#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9H668 intact:EBI-9009305 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 - psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:telg31(display_short)|psi-mi:EBI-9009305(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8789182|imex:IM-22139-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N|interpro:IPR015253(Region of unknown function DUF1879) - go:"GO:0005634"(nucleus) - - figure legend:Figure 3 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/04 2014/10/16 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 - intact-crc:F2D7111F08F14E04 false glutathione s tranferase tag:?-? 32p radiolabel:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q9NYB0 uniprotkb:Q9H668 intact:EBI-750109|uniprotkb:B4DQN4|uniprotkb:Q4W4Y2|uniprotkb:Q8WYZ3|uniprotkb:Q9NWR2|ensembl:ENSP00000300086 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 psi-mi:te2ip_human(display_long)|uniprotkb:DRIP5(gene name synonym)|uniprotkb:TERF2IP(gene name)|psi-mi:TERF2IP(display_short)|uniprotkb:RAP1(gene name synonym)|uniprotkb:PP8000(orf name)|uniprotkb:Dopamine receptor-interacting protein 5(gene name synonym)|uniprotkb:Repressor/activator protein 1 homolog(gene name synonym) psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8789527|imex:IM-22139-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000300086(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000166848(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016604"(nuclear body)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|refseq:NP_061848.2|dip:DIP-34868N|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR001357(BRCT)|interpro:IPR009057(Homeodomain-like)|interpro:IPR015010(Rap1 Myb)|interpro:IPR021661|interpro:IPR036420|interpro:IPR038104|interpro:IPR039595|mint:Q9NYB0|rcsb pdb:1FEX|rcsb pdb:3K6G|rcsb pdb:4RQI|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095 refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus) - - figure legend:Figure 3 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2013/10/04 2014/10/16 rogid:rH6GKcTfjxpXw0MAcOHQk29nz+09606 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 intact-crc:EE31A86FE9D6A9DF|rigid:V3Hgsfaj6MI9x10BeuLXbXZcIlg false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q96AP0 uniprotkb:Q9H668 intact:EBI-717666|uniprotkb:Q562H5|uniprotkb:Q9H8F9|uniprotkb:A0A0C4DGT6|ensembl:ENSP00000478084 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 psi-mi:acd_human(display_long)|uniprotkb:POT1 and TIN2-interacting protein(gene name synonym)|uniprotkb:ACD(gene name)|psi-mi:ACD(display_short)|uniprotkb:PIP1(gene name synonym)|uniprotkb:PTOP(gene name synonym)|uniprotkb:TINT1(gene name synonym)|uniprotkb:TPP1(gene name synonym) psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8788092|imex:IM-22139-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001075955.1|refseq:NP_001075956.1|refseq:NP_075065.2|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|rcsb pdb:2I46|rcsb pdb:5H65|rcsb pdb:5I2X|rcsb pdb:5I2Y|rcsb pdb:5UN7|rcsb pdb:5XYF|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|ensembl:ENSG00000102977(gene)|ensembl:ENST00000620761(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|dip:DIP-29611N refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N go:"GO:0005634"(nucleus) - - figure legend:Figure 2 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/10/04 2019/09/20 rogid:Z073GMd5V0shLNtElKVeCwr5fCA9606 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 intact-crc:16C557B5E9A429A3|rigid:P+lJ8reSXQbIC82JGZae0KaSNfU false - flag tag:?-? - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q96AP0 uniprotkb:Q9H668 intact:EBI-717666|uniprotkb:Q562H5|uniprotkb:Q9H8F9|uniprotkb:A0A0C4DGT6|ensembl:ENSP00000478084 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 psi-mi:acd_human(display_long)|uniprotkb:POT1 and TIN2-interacting protein(gene name synonym)|uniprotkb:ACD(gene name)|psi-mi:ACD(display_short)|uniprotkb:PIP1(gene name synonym)|uniprotkb:PTOP(gene name synonym)|uniprotkb:TINT1(gene name synonym)|uniprotkb:TPP1(gene name synonym) psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0809"(bimolecular fluorescence complementation) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8788514|imex:IM-22139-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001075955.1|refseq:NP_001075956.1|refseq:NP_075065.2|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|rcsb pdb:2I46|rcsb pdb:5H65|rcsb pdb:5I2X|rcsb pdb:5I2Y|rcsb pdb:5UN7|rcsb pdb:5XYF|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|ensembl:ENSG00000102977(gene)|ensembl:ENST00000620761(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|dip:DIP-29611N refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N|interpro:IPR015253(Region of unknown function DUF1879) - - - figure legend:Figure 2 E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-htc75)|taxid:9606(Homo sapiens) - 2013/10/04 2019/09/20 rogid:Z073GMd5V0shLNtElKVeCwr5fCA9606 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 intact-crc:E7C190A09178104F|rigid:P+lJ8reSXQbIC82JGZae0KaSNfU false nYFP:n-n necessary binding region:57..57-368|cYFP:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q9H668 uniprotkb:Q96AP0 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 intact:EBI-717666|uniprotkb:Q562H5|uniprotkb:Q9H8F9|uniprotkb:A0A0C4DGT6|ensembl:ENSP00000478084 psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:acd_human(display_long)|uniprotkb:POT1 and TIN2-interacting protein(gene name synonym)|uniprotkb:ACD(gene name)|psi-mi:ACD(display_short)|uniprotkb:PIP1(gene name synonym)|uniprotkb:PTOP(gene name synonym)|uniprotkb:TINT1(gene name synonym)|uniprotkb:TPP1(gene name synonym) psi-mi:"MI:0809"(bimolecular fluorescence complementation) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8788364|imex:IM-22139-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N refseq:NP_001075955.1|refseq:NP_001075956.1|refseq:NP_075065.2|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|rcsb pdb:2I46|rcsb pdb:5H65|rcsb pdb:5I2X|rcsb pdb:5I2Y|rcsb pdb:5UN7|rcsb pdb:5XYF|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|ensembl:ENSG00000102977(gene)|ensembl:ENST00000620761(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|dip:DIP-29611N - - - figure legend:Figures 2 C & D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-htc75)|taxid:9606(Homo sapiens) - 2013/10/04 2019/09/20 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 rogid:Z073GMd5V0shLNtElKVeCwr5fCA9606 intact-crc:24825666D397D770|rigid:P+lJ8reSXQbIC82JGZae0KaSNfU false nYFP:n-n necessary binding region:1-458|cYFP:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q96AP0 uniprotkb:Q9H668 intact:EBI-717666|uniprotkb:Q562H5|uniprotkb:Q9H8F9|uniprotkb:A0A0C4DGT6|ensembl:ENSP00000478084 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 psi-mi:acd_human(display_long)|uniprotkb:POT1 and TIN2-interacting protein(gene name synonym)|uniprotkb:ACD(gene name)|psi-mi:ACD(display_short)|uniprotkb:PIP1(gene name synonym)|uniprotkb:PTOP(gene name synonym)|uniprotkb:TINT1(gene name synonym)|uniprotkb:TPP1(gene name synonym) psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0809"(bimolecular fluorescence complementation) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8789117|imex:IM-22139-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001075955.1|refseq:NP_001075956.1|refseq:NP_075065.2|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|rcsb pdb:2I46|rcsb pdb:5H65|rcsb pdb:5I2X|rcsb pdb:5I2Y|rcsb pdb:5UN7|rcsb pdb:5XYF|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|ensembl:ENSG00000102977(gene)|ensembl:ENST00000620761(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|dip:DIP-29611N refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N|interpro:IPR015253(Region of unknown function DUF1879) go:"GO:0005634"(nucleus) - - figure legend:Figure 2 F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2013/10/04 2019/09/20 rogid:Z073GMd5V0shLNtElKVeCwr5fCA9606 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 intact-crc:2530B1BC1DE90326|rigid:P+lJ8reSXQbIC82JGZae0KaSNfU false nYFP:n-n cYFP:c-c|necessary binding region:156..156-368 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q15554 uniprotkb:Q9H668 intact:EBI-706637|ensembl:ENSP00000254942|intact:EBI-706651 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 psi-mi:terf2_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)|uniprotkb:TERF2(gene name)|psi-mi:TERF2(display_short)|uniprotkb:TRF2(gene name synonym)|uniprotkb:TRBF2(gene name synonym) psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9009294|imex:IM-22139-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0090398"(cellular senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1903824"(negative regulation of telomere single strand break repair)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0032205"(negative regulation of telomere maintenance)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|ensembl:ENSG00000132604(gene)|ensembl:ENST00000254942(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:Q15554|rcsb pdb:1H6P|rcsb pdb:1VF9|rcsb pdb:1VFC|rcsb pdb:1W0U|rcsb pdb:1XG1|rcsb pdb:3BU8|rcsb pdb:3BUA|rcsb pdb:3K6G|rcsb pdb:3SJM|rcsb pdb:4M7C|rcsb pdb:4RQI|rcsb pdb:5WQD|rcsb pdb:5XYF|rcsb pdb:6J67|rcsb pdb:7C5D|reactome:R-HSA-110328|reactome:R-HSA-110329|go:"GO:1904354"(negative regulation of telomere capping)|refseq:NP_005643.2|dip:DIP-34052N refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N go:"GO:0005634"(nucleus)|go:"GO:0000781"(chromosome, telomeric region) - - figure legend:Figure 3 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-htc75)|taxid:9606(Homo sapiens) - 2013/10/04 2014/10/16 rogid:MzPf3uCpzJzkIKvgaP0Xro7xnHo9606 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 intact-crc:0F7342D21D1F3F46|rigid:DDiWLL/ze9ihmsK8ktzh0tWJlDg false - necessary binding region:156..156-368|flag tag:?-? - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1201"(anti-tag immunocytochemistry) uniprotkb:Q9H668 intact:EBI-9009305 intact:EBI-746930|uniprotkb:Q5TCZ0|uniprotkb:D3DR99|ensembl:ENSP00000224950|ensembl:ENSP00000358779 - psi-mi:stn1_human(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:OBFC1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:telg31(display_short)|psi-mi:EBI-9009305(display_long) psi-mi:"MI:0412"(electrophoretic mobility supershift assay) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9009333|imex:IM-22139-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) refseq:XP_006718039.1|refseq:NP_079204.2|ensembl:ENSG00000107960(gene)|ensembl:ENST00000224950(transcript)|ensembl:ENST00000369764(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082|rcsb pdb:4JOI|rcsb pdb:4JQF|rcsb pdb:6W6W|reactome:R-HSA-174411|reactome:R-HSA-174430|refseq:XP_016872158.1|refseq:XP_016872159.1|dip:DIP-59914N|interpro:IPR015253(Region of unknown function DUF1879) - go:"GO:0005634"(nucleus) - - figure legend:Figure 3 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/04 2014/10/16 rogid:bcmazDHRYRmgdk1waIzSspUjupY9606 - intact-crc:2DC5B43E89C308E1 false glutathione s tranferase tag:?-? 32p radiolabel:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q5EE38 uniprotkb:Q8K2X3 intact:EBI-6258642|ensembl:ENSMUSP00000048180|uniprotkb:Q3TBB1|uniprotkb:Q3TUR7|uniprotkb:Q3UKL6|uniprotkb:Q3V3Y1|uniprotkb:Q99KF8 intact:EBI-2553883|uniprotkb:Q8C6I6|uniprotkb:Q3TPH0|ensembl:ENSMUSP00000040944 psi-mi:acd_mouse(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short) psi-mi:stn1_mouse(display_long)|uniprotkb:Stn1(gene name)|psi-mi:Stn1(display_short)|uniprotkb:Alpha-accessory factor of 44 kDa(gene name synonym)|uniprotkb:Obfc1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9009354|imex:IM-22139-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:XP_011246737.1|refseq:XP_006531237.1|refseq:XP_006531238.1|refseq:XP_006531239.1|refseq:NP_001012656.1|refseq:NP_001335278.1|refseq:XP_017168377.1|dip:DIP-29612N refseq:NP_780569.1|ensembl:ENSMUSG00000042694(gene)|ensembl:ENSMUST00000049369(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|rcsb pdb:1WJ5|go:"GO:0043047"(single-stranded telomeric DNA binding)|reactome:R-MMU-174411|reactome:R-MMU-174430|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082 go:"GO:0005634"(nucleus) - - figure legend:Figure 2 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/04 2014/10/16 rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090 rogid:N2QA+Bs0g8hsUHFMHX+eGDr8H1o10090 intact-crc:AC1F8D269D89F0D7|rigid:ep7cPhQqXk9hGm2Bsjib85gHPi4 false - - - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q5EE38 uniprotkb:Q91WC1 intact:EBI-6258642|ensembl:ENSMUSP00000048180|uniprotkb:Q3TBB1|uniprotkb:Q3TUR7|uniprotkb:Q3UKL6|uniprotkb:Q3V3Y1|uniprotkb:Q99KF8 intact:EBI-7051001|ensembl:ENSMUSP00000110986|ensembl:ENSMUSP00000131928|uniprotkb:Q8BUH9|intact:MINT-3379580 psi-mi:acd_mouse(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short) psi-mi:pote1_mouse(display_long)|uniprotkb:Pot1(gene name)|psi-mi:Pot1(display_short)|uniprotkb:Pot1a(gene name synonym)|uniprotkb:POT1-like telomere end-binding protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8787999|imex:IM-22139-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:XP_011246737.1|refseq:XP_006531237.1|refseq:XP_006531238.1|refseq:XP_006531239.1|refseq:NP_001012656.1|refseq:NP_001335278.1|refseq:XP_017168377.1|dip:DIP-29612N ensembl:ENSMUSG00000029676(gene)|ensembl:ENSMUST00000115330(transcript)|ensembl:ENSMUST00000166445(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0032202"(telomere assembly)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051276"(chromosome organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060383"(positive regulation of DNA strand elongation)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1905774"(regulation of DNA helicase activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:1905776"(positive regulation of DNA helicase activity)|go:"GO:1990955"(G-rich single-stranded DNA binding)|go:"GO:2001032"(regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|mint:Q91WC1|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:NP_598692.1|dip:DIP-29608N go:"GO:0005634"(nucleus) - comment:mint|function:"Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity" figure legend:Figure 1 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/04 2014/10/16 rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090 rogid:eWtXiaGr1uIBoKk4po2tJ+EwGRc10090 intact-crc:F521F264A67B55D6|rigid:88cs0n9U8fUX3i7Llrn5ID4iNV0 false - - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q5EE38 uniprotkb:Q91VL8 intact:EBI-6258642|ensembl:ENSMUSP00000048180|uniprotkb:Q3TBB1|uniprotkb:Q3TUR7|uniprotkb:Q3UKL6|uniprotkb:Q3V3Y1|uniprotkb:Q99KF8 intact:EBI-8341040|intact:MINT-4137361|uniprotkb:Q8C2Y1|uniprotkb:Q9JJE8|uniprotkb:Q9JJE9|uniprotkb:D3YWE8|uniprotkb:Q543F4|ensembl:ENSMUSP00000052170 psi-mi:acd_mouse(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short) psi-mi:te2ip_mouse(display_long)|uniprotkb:Terf2ip(gene name)|psi-mi:Terf2ip(display_short)|uniprotkb:Rap1(gene name synonym)|uniprotkb:Repressor/activator protein 1 homolog(gene name synonym)|uniprotkb:MNCb-0448(orf name)|uniprotkb:MNCb-0628(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8787999|imex:IM-22139-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:XP_011246737.1|refseq:XP_006531237.1|refseq:XP_006531238.1|refseq:XP_006531239.1|refseq:NP_001012656.1|refseq:NP_001335278.1|refseq:XP_017168377.1|dip:DIP-29612N refseq:NP_065609.2|ensembl:ENSMUSG00000033430(gene)|ensembl:ENSMUST00000052138(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016604"(nuclear body)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR001357(BRCT)|interpro:IPR009057(Homeodomain-like)|interpro:IPR015010(Rap1 Myb)|interpro:IPR021661|interpro:IPR036420|interpro:IPR039595|mint:Q91VL8|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095 go:"GO:0005634"(nucleus) - comment:mint|function:May play a role in telomere length regulation figure legend:Figure 1 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/04 2014/10/16 rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090 rogid:CC9B4VdqYwE5YntQ1GBAGJ9lzvI10090 intact-crc:F521F264A67B55D6|rigid:88cs0n9U8fUX3i7Llrn5ID4iNV0 false - - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q5EE38 uniprotkb:Q9QXG9 intact:EBI-6258642|ensembl:ENSMUSP00000048180|uniprotkb:Q3TBB1|uniprotkb:Q3TUR7|uniprotkb:Q3UKL6|uniprotkb:Q3V3Y1|uniprotkb:Q99KF8 intact:EBI-8788053|uniprotkb:E9Q126 psi-mi:acd_mouse(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short) psi-mi:tinf2_mouse(display_long)|uniprotkb:Tinf2(gene name)|psi-mi:Tinf2(display_short)|uniprotkb:Tin2(gene name synonym)|uniprotkb:TRF1-interacting nuclear protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8787999|imex:IM-22139-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:XP_011246737.1|refseq:XP_006531237.1|refseq:XP_006531238.1|refseq:XP_006531239.1|refseq:NP_001012656.1|refseq:NP_001335278.1|refseq:XP_017168377.1|dip:DIP-29612N interpro:IPR039098|interpro:IPR029400|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0010370"(perinucleolar chromocenter)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0032202"(telomere assembly)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:1904356"(regulation of telomere maintenance via telomere lengthening)|go:"GO:0005654"(nucleoplasm)|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-2559586|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-9670095 go:"GO:0005634"(nucleus) - - figure legend:Figure 1 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/04 2014/10/16 rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090 rogid:IA6cSZz0XzqX19fQDXcO/ZR419U10090 intact-crc:F521F264A67B55D6|rigid:88cs0n9U8fUX3i7Llrn5ID4iNV0 false - - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q5EE38 uniprotkb:Q8K2X3 intact:EBI-6258642|ensembl:ENSMUSP00000048180|uniprotkb:Q3TBB1|uniprotkb:Q3TUR7|uniprotkb:Q3UKL6|uniprotkb:Q3V3Y1|uniprotkb:Q99KF8 intact:EBI-2553883|uniprotkb:Q8C6I6|uniprotkb:Q3TPH0|ensembl:ENSMUSP00000040944 psi-mi:acd_mouse(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short) psi-mi:stn1_mouse(display_long)|uniprotkb:Stn1(gene name)|psi-mi:Stn1(display_short)|uniprotkb:Alpha-accessory factor of 44 kDa(gene name synonym)|uniprotkb:Obfc1(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 1(gene name synonym)|uniprotkb:Suppressor of cdc thirteen homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8787999|imex:IM-22139-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:XP_011246737.1|refseq:XP_006531237.1|refseq:XP_006531238.1|refseq:XP_006531239.1|refseq:NP_001012656.1|refseq:NP_001335278.1|refseq:XP_017168377.1|dip:DIP-29612N refseq:NP_780569.1|ensembl:ENSMUSG00000042694(gene)|ensembl:ENSMUST00000049369(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|rcsb pdb:1WJ5|go:"GO:0043047"(single-stranded telomeric DNA binding)|reactome:R-MMU-174411|reactome:R-MMU-174430|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:1990879"(CST complex)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014647(Uncharacterised protein with OB-fold)|interpro:IPR015253(Region of unknown function DUF1879)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|interpro:IPR042082 go:"GO:0005634"(nucleus) - - figure legend:Figure 1 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/04 2014/10/16 rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090 rogid:N2QA+Bs0g8hsUHFMHX+eGDr8H1o10090 intact-crc:F521F264A67B55D6|rigid:88cs0n9U8fUX3i7Llrn5ID4iNV0 false - - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q5EE38 uniprotkb:O35144 intact:EBI-6258642|ensembl:ENSMUSP00000048180|uniprotkb:Q3TBB1|uniprotkb:Q3TUR7|uniprotkb:Q3UKL6|uniprotkb:Q3V3Y1|uniprotkb:Q99KF8 intact:EBI-6919263|ensembl:ENSMUSP00000068948|uniprotkb:D3YVG5|uniprotkb:Q80VE2|uniprotkb:Q8BQJ9 psi-mi:acd_mouse(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short) psi-mi:terf2_mouse(display_long)|uniprotkb:Terf2(gene name)|psi-mi:Terf2(display_short)|uniprotkb:Trf2(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8787999|imex:IM-22139-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:XP_011246737.1|refseq:XP_006531237.1|refseq:XP_006531238.1|refseq:XP_006531239.1|refseq:NP_001012656.1|refseq:NP_001335278.1|refseq:XP_017168377.1|dip:DIP-29612N refseq:NP_001273129.1|refseq:XP_006530899.1|ensembl:ENSMUSG00000031921(gene)|ensembl:ENSMUST00000068421(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:O35144|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001076587.1 go:"GO:0005634"(nucleus) - - figure legend:Figure 1 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/04 2014/10/16 rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090 rogid:m2J9ZCnP5jMyGlT41WK3HqacWvA10090 intact-crc:F521F264A67B55D6|rigid:88cs0n9U8fUX3i7Llrn5ID4iNV0 false - - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q5EE38 uniprotkb:P70371 intact:EBI-6258642|ensembl:ENSMUSP00000048180|uniprotkb:Q3TBB1|uniprotkb:Q3TUR7|uniprotkb:Q3UKL6|uniprotkb:Q3V3Y1|uniprotkb:Q99KF8 intact:EBI-6919183|ensembl:ENSMUSP00000140744|uniprotkb:Q9CY71 psi-mi:acd_mouse(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short) psi-mi:terf1_mouse(display_long)|uniprotkb:Terf1(gene name)|psi-mi:Terf1(display_short)|uniprotkb:Trf1(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wan et al. (2009) pubmed:19648609|imex:IM-22139 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8787999|imex:IM-22139-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:XP_011246737.1|refseq:XP_006531237.1|refseq:XP_006531238.1|refseq:XP_006531239.1|refseq:NP_001012656.1|refseq:NP_001335278.1|refseq:XP_017168377.1|dip:DIP-29612N ensembl:ENSMUSG00000025925(gene)|ensembl:ENSMUST00000188371(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0051301"(cell division)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P70371|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|reactome:R-MMU-9670095|refseq:NP_033378.1|dip:DIP-44231N go:"GO:0005634"(nucleus) - - figure legend:Figure 1 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/04 2014/10/16 rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090 rogid:jpK0DXdrNcuBqR96dkp45t/W5+M10090 intact-crc:F521F264A67B55D6|rigid:88cs0n9U8fUX3i7Llrn5ID4iNV0 false - - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)