#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96T60	uniprotkb:P18887	intact:EBI-1045072|uniprotkb:Q9P1V2|uniprotkb:Q9UKU8|uniprotkb:Q9UNF8|uniprotkb:Q9UNI0|ensembl:ENSP00000323511|ensembl:ENSP00000472300|uniprotkb:Q9BUL2	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	psi-mi:pnkp_human(display_long)|uniprotkb:Polynucleotide kinase-3'-phosphatase(gene name synonym)|uniprotkb:DNA 5'-kinase/3'-phosphatase(gene name synonym)|uniprotkb:PNKP(gene name)|psi-mi:PNKP(display_short)	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Ali et al. (2009)	imex:IM-21654|pubmed:19155274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790134|rcsb pdb:2W3O|imex:IM-21654-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000039650(gene)|ensembl:ENST00000322344(transcript)|ensembl:ENST00000596014(transcript)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0000718"(nucleotide-excision repair, DNA damage removal)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0017076"(purine nucleotide binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0035861"(site of double-strand break)|go:"GO:0006281"(DNA repair)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0046403"(polynucleotide 3'-phosphatase activity)|go:"GO:0046404"(polydeoxyribonucleotide 5'-hydroxyl-kinase activity)|go:"GO:0046939"(nucleotide phosphorylation)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR006549(HAD-superfamily hydrolase, subfamily IIIA)|interpro:IPR006550(Polynucleotide kinase 3-phosphatase)|interpro:IPR006551(DNA 3-phosphatase)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013954(Polynucleotide kinase 3 phosphatase, central region)|interpro:IPR023214|interpro:IPR027417|interpro:IPR036412|interpro:IPR041388|mint:Q96T60|rcsb pdb:2BRF|rcsb pdb:2W3O|reactome:R-HSA-5649702|refseq:NP_009185.2	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	-	-	-	figure legend:Fig. 3, Fig. 4a, Fig. 5a, Suppl. Table S1|3d-r-factors:working 18%, free 24%|3d-resolution:1.85A|3d-structure:Residues 523 to 526 of the XRCC1 peptide are not visible in the structure.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/08	2014/10/16	rogid:wlLm6ja4qrCmWB44mE+C4w3wnyQ9606	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	intact-crc:31CD1A0F514A88EF|rigid:qf+3K4OFvKrh7t6QT/rQj+7EdrA	false	sufficient binding region:1-109(IPR000253)|mutation:99-99	O-phospho-L-serine:518-518|sufficient binding region:515-526|O-phospho-L-threonine:519-519|O-phospho-L-threonine:523-523	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96T60	uniprotkb:P18887	intact:EBI-1045072|uniprotkb:Q9P1V2|uniprotkb:Q9UKU8|uniprotkb:Q9UNF8|uniprotkb:Q9UNI0|ensembl:ENSP00000323511|ensembl:ENSP00000472300|uniprotkb:Q9BUL2	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	psi-mi:pnkp_human(display_long)|uniprotkb:Polynucleotide kinase-3'-phosphatase(gene name synonym)|uniprotkb:DNA 5'-kinase/3'-phosphatase(gene name synonym)|uniprotkb:PNKP(gene name)|psi-mi:PNKP(display_short)	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Ali et al. (2009)	imex:IM-21654|pubmed:19155274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790201|imex:IM-21654-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000039650(gene)|ensembl:ENST00000322344(transcript)|ensembl:ENST00000596014(transcript)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0000718"(nucleotide-excision repair, DNA damage removal)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0017076"(purine nucleotide binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0035861"(site of double-strand break)|go:"GO:0006281"(DNA repair)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0046403"(polynucleotide 3'-phosphatase activity)|go:"GO:0046404"(polydeoxyribonucleotide 5'-hydroxyl-kinase activity)|go:"GO:0046939"(nucleotide phosphorylation)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR006549(HAD-superfamily hydrolase, subfamily IIIA)|interpro:IPR006550(Polynucleotide kinase 3-phosphatase)|interpro:IPR006551(DNA 3-phosphatase)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013954(Polynucleotide kinase 3 phosphatase, central region)|interpro:IPR023214|interpro:IPR027417|interpro:IPR036412|interpro:IPR041388|mint:Q96T60|rcsb pdb:2BRF|rcsb pdb:2W3O|reactome:R-HSA-5649702|refseq:NP_009185.2	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	-	-	-	figure legend:Fig. 2a, Fig. 2b, Fig. 2c, Fig. 2e, Table 1|kinetics:"Kd values were determined for several XRCC1 phosphopeptides (515-526). No phosphorylated residues: no binding; pS518: no binding; pS525: no binding; pT523: Kd = 13.49 +/- 1.296 x 10e-6 M; pT519-pT523: Kd = 0.76 +/- 0.22 x 10e-6 M; pS518-pT519: Kd = 1.23 +/- 0.04 x 10e-6 M; pS518-pT519-pT523: Kd = 0.19 +/- 0.02 x 10e-6 M; pS518-pT519-pT523-pS525: Kd = 0.14 +/- 0.01 x 10e-6 M; pS518-pT523: Kd = 24.18 +/- 1.44 x 10e-6 M. The thr523val mutation in the pS518-pT519 peptide lowered the affinity to Kd = 1.7 +/- 0.06 x 10e-6 M.  In contrast to all other peptides, the pT523 and pS518-pT519-thr523val peptides bound with a 1:1 stoichiometry."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.06x10^-5 ~0.28(molar)	2013/10/08	2014/10/16	rogid:wlLm6ja4qrCmWB44mE+C4w3wnyQ9606	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	intact-crc:0BFA1AFDD6FE6B7A|rigid:qf+3K4OFvKrh7t6QT/rQj+7EdrA	false	sufficient binding region:1-109(IPR000253)	O-phospho-L-threonine:523-523|sufficient binding region:515-526|O-phospho-L-threonine:519-519|O-phospho-L-serine:518-518|O-phospho-L-serine:525-525|mutation decreasing interaction:523-523	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96T60	uniprotkb:P18887	intact:EBI-1045072|uniprotkb:Q9P1V2|uniprotkb:Q9UKU8|uniprotkb:Q9UNF8|uniprotkb:Q9UNI0|ensembl:ENSP00000323511|ensembl:ENSP00000472300|uniprotkb:Q9BUL2	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	psi-mi:pnkp_human(display_long)|uniprotkb:Polynucleotide kinase-3'-phosphatase(gene name synonym)|uniprotkb:DNA 5'-kinase/3'-phosphatase(gene name synonym)|uniprotkb:PNKP(gene name)|psi-mi:PNKP(display_short)	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Ali et al. (2009)	imex:IM-21654|pubmed:19155274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790222|imex:IM-21654-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000039650(gene)|ensembl:ENST00000322344(transcript)|ensembl:ENST00000596014(transcript)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0000718"(nucleotide-excision repair, DNA damage removal)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0017076"(purine nucleotide binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0035861"(site of double-strand break)|go:"GO:0006281"(DNA repair)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0046403"(polynucleotide 3'-phosphatase activity)|go:"GO:0046404"(polydeoxyribonucleotide 5'-hydroxyl-kinase activity)|go:"GO:0046939"(nucleotide phosphorylation)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR006549(HAD-superfamily hydrolase, subfamily IIIA)|interpro:IPR006550(Polynucleotide kinase 3-phosphatase)|interpro:IPR006551(DNA 3-phosphatase)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013954(Polynucleotide kinase 3 phosphatase, central region)|interpro:IPR023214|interpro:IPR027417|interpro:IPR036412|interpro:IPR041388|mint:Q96T60|rcsb pdb:2BRF|rcsb pdb:2W3O|reactome:R-HSA-5649702|refseq:NP_009185.2	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	-	-	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.23x10^-6(molar)	2013/10/08	2014/10/16	rogid:wlLm6ja4qrCmWB44mE+C4w3wnyQ9606	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	intact-crc:A4F0BA7DC9E5B39E|rigid:qf+3K4OFvKrh7t6QT/rQj+7EdrA	false	sufficient binding region:1-109(IPR000253)	sufficient binding region:515-526|O-phospho-L-threonine:519-519|O-phospho-L-serine:518-518	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96T60	uniprotkb:P18887	intact:EBI-1045072|uniprotkb:Q9P1V2|uniprotkb:Q9UKU8|uniprotkb:Q9UNF8|uniprotkb:Q9UNI0|ensembl:ENSP00000323511|ensembl:ENSP00000472300|uniprotkb:Q9BUL2	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	psi-mi:pnkp_human(display_long)|uniprotkb:Polynucleotide kinase-3'-phosphatase(gene name synonym)|uniprotkb:DNA 5'-kinase/3'-phosphatase(gene name synonym)|uniprotkb:PNKP(gene name)|psi-mi:PNKP(display_short)	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ali et al. (2009)	imex:IM-21654|pubmed:19155274	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790244|imex:IM-21654-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000039650(gene)|ensembl:ENST00000322344(transcript)|ensembl:ENST00000596014(transcript)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0000718"(nucleotide-excision repair, DNA damage removal)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0017076"(purine nucleotide binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0035861"(site of double-strand break)|go:"GO:0006281"(DNA repair)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0046403"(polynucleotide 3'-phosphatase activity)|go:"GO:0046404"(polydeoxyribonucleotide 5'-hydroxyl-kinase activity)|go:"GO:0046939"(nucleotide phosphorylation)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR006549(HAD-superfamily hydrolase, subfamily IIIA)|interpro:IPR006550(Polynucleotide kinase 3-phosphatase)|interpro:IPR006551(DNA 3-phosphatase)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013954(Polynucleotide kinase 3 phosphatase, central region)|interpro:IPR023214|interpro:IPR027417|interpro:IPR036412|interpro:IPR041388|mint:Q96T60|rcsb pdb:2BRF|rcsb pdb:2W3O|reactome:R-HSA-5649702|refseq:NP_009185.2	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	-	-	-	figure legend:Fig. 1d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/08	2014/10/16	rogid:wlLm6ja4qrCmWB44mE+C4w3wnyQ9606	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	intact-crc:CF695AFF1329DF4A|rigid:qf+3K4OFvKrh7t6QT/rQj+7EdrA	false	glutathione s tranferase tag:n-n|sufficient binding region:1-109(IPR000253)	his tag:n-n|sufficient binding region:218-633	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P28523	uniprotkb:P18887	intact:EBI-8790265|ensemblplants:Zm00001eb118100_P001	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	psi-mi:csk2a_maize(display_long)|uniprotkb:ACK2(gene name)|psi-mi:ACK2(display_short)|uniprotkb:CK II(gene name synonym)|uniprotkb:CK2-alpha(gene name synonym)	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Ali et al. (2009)	imex:IM-21654|pubmed:19155274	taxid:4577(maize)|taxid:4577("Zea mays (Maize)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790317|imex:IM-21654-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008668648.1|rcsb pdb:4RLK|ensemblplants:Zm00001eb118100(gene)|ensemblplants:Zm00001eb118100_T001(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rcsb pdb:1DAW|rcsb pdb:1DAY|rcsb pdb:1DS5|rcsb pdb:1F0Q|rcsb pdb:1J91|rcsb pdb:1JAM|rcsb pdb:1LP4|rcsb pdb:1LPU|rcsb pdb:1LR4|rcsb pdb:1M2P|rcsb pdb:1M2Q|rcsb pdb:1M2R|rcsb pdb:1OM1|rcsb pdb:1ZOE|rcsb pdb:1ZOG|rcsb pdb:1ZOH|rcsb pdb:2OXD|rcsb pdb:2OXX|rcsb pdb:2OXY|rcsb pdb:2PVH|rcsb pdb:2PVJ|rcsb pdb:2PVK|rcsb pdb:2PVL|rcsb pdb:2PVM|rcsb pdb:2PVN|rcsb pdb:2QC6|rcsb pdb:3BE9|rcsb pdb:3FL5|rcsb pdb:3KXG|rcsb pdb:3KXH|rcsb pdb:3KXM|rcsb pdb:3KXN|rcsb pdb:3PVG|rcsb pdb:3PWD|rcsb pdb:3PZH|rcsb pdb:4ANM|rcsb pdb:4DGM|rcsb pdb:4DGN|rcsb pdb:5TS8|rcsb pdb:6QS5	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 1c|resulting-ptm:phosphorylation of XRCC1 on ser518, thr519 and thr523|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/08	2014/10/16	rogid:T3kIMY+Qp038hMUJ5BHWUSat7Gw4577	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	intact-crc:B73B6DAF4C35A5CC|rigid:TnRKwOFpEDh8yZw6ZUf/tVEj6UI	false	-	sufficient binding region:218-633	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)