#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q922J3	uniprotkb:O08808	intact:EBI-776187|uniprotkb:Q571L7|ensembl:ENSMUSP00000107192	intact:EBI-1026445|ensembl:ENSMUSP00000111297	psi-mi:clip1_mouse(display_long)|uniprotkb:Restin(gene name synonym)|uniprotkb:Clip1(gene name)|psi-mi:Clip1(display_short)|uniprotkb:Kiaa4046(gene name synonym)|uniprotkb:Rsn(gene name synonym)|uniprotkb:Cytoplasmic linker protein 170(gene name synonym)	psi-mi:diap1_mouse(display_long)|uniprotkb:Diaphanous-related formin-1(gene name synonym)|uniprotkb:p140mDIA(gene name synonym)|uniprotkb:Diaph1(gene name)|psi-mi:Diaph1(display_short)|uniprotkb:Diap1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lewkowicz et al. (2008)	imex:IM-18850|pubmed:19114595	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6479958|imex:IM-18850-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062739.2|refseq:NP_001278158.1|ensembl:ENSMUSG00000049550(gene)|ensembl:ENSMUST00000111566(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001726"(ruffle)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042802"(identical protein binding)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0051010"(microtubule plus-end binding)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR032108|interpro:IPR036859|mint:Q922J3|rcsb pdb:2CP7|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025	refseq:NP_031884.1|ensembl:ENSMUSG00000024456(gene)|ensembl:ENSMUST00000115634(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007420"(brain development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O08808|rcsb pdb:1Z2C|rcsb pdb:2BAP|rcsb pdb:2BNX|rcsb pdb:2F31|rcsb pdb:2V8F|rcsb pdb:3EG5|rcsb pdb:3O4X|rcsb pdb:3OBV|rcsb pdb:4UWX|reactome:R-MMU-5663220|reactome:R-MMU-6785631|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013405|reactome:R-MMU-9035034|rcsb pdb:1V9D|dip:DIP-29028N	-	-	-	figure legend:Fig 5A, 6A, 6B, 6C.|comment:"The interaction between mDia1 and CLIP170 was unaffected in the presence of drugs such as taxol, latrunculin A or nocodazole (Fig 6A). The interaction was unaffected during FcR-mediated phagocytosis (Fig 6C). The interaction was inhibited initially during CR3-mediated phagocytosis, but the proteins are found to associating after 30 min (Fig 6B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2013/01/17	2014/10/16	rogid:VamQo+KVLXsd4aHycgXJlQF2Bw010090	rogid:cSWfzfilw9WnzAOYZE3i+0x9G5c10090	intact-crc:3B15E29B5E69213E|rigid:/98IpsdYqu81JCr6cTUMn5PGK2c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30622-2	uniprotkb:O60610	intact:EBI-6479976|ensembl:ENSP00000445531	intact:EBI-3959709|uniprotkb:Q59FH8|uniprotkb:B7ZKW2|uniprotkb:A6NF18|uniprotkb:Q9UC76|intact:EBI-6137912|uniprotkb:E9PEZ2|uniprotkb:Q17RN4|ensembl:ENSP00000373706	psi-mi:p30622-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:CLIP1(gene name)|psi-mi:CLIP1(display_short)|uniprotkb:CYLN1(gene name synonym)|uniprotkb:RSN(gene name synonym)|uniprotkb:Cytoplasmic linker protein 1(gene name synonym)|uniprotkb:Cytoplasmic linker protein 170 alpha-2(gene name synonym)|uniprotkb:Reed-Sternberg intermediate filament-associated protein(gene name synonym)|uniprotkb:Restin(gene name synonym)	psi-mi:diap1_human(display_long)|uniprotkb:DIAPH1(gene name)|psi-mi:DIAPH1(display_short)|uniprotkb:DIAP1(gene name synonym)|uniprotkb:Diaphanous-related formin-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lewkowicz et al. (2008)	imex:IM-18850|pubmed:19114595	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6479970|imex:IM-18850-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2683569(isoform-parent)|ensembl:ENSG00000130779(gene)|ensembl:ENST00000537178(transcript)	refseq:NP_001073280.1|refseq:NP_005210.3|ensembl:ENSG00000131504(gene)|ensembl:ENST00000389054(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O60610|reactome:R-HSA-5663220|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013405|reactome:R-HSA-9035034	-	-	-	figure legend:Fig 5B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/01/17	2014/10/16	rogid:2rtFj4hVTdIIVNC8pCXgnPg/i8w9606	rogid:m8uSwdWB9ePt8wzBRQBVujfEBfo9606	intact-crc:3F9564E00ACBC481|rigid:MFDQuDr282Qg0qUJ6sI84nIRVkM	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O08808	uniprotkb:P30622-2	intact:EBI-1026445|ensembl:ENSMUSP00000111297	intact:EBI-6479976|ensembl:ENSP00000445531	psi-mi:diap1_mouse(display_long)|uniprotkb:Diaphanous-related formin-1(gene name synonym)|uniprotkb:p140mDIA(gene name synonym)|uniprotkb:Diaph1(gene name)|psi-mi:Diaph1(display_short)|uniprotkb:Diap1(gene name synonym)	psi-mi:p30622-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:CLIP1(gene name)|psi-mi:CLIP1(display_short)|uniprotkb:CYLN1(gene name synonym)|uniprotkb:RSN(gene name synonym)|uniprotkb:Cytoplasmic linker protein 1(gene name synonym)|uniprotkb:Cytoplasmic linker protein 170 alpha-2(gene name synonym)|uniprotkb:Reed-Sternberg intermediate filament-associated protein(gene name synonym)|uniprotkb:Restin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lewkowicz et al. (2008)	imex:IM-18850|pubmed:19114595	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6480001|imex:IM-18850-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031884.1|ensembl:ENSMUSG00000024456(gene)|ensembl:ENSMUST00000115634(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007420"(brain development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O08808|rcsb pdb:1Z2C|rcsb pdb:2BAP|rcsb pdb:2BNX|rcsb pdb:2F31|rcsb pdb:2V8F|rcsb pdb:3EG5|rcsb pdb:3O4X|rcsb pdb:3OBV|rcsb pdb:4UWX|reactome:R-MMU-5663220|reactome:R-MMU-6785631|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013405|reactome:R-MMU-9035034|rcsb pdb:1V9D|dip:DIP-29028N	intact:EBI-2683569(isoform-parent)|ensembl:ENSG00000130779(gene)|ensembl:ENST00000537178(transcript)	-	-	-	figure legend:Fig 5E, 5F, 5G.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.8x10^-6(molar)	2013/01/17	2014/10/16	rogid:cSWfzfilw9WnzAOYZE3i+0x9G5c10090	rogid:2rtFj4hVTdIIVNC8pCXgnPg/i8w9606	intact-crc:E0A6E11289700C6E|rigid:igQZcLwo7GqtYRVLnlbHDnc7KVc	false	sufficient binding region:752-1194(IPR003104)|his tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:620-1392	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O08808	uniprotkb:Q922J3	intact:EBI-1026445|ensembl:ENSMUSP00000111297	intact:EBI-776187|uniprotkb:Q571L7|ensembl:ENSMUSP00000107192	psi-mi:diap1_mouse(display_long)|uniprotkb:Diaphanous-related formin-1(gene name synonym)|uniprotkb:p140mDIA(gene name synonym)|uniprotkb:Diaph1(gene name)|psi-mi:Diaph1(display_short)|uniprotkb:Diap1(gene name synonym)	psi-mi:clip1_mouse(display_long)|uniprotkb:Restin(gene name synonym)|uniprotkb:Clip1(gene name)|psi-mi:Clip1(display_short)|uniprotkb:Kiaa4046(gene name synonym)|uniprotkb:Rsn(gene name synonym)|uniprotkb:Cytoplasmic linker protein 170(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Lewkowicz et al. (2008)	imex:IM-18850|pubmed:19114595	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6480023|imex:IM-18850-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031884.1|ensembl:ENSMUSG00000024456(gene)|ensembl:ENSMUST00000115634(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007420"(brain development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O08808|rcsb pdb:1Z2C|rcsb pdb:2BAP|rcsb pdb:2BNX|rcsb pdb:2F31|rcsb pdb:2V8F|rcsb pdb:3EG5|rcsb pdb:3O4X|rcsb pdb:3OBV|rcsb pdb:4UWX|reactome:R-MMU-5663220|reactome:R-MMU-6785631|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013405|reactome:R-MMU-9035034|rcsb pdb:1V9D|dip:DIP-29028N	refseq:NP_062739.2|refseq:NP_001278158.1|ensembl:ENSMUSG00000049550(gene)|ensembl:ENSMUST00000111566(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001726"(ruffle)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042802"(identical protein binding)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0051010"(microtubule plus-end binding)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR032108|interpro:IPR036859|mint:Q922J3|rcsb pdb:2CP7|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025	-	-	-	figure legend:"Fig 6D, 6E (left)."|comment:mDia1 and CLIP170 colocalized to the non-phagocytosing regions of the macrophages.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2013/01/17	2014/10/16	rogid:cSWfzfilw9WnzAOYZE3i+0x9G5c10090	rogid:VamQo+KVLXsd4aHycgXJlQF2Bw010090	intact-crc:9E7C0A0866691BA2|rigid:/98IpsdYqu81JCr6cTUMn5PGK2c	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)