000020660(gene)|ensembl:ENSRNOT00000015962(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0009615"(response to virus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071362"(cellular response to ether)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P45592	ensembl:ENSRNOG00000047280(gene)|ensembl:ENSRNOG00000050994(gene)|ensembl:ENSRNOT00000028283(transcript)|ensembl:ENSRNOT00000079805(transcript)|ensembl:ENSRNOT00000092916(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007420"(brain development)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|reactome:R-RNO-8856828|refseq:XP_017445759.1|rgd:619839|refseq:NP_068640.2	go:"GO:0071437"(obsolete invadopodium)	-	-	figure legend:Fig 5A, 5B.|comment:"The FRET efficiency was increased in starved MLTn3 cells, decreased 1 min after EGF stimulation and increased again after 5 min of EGF stimulation (Fig 5B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-mtln3)|taxid:10116(Rat mammary adenocarcinoma)	-	2013/03/06	2014/10/16	rogid:xwFEqVHm0stGEHpMoijBFH/LwPY10116	rogid:M1+xAihoVAXproQ2m3EIc8qnwlg10116	intact-crc:5D29B9852F318DDF|rigid:XKudM0RjZD8EFww57nNzaOE0RRs	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P45592	uniprotkb:Q60598	intact:EBI-917556|ensembl:ENSRNOP00000059624	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:cof1_rat(display_long)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Oser et al. (2009)	imex:IM-18856|pubmed:19704022	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6555309|imex:IM-18856-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69285|refseq:NP_058843.1|ensembl:ENSRNOG00000020660(gene)|ensembl:ENSRNOT00000015962(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0009615"(response to virus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071362"(cellular response to ether)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P45592	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N	-	-	-	figure legend:Fig 5C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-mtln3)|taxid:10116(Rat mammary adenocarcinoma)	-	2013/03/06	2014/10/16	rogid:xwFEqVHm0stGEHpMoijBFH/LwPY10116	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:310B91E940BA574F|rigid:Z6acsYX0cCjh9fzMESbzLbzUFdo	false	-	mutation decreasing interaction:421-421,466-466,482-482	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P45592	uniprotkb:P60711	intact:EBI-917556|ensembl:ENSRNOP00000059624	intact:EBI-349272|uniprotkb:Q64316|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|ensembl:ENSRNOP00000044296	psi-mi:cof1_rat(display_long)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)	psi-mi:actb_rat(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Oser et al. (2009)	imex:IM-18856|pubmed:19704022	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6555880|imex:IM-18856-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69285|refseq:NP_058843.1|ensembl:ENSRNOG00000020660(gene)|ensembl:ENSRNOT00000015962(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0009615"(response to virus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071362"(cellular response to ether)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P45592	rgd:628837|refseq:NP_112406.1|ensembl:ENSRNOG00000034254(gene)|ensembl:ENSRNOT00000042459(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070160"(tight junction)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|reactome:R-RNO-190873|reactome:R-RNO-196025|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|reactome:R-RNO-2029482|reactome:R-RNO-3928662|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|reactome:R-RNO-418990|reactome:R-RNO-437239|go:"GO:1903076"(regulation of protein localization to plasma membrane)|reactome:R-RNO-4420097|reactome:R-RNO-445095|reactome:R-RNO-446353|reactome:R-RNO-5250924|reactome:R-RNO-5626467|reactome:R-RNO-5663213|reactome:R-RNO-5663220|reactome:R-RNO-5674135|reactome:R-RNO-5689603|reactome:R-RNO-5696394|reactome:R-RNO-8856828|reactome:R-RNO-9035034|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60711	-	-	-	figure legend:Fig 6F, 6G.|comment:The FRET efficiency between cofilin and beta-actin increased in the presence of EGF stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-mtln3)|taxid:10116(Rat mammary adenocarcinoma)	-	2013/03/06	2014/10/16	rogid:xwFEqVHm0stGEHpMoijBFH/LwPY10116	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10116	intact-crc:0C0CD8E254E234D3|rigid:+gn0+pmNypuNjUJAtol8ikjByro	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q66HL2	uniprotkb:P45592	intact:EBI-6273816|ensembl:ENSRNOP00000028283|ensembl:ENSRNOP00000072540|ensembl:ENSRNOP00000075952|uniprotkb:D3ZRB0	intact:EBI-917556|ensembl:ENSRNOP00000059624	psi-mi:src8_rat(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)	psi-mi:cof1_rat(display_long)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Oser et al. (2009)	imex:IM-18856|pubmed:19704022	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6555334|imex:IM-18856-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047280(gene)|ensembl:ENSRNOG00000050994(gene)|ensembl:ENSRNOT00000028283(transcript)|ensembl:ENSRNOT00000079805(transcript)|ensembl:ENSRNOT00000092916(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007420"(brain development)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|reactome:R-RNO-8856828|refseq:XP_017445759.1|rgd:619839|refseq:NP_068640.2	rgd:69285|refseq:NP_058843.1|ensembl:ENSRNOG00000020660(gene)|ensembl:ENSRNOT00000015962(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0009615"(response to virus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071362"(cellular response to ether)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P45592	-	-	-	figure legend:Fig 5D, 5E.|comment:Cortactin coprecipitation by cofilin was decreased in the presence of EGF stimulation. Cofilin did not interact with phosphorylated cortactin.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-mtln3)|taxid:10116(Rat mammary adenocarcinoma)	-	2013/03/06	2014/10/16	rogid:M1+xAihoVAXproQ2m3EIc8qnwlg10116	rogid:xwFEqVHm0stGEHpMoijBFH/LwPY10116	intact-crc:BD04061C40BE29FD|rigid:XKudM0RjZD8EFww57nNzaOE0RRs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P45592	uniprotkb:Q66HL2	intact:EBI-917556|ensembl:ENSRNOP00000059624	intact:EBI-6273816|ensembl:ENSRNOP00000028283|ensembl:ENSRNOP00000072540|ensembl:ENSRNOP00000075952|uniprotkb:D3ZRB0	psi-mi:cof1_rat(display_long)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)	psi-mi:src8_rat(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Oser et al. (2009)	imex:IM-18856|pubmed:19704022	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6555697|imex:IM-18856-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69285|refseq:NP_058843.1|ensembl:ENSRNOG00000020660(gene)|ensembl:ENSRNOT00000015962(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0009615"(response to virus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071362"(cellular response to ether)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P45592	ensembl:ENSRNOG00000047280(gene)|ensembl:ENSRNOG00000050994(gene)|ensembl:ENSRNOT00000028283(transcript)|ensembl:ENSRNOT00000079805(transcript)|ensembl:ENSRNOT00000092916(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007420"(brain development)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|reactome:R-RNO-8856828|refseq:XP_017445759.1|rgd:619839|refseq:NP_068640.2	-	-	-	figure legend:Fig. 5F, 5G|comment:The amount of cofilin coprecipitated by cortactin decreased in the presence of EGF stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-mtln3)|taxid:10116(Rat mammary adenocarcinoma)	-	2013/03/06	2014/10/16	rogid:xwFEqVHm0stGEHpMoijBFH/LwPY10116	rogid:M1+xAihoVAXproQ2m3EIc8qnwlg10116	intact-crc:D38C61A43D49D173|rigid:XKudM0RjZD8EFww57nNzaOE0RRs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60598	uniprotkb:P45592	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	intact:EBI-917556|ensembl:ENSRNOP00000059624	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:cof1_rat(display_long)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Oser et al. (2009)	imex:IM-18856|pubmed:19704022	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6555718|imex:IM-18856-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N	rgd:69285|refseq:NP_058843.1|ensembl:ENSRNOG00000020660(gene)|ensembl:ENSRNOT00000015962(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0009615"(response to virus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071362"(cellular response to ether)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P45592	-	-	-	figure legend:Fig 5H, 5I.|comment:Cortactin 3YF mutant coprecipitated increased levels of cofilin, when compared to WT cortactin, suggesting that cofilin interacts chiefly with dephosphorylated cortactin.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-mtln3)|taxid:10116(Rat mammary adenocarcinoma)	-	2013/03/06	2014/10/16	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	rogid:xwFEqVHm0stGEHpMoijBFH/LwPY10116	intact-crc:CA4B69B3927B7EC7|rigid:Z6acsYX0cCjh9fzMESbzLbzUFdo	false	mutation increasing interaction:421-421,466-466,482-482	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q66HL2	uniprotkb:B2RZ33	intact:EBI-6273816|ensembl:ENSRNOP00000028283|ensembl:ENSRNOP00000072540|ensembl:ENSRNOP00000075952|uniprotkb:D3ZRB0	intact:EBI-6556369	psi-mi:src8_rat(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)	psi-mi:b2rz33_rat(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:Nck1_predicted(gene name synonym)|uniprotkb:rCG_25905(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Oser et al. (2009)	imex:IM-18856|pubmed:19704022	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6556367|imex:IM-18856-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047280(gene)|ensembl:ENSRNOG00000050994(gene)|ensembl:ENSRNOT00000028283(transcript)|ensembl:ENSRNOT00000079805(transcript)|ensembl:ENSRNOT00000092916(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007420"(brain development)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|reactome:R-RNO-8856828|refseq:XP_017445759.1|rgd:619839|refseq:NP_068640.2	go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR035564|interpro:IPR035565|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|refseq:NP_001100321.1|rgd:1310688|interpro:IPR035562|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|interpro:IPR028526	-	comment:Required phosphorylation	-	figure legend:Fig 7E.|comment:Nck1 coprecipitated phosphorylated cortactin as detected by anti-phospho antibody. Nck1 did not coprecipitate non-phosphorylated  cortactin.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-mtln3)|taxid:10116(Rat mammary adenocarcinoma)	-	2013/03/06	2014/10/16	rogid:M1+xAihoVAXproQ2m3EIc8qnwlg10116	rogid:IYoq1up0Ib37s7BYRyIBFIxGZdg10116	intact-crc:8D1F0792D42CEE70|rigid:mvj7o4bSi9b0Svmgfd0eyumY1k8	false	O4'-phospho-L-tyrosine:421-421	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60598	uniprotkb:P0DJ26	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	intact:EBI-6555824|ensemblprotists:EAL68089|uniprotkb:P54706|uniprotkb:Q54DU6	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:cofa_dicdi(display_long)|uniprotkb:cofA(gene name)|psi-mi:cofA(display_short)|uniprotkb:cof1(gene name synonym)|uniprotkb:dcof1(gene name synonym)|uniprotkb:DDB_G0277833(orf name)	psi-mi:"MI:0004"(affinity chromatography technology)	Oser et al. (2009)	imex:IM-18856|pubmed:19704022	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6555822|imex:IM-18856-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N	ensemblprotists:EAL68089(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0061836"(intranuclear rod)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR029006|refseq:XP_629776.1|refseq:XP_642259.1|ensemblprotists:DDB_G0277833(gene)|dictybase:DDB_G0277833	-	-	-	figure legend:Fig 6A, 6B.|comment:The recombinant cofilin had a higher affinity for the 3YF cortactin mutant, when compared to the WT cortactin, as inferred from the Kd values.|comment:The Kd value for the cofilin-cortactin  WT interaction was 3.5+/_ 1.1 micromoles and the Kd value for the cofilin-cortactin 3YF mutant was 2.8+/_ 0.34 micromoles.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.5x10^-6(molar)	2013/03/06	2014/10/16	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	rogid:6oDPhamGIufTSA4wvco/PqMQB+044689	intact-crc:48A6C93C7E11303E|rigid:KeyjYI3ljQQ5akLJYXsgRLBjOTI	false	mutation increasing interaction:421-421,466-466,482-482	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q66HL2	uniprotkb:P45592	intact:EBI-6273816|ensembl:ENSRNOP00000028283|ensembl:ENSRNOP00000072540|ensembl:ENSRNOP00000075952|uniprotkb:D3ZRB0	intact:EBI-917556|ensembl:ENSRNOP00000059624	psi-mi:src8_rat(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)	psi-mi:cof1_rat(display_long)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Oser et al. (2009)	imex:IM-18856|pubmed:19704022	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6556393|imex:IM-18856-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000047280(gene)|ensembl:ENSRNOG00000050994(gene)|ensembl:ENSRNOT00000028283(transcript)|ensembl:ENSRNOT00000079805(transcript)|ensembl:ENSRNOT00000092916(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007420"(brain development)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|reactome:R-RNO-8856828|refseq:XP_017445759.1|rgd:619839|refseq:NP_068640.2	rgd:69285|refseq:NP_058843.1|ensembl:ENSRNOG00000020660(gene)|ensembl:ENSRNOT00000015962(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0009615"(response to virus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071362"(cellular response to ether)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P45592	-	-	-	figure legend:"Fig S5(B,C)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-mtln3)|taxid:10116(Rat mammary adenocarcinoma)	-	2013/03/06	2014/10/16	rogid:M1+xAihoVAXproQ2m3EIc8qnwlg10116	rogid:xwFEqVHm0stGEHpMoijBFH/LwPY10116	intact-crc:50FD3C665A479040|rigid:XKudM0RjZD8EFww57nNzaOE0RRs	false	mutation increasing interaction:421-421,466-466,482-482|red fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O08816	-	intact:EBI-6142604	-	psi-mi:wasl_rat(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)	-	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Oser et al. (2009)	imex:IM-18856|pubmed:19704022	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	psi-mi:"MI:1126"(self interaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6559088|imex:IM-18856-10	-	-	psi-mi:"MI:0499"(unspecified role)	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0326"(protein)	-	mint:O08816|rgd:735144|dip:DIP-17016N|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010324"(membrane invagination)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|rcsb pdb:1MKE|rcsb pdb:2IFS|go:"GO:0000139"(Golgi membrane)	-	-	-	-	figure legend:Fig 7F, 7G.|comment:The intramolecular interaction within N-Wasp was decreased in MTLn3 cells expressing 3YF cortactin, but not in cells expressing WT cortactin.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-mtln3)|taxid:10116(Rat mammary adenocarcinoma)	-	2013/03/06	2014/10/16	rogid:lKgHtUQQEc8C14/X9D8WOvry2iM10116	-	intact-crc:CA222CA0E817D2A7	false	cyan fluorescent protein tag:n-n|yellow fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	-