#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BYX4 uniprotkb:Q997F2 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 intact:EBI-6147833|uniprotkb:Q8QU01 psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:v_nipav(display_long)|uniprotkb:P/V/C(gene name)|psi-mi:P/V/C(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:121791(nipav)|taxid:121791(Nipah virus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599205 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 mint:Q997F2|interpro:IPR024279|refseq:NP_112023.1|interpro:IPR025909|interpro:IPR035430|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding) - - - figure legend:3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 rogid:91tF+j3UAen7MFN3EfWx+YffknI121791 intact-crc:7A44D3E2E7058F14|rigid:23qblO1rjuC9YdHL/y4N51pBXak false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P11207 uniprotkb:Q9BYX4 intact:EBI-6148694 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599289 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 - - - figure legend:3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 intact-crc:EA89E3825DBF2B07|rigid:plT166ORYovX+dMGu5ZJJa8sotw false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9EMA9 uniprotkb:Q9BYX4 intact:EBI-6598728 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 psi-mi:v_mease(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:11235(mease)|taxid:11235("Measles virus (strain Edmonston)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6598743 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR028243 refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 - - - figure legend:1B-E, , 2A and B. 3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:JVHryKwyX6b3pfBTW9YkX6Jgodk11235 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 intact-crc:25B3A6F1206DD4AD|rigid:zV/WMwgwKsCtq4ezGaNc8TOpgOs false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P19847 uniprotkb:Q96C10 intact:EBI-6599148 intact:EBI-744193|uniprotkb:Q9HAM6|ensembl:ENSP00000251642 psi-mi:v_pi2h(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:dhx58_human(display_long)|uniprotkb:Probable ATP-dependent helicase LGP2(gene name synonym)|uniprotkb:Protein D11Lgp2 homolog(gene name synonym)|uniprotkb:DHX58(gene name)|psi-mi:DHX58(display_short)|uniprotkb:D11LGP2E(gene name synonym)|uniprotkb:LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:2560525(pi2h)|taxid:2560525(human-parainfluenza-2-virus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599054 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909 refseq:NP_077024.2|ensembl:ENSG00000108771(gene)|ensembl:ENST00000251642(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQA|rcsb pdb:2W4R|rcsb pdb:3EQT|reactome:R-HSA-168928|go:"GO:0045824"(negative regulation of innate immune response)|refseq:XP_016880548.1|refseq:XP_016880549.1|dip:DIP-60792N - - - figure legend:3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2021/04/27 rogid:Vzjud4s5pMjEBzdOtx4W6wFIqAo2560525 rogid:CSy2ThXaTTCmqGNqf8LrJvUXIBA9606 intact-crc:0200F4B21AB644F8|rigid:R3OeCj8AOxsYIt9zBW+hPCBm+2s false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O55777 uniprotkb:Q9BYX4 intact:EBI-6150653 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 psi-mi:v_hendh(display_long)|uniprotkb:P/V/C(gene name)|psi-mi:P/V/C(display_short) psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:928303(hendh)|taxid:928303("Hendra virus (isolate Horse/Autralia/Hendra/1994)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599201 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR024279|refseq:NP_047108.1|interpro:IPR025909|interpro:IPR035430|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding) refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 - - - figure legend:3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:cygnm+WurCfFkldzbOmiGHXlsI4928303 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 intact-crc:1CF23A02548E5723|rigid:CR13BG5f728Em7/ZXOk+OZruEZ0 false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P11207 uniprotkb:Q96C10 intact:EBI-6148694 intact:EBI-744193|uniprotkb:Q9HAM6|ensembl:ENSP00000251642 psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:dhx58_human(display_long)|uniprotkb:Probable ATP-dependent helicase LGP2(gene name synonym)|uniprotkb:Protein D11Lgp2 homolog(gene name synonym)|uniprotkb:DHX58(gene name)|psi-mi:DHX58(display_short)|uniprotkb:D11LGP2E(gene name synonym)|uniprotkb:LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599293 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L refseq:NP_077024.2|ensembl:ENSG00000108771(gene)|ensembl:ENST00000251642(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQA|rcsb pdb:2W4R|rcsb pdb:3EQT|reactome:R-HSA-168928|go:"GO:0045824"(negative regulation of innate immune response)|refseq:XP_016880548.1|refseq:XP_016880549.1|dip:DIP-60792N - - - figure legend:3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rogid:CSy2ThXaTTCmqGNqf8LrJvUXIBA9606 intact-crc:E9364EB95E17E354|rigid:/pDIZvXvJjADIZqfH8ZuNcMNXlo false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9BYX4 uniprotkb:P30927 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 intact:EBI-6599165 psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:v_mumpe(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short)|uniprotkb:Non-structural protein NS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11167(mumpe)|taxid:11167("Mumps virus (strain Enders)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599196 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279 - - - figure legend:3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 rogid:+0pjcLGk1qVw+UKaGbv3g8dXVfs11167 intact-crc:E96A405CCF4375CA|rigid:d+eSunGYiYn6MF/Yts5oCXYS3Cw false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9EMA9 uniprotkb:Q96C10 intact:EBI-6598728 intact:EBI-744193|uniprotkb:Q9HAM6|ensembl:ENSP00000251642 psi-mi:v_mease(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:dhx58_human(display_long)|uniprotkb:Probable ATP-dependent helicase LGP2(gene name synonym)|uniprotkb:Protein D11Lgp2 homolog(gene name synonym)|uniprotkb:DHX58(gene name)|psi-mi:DHX58(display_short)|uniprotkb:D11LGP2E(gene name synonym)|uniprotkb:LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:11235(mease)|taxid:11235("Measles virus (strain Edmonston)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6598739 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR028243 refseq:NP_077024.2|ensembl:ENSG00000108771(gene)|ensembl:ENST00000251642(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQA|rcsb pdb:2W4R|rcsb pdb:3EQT|reactome:R-HSA-168928|go:"GO:0045824"(negative regulation of innate immune response)|refseq:XP_016880548.1|refseq:XP_016880549.1|dip:DIP-60792N - - - figure legend:1B, 2A and B, 3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:JVHryKwyX6b3pfBTW9YkX6Jgodk11235 rogid:CSy2ThXaTTCmqGNqf8LrJvUXIBA9606 intact-crc:2E8B961DAD480C9C|rigid:9CbjZcM7xWw1NtaSrcGGMOa8X+M false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P19847 uniprotkb:Q9BYX4 intact:EBI-6599148 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 psi-mi:v_pi2h(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:2560525(pi2h)|taxid:2560525(human-parainfluenza-2-virus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599192 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909 refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 - - - figure legend:3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2021/04/27 rogid:Vzjud4s5pMjEBzdOtx4W6wFIqAo2560525 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 intact-crc:ACB37275EB893893|rigid:FlLjMPOoeFDgQUXBRJGI+DjKXXA false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96C10 uniprotkb:P30927 intact:EBI-744193|uniprotkb:Q9HAM6|ensembl:ENSP00000251642 intact:EBI-6599165 psi-mi:dhx58_human(display_long)|uniprotkb:Probable ATP-dependent helicase LGP2(gene name synonym)|uniprotkb:Protein D11Lgp2 homolog(gene name synonym)|uniprotkb:DHX58(gene name)|psi-mi:DHX58(display_short)|uniprotkb:D11LGP2E(gene name synonym)|uniprotkb:LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor 3(gene name synonym) psi-mi:v_mumpe(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short)|uniprotkb:Non-structural protein NS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11167(mumpe)|taxid:11167("Mumps virus (strain Enders)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599160 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077024.2|ensembl:ENSG00000108771(gene)|ensembl:ENST00000251642(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQA|rcsb pdb:2W4R|rcsb pdb:3EQT|reactome:R-HSA-168928|go:"GO:0045824"(negative regulation of innate immune response)|refseq:XP_016880548.1|refseq:XP_016880549.1|dip:DIP-60792N go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279 - - - figure legend:3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:CSy2ThXaTTCmqGNqf8LrJvUXIBA9606 rogid:+0pjcLGk1qVw+UKaGbv3g8dXVfs11167 intact-crc:47D9C69B3E7C09A1|rigid:s2TAt0OoH0qdl/VONRh6pwgbO8E false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96C10 uniprotkb:Q997F2 intact:EBI-744193|uniprotkb:Q9HAM6|ensembl:ENSP00000251642 intact:EBI-6147833|uniprotkb:Q8QU01 psi-mi:dhx58_human(display_long)|uniprotkb:Probable ATP-dependent helicase LGP2(gene name synonym)|uniprotkb:Protein D11Lgp2 homolog(gene name synonym)|uniprotkb:DHX58(gene name)|psi-mi:DHX58(display_short)|uniprotkb:D11LGP2E(gene name synonym)|uniprotkb:LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor 3(gene name synonym) psi-mi:v_nipav(display_long)|uniprotkb:P/V/C(gene name)|psi-mi:P/V/C(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:121791(nipav)|taxid:121791(Nipah virus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599188 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077024.2|ensembl:ENSG00000108771(gene)|ensembl:ENST00000251642(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQA|rcsb pdb:2W4R|rcsb pdb:3EQT|reactome:R-HSA-168928|go:"GO:0045824"(negative regulation of innate immune response)|refseq:XP_016880548.1|refseq:XP_016880549.1|dip:DIP-60792N mint:Q997F2|interpro:IPR024279|refseq:NP_112023.1|interpro:IPR025909|interpro:IPR035430|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding) - - - figure legend:3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:CSy2ThXaTTCmqGNqf8LrJvUXIBA9606 rogid:91tF+j3UAen7MFN3EfWx+YffknI121791 intact-crc:2D4E578B0077F7F5|rigid:DZntHOsBourOgxQbponjMYs39gc false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O55777 uniprotkb:Q96C10 intact:EBI-6150653 intact:EBI-744193|uniprotkb:Q9HAM6|ensembl:ENSP00000251642 psi-mi:v_hendh(display_long)|uniprotkb:P/V/C(gene name)|psi-mi:P/V/C(display_short) psi-mi:dhx58_human(display_long)|uniprotkb:Probable ATP-dependent helicase LGP2(gene name synonym)|uniprotkb:Protein D11Lgp2 homolog(gene name synonym)|uniprotkb:DHX58(gene name)|psi-mi:DHX58(display_short)|uniprotkb:D11LGP2E(gene name synonym)|uniprotkb:LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:928303(hendh)|taxid:928303("Hendra virus (isolate Horse/Autralia/Hendra/1994)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599177 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR024279|refseq:NP_047108.1|interpro:IPR025909|interpro:IPR035430|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding) refseq:NP_077024.2|ensembl:ENSG00000108771(gene)|ensembl:ENST00000251642(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQA|rcsb pdb:2W4R|rcsb pdb:3EQT|reactome:R-HSA-168928|go:"GO:0045824"(negative regulation of innate immune response)|refseq:XP_016880548.1|refseq:XP_016880549.1|dip:DIP-60792N - - - figure legend:3A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:cygnm+WurCfFkldzbOmiGHXlsI4928303 rogid:CSy2ThXaTTCmqGNqf8LrJvUXIBA9606 intact-crc:B241BCC5A5B12B48|rigid:5GDgE2aj2ewQr4n4ysyIlQAzFiA false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9EMA9 uniprotkb:Q96C10 intact:EBI-6598728 intact:EBI-744193|uniprotkb:Q9HAM6|ensembl:ENSP00000251642 psi-mi:v_mease(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:dhx58_human(display_long)|uniprotkb:Probable ATP-dependent helicase LGP2(gene name synonym)|uniprotkb:Protein D11Lgp2 homolog(gene name synonym)|uniprotkb:DHX58(gene name)|psi-mi:DHX58(display_short)|uniprotkb:D11LGP2E(gene name synonym)|uniprotkb:LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:11235(mease)|taxid:11235("Measles virus (strain Edmonston)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599225 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR028243 refseq:NP_077024.2|ensembl:ENSG00000108771(gene)|ensembl:ENST00000251642(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQA|rcsb pdb:2W4R|rcsb pdb:3EQT|reactome:R-HSA-168928|go:"GO:0045824"(negative regulation of innate immune response)|refseq:XP_016880548.1|refseq:XP_016880549.1|dip:DIP-60792N - - - figure legend:3B|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:JVHryKwyX6b3pfBTW9YkX6Jgodk11235 rogid:CSy2ThXaTTCmqGNqf8LrJvUXIBA9606 intact-crc:8F9EE07F3A9934A9|rigid:9CbjZcM7xWw1NtaSrcGGMOa8X+M false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9EMA9 uniprotkb:Q9BYX4 intact:EBI-6598728 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 psi-mi:v_mease(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:11235(mease)|taxid:11235("Measles virus (strain Edmonston)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599213 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR028243 refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 - - - figure legend:3B|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:JVHryKwyX6b3pfBTW9YkX6Jgodk11235 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 intact-crc:B6FB36BB7FF4CCB2|rigid:zV/WMwgwKsCtq4ezGaNc8TOpgOs false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96C10 uniprotkb:P30927 intact:EBI-744193|uniprotkb:Q9HAM6|ensembl:ENSP00000251642 intact:EBI-6599165 psi-mi:dhx58_human(display_long)|uniprotkb:Probable ATP-dependent helicase LGP2(gene name synonym)|uniprotkb:Protein D11Lgp2 homolog(gene name synonym)|uniprotkb:DHX58(gene name)|psi-mi:DHX58(display_short)|uniprotkb:D11LGP2E(gene name synonym)|uniprotkb:LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor 3(gene name synonym) psi-mi:v_mumpe(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short)|uniprotkb:Non-structural protein NS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11167(mumpe)|taxid:11167("Mumps virus (strain Enders)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599221 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077024.2|ensembl:ENSG00000108771(gene)|ensembl:ENST00000251642(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQA|rcsb pdb:2W4R|rcsb pdb:3EQT|reactome:R-HSA-168928|go:"GO:0045824"(negative regulation of innate immune response)|refseq:XP_016880548.1|refseq:XP_016880549.1|dip:DIP-60792N go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279 - - - figure legend:3B|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:CSy2ThXaTTCmqGNqf8LrJvUXIBA9606 rogid:+0pjcLGk1qVw+UKaGbv3g8dXVfs11167 intact-crc:B57D91D88C444E6C|rigid:s2TAt0OoH0qdl/VONRh6pwgbO8E false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P30927 uniprotkb:Q9BYX4 intact:EBI-6599165 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 psi-mi:v_mumpe(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short)|uniprotkb:Non-structural protein NS1(gene name synonym) psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:11167(mumpe)|taxid:11167("Mumps virus (strain Enders)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599217 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279 refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 - - - figure legend:3B|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:+0pjcLGk1qVw+UKaGbv3g8dXVfs11167 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 intact-crc:1BCE171F7D7B3207|rigid:d+eSunGYiYn6MF/Yts5oCXYS3Cw false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9BYX4 uniprotkb:P11207 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 intact:EBI-6148694 psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599305 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L - - - figure legend:4 and 6A|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 intact-crc:7150472081F00E54|rigid:plT166ORYovX+dMGu5ZJJa8sotw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P11207 uniprotkb:Q96C10 intact:EBI-6148694 intact:EBI-744193|uniprotkb:Q9HAM6|ensembl:ENSP00000251642 psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:dhx58_human(display_long)|uniprotkb:Probable ATP-dependent helicase LGP2(gene name synonym)|uniprotkb:Protein D11Lgp2 homolog(gene name synonym)|uniprotkb:DHX58(gene name)|psi-mi:DHX58(display_short)|uniprotkb:D11LGP2E(gene name synonym)|uniprotkb:LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor LGP2(gene name synonym)|uniprotkb:RIG-I-like receptor 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Parisien et al. (2009) pubmed:19403670 taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6599309 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L refseq:NP_077024.2|ensembl:ENSG00000108771(gene)|ensembl:ENST00000251642(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQA|rcsb pdb:2W4R|rcsb pdb:3EQT|reactome:R-HSA-168928|go:"GO:0045824"(negative regulation of innate immune response)|refseq:XP_016880548.1|refseq:XP_016880549.1|dip:DIP-60792N - - - figure legend:4 and 6B|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/04/03 2014/10/16 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rogid:CSy2ThXaTTCmqGNqf8LrJvUXIBA9606 intact-crc:2BB50F0479DBD172|rigid:/pDIZvXvJjADIZqfH8ZuNcMNXlo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)