#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00308	uniprotkb:Q01860	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	intact:EBI-475687|uniprotkb:P31359|uniprotkb:Q15167|uniprotkb:Q15168|uniprotkb:Q16422|uniprotkb:A6NCS1|uniprotkb:A6NLL8|uniprotkb:Q5STF3|uniprotkb:Q5STF4|ensembl:ENSP00000259915|ensembl:ENSP00000373016|ensembl:ENSP00000388842|ensembl:ENSP00000391681|ensembl:ENSP00000392877|ensembl:ENSP00000400047|ensembl:ENSP00000405041|uniprotkb:D2IYK4	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:po5f1_human(display_long)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:POU5F1(gene name)|psi-mi:POU5F1(display_short)|uniprotkb:OCT3(gene name synonym)|uniprotkb:OCT4(gene name synonym)|uniprotkb:OTF3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xu et al. (2009)	pubmed:19274063|imex:IM-22119	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6920467|imex:IM-22119-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	refseq:NP_001272916.1|refseq:NP_002692.2|ensembl:ENSG00000204531(gene)|ensembl:ENSG00000206454(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0003723"(RNA binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|mint:Q01860|rcsb pdb:6T90|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-452723|ensembl:ENSG00000230336(gene)|ensembl:ENSG00000233911(gene)|ensembl:ENSG00000235068(gene)|ensembl:ENSG00000237582(gene)|ensembl:ENST00000259915(transcript)|ensembl:ENST00000383524(transcript)|ensembl:ENST00000429603(transcript)|ensembl:ENST00000433063(transcript)|ensembl:ENST00000434616(transcript)|ensembl:ENST00000437747(transcript)|ensembl:ENSG00000229094(gene)|ensembl:ENST00000454714(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|dip:DIP-33440N	go:"GO:0005634"(nucleus)	-	-	figure legend:Figure 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)")	-	2013/08/06	2014/10/16	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rogid:eMEp6g1n+kU2YnuRprn2B79q7OM9606	intact-crc:0596D8DA0EDFC695|rigid:jecCJloFhg566Z1bG+JTRclEV8s	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q01860	uniprotkb:O00308	intact:EBI-475687|uniprotkb:P31359|uniprotkb:Q15167|uniprotkb:Q15168|uniprotkb:Q16422|uniprotkb:A6NCS1|uniprotkb:A6NLL8|uniprotkb:Q5STF3|uniprotkb:Q5STF4|ensembl:ENSP00000259915|ensembl:ENSP00000373016|ensembl:ENSP00000388842|ensembl:ENSP00000391681|ensembl:ENSP00000392877|ensembl:ENSP00000400047|ensembl:ENSP00000405041|uniprotkb:D2IYK4	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:po5f1_human(display_long)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:POU5F1(gene name)|psi-mi:POU5F1(display_short)|uniprotkb:OCT3(gene name synonym)|uniprotkb:OCT4(gene name synonym)|uniprotkb:OTF3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Xu et al. (2009)	pubmed:19274063|imex:IM-22119	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6919991|imex:IM-22119-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272916.1|refseq:NP_002692.2|ensembl:ENSG00000204531(gene)|ensembl:ENSG00000206454(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0003723"(RNA binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|mint:Q01860|rcsb pdb:6T90|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-452723|ensembl:ENSG00000230336(gene)|ensembl:ENSG00000233911(gene)|ensembl:ENSG00000235068(gene)|ensembl:ENSG00000237582(gene)|ensembl:ENST00000259915(transcript)|ensembl:ENST00000383524(transcript)|ensembl:ENST00000429603(transcript)|ensembl:ENST00000433063(transcript)|ensembl:ENST00000434616(transcript)|ensembl:ENST00000437747(transcript)|ensembl:ENSG00000229094(gene)|ensembl:ENST00000454714(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|dip:DIP-33440N	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:"Figures: 1 A, 2 B and 2 C"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/06	2014/10/16	rogid:eMEp6g1n+kU2YnuRprn2B79q7OM9606	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	intact-crc:DF3D09AB771198EF|rigid:jecCJloFhg566Z1bG+JTRclEV8s	false	his tag:?-?	glutathione s tranferase tag:?-?|necessary binding region:300-477(IPR001202)|sufficient binding region:330-363(PS50020)|sufficient binding region:405-437|sufficient binding region:444-477|sufficient binding region:300-333(PS01159)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O00308	uniprotkb:Q01860	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	intact:EBI-475687|uniprotkb:P31359|uniprotkb:Q15167|uniprotkb:Q15168|uniprotkb:Q16422|uniprotkb:A6NCS1|uniprotkb:A6NLL8|uniprotkb:Q5STF3|uniprotkb:Q5STF4|ensembl:ENSP00000259915|ensembl:ENSP00000373016|ensembl:ENSP00000388842|ensembl:ENSP00000391681|ensembl:ENSP00000392877|ensembl:ENSP00000400047|ensembl:ENSP00000405041|uniprotkb:D2IYK4	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:po5f1_human(display_long)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:POU5F1(gene name)|psi-mi:POU5F1(display_short)|uniprotkb:OCT3(gene name synonym)|uniprotkb:OCT4(gene name synonym)|uniprotkb:OTF3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xu et al. (2009)	pubmed:19274063|imex:IM-22119	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6920337|imex:IM-22119-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	refseq:NP_001272916.1|refseq:NP_002692.2|ensembl:ENSG00000204531(gene)|ensembl:ENSG00000206454(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0003723"(RNA binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|mint:Q01860|rcsb pdb:6T90|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-452723|ensembl:ENSG00000230336(gene)|ensembl:ENSG00000233911(gene)|ensembl:ENSG00000235068(gene)|ensembl:ENSG00000237582(gene)|ensembl:ENST00000259915(transcript)|ensembl:ENST00000383524(transcript)|ensembl:ENST00000429603(transcript)|ensembl:ENST00000433063(transcript)|ensembl:ENST00000434616(transcript)|ensembl:ENST00000437747(transcript)|ensembl:ENSG00000229094(gene)|ensembl:ENST00000454714(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|dip:DIP-33440N	-	-	-	figure legend:Figure 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/08/06	2014/10/16	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rogid:eMEp6g1n+kU2YnuRprn2B79q7OM9606	intact-crc:18B11C9B65DE0557|rigid:jecCJloFhg566Z1bG+JTRclEV8s	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q01860	uniprotkb:P51965	intact:EBI-475687|uniprotkb:P31359|uniprotkb:Q15167|uniprotkb:Q15168|uniprotkb:Q16422|uniprotkb:A6NCS1|uniprotkb:A6NLL8|uniprotkb:Q5STF3|uniprotkb:Q5STF4|ensembl:ENSP00000259915|ensembl:ENSP00000373016|ensembl:ENSP00000388842|ensembl:ENSP00000391681|ensembl:ENSP00000392877|ensembl:ENSP00000400047|ensembl:ENSP00000405041|uniprotkb:D2IYK4	intact:EBI-348546|uniprotkb:B2RBX4|ensembl:ENSP00000303709|uniprotkb:C9J8K2|uniprotkb:K4DI90	psi-mi:po5f1_human(display_long)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:POU5F1(gene name)|psi-mi:POU5F1(display_short)|uniprotkb:OCT3(gene name synonym)|uniprotkb:OCT4(gene name synonym)|uniprotkb:OTF3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:ub2e1_human(display_long)|uniprotkb:UBE2E1(gene name)|psi-mi:UBE2E1(display_short)|uniprotkb:UBCH6(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E1(gene name synonym)|uniprotkb:Ubiquitin carrier protein E1(gene name synonym)|uniprotkb:UbcH6(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme E1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme E1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Xu et al. (2009)	pubmed:19274063|imex:IM-22119	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6925616|imex:IM-22119-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272916.1|refseq:NP_002692.2|ensembl:ENSG00000204531(gene)|ensembl:ENSG00000206454(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0003723"(RNA binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|mint:Q01860|rcsb pdb:6T90|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-452723|ensembl:ENSG00000230336(gene)|ensembl:ENSG00000233911(gene)|ensembl:ENSG00000235068(gene)|ensembl:ENSG00000237582(gene)|ensembl:ENST00000259915(transcript)|ensembl:ENST00000383524(transcript)|ensembl:ENST00000429603(transcript)|ensembl:ENST00000433063(transcript)|ensembl:ENST00000434616(transcript)|ensembl:ENST00000437747(transcript)|ensembl:ENSG00000229094(gene)|ensembl:ENST00000454714(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|dip:DIP-33440N	refseq:NP_003332.1|refseq:NP_872607.1|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR023313|rcsb pdb:1XR9|rcsb pdb:3BZH|rcsb pdb:4JJQ|rcsb pdb:5LBN|rcsb pdb:6FGA|reactome:R-HSA-1169408|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-9687136|reactome:R-HSA-983168|ensembl:ENST00000306627(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|ensembl:ENSG00000170142(gene)|refseq:NP_001189405.1	go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Figure 3 A|resulting-ptm:protein ubiquitination of pou5f1|comment:E1 = Ubiquitin Activating Enzyme 1 Q29504 is cited in reference Xu et al., 2004.   UbcH6 = Ubiquitin-conjugating enzyme E2 E1 = P51965.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/06	2014/10/16	rogid:eMEp6g1n+kU2YnuRprn2B79q7OM9606	rogid:pPIqYniSQn5Jh7u5x0Lm2NXppQU9606	intact-crc:F6EAE293326B799F|rigid:nurCEG5wtHzH9QdqxEHc6zFlklE	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q01860	uniprotkb:Q29504	intact:EBI-475687|uniprotkb:P31359|uniprotkb:Q15167|uniprotkb:Q15168|uniprotkb:Q16422|uniprotkb:A6NCS1|uniprotkb:A6NLL8|uniprotkb:Q5STF3|uniprotkb:Q5STF4|ensembl:ENSP00000259915|ensembl:ENSP00000373016|ensembl:ENSP00000388842|ensembl:ENSP00000391681|ensembl:ENSP00000392877|ensembl:ENSP00000400047|ensembl:ENSP00000405041|uniprotkb:D2IYK4	intact:EBI-975625	psi-mi:po5f1_human(display_long)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:POU5F1(gene name)|psi-mi:POU5F1(display_short)|uniprotkb:OCT3(gene name synonym)|uniprotkb:OCT4(gene name synonym)|uniprotkb:OTF3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:uba1_rabit(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Xu et al. (2009)	pubmed:19274063|imex:IM-22119	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6925616|imex:IM-22119-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272916.1|refseq:NP_002692.2|ensembl:ENSG00000204531(gene)|ensembl:ENSG00000206454(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0003723"(RNA binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|mint:Q01860|rcsb pdb:6T90|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-452723|ensembl:ENSG00000230336(gene)|ensembl:ENSG00000233911(gene)|ensembl:ENSG00000235068(gene)|ensembl:ENSG00000237582(gene)|ensembl:ENST00000259915(transcript)|ensembl:ENST00000383524(transcript)|ensembl:ENST00000429603(transcript)|ensembl:ENST00000433063(transcript)|ensembl:ENST00000434616(transcript)|ensembl:ENST00000437747(transcript)|ensembl:ENSG00000229094(gene)|ensembl:ENST00000454714(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|dip:DIP-33440N	go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|interpro:IPR042302|refseq:NP_001075840.1|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018965|interpro:IPR019572|interpro:IPR018075|interpro:IPR018074|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR038252|interpro:IPR033127|interpro:IPR032418|interpro:IPR032420|interpro:IPR042449|interpro:IPR035985|interpro:IPR042063	go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Figure 3 A|resulting-ptm:protein ubiquitination of pou5f1|comment:E1 = Ubiquitin Activating Enzyme 1 Q29504 is cited in reference Xu et al., 2004.   UbcH6 = Ubiquitin-conjugating enzyme E2 E1 = P51965.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/06	2014/10/16	rogid:eMEp6g1n+kU2YnuRprn2B79q7OM9606	rogid:kBSF1JlX6FGGw2Fs4klp7fFz5cQ9986	intact-crc:F6EAE293326B799F|rigid:nurCEG5wtHzH9QdqxEHc6zFlklE	false	his tag:?-?	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q01860	uniprotkb:O00308	intact:EBI-475687|uniprotkb:P31359|uniprotkb:Q15167|uniprotkb:Q15168|uniprotkb:Q16422|uniprotkb:A6NCS1|uniprotkb:A6NLL8|uniprotkb:Q5STF3|uniprotkb:Q5STF4|ensembl:ENSP00000259915|ensembl:ENSP00000373016|ensembl:ENSP00000388842|ensembl:ENSP00000391681|ensembl:ENSP00000392877|ensembl:ENSP00000400047|ensembl:ENSP00000405041|uniprotkb:D2IYK4	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:po5f1_human(display_long)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:POU5F1(gene name)|psi-mi:POU5F1(display_short)|uniprotkb:OCT3(gene name synonym)|uniprotkb:OCT4(gene name synonym)|uniprotkb:OTF3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Xu et al. (2009)	pubmed:19274063|imex:IM-22119	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6925616|imex:IM-22119-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272916.1|refseq:NP_002692.2|ensembl:ENSG00000204531(gene)|ensembl:ENSG00000206454(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0003723"(RNA binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|mint:Q01860|rcsb pdb:6T90|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-452723|ensembl:ENSG00000230336(gene)|ensembl:ENSG00000233911(gene)|ensembl:ENSG00000235068(gene)|ensembl:ENSG00000237582(gene)|ensembl:ENST00000259915(transcript)|ensembl:ENST00000383524(transcript)|ensembl:ENST00000429603(transcript)|ensembl:ENST00000433063(transcript)|ensembl:ENST00000434616(transcript)|ensembl:ENST00000437747(transcript)|ensembl:ENSG00000229094(gene)|ensembl:ENST00000454714(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|dip:DIP-33440N	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Figure 3 A|resulting-ptm:protein ubiquitination of pou5f1|comment:E1 = Ubiquitin Activating Enzyme 1 Q29504 is cited in reference Xu et al., 2004.   UbcH6 = Ubiquitin-conjugating enzyme E2 E1 = P51965.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/06	2014/10/16	rogid:eMEp6g1n+kU2YnuRprn2B79q7OM9606	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	intact-crc:F6EAE293326B799F|rigid:nurCEG5wtHzH9QdqxEHc6zFlklE	false	his tag:?-?	mutation disrupting interaction rate:838-838(IPR000569)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)