#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-6662444	uniprotkb:Q5F3W0	-	intact:EBI-6621584|ensembl:ENSGALP00000007002	psi-mi:f1n9k8_chick(display_short)|psi-mi:EBI-6662444(display_long)|uniprotkb:PRKCB(gene name)|psi-mi:PRKCB(display_short)	psi-mi:q5f3w0_chick(display_long)|uniprotkb:CARD11(gene name)|psi-mi:CARD11(display_short)|uniprotkb:RCJMB04_5k17(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Shinohara et al. (2007)	pubmed:18086859|imex:IM-26003	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6662394|imex:IM-26003-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:F1N9K8(uniprot-removed-ac)	ensembl:ENSGALG00000004398(gene)|ensembl:ENSGALT00000007013(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0089720"(caspase binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|reactome:R-GGA-1169091|reactome:R-GGA-202424|reactome:R-GGA-2871837|refseq:XP_015149649.1|refseq:NP_001006161.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:2B and C|comment:PKCB phosphorylate Ser668 on CARMA1. PKCB deficient DT40 cells abolished Ser668 phosphorylation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/01	2014/10/16	rogid:2u3W7zYnqa1hErIZodHjlngL5dc9031	rogid:lpSfH9WZ+nCo2PkHAv/SFhKEb9I9031	intact-crc:BF17D5D8BFA3270A|rigid:SJBvZmz7sB7Q+AXxGvMqhUAg5Ys	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:A0A1D5PFV1	uniprotkb:Q5F3W0	intact:EBI-6693686|ensembl:ENSGALP00000051668	intact:EBI-6621584|ensembl:ENSGALP00000007002	psi-mi:a0a1d5pfv1_chick(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)	psi-mi:q5f3w0_chick(display_long)|uniprotkb:CARD11(gene name)|psi-mi:CARD11(display_short)|uniprotkb:RCJMB04_5k17(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Shinohara et al. (2007)	pubmed:18086859|imex:IM-26003	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6662473|imex:IM-26003-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0495"(experimental role)	psi-mi:"MI:0495"(experimental role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_015152864.1|refseq:XP_015152865.1|refseq:XP_015152866.1|ensembl:ENSGALT00000046784(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|reactome:R-GGA-9020702|ensembl:ENSGALG00000031832(gene)|uniprotkb:E1BQV3(uniprot-removed-ac)	ensembl:ENSGALG00000004398(gene)|ensembl:ENSGALT00000007013(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0089720"(caspase binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|reactome:R-GGA-1169091|reactome:R-GGA-202424|reactome:R-GGA-2871837|refseq:XP_015149649.1|refseq:NP_001006161.2	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:4F|comment:IKKB phosphorylate Ser578 on CARMA1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/01	2017/09/02	rogid:j51ksaDEffKv+OnXGDqHJL0ffDE9031	rogid:lpSfH9WZ+nCo2PkHAv/SFhKEb9I9031	intact-crc:80C3D501BA75EE5B|rigid:7mSRaMEkZP6NGLY8UUN2Ig5F3hM	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5F3W0	intact:EBI-6621732	intact:EBI-6621584|ensembl:ENSGALP00000007002	-	psi-mi:q5f3w0_chick(display_long)|uniprotkb:CARD11(gene name)|psi-mi:CARD11(display_short)|uniprotkb:RCJMB04_5k17(orf name)	psi-mi:f1nkg4_chick(display_short)|psi-mi:EBI-6621732(display_long)|uniprotkb:BCL10(gene name)|psi-mi:BCL10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shinohara et al. (2007)	pubmed:18086859|imex:IM-26003	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6662511|imex:IM-26003-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000004398(gene)|ensembl:ENSGALT00000007013(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0089720"(caspase binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|reactome:R-GGA-1169091|reactome:R-GGA-202424|reactome:R-GGA-2871837|refseq:XP_015149649.1|refseq:NP_001006161.2	uniprotkb:F1NKG4(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:2D, 4E and 5B|comment:"S668A or Sre578 CARMA1 mutant failed to make inducible association with Bcl10 and MALT1.  In IKKB deficient (Fig 5C) and kinase-inactive IKKB (Fig 4B), the initial CARMA-Bcl10-MALT1 association was significantly reduced. You also need to add an anti-bait coip expt for the interaction with the non-tagged, endogenous protein in 5C - treat this as one interaction , not 2."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma)	-	2013/05/01	2014/10/16	rogid:lpSfH9WZ+nCo2PkHAv/SFhKEb9I9031	rogid:CdBa2LomNT7Ivi0KQ7r6qZW7IkE9031	intact-crc:E403C66E9F0FA347|rigid:xkOml5qfv/Fv8iPHLjAueXAPQas	false	mutation decreasing interaction strength:119-119|mutation decreasing interaction strength:578-578|mutation decreasing interaction strength:668-668|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5F3W0	intact:EBI-6621774	intact:EBI-6621584|ensembl:ENSGALP00000007002	-	psi-mi:q5f3w0_chick(display_long)|uniprotkb:CARD11(gene name)|psi-mi:CARD11(display_short)|uniprotkb:RCJMB04_5k17(orf name)	psi-mi:e1c736_chick(display_short)|psi-mi:EBI-6621774(display_long)|uniprotkb:MALT1(gene name)|psi-mi:MALT1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shinohara et al. (2007)	pubmed:18086859|imex:IM-26003	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6662511|imex:IM-26003-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000004398(gene)|ensembl:ENSGALT00000007013(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0089720"(caspase binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|reactome:R-GGA-1169091|reactome:R-GGA-202424|reactome:R-GGA-2871837|refseq:XP_015149649.1|refseq:NP_001006161.2	uniprotkb:E1C736(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:2D, 4E and 5B|comment:"S668A or Sre578 CARMA1 mutant failed to make inducible association with Bcl10 and MALT1.  In IKKB deficient (Fig 5C) and kinase-inactive IKKB (Fig 4B), the initial CARMA-Bcl10-MALT1 association was significantly reduced. You also need to add an anti-bait coip expt for the interaction with the non-tagged, endogenous protein in 5C - treat this as one interaction , not 2."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9031(chick-dt40)|taxid:9031(Gallus gallus bursa lymphoma)	-	2013/05/01	2014/10/16	rogid:lpSfH9WZ+nCo2PkHAv/SFhKEb9I9031	rogid:2RP65NJXT5+0U2quxDpQ274aw9c9031	intact-crc:E403C66E9F0FA347|rigid:xkOml5qfv/Fv8iPHLjAueXAPQas	false	mutation decreasing interaction strength:119-119|mutation decreasing interaction strength:578-578|mutation decreasing interaction strength:668-668|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)