#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6IMN6	uniprotkb:O75581	intact:EBI-6918449|uniprotkb:E4NKG2|uniprotkb:Q149P6|uniprotkb:Q149P7|uniprotkb:Q6IMN5|uniprotkb:Q7Z371|uniprotkb:Q8TE70|uniprotkb:Q8TE71|uniprotkb:Q96RN6|uniprotkb:Q9H667|uniprotkb:Q9HAL4	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	psi-mi:capr2_human(display_long)|uniprotkb:CAPRIN2(gene name)|psi-mi:CAPRIN2(display_short)|uniprotkb:C1QDC1(gene name synonym)|uniprotkb:EEG1(gene name synonym)|uniprotkb:KIAA1873(gene name synonym)|uniprotkb:RNG140(gene name synonym)|uniprotkb:C1q domain-containing protein 1(gene name synonym)|uniprotkb:Cytoplasmic activation/proliferation-associated protein 2(gene name synonym)|uniprotkb:Gastric cancer multidrug resistance-associated protein(gene name synonym)|uniprotkb:Protein EEG-1(gene name synonym)|uniprotkb:RNA granule protein 140(gene name synonym)	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ding et al. (2008)	pubmed:18762581|imex:IM-22134	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6920985|imex:IM-22134-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4OUL|rcsb pdb:4OUM|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0017148"(negative regulation of translation)|interpro:IPR028816|refseq:NP_001306771.1|refseq:NP_001306772.1|interpro:IPR001073(Complement C1q protein)|interpro:IPR022070|interpro:IPR008983(Tumour necrosis factor-like)|refseq:NP_001002259.1|refseq:NP_001193785.1|refseq:NP_076414.2|refseq:NP_115532.3|refseq:XP_006719210.1|rcsb pdb:5J97|interpro:IPR041637	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	-	-	-	figure legend:Figure 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/08/05	2014/10/16	rogid:doFlseJcb6jzptDJuo58S3EOO309606	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	intact-crc:815417F428925EFC|rigid:Q9easIm3T6QrRbG02PTqGm3b2Eg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IMN6	uniprotkb:O75197	intact:EBI-6918449|uniprotkb:E4NKG2|uniprotkb:Q149P6|uniprotkb:Q149P7|uniprotkb:Q6IMN5|uniprotkb:Q7Z371|uniprotkb:Q8TE70|uniprotkb:Q8TE71|uniprotkb:Q96RN6|uniprotkb:Q9H667|uniprotkb:Q9HAL4	intact:EBI-2466421|ensembl:ENSP00000294304|uniprotkb:Q96TD6|uniprotkb:Q9UP66|uniprotkb:Q9UES7	psi-mi:capr2_human(display_long)|uniprotkb:CAPRIN2(gene name)|psi-mi:CAPRIN2(display_short)|uniprotkb:C1QDC1(gene name synonym)|uniprotkb:EEG1(gene name synonym)|uniprotkb:KIAA1873(gene name synonym)|uniprotkb:RNG140(gene name synonym)|uniprotkb:C1q domain-containing protein 1(gene name synonym)|uniprotkb:Cytoplasmic activation/proliferation-associated protein 2(gene name synonym)|uniprotkb:Gastric cancer multidrug resistance-associated protein(gene name synonym)|uniprotkb:Protein EEG-1(gene name synonym)|uniprotkb:RNA granule protein 140(gene name synonym)	psi-mi:lrp5_human(display_long)|uniprotkb:LRP5(gene name)|psi-mi:LRP5(display_short)|uniprotkb:LRP7(gene name synonym)|uniprotkb:LR3(gene name synonym)|uniprotkb:Low-density lipoprotein receptor-related protein 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ding et al. (2008)	pubmed:18762581|imex:IM-22134	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6918447|imex:IM-22134-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4OUL|rcsb pdb:4OUM|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0017148"(negative regulation of translation)|interpro:IPR028816|refseq:NP_001306771.1|refseq:NP_001306772.1|interpro:IPR001073(Complement C1q protein)|interpro:IPR022070|interpro:IPR008983(Tumour necrosis factor-like)|refseq:NP_001002259.1|refseq:NP_001193785.1|refseq:NP_076414.2|refseq:NP_115532.3|refseq:XP_006719210.1|rcsb pdb:5J97|interpro:IPR041637	ensembl:ENSG00000162337(gene)|ensembl:ENST00000294304(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048539"(bone marrow development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060764"(cell-cell signaling involved in mammary gland development)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75197|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5339717|reactome:R-HSA-5340588|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|refseq:NP_002326.2|refseq:NP_001278831.1|dip:DIP-47265N	-	-	-	figure legend:Figure 1 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/08/05	2014/10/16	rogid:doFlseJcb6jzptDJuo58S3EOO309606	rogid:5Or5NJwtSvZrk2kM2bBAQQOCW749606	intact-crc:F3937166C698A5DD|rigid:ZeM2KjorWpeEKyh5z1HVAB3FhlQ	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75197	uniprotkb:Q6IMN6	intact:EBI-2466421|ensembl:ENSP00000294304|uniprotkb:Q96TD6|uniprotkb:Q9UP66|uniprotkb:Q9UES7	intact:EBI-6918449|uniprotkb:E4NKG2|uniprotkb:Q149P6|uniprotkb:Q149P7|uniprotkb:Q6IMN5|uniprotkb:Q7Z371|uniprotkb:Q8TE70|uniprotkb:Q8TE71|uniprotkb:Q96RN6|uniprotkb:Q9H667|uniprotkb:Q9HAL4	psi-mi:lrp5_human(display_long)|uniprotkb:LRP5(gene name)|psi-mi:LRP5(display_short)|uniprotkb:LRP7(gene name synonym)|uniprotkb:LR3(gene name synonym)|uniprotkb:Low-density lipoprotein receptor-related protein 7(gene name synonym)	psi-mi:capr2_human(display_long)|uniprotkb:CAPRIN2(gene name)|psi-mi:CAPRIN2(display_short)|uniprotkb:C1QDC1(gene name synonym)|uniprotkb:EEG1(gene name synonym)|uniprotkb:KIAA1873(gene name synonym)|uniprotkb:RNG140(gene name synonym)|uniprotkb:C1q domain-containing protein 1(gene name synonym)|uniprotkb:Cytoplasmic activation/proliferation-associated protein 2(gene name synonym)|uniprotkb:Gastric cancer multidrug resistance-associated protein(gene name synonym)|uniprotkb:Protein EEG-1(gene name synonym)|uniprotkb:RNA granule protein 140(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ding et al. (2008)	pubmed:18762581|imex:IM-22134	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6919043|imex:IM-22134-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162337(gene)|ensembl:ENST00000294304(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048539"(bone marrow development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060764"(cell-cell signaling involved in mammary gland development)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75197|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5339717|reactome:R-HSA-5340588|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|refseq:NP_002326.2|refseq:NP_001278831.1|dip:DIP-47265N	rcsb pdb:4OUL|rcsb pdb:4OUM|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0017148"(negative regulation of translation)|interpro:IPR028816|refseq:NP_001306771.1|refseq:NP_001306772.1|interpro:IPR001073(Complement C1q protein)|interpro:IPR022070|interpro:IPR008983(Tumour necrosis factor-like)|refseq:NP_001002259.1|refseq:NP_001193785.1|refseq:NP_076414.2|refseq:NP_115532.3|refseq:XP_006719210.1|rcsb pdb:5J97|interpro:IPR041637	-	comment:"LRP5C3 was used which is a truncated form of LRP5. This is cited in the paper as reference: Mao et al, 2001.b. PMID 11336703"	-	figure legend:Figure 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/05	2014/10/16	rogid:5Or5NJwtSvZrk2kM2bBAQQOCW749606	rogid:doFlseJcb6jzptDJuo58S3EOO309606	intact-crc:8C8E97C0520E85C0|rigid:ZeM2KjorWpeEKyh5z1HVAB3FhlQ	false	sufficient binding region:1419-1615|sufficient binding region:1419-1615|glutathione s tranferase tag:?-?	sufficient binding region:313-978|sufficient binding region:973-1127|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IMN6	uniprotkb:O75197	intact:EBI-6918449|uniprotkb:E4NKG2|uniprotkb:Q149P6|uniprotkb:Q149P7|uniprotkb:Q6IMN5|uniprotkb:Q7Z371|uniprotkb:Q8TE70|uniprotkb:Q8TE71|uniprotkb:Q96RN6|uniprotkb:Q9H667|uniprotkb:Q9HAL4	intact:EBI-2466421|ensembl:ENSP00000294304|uniprotkb:Q96TD6|uniprotkb:Q9UP66|uniprotkb:Q9UES7	psi-mi:capr2_human(display_long)|uniprotkb:CAPRIN2(gene name)|psi-mi:CAPRIN2(display_short)|uniprotkb:C1QDC1(gene name synonym)|uniprotkb:EEG1(gene name synonym)|uniprotkb:KIAA1873(gene name synonym)|uniprotkb:RNG140(gene name synonym)|uniprotkb:C1q domain-containing protein 1(gene name synonym)|uniprotkb:Cytoplasmic activation/proliferation-associated protein 2(gene name synonym)|uniprotkb:Gastric cancer multidrug resistance-associated protein(gene name synonym)|uniprotkb:Protein EEG-1(gene name synonym)|uniprotkb:RNA granule protein 140(gene name synonym)	psi-mi:lrp5_human(display_long)|uniprotkb:LRP5(gene name)|psi-mi:LRP5(display_short)|uniprotkb:LRP7(gene name synonym)|uniprotkb:LR3(gene name synonym)|uniprotkb:Low-density lipoprotein receptor-related protein 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ding et al. (2008)	pubmed:18762581|imex:IM-22134	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-6921238|imex:IM-22134-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4OUL|rcsb pdb:4OUM|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0017148"(negative regulation of translation)|interpro:IPR028816|refseq:NP_001306771.1|refseq:NP_001306772.1|interpro:IPR001073(Complement C1q protein)|interpro:IPR022070|interpro:IPR008983(Tumour necrosis factor-like)|refseq:NP_001002259.1|refseq:NP_001193785.1|refseq:NP_076414.2|refseq:NP_115532.3|refseq:XP_006719210.1|rcsb pdb:5J97|interpro:IPR041637	ensembl:ENSG00000162337(gene)|ensembl:ENST00000294304(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048539"(bone marrow development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060764"(cell-cell signaling involved in mammary gland development)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75197|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5339717|reactome:R-HSA-5340588|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|refseq:NP_002326.2|refseq:NP_001278831.1|dip:DIP-47265N	-	comment:"Results and Discussion section: first paragraph states that protein was identified by: \"......mass spectrometry analysis followed by protein database searching\"."	comment:"LRP5C3 was used which is a truncated form of LRP5. This is cited in the paper as reference: Mao et al, 2001.b. PMID 11336703"	figure legend:"Text body in paper. Results and Discussion section: first paragraph."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/08/05	2014/10/16	rogid:doFlseJcb6jzptDJuo58S3EOO309606	rogid:5Or5NJwtSvZrk2kM2bBAQQOCW749606	intact-crc:90A66B4D388E80F7|rigid:ZeM2KjorWpeEKyh5z1HVAB3FhlQ	false	-	flag tag:?-?|sufficient binding region:1419-1615	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)