#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9ULV1	uniprotkb:Q00604	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	intact:EBI-2466352|ensembl:ENSP00000495811|ensembl:ENSP00000495972|uniprotkb:B2R8K6|uniprotkb:Q5JYH5	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:ndp_human(display_long)|uniprotkb:NDP(gene name)|psi-mi:NDP(display_short)|uniprotkb:EVR2(gene name synonym)|uniprotkb:Norrie disease protein(gene name synonym)|uniprotkb:X-linked exudative vitreoretinopathy 2 protein(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Qin et al. (2008)	pubmed:17955262|imex:IM-22153	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8803168|imex:IM-22153-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	ensembl:ENSG00000124479(gene)|ensembl:ENST00000642620(transcript)|ensembl:ENST00000647044(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0007033"(vacuole organization)|go:"GO:0007601"(visual perception)|go:"GO:0009986"(cell surface)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0110135"(Norrin signaling pathway)|interpro:IPR003064(Norrie disease protein)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|rcsb pdb:4MY2|rcsb pdb:5BPU|rcsb pdb:5BQ8|rcsb pdb:5BQB|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|refseq:NP_000257.1	-	-	-	figure legend:Fig. 2A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/18	2014/10/16	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	rogid:txldiltjgs1N5AzEoO3c/RWXit09606	intact-crc:9D68F4495F148BA8|rigid:+Xm8hSxxhs+tZ/gbBRJA57x1wig	false	mutation decreasing interaction:105-105|necessary binding region:319-537	myc tag:?-?|fusion protein:?-?|mutation decreasing interaction:54-54|mutation decreasing interaction:115-115	-	-	psi-mi:"MI:0362"(inference)	psi-mi:"MI:0980"(tag visualisation by enzyme assay)