#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03004	uniprotkb:P66817	intact:EBI-548951|uniprotkb:P78122|uniprotkb:Q2M814|ensemblbacteria:AAC76725|ensemblbacteria:BAE77592	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	psi-mi:dnaa_ecoli(display_long)|uniprotkb:dnaA(gene name)|psi-mi:dnaA(display_short)|uniprotkb:b3702(locus name)|uniprotkb:JW3679(locus name)	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Keyamura et al. (2009)	pubmed:19632993|imex:IM-18690	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6552072|imex:IM-18690-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418157.1|refseq:WP_000059111.1|dip:DIP-9455N|ensemblbacteria:AAC76725(transcript)|ensemblbacteria:b3702(gene)|ensemblbacteria:BAE77592(gene)|ensemblbacteria:BAE77592(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010921(Trp repressor/replication initiator)|interpro:IPR013159(Chromosomal replication initiator, DnaA C-terminal)|interpro:IPR013317(Chromosomal replication initiator, DnaA)|interpro:IPR018312|interpro:IPR020591|interpro:IPR024633|interpro:IPR027417|interpro:IPR038454|rcsb pdb:1J1V|rcsb pdb:2E0G|interpro:IPR001957(Bacterial chromosomal replication initiator protein, DnaA)	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	-	-	-	figure legend:Fig. 1a-d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/26	2014/10/16	rogid:p07cXpfl7bzSh/kImTD/+Zr0Ma883333	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	intact-crc:4FB3FE43E42A2579|rigid:XFN1kY4F7YYXj4Y4eg5HFv6KiRs	false	sufficient binding region:1-108|15n label:?-?	mutation:72-72	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03004	uniprotkb:P66817	intact:EBI-548951|uniprotkb:P78122|uniprotkb:Q2M814|ensemblbacteria:AAC76725|ensemblbacteria:BAE77592	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	psi-mi:dnaa_ecoli(display_long)|uniprotkb:dnaA(gene name)|psi-mi:dnaA(display_short)|uniprotkb:b3702(locus name)|uniprotkb:JW3679(locus name)	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Keyamura et al. (2009)	pubmed:19632993|imex:IM-18690	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6552171|imex:IM-18690-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418157.1|refseq:WP_000059111.1|dip:DIP-9455N|ensemblbacteria:AAC76725(transcript)|ensemblbacteria:b3702(gene)|ensemblbacteria:BAE77592(gene)|ensemblbacteria:BAE77592(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010921(Trp repressor/replication initiator)|interpro:IPR013159(Chromosomal replication initiator, DnaA C-terminal)|interpro:IPR013317(Chromosomal replication initiator, DnaA)|interpro:IPR018312|interpro:IPR020591|interpro:IPR024633|interpro:IPR027417|interpro:IPR038454|rcsb pdb:1J1V|rcsb pdb:2E0G|interpro:IPR001957(Bacterial chromosomal replication initiator protein, DnaA)	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	-	-	-	figure legend:Fig. 2a-b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/26	2014/10/16	rogid:p07cXpfl7bzSh/kImTD/+Zr0Ma883333	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	intact-crc:2745C548E5BA83A5|rigid:XFN1kY4F7YYXj4Y4eg5HFv6KiRs	false	mutation disrupting interaction:46-46|mutation decreasing interaction:21-21	his tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:16761"	uniprotkb:P03004	intact:EBI-1188073	intact:EBI-548951|uniprotkb:P78122|uniprotkb:Q2M814|ensemblbacteria:AAC76725|ensemblbacteria:BAE77592	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:dnaa_ecoli(display_long)|uniprotkb:dnaA(gene name)|psi-mi:dnaA(display_short)|uniprotkb:b3702(locus name)|uniprotkb:JW3679(locus name)	psi-mi:"MI:0928"(filter trap assay)	Keyamura et al. (2009)	pubmed:19632993|imex:IM-18690	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6552329|imex:IM-18690-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_418157.1|refseq:WP_000059111.1|dip:DIP-9455N|ensemblbacteria:AAC76725(transcript)|ensemblbacteria:b3702(gene)|ensemblbacteria:BAE77592(gene)|ensemblbacteria:BAE77592(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010921(Trp repressor/replication initiator)|interpro:IPR013159(Chromosomal replication initiator, DnaA C-terminal)|interpro:IPR013317(Chromosomal replication initiator, DnaA)|interpro:IPR018312|interpro:IPR020591|interpro:IPR024633|interpro:IPR027417|interpro:IPR038454|rcsb pdb:1J1V|rcsb pdb:2E0G|interpro:IPR001957(Bacterial chromosomal replication initiator protein, DnaA)	go:"GO:0043531"(ADP binding)	-	-	figure legend:Fig. 2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.1x10^-8(molar)	2013/02/26	2014/10/16	-	rogid:p07cXpfl7bzSh/kImTD/+Zr0Ma883333	intact-crc:563AB59B36A389C0	false	-	mutation:46-46	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15422"	uniprotkb:P03004	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-548951|uniprotkb:P78122|uniprotkb:Q2M814|ensemblbacteria:AAC76725|ensemblbacteria:BAE77592	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:dnaa_ecoli(display_long)|uniprotkb:dnaA(gene name)|psi-mi:dnaA(display_short)|uniprotkb:b3702(locus name)|uniprotkb:JW3679(locus name)	psi-mi:"MI:0928"(filter trap assay)	Keyamura et al. (2009)	pubmed:19632993|imex:IM-18690	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6552216|imex:IM-18690-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_418157.1|refseq:WP_000059111.1|dip:DIP-9455N|ensemblbacteria:AAC76725(transcript)|ensemblbacteria:b3702(gene)|ensemblbacteria:BAE77592(gene)|ensemblbacteria:BAE77592(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010921(Trp repressor/replication initiator)|interpro:IPR013159(Chromosomal replication initiator, DnaA C-terminal)|interpro:IPR013317(Chromosomal replication initiator, DnaA)|interpro:IPR018312|interpro:IPR020591|interpro:IPR024633|interpro:IPR027417|interpro:IPR038454|rcsb pdb:1J1V|rcsb pdb:2E0G|interpro:IPR001957(Bacterial chromosomal replication initiator protein, DnaA)	go:"GO:0005524"(ATP binding)	-	-	figure legend:Fig. 2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.5x10^-8(molar)	2013/02/26	2014/10/16	-	rogid:p07cXpfl7bzSh/kImTD/+Zr0Ma883333	intact-crc:F5F89B1F2C452867	false	-	mutation:46-46	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)