#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P29590-8 uniprotkb:O14746 intact:EBI-6692454|ensembl:ENSP00000268059 intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572 psi-mi:p29590-8(display_long)|uniprotkb:PML-II(isoform synonym)|uniprotkb:TRIM19kappa(isoform synonym)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym) psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Oh et al. (2009) pubmed:19567472|imex:IM-22113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8761614 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140464(gene)|ensembl:ENST00000268059(transcript)|intact:EBI-295890(isoform-parent) refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ intact:EBI-8763377(see-also) - - figure legend:Figure 2 C|negative:The interaction does not occur under these experimental conditions.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma) - 2013/09/13 2014/10/16 rogid:9wX6YVhiy58Q92O5eYXFEJQRwQ89606 rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606 intact-crc:AD5AA5DBFB3FD577|rigid:5nGwyxbcq4OAGeDGO3RY0su0P7o true flag tag:?-? ha tag:?-? - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:P29590-9 uniprotkb:O14746 intact:EBI-6861318|ensembl:ENSP00000455612 intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572 psi-mi:p29590-9(display_long)|uniprotkb:PML-III(isoform synonym)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym) psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Oh et al. (2009) pubmed:19567472|imex:IM-22113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8761626 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140464(gene)|ensembl:ENST00000569477(transcript)|intact:EBI-295890(isoform-parent) refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ intact:EBI-8763377(see-also) - - figure legend:Figure 2 C|negative:The interaction does not occur under these experimental conditions.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma) - 2013/09/13 2014/10/16 rogid:9aXmsurp88slsomTzxBdfrfEomw9606 rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606 intact-crc:E02BA5DBFB3F8988|rigid:uwjeQpS1O343paI9C5OYDn5jyzw true flag tag:?-? ha tag:?-? - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:P29590-1 uniprotkb:O14746 intact:EBI-303992|ensembl:ENSP00000268058 intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572 psi-mi:p29590-1(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-I(isoform synonym)|uniprotkb:TRIM19alpha(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym) psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Oh et al. (2009) pubmed:19567472|imex:IM-22113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8761618 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000268058(transcript) refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ intact:EBI-8763377(see-also) - - figure legend:Figure 2 C|negative:The interaction does not occur under these experimental conditions.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma) - 2013/09/13 2014/10/16 rogid:FdAh5Rbyu37luTScMzCopbbwXvk9606 rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606 intact-crc:5BA3A5DBFB3D6E73|rigid:0lNnIRL8KZ78Qw1gKkcmapT5mOE true flag tag:?-? ha tag:?-? - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:P29590-2 uniprotkb:O14746 intact:EBI-303996|ensembl:ENSP00000395576 intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572 psi-mi:p29590-2(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-2(isoform synonym)|uniprotkb:PML-V(isoform synonym)|uniprotkb:TRIM19beta(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym) psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Oh et al. (2009) pubmed:19567472|imex:IM-22113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8761622 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000435786(transcript)|uniprotkb:P29590-2(isoform-parent) refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ intact:EBI-8763377(see-also) isoform-comment:"Ref.5 (AAG50181) sequence is in conflict in position: 578:P->A. Contains a phosphoserine at position 565." - figure legend:Figure 2 C|negative:The interaction does not occur under these experimental conditions.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma) - 2013/09/13 2014/10/16 rogid:+fRuye0ANEW1KaFIUBFhHCMymZ09606 rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606 intact-crc:8C30A5DBFB3D8B72|rigid:5CY+zOgcrxHmGoavB1DhPQ8Zmis true flag tag:?-? ha tag:?-? - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:P29590-4 uniprotkb:O14746 intact:EBI-304004|ensembl:ENSP00000394642|ensembl:ENSP00000456486 intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572 psi-mi:p29590-4(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-3B(isoform synonym)|uniprotkb:PML-VI(isoform synonym)|uniprotkb:TRIM19epsilon(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym) psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Oh et al. (2009) pubmed:19567472|imex:IM-22113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8761630 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000436891(transcript)|ensembl:ENST00000569965(transcript) refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ intact:EBI-8763377(see-also) isoform-comment:Contains a phosphoserine at position 518. Contains a phosphoserine at position 527. Contains a phosphoserine at position 530. - figure legend:Figure 2 C|negative:The interaction does not occur under these experimental conditions.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma) - 2013/09/13 2014/10/16 rogid:7Qv+/MeEQm0nHBnZdudPQApmaQk9606 rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606 intact-crc:9316A5DBFB3C4171|rigid:QeV7Dm2yZEHtHG4CYMyvoddI8mU true flag tag:?-? ha tag:?-? - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:P29590-1 uniprotkb:O14746 intact:EBI-303992|ensembl:ENSP00000268058 intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572 psi-mi:p29590-1(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-I(isoform synonym)|uniprotkb:TRIM19alpha(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym) psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Oh et al. (2009) pubmed:19567472|imex:IM-22113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8761261 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000268058(transcript) refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ intact:EBI-8761199(see-also) - - figure legend:Figure 2 B|negative:The interaction does not occur under these experimental conditions.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/13 2014/10/16 rogid:FdAh5Rbyu37luTScMzCopbbwXvk9606 rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606 intact-crc:1DB8780C2F000482|rigid:0lNnIRL8KZ78Qw1gKkcmapT5mOE true flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P29590-8 uniprotkb:O14746 intact:EBI-6692454|ensembl:ENSP00000268059 intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572 psi-mi:p29590-8(display_long)|uniprotkb:PML-II(isoform synonym)|uniprotkb:TRIM19kappa(isoform synonym)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym) psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Oh et al. (2009) pubmed:19567472|imex:IM-22113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8761574 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140464(gene)|ensembl:ENST00000268059(transcript)|intact:EBI-295890(isoform-parent) refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ intact:EBI-8761199(see-also) - - figure legend:Figure 2 B|negative:The interaction does not occur under these experimental conditions.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/13 2014/10/16 rogid:9wX6YVhiy58Q92O5eYXFEJQRwQ89606 rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606 intact-crc:124787F3D0FC893F|rigid:5nGwyxbcq4OAGeDGO3RY0su0P7o true flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O14746 uniprotkb:P29590-2 intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572 intact:EBI-303996|ensembl:ENSP00000395576 psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym) psi-mi:p29590-2(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-2(isoform synonym)|uniprotkb:PML-V(isoform synonym)|uniprotkb:TRIM19beta(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Oh et al. (2009) pubmed:19567472|imex:IM-22113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8761476 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000435786(transcript)|uniprotkb:P29590-2(isoform-parent) intact:EBI-8761199(see-also) - isoform-comment:"Ref.5 (AAG50181) sequence is in conflict in position: 578:P->A. Contains a phosphoserine at position 565." figure legend:Figure 2 B|negative:The interaction does not occur under these experimental conditions.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/13 2014/10/16 rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606 rogid:+fRuye0ANEW1KaFIUBFhHCMymZ09606 intact-crc:EFF15C9E662430D0|rigid:5CY+zOgcrxHmGoavB1DhPQ8Zmis true ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P29590-9 uniprotkb:O14746 intact:EBI-6861318|ensembl:ENSP00000455612 intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572 psi-mi:p29590-9(display_long)|uniprotkb:PML-III(isoform synonym)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym) psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Oh et al. (2009) pubmed:19567472|imex:IM-22113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8761436 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140464(gene)|ensembl:ENST00000569477(transcript)|intact:EBI-295890(isoform-parent) refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ intact:EBI-8761199(see-also) - - figure legend:Figure 2 B|negative:The interaction does not occur under these experimental conditions.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/13 2014/10/16 rogid:9aXmsurp88slsomTzxBdfrfEomw9606 rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606 intact-crc:43809B8217E09AF1|rigid:uwjeQpS1O343paI9C5OYDn5jyzw true flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P29590-4 uniprotkb:O14746 intact:EBI-304004|ensembl:ENSP00000394642|ensembl:ENSP00000456486 intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572 psi-mi:p29590-4(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-3B(isoform synonym)|uniprotkb:PML-VI(isoform synonym)|uniprotkb:TRIM19epsilon(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym) psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Oh et al. (2009) pubmed:19567472|imex:IM-22113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8761456 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000436891(transcript)|ensembl:ENST00000569965(transcript) refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ intact:EBI-8761199(see-also) isoform-comment:Contains a phosphoserine at position 518. Contains a phosphoserine at position 527. Contains a phosphoserine at position 530. - figure legend:Figure 2 B|negative:The interaction does not occur under these experimental conditions.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/13 2014/10/16 rogid:7Qv+/MeEQm0nHBnZdudPQApmaQk9606 rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606 intact-crc:BB6315BAF46C5875|rigid:QeV7Dm2yZEHtHG4CYMyvoddI8mU true flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)