#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chembl target:CHEMBL1907598	uniprotkb:P05230	intact:EBI-2550735|reactome:R-HSA-210216|matrixdb:MULT_16_human|wwpdb:3ije|wwpdb:4g1e|wwpdb:1U8C|wwpdb:1jv2|wwpdb:1m1x|wwpdb:4g1m|signor:SIGNOR-C177	intact:EBI-698068|uniprotkb:P07502|uniprotkb:Q16588|uniprotkb:B2R5T0|uniprotkb:D3DQF2|ensembl:ENSP00000338548|ensembl:ENSP00000352329|ensembl:ENSP00000367285|ensembl:ENSP00000396195|ensembl:ENSP00000404742|ensembl:ENSP00000479024|ensembl:ENSP00000480791|ensembl:ENSP00000480980|ensembl:ENSP00000481868	psi-mi:intg_av_b3_human(display_short)|psi-mi:CHEMBL1907598(display_long)|intact:alphav-beta3 integrin complex(complex synonym)|intact:alpha-v/beta-3 integrin complex(complex synonym)|intact:Integrin alphav-beta3 complex(complex recommended name)|intact:"ITGAV:ITGB3"(complex systematic name)	psi-mi:fgf1_human(display_long)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:FGFA(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Mori et al. (2008)	imex:IM-18768|pubmed:18441324	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6509705|imex:IM-18768-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0034683"(integrin alphav-beta3 complex)|pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|intact:EBI-1039821(exp-evidence)|complex portal:CPX-1795(complex-primary)|evidence ontology:"ECO:0000353"	refseq:NP_000791.1|refseq:NP_001138364.1|refseq:NP_001138406.1|refseq:NP_001138407.1|refseq:NP_149127.1|refseq:NP_001244134.1|refseq:NP_001244136.1|refseq:NP_001244137.1|refseq:NP_001244138.1|refseq:NP_001244139.1|dip:DIP-3787N|ensembl:ENSG00000113578(gene)|ensembl:ENST00000337706(transcript)|ensembl:ENST00000359370(transcript)|ensembl:ENST00000378046(transcript)|ensembl:ENST00000419524(transcript)|ensembl:ENST00000441680(transcript)|ensembl:ENST00000610990(transcript)|ensembl:ENST00000612258(transcript)|ensembl:ENST00000619447(transcript)|ensembl:ENST00000621536(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AXM|rcsb pdb:1DJS|rcsb pdb:1DZC|rcsb pdb:1DZD|rcsb pdb:1E0O|rcsb pdb:1EVT|rcsb pdb:1HKN|rcsb pdb:1JQZ|rcsb pdb:1JT3|rcsb pdb:1JT4|rcsb pdb:1JT5|rcsb pdb:1JT7|rcsb pdb:1JTC|rcsb pdb:1JY0|rcsb pdb:1K5U|rcsb pdb:1K5V|rcsb pdb:1M16|rcsb pdb:1NZK|rcsb pdb:1P63|rcsb pdb:1PZZ|rcsb pdb:1Q03|rcsb pdb:1Q04|rcsb pdb:1QCT|rcsb pdb:1RG8|rcsb pdb:1RML|rcsb pdb:1RY7|rcsb pdb:1YTO|rcsb pdb:1Z2V|rcsb pdb:1Z4S|rcsb pdb:2AFG|rcsb pdb:2AQZ|rcsb pdb:2AXM|rcsb pdb:2ERM|rcsb pdb:2HW9|rcsb pdb:2HWA|rcsb pdb:2HWM|rcsb pdb:2HZ9|rcsb pdb:2K43|rcsb pdb:2K4A|rcsb pdb:2K8R|rcsb pdb:2KI4|rcsb pdb:2KI6|rcsb pdb:2NTD|rcsb pdb:2Q9X|rcsb pdb:2RQ9|rcsb pdb:3B9U|rcsb pdb:3BA4|rcsb pdb:3BA5|rcsb pdb:3BA7|rcsb pdb:3BAD|rcsb pdb:3BAG|rcsb pdb:3BAH|rcsb pdb:3BAO|rcsb pdb:3BAQ|rcsb pdb:3BAU|rcsb pdb:3BAV|rcsb pdb:3BB2|rcsb pdb:3CQA|rcsb pdb:3CRG|rcsb pdb:3CRH|rcsb pdb:3CRI|rcsb pdb:3CU1|rcsb pdb:3FGM|rcsb pdb:3FJ8|rcsb pdb:3FJ9|rcsb pdb:3FJA|rcsb pdb:3FJB|rcsb pdb:3FJC|rcsb pdb:3FJD|rcsb pdb:3FJE|rcsb pdb:3FJF|rcsb pdb:3FJH|rcsb pdb:3FJI|rcsb pdb:3FJJ|rcsb pdb:3FJK|rcsb pdb:3HOM|rcsb pdb:3JUT|rcsb pdb:3K1X|rcsb pdb:3O3Q|rcsb pdb:3OJ2|rcsb pdb:3OJM|rcsb pdb:3OJV|rcsb pdb:3UD7|rcsb pdb:3UD8|rcsb pdb:3UD9|rcsb pdb:3UDA|rcsb pdb:4J23|rcsb pdb:4Q91|rcsb pdb:4Q9G|rcsb pdb:4Q9P|rcsb pdb:4QAL|rcsb pdb:4QBC|rcsb pdb:4QBV|rcsb pdb:4QC4|rcsb pdb:4QO3|rcsb pdb:4XKI|rcsb pdb:4YOL|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190370|reactome:R-HSA-190371|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor which its binds via the sequence R-G-D in the ligand.|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer	-	figure legend:1a, 3a, 3b|comment:The binding to FGF1 is cation-dependent and requires an intact three-dimensional  structure of FGF1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/07	2019/02/06	-	rogid:k1O8U8SRvl73sZ+J+gxmlUjAGow9606	intact-crc:AA2F654368776670	false	his tag:c-c	mutation decreasing interaction:127-127,128-128|mutation decreasing interaction:133-133,134-134|mutation decreasing interaction:127-127,128-128,133-133,134-134|mutation decreasing interaction:50-50	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05230	chembl target:CHEMBL1907598	intact:EBI-698068|uniprotkb:P07502|uniprotkb:Q16588|uniprotkb:B2R5T0|uniprotkb:D3DQF2|ensembl:ENSP00000338548|ensembl:ENSP00000352329|ensembl:ENSP00000367285|ensembl:ENSP00000396195|ensembl:ENSP00000404742|ensembl:ENSP00000479024|ensembl:ENSP00000480791|ensembl:ENSP00000480980|ensembl:ENSP00000481868	intact:EBI-2550735|reactome:R-HSA-210216|matrixdb:MULT_16_human|wwpdb:3ije|wwpdb:4g1e|wwpdb:1U8C|wwpdb:1jv2|wwpdb:1m1x|wwpdb:4g1m|signor:SIGNOR-C177	psi-mi:fgf1_human(display_long)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:FGFA(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)	psi-mi:intg_av_b3_human(display_short)|psi-mi:CHEMBL1907598(display_long)|intact:alphav-beta3 integrin complex(complex synonym)|intact:alpha-v/beta-3 integrin complex(complex synonym)|intact:Integrin alphav-beta3 complex(complex recommended name)|intact:"ITGAV:ITGB3"(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Mori et al. (2008)	imex:IM-18768|pubmed:18441324	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6509751|imex:IM-18768-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_000791.1|refseq:NP_001138364.1|refseq:NP_001138406.1|refseq:NP_001138407.1|refseq:NP_149127.1|refseq:NP_001244134.1|refseq:NP_001244136.1|refseq:NP_001244137.1|refseq:NP_001244138.1|refseq:NP_001244139.1|dip:DIP-3787N|ensembl:ENSG00000113578(gene)|ensembl:ENST00000337706(transcript)|ensembl:ENST00000359370(transcript)|ensembl:ENST00000378046(transcript)|ensembl:ENST00000419524(transcript)|ensembl:ENST00000441680(transcript)|ensembl:ENST00000610990(transcript)|ensembl:ENST00000612258(transcript)|ensembl:ENST00000619447(transcript)|ensembl:ENST00000621536(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AXM|rcsb pdb:1DJS|rcsb pdb:1DZC|rcsb pdb:1DZD|rcsb pdb:1E0O|rcsb pdb:1EVT|rcsb pdb:1HKN|rcsb pdb:1JQZ|rcsb pdb:1JT3|rcsb pdb:1JT4|rcsb pdb:1JT5|rcsb pdb:1JT7|rcsb pdb:1JTC|rcsb pdb:1JY0|rcsb pdb:1K5U|rcsb pdb:1K5V|rcsb pdb:1M16|rcsb pdb:1NZK|rcsb pdb:1P63|rcsb pdb:1PZZ|rcsb pdb:1Q03|rcsb pdb:1Q04|rcsb pdb:1QCT|rcsb pdb:1RG8|rcsb pdb:1RML|rcsb pdb:1RY7|rcsb pdb:1YTO|rcsb pdb:1Z2V|rcsb pdb:1Z4S|rcsb pdb:2AFG|rcsb pdb:2AQZ|rcsb pdb:2AXM|rcsb pdb:2ERM|rcsb pdb:2HW9|rcsb pdb:2HWA|rcsb pdb:2HWM|rcsb pdb:2HZ9|rcsb pdb:2K43|rcsb pdb:2K4A|rcsb pdb:2K8R|rcsb pdb:2KI4|rcsb pdb:2KI6|rcsb pdb:2NTD|rcsb pdb:2Q9X|rcsb pdb:2RQ9|rcsb pdb:3B9U|rcsb pdb:3BA4|rcsb pdb:3BA5|rcsb pdb:3BA7|rcsb pdb:3BAD|rcsb pdb:3BAG|rcsb pdb:3BAH|rcsb pdb:3BAO|rcsb pdb:3BAQ|rcsb pdb:3BAU|rcsb pdb:3BAV|rcsb pdb:3BB2|rcsb pdb:3CQA|rcsb pdb:3CRG|rcsb pdb:3CRH|rcsb pdb:3CRI|rcsb pdb:3CU1|rcsb pdb:3FGM|rcsb pdb:3FJ8|rcsb pdb:3FJ9|rcsb pdb:3FJA|rcsb pdb:3FJB|rcsb pdb:3FJC|rcsb pdb:3FJD|rcsb pdb:3FJE|rcsb pdb:3FJF|rcsb pdb:3FJH|rcsb pdb:3FJI|rcsb pdb:3FJJ|rcsb pdb:3FJK|rcsb pdb:3HOM|rcsb pdb:3JUT|rcsb pdb:3K1X|rcsb pdb:3O3Q|rcsb pdb:3OJ2|rcsb pdb:3OJM|rcsb pdb:3OJV|rcsb pdb:3UD7|rcsb pdb:3UD8|rcsb pdb:3UD9|rcsb pdb:3UDA|rcsb pdb:4J23|rcsb pdb:4Q91|rcsb pdb:4Q9G|rcsb pdb:4Q9P|rcsb pdb:4QAL|rcsb pdb:4QBC|rcsb pdb:4QBV|rcsb pdb:4QC4|rcsb pdb:4QO3|rcsb pdb:4XKI|rcsb pdb:4YOL|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190370|reactome:R-HSA-190371|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338	go:"GO:0034683"(integrin alphav-beta3 complex)|pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|intact:EBI-1039821(exp-evidence)|complex portal:CPX-1795(complex-primary)|evidence ontology:"ECO:0000353"	-	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor which its binds via the sequence R-G-D in the ligand.|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer	figure legend:3c, 3d|comment:"The R50E mutant showed much lower Rmax value and enhanced off-rate to alpha beta 3, whereas it has a KD value to alpha beta 3 (1.31 uM) similar to WT FGF1"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.1x10^-6(molar)	2013/02/07	2019/02/06	rogid:k1O8U8SRvl73sZ+J+gxmlUjAGow9606	-	intact-crc:D731C810C34C30F3	false	mutation decreasing interaction:50-50	his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11362	uniprotkb:P05230	intact:EBI-1028277|uniprotkb:P17049|uniprotkb:Q02063|uniprotkb:Q02065|uniprotkb:Q14306|uniprotkb:Q14307|uniprotkb:Q8N685|uniprotkb:C1KBH8|uniprotkb:Q9UDF0|uniprotkb:Q9UDF1|uniprotkb:Q9UDF2|uniprotkb:Q59H40|uniprotkb:Q5BJG2|uniprotkb:A8K6T9|uniprotkb:A8K8V5|uniprotkb:Q53H63|uniprotkb:Q9UD50|intact:EBI-1058611|ensembl:ENSP00000400162	intact:EBI-698068|uniprotkb:P07502|uniprotkb:Q16588|uniprotkb:B2R5T0|uniprotkb:D3DQF2|ensembl:ENSP00000338548|ensembl:ENSP00000352329|ensembl:ENSP00000367285|ensembl:ENSP00000396195|ensembl:ENSP00000404742|ensembl:ENSP00000479024|ensembl:ENSP00000480791|ensembl:ENSP00000480980|ensembl:ENSP00000481868	psi-mi:fgfr1_human(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:N-sam(gene name synonym)	psi-mi:fgf1_human(display_long)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:FGFA(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mori et al. (2008)	imex:IM-18768|pubmed:18441324	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6509819|imex:IM-18768-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001167534.1|refseq:NP_001167535.1|refseq:NP_001167536.1|refseq:NP_001167537.1|refseq:NP_001167538.1|refseq:NP_056934.2|refseq:NP_075593.1|refseq:NP_075594.1|refseq:NP_075598.2|ensembl:ENSG00000077782(gene)|ensembl:ENST00000447712(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P11362|rcsb pdb:1AGW|rcsb pdb:1CVS|rcsb pdb:1EVT|rcsb pdb:1FGI|rcsb pdb:1FGK|rcsb pdb:1FQ9|go:"GO:0045666"(positive regulation of neuron differentiation)|rcsb pdb:1XR0|rcsb pdb:2CR3|rcsb pdb:2FGI|rcsb pdb:3C4F|rcsb pdb:3DPK|rcsb pdb:3GQI|rcsb pdb:3GQL|rcsb pdb:3JS2|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3KXX|rcsb pdb:3KY2|rcsb pdb:3OJV|rcsb pdb:3RHX|rcsb pdb:3TT0|rcsb pdb:4F63|rcsb pdb:4F64|rcsb pdb:4F65|rcsb pdb:4NK9|rcsb pdb:4NKA|rcsb pdb:4NKS|rcsb pdb:4RWI|rcsb pdb:4RWJ|rcsb pdb:4RWK|rcsb pdb:4RWL|rcsb pdb:4UWC|rcsb pdb:4UWY|rcsb pdb:4V01|rcsb pdb:4V04|rcsb pdb:4V05|rcsb pdb:4WUN|rcsb pdb:4ZSA|rcsb pdb:5A46|rcsb pdb:5A4C|rcsb pdb:5AM6|rcsb pdb:5AM7|rcsb pdb:5B7V|rcsb pdb:5EW8|rcsb pdb:5FLF|rcsb pdb:5O49|rcsb pdb:5O4A|rcsb pdb:5UQ0|rcsb pdb:5UR1|rcsb pdb:5VND|rcsb pdb:5W21|rcsb pdb:5W59|rcsb pdb:5Z0S|rcsb pdb:5ZV2|rcsb pdb:6C18|rcsb pdb:6C19|rcsb pdb:6C1B|rcsb pdb:6C1C|rcsb pdb:6C1O|rcsb pdb:6ITJ|rcsb pdb:6MZQ|rcsb pdb:6MZW|rcsb pdb:6NVL|rcsb pdb:6P68|rcsb pdb:6P69|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839120|rcsb pdb:4UWB|reactome:R-HSA-1839122|reactome:R-HSA-190370|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-2219530|reactome:R-HSA-375165|reactome:R-HSA-445144|reactome:R-HSA-5654219|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853336|reactome:R-HSA-5654726|dip:DIP-4019N	refseq:NP_000791.1|refseq:NP_001138364.1|refseq:NP_001138406.1|refseq:NP_001138407.1|refseq:NP_149127.1|refseq:NP_001244134.1|refseq:NP_001244136.1|refseq:NP_001244137.1|refseq:NP_001244138.1|refseq:NP_001244139.1|dip:DIP-3787N|ensembl:ENSG00000113578(gene)|ensembl:ENST00000337706(transcript)|ensembl:ENST00000359370(transcript)|ensembl:ENST00000378046(transcript)|ensembl:ENST00000419524(transcript)|ensembl:ENST00000441680(transcript)|ensembl:ENST00000610990(transcript)|ensembl:ENST00000612258(transcript)|ensembl:ENST00000619447(transcript)|ensembl:ENST00000621536(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AXM|rcsb pdb:1DJS|rcsb pdb:1DZC|rcsb pdb:1DZD|rcsb pdb:1E0O|rcsb pdb:1EVT|rcsb pdb:1HKN|rcsb pdb:1JQZ|rcsb pdb:1JT3|rcsb pdb:1JT4|rcsb pdb:1JT5|rcsb pdb:1JT7|rcsb pdb:1JTC|rcsb pdb:1JY0|rcsb pdb:1K5U|rcsb pdb:1K5V|rcsb pdb:1M16|rcsb pdb:1NZK|rcsb pdb:1P63|rcsb pdb:1PZZ|rcsb pdb:1Q03|rcsb pdb:1Q04|rcsb pdb:1QCT|rcsb pdb:1RG8|rcsb pdb:1RML|rcsb pdb:1RY7|rcsb pdb:1YTO|rcsb pdb:1Z2V|rcsb pdb:1Z4S|rcsb pdb:2AFG|rcsb pdb:2AQZ|rcsb pdb:2AXM|rcsb pdb:2ERM|rcsb pdb:2HW9|rcsb pdb:2HWA|rcsb pdb:2HWM|rcsb pdb:2HZ9|rcsb pdb:2K43|rcsb pdb:2K4A|rcsb pdb:2K8R|rcsb pdb:2KI4|rcsb pdb:2KI6|rcsb pdb:2NTD|rcsb pdb:2Q9X|rcsb pdb:2RQ9|rcsb pdb:3B9U|rcsb pdb:3BA4|rcsb pdb:3BA5|rcsb pdb:3BA7|rcsb pdb:3BAD|rcsb pdb:3BAG|rcsb pdb:3BAH|rcsb pdb:3BAO|rcsb pdb:3BAQ|rcsb pdb:3BAU|rcsb pdb:3BAV|rcsb pdb:3BB2|rcsb pdb:3CQA|rcsb pdb:3CRG|rcsb pdb:3CRH|rcsb pdb:3CRI|rcsb pdb:3CU1|rcsb pdb:3FGM|rcsb pdb:3FJ8|rcsb pdb:3FJ9|rcsb pdb:3FJA|rcsb pdb:3FJB|rcsb pdb:3FJC|rcsb pdb:3FJD|rcsb pdb:3FJE|rcsb pdb:3FJF|rcsb pdb:3FJH|rcsb pdb:3FJI|rcsb pdb:3FJJ|rcsb pdb:3FJK|rcsb pdb:3HOM|rcsb pdb:3JUT|rcsb pdb:3K1X|rcsb pdb:3O3Q|rcsb pdb:3OJ2|rcsb pdb:3OJM|rcsb pdb:3OJV|rcsb pdb:3UD7|rcsb pdb:3UD8|rcsb pdb:3UD9|rcsb pdb:3UDA|rcsb pdb:4J23|rcsb pdb:4Q91|rcsb pdb:4Q9G|rcsb pdb:4Q9P|rcsb pdb:4QAL|rcsb pdb:4QBC|rcsb pdb:4QBV|rcsb pdb:4QC4|rcsb pdb:4QO3|rcsb pdb:4XKI|rcsb pdb:4YOL|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190370|reactome:R-HSA-190371|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338	-	-	-	figure legend:4a-c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.0x10^-11(molar)	2013/02/07	2014/10/16	rogid:th/BEfNYh60oKK7G0HFX+O1pXh89606	rogid:k1O8U8SRvl73sZ+J+gxmlUjAGow9606	intact-crc:BEF53501D642A90B|rigid:i6yP4lX+fDXMrjIeeuzilPpQz5E	false	sufficient binding region:140-365	mutation decreasing interaction strength:102-102,109-109,110-110|mutation decreasing interaction strength:127-127,128-128,133-133,134-134	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:28304"	uniprotkb:P05230	intact:EBI-1379423	intact:EBI-698068|uniprotkb:P07502|uniprotkb:Q16588|uniprotkb:B2R5T0|uniprotkb:D3DQF2|ensembl:ENSP00000338548|ensembl:ENSP00000352329|ensembl:ENSP00000367285|ensembl:ENSP00000396195|ensembl:ENSP00000404742|ensembl:ENSP00000479024|ensembl:ENSP00000480791|ensembl:ENSP00000480980|ensembl:ENSP00000481868	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:fgf1_human(display_long)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:FGFA(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mori et al. (2008)	imex:IM-18768|pubmed:18441324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6509859|imex:IM-18768-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000791.1|refseq:NP_001138364.1|refseq:NP_001138406.1|refseq:NP_001138407.1|refseq:NP_149127.1|refseq:NP_001244134.1|refseq:NP_001244136.1|refseq:NP_001244137.1|refseq:NP_001244138.1|refseq:NP_001244139.1|dip:DIP-3787N|ensembl:ENSG00000113578(gene)|ensembl:ENST00000337706(transcript)|ensembl:ENST00000359370(transcript)|ensembl:ENST00000378046(transcript)|ensembl:ENST00000419524(transcript)|ensembl:ENST00000441680(transcript)|ensembl:ENST00000610990(transcript)|ensembl:ENST00000612258(transcript)|ensembl:ENST00000619447(transcript)|ensembl:ENST00000621536(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AXM|rcsb pdb:1DJS|rcsb pdb:1DZC|rcsb pdb:1DZD|rcsb pdb:1E0O|rcsb pdb:1EVT|rcsb pdb:1HKN|rcsb pdb:1JQZ|rcsb pdb:1JT3|rcsb pdb:1JT4|rcsb pdb:1JT5|rcsb pdb:1JT7|rcsb pdb:1JTC|rcsb pdb:1JY0|rcsb pdb:1K5U|rcsb pdb:1K5V|rcsb pdb:1M16|rcsb pdb:1NZK|rcsb pdb:1P63|rcsb pdb:1PZZ|rcsb pdb:1Q03|rcsb pdb:1Q04|rcsb pdb:1QCT|rcsb pdb:1RG8|rcsb pdb:1RML|rcsb pdb:1RY7|rcsb pdb:1YTO|rcsb pdb:1Z2V|rcsb pdb:1Z4S|rcsb pdb:2AFG|rcsb pdb:2AQZ|rcsb pdb:2AXM|rcsb pdb:2ERM|rcsb pdb:2HW9|rcsb pdb:2HWA|rcsb pdb:2HWM|rcsb pdb:2HZ9|rcsb pdb:2K43|rcsb pdb:2K4A|rcsb pdb:2K8R|rcsb pdb:2KI4|rcsb pdb:2KI6|rcsb pdb:2NTD|rcsb pdb:2Q9X|rcsb pdb:2RQ9|rcsb pdb:3B9U|rcsb pdb:3BA4|rcsb pdb:3BA5|rcsb pdb:3BA7|rcsb pdb:3BAD|rcsb pdb:3BAG|rcsb pdb:3BAH|rcsb pdb:3BAO|rcsb pdb:3BAQ|rcsb pdb:3BAU|rcsb pdb:3BAV|rcsb pdb:3BB2|rcsb pdb:3CQA|rcsb pdb:3CRG|rcsb pdb:3CRH|rcsb pdb:3CRI|rcsb pdb:3CU1|rcsb pdb:3FGM|rcsb pdb:3FJ8|rcsb pdb:3FJ9|rcsb pdb:3FJA|rcsb pdb:3FJB|rcsb pdb:3FJC|rcsb pdb:3FJD|rcsb pdb:3FJE|rcsb pdb:3FJF|rcsb pdb:3FJH|rcsb pdb:3FJI|rcsb pdb:3FJJ|rcsb pdb:3FJK|rcsb pdb:3HOM|rcsb pdb:3JUT|rcsb pdb:3K1X|rcsb pdb:3O3Q|rcsb pdb:3OJ2|rcsb pdb:3OJM|rcsb pdb:3OJV|rcsb pdb:3UD7|rcsb pdb:3UD8|rcsb pdb:3UD9|rcsb pdb:3UDA|rcsb pdb:4J23|rcsb pdb:4Q91|rcsb pdb:4Q9G|rcsb pdb:4Q9P|rcsb pdb:4QAL|rcsb pdb:4QBC|rcsb pdb:4QBV|rcsb pdb:4QC4|rcsb pdb:4QO3|rcsb pdb:4XKI|rcsb pdb:4YOL|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190370|reactome:R-HSA-190371|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338	-	-	-	figure legend:4e, 4f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:16.6x10^-9(molar)	2013/02/07	2014/10/16	-	rogid:k1O8U8SRvl73sZ+J+gxmlUjAGow9606	intact-crc:E55CE7230FC823C9	false	-	mutation decreasing interaction strength:50-50|mutation decreasing interaction strength:102-102,109-109,110-110	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:28304"	uniprotkb:P05230	intact:EBI-1379423	intact:EBI-698068|uniprotkb:P07502|uniprotkb:Q16588|uniprotkb:B2R5T0|uniprotkb:D3DQF2|ensembl:ENSP00000338548|ensembl:ENSP00000352329|ensembl:ENSP00000367285|ensembl:ENSP00000396195|ensembl:ENSP00000404742|ensembl:ENSP00000479024|ensembl:ENSP00000480791|ensembl:ENSP00000480980|ensembl:ENSP00000481868	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:fgf1_human(display_long)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:FGFA(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Mori et al. (2008)	imex:IM-18768|pubmed:18441324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6509878|imex:IM-18768-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000791.1|refseq:NP_001138364.1|refseq:NP_001138406.1|refseq:NP_001138407.1|refseq:NP_149127.1|refseq:NP_001244134.1|refseq:NP_001244136.1|refseq:NP_001244137.1|refseq:NP_001244138.1|refseq:NP_001244139.1|dip:DIP-3787N|ensembl:ENSG00000113578(gene)|ensembl:ENST00000337706(transcript)|ensembl:ENST00000359370(transcript)|ensembl:ENST00000378046(transcript)|ensembl:ENST00000419524(transcript)|ensembl:ENST00000441680(transcript)|ensembl:ENST00000610990(transcript)|ensembl:ENST00000612258(transcript)|ensembl:ENST00000619447(transcript)|ensembl:ENST00000621536(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AXM|rcsb pdb:1DJS|rcsb pdb:1DZC|rcsb pdb:1DZD|rcsb pdb:1E0O|rcsb pdb:1EVT|rcsb pdb:1HKN|rcsb pdb:1JQZ|rcsb pdb:1JT3|rcsb pdb:1JT4|rcsb pdb:1JT5|rcsb pdb:1JT7|rcsb pdb:1JTC|rcsb pdb:1JY0|rcsb pdb:1K5U|rcsb pdb:1K5V|rcsb pdb:1M16|rcsb pdb:1NZK|rcsb pdb:1P63|rcsb pdb:1PZZ|rcsb pdb:1Q03|rcsb pdb:1Q04|rcsb pdb:1QCT|rcsb pdb:1RG8|rcsb pdb:1RML|rcsb pdb:1RY7|rcsb pdb:1YTO|rcsb pdb:1Z2V|rcsb pdb:1Z4S|rcsb pdb:2AFG|rcsb pdb:2AQZ|rcsb pdb:2AXM|rcsb pdb:2ERM|rcsb pdb:2HW9|rcsb pdb:2HWA|rcsb pdb:2HWM|rcsb pdb:2HZ9|rcsb pdb:2K43|rcsb pdb:2K4A|rcsb pdb:2K8R|rcsb pdb:2KI4|rcsb pdb:2KI6|rcsb pdb:2NTD|rcsb pdb:2Q9X|rcsb pdb:2RQ9|rcsb pdb:3B9U|rcsb pdb:3BA4|rcsb pdb:3BA5|rcsb pdb:3BA7|rcsb pdb:3BAD|rcsb pdb:3BAG|rcsb pdb:3BAH|rcsb pdb:3BAO|rcsb pdb:3BAQ|rcsb pdb:3BAU|rcsb pdb:3BAV|rcsb pdb:3BB2|rcsb pdb:3CQA|rcsb pdb:3CRG|rcsb pdb:3CRH|rcsb pdb:3CRI|rcsb pdb:3CU1|rcsb pdb:3FGM|rcsb pdb:3FJ8|rcsb pdb:3FJ9|rcsb pdb:3FJA|rcsb pdb:3FJB|rcsb pdb:3FJC|rcsb pdb:3FJD|rcsb pdb:3FJE|rcsb pdb:3FJF|rcsb pdb:3FJH|rcsb pdb:3FJI|rcsb pdb:3FJJ|rcsb pdb:3FJK|rcsb pdb:3HOM|rcsb pdb:3JUT|rcsb pdb:3K1X|rcsb pdb:3O3Q|rcsb pdb:3OJ2|rcsb pdb:3OJM|rcsb pdb:3OJV|rcsb pdb:3UD7|rcsb pdb:3UD8|rcsb pdb:3UD9|rcsb pdb:3UDA|rcsb pdb:4J23|rcsb pdb:4Q91|rcsb pdb:4Q9G|rcsb pdb:4Q9P|rcsb pdb:4QAL|rcsb pdb:4QBC|rcsb pdb:4QBV|rcsb pdb:4QC4|rcsb pdb:4QO3|rcsb pdb:4XKI|rcsb pdb:4YOL|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190370|reactome:R-HSA-190371|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338	-	-	-	figure legend:4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/07	2014/10/16	-	rogid:k1O8U8SRvl73sZ+J+gxmlUjAGow9606	intact-crc:21C703B09A1BB4B6	false	-	mutation disrupting interaction strength:127-127,128-128,133-133,134-134	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)