#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P12815	uniprotkb:Q8N114	intact:EBI-309164|uniprotkb:Q545I0|uniprotkb:Q61145|ensembl:ENSMUSP00000022060|intact:EBI-6896040	intact:EBI-2115556|uniprotkb:Q69YY9|uniprotkb:Q7Z433|uniprotkb:Q8NHL9|uniprotkb:Q96MW8|uniprotkb:Q9BV58|uniprotkb:B3KW99|uniprotkb:F8W9N8|intact:EBI-28987597|ensembl:ENSP00000296444	psi-mi:pdcd6_mouse(display_long)|uniprotkb:Pdcd6(gene name)|psi-mi:Pdcd6(display_short)|uniprotkb:Alg2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein(gene name synonym)|uniprotkb:PMP41(gene name synonym)|uniprotkb:ALG-257(gene name synonym)	psi-mi:shsa5_human(display_long)|uniprotkb:SHISA5(gene name)|psi-mi:SHISA5(display_short)|uniprotkb:SCOTIN(gene name synonym)|uniprotkb:Scotin(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 120(gene name synonym)|uniprotkb:PSEC0133(orf name)	psi-mi:"MI:0096"(pull down)	Draeby et al. (2007)	imex:IM-20894|pubmed:17889823	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6693554|imex:IM-20894-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035181.1|refseq:XP_006517219.1|ensembl:ENSMUSG00000021576(gene)|ensembl:ENSMUST00000022060(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1HQV|rcsb pdb:5JJG	refseq:XP_011532098.1|refseq:NP_057563.3|refseq:XP_006713251.1|ensembl:ENSP00000296444|ensembl:ENST00000426002|ensembl:ENSP00000390388|ensembl:ENST00000442747|ensembl:ENSP00000408223|ensembl:ENST00000443308|ensembl:ENSP00000395373|ensembl:ENST00000444115|ensembl:ENSP00000407957|ensembl:ENST00000619810|ensembl:ENSP00000484992|refseq:NP_001258995.1|refseq:NP_001258996.1|refseq:NP_001258997.1|refseq:NP_001259011.1|refseq:NP_001259012.1|refseq:NP_001258994.1|refseq:XP_005265262.1|ensembl:ENSG00000164054(gene)|ensembl:ENST00000296444(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050699"(WW domain binding)|interpro:IPR026910|reactome:R-HSA-381426|reactome:R-HSA-8957275	intact:EBI-6693634(see-also)	-	-	figure legend:Fig. 2a|stimulant:"Interaction is Ca2+ dependent. It occurs in the presence of 1mM CaCl2 but not in the presence of 1mM ethylene glycol tetraacetate (EGTA) chelating agent."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/29	2014/10/16	rogid:JgwCqMEgIZ12mnBk898EvUlOQOc10090	rogid:MLYJ9JCjKJoqnxTae9YhMWaWOM49606	intact-crc:90484DE1F611D447|rigid:E9m6bi20KzPvRmuH91C4Z3FjJig	false	glutathione s tranferase tag:n-n	his tag:c-c|sufficient binding region:68-240	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12815	uniprotkb:Q8N114	intact:EBI-309164|uniprotkb:Q545I0|uniprotkb:Q61145|ensembl:ENSMUSP00000022060|intact:EBI-6896040	intact:EBI-2115556|uniprotkb:Q69YY9|uniprotkb:Q7Z433|uniprotkb:Q8NHL9|uniprotkb:Q96MW8|uniprotkb:Q9BV58|uniprotkb:B3KW99|uniprotkb:F8W9N8|intact:EBI-28987597|ensembl:ENSP00000296444	psi-mi:pdcd6_mouse(display_long)|uniprotkb:Pdcd6(gene name)|psi-mi:Pdcd6(display_short)|uniprotkb:Alg2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein(gene name synonym)|uniprotkb:PMP41(gene name synonym)|uniprotkb:ALG-257(gene name synonym)	psi-mi:shsa5_human(display_long)|uniprotkb:SHISA5(gene name)|psi-mi:SHISA5(display_short)|uniprotkb:SCOTIN(gene name synonym)|uniprotkb:Scotin(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 120(gene name synonym)|uniprotkb:PSEC0133(orf name)	psi-mi:"MI:0047"(far western blotting)	Draeby et al. (2007)	imex:IM-20894|pubmed:17889823	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6693661|imex:IM-20894-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035181.1|refseq:XP_006517219.1|ensembl:ENSMUSG00000021576(gene)|ensembl:ENSMUST00000022060(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1HQV|rcsb pdb:5JJG	refseq:XP_011532098.1|refseq:NP_057563.3|refseq:XP_006713251.1|ensembl:ENSP00000296444|ensembl:ENST00000426002|ensembl:ENSP00000390388|ensembl:ENST00000442747|ensembl:ENSP00000408223|ensembl:ENST00000443308|ensembl:ENSP00000395373|ensembl:ENST00000444115|ensembl:ENSP00000407957|ensembl:ENST00000619810|ensembl:ENSP00000484992|refseq:NP_001258995.1|refseq:NP_001258996.1|refseq:NP_001258997.1|refseq:NP_001259011.1|refseq:NP_001259012.1|refseq:NP_001258994.1|refseq:XP_005265262.1|ensembl:ENSG00000164054(gene)|ensembl:ENST00000296444(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050699"(WW domain binding)|interpro:IPR026910|reactome:R-HSA-381426|reactome:R-HSA-8957275	-	-	-	figure legend:Fig. 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/29	2014/10/16	rogid:JgwCqMEgIZ12mnBk898EvUlOQOc10090	rogid:MLYJ9JCjKJoqnxTae9YhMWaWOM49606	intact-crc:7219F085C367E316|rigid:E9m6bi20KzPvRmuH91C4Z3FjJig	false	glutathione s tranferase tag:n-n	sufficient binding region:123-240|flag tag:c-c|glutathione s tranferase tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12815	uniprotkb:Q8N114	intact:EBI-309164|uniprotkb:Q545I0|uniprotkb:Q61145|ensembl:ENSMUSP00000022060|intact:EBI-6896040	intact:EBI-2115556|uniprotkb:Q69YY9|uniprotkb:Q7Z433|uniprotkb:Q8NHL9|uniprotkb:Q96MW8|uniprotkb:Q9BV58|uniprotkb:B3KW99|uniprotkb:F8W9N8|intact:EBI-28987597|ensembl:ENSP00000296444	psi-mi:pdcd6_mouse(display_long)|uniprotkb:Pdcd6(gene name)|psi-mi:Pdcd6(display_short)|uniprotkb:Alg2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein(gene name synonym)|uniprotkb:PMP41(gene name synonym)|uniprotkb:ALG-257(gene name synonym)	psi-mi:shsa5_human(display_long)|uniprotkb:SHISA5(gene name)|psi-mi:SHISA5(display_short)|uniprotkb:SCOTIN(gene name synonym)|uniprotkb:Scotin(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 120(gene name synonym)|uniprotkb:PSEC0133(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draeby et al. (2007)	imex:IM-20894|pubmed:17889823	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6857386|imex:IM-20894-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035181.1|refseq:XP_006517219.1|ensembl:ENSMUSG00000021576(gene)|ensembl:ENSMUST00000022060(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1HQV|rcsb pdb:5JJG	refseq:XP_011532098.1|refseq:NP_057563.3|refseq:XP_006713251.1|ensembl:ENSP00000296444|ensembl:ENST00000426002|ensembl:ENSP00000390388|ensembl:ENST00000442747|ensembl:ENSP00000408223|ensembl:ENST00000443308|ensembl:ENSP00000395373|ensembl:ENST00000444115|ensembl:ENSP00000407957|ensembl:ENST00000619810|ensembl:ENSP00000484992|refseq:NP_001258995.1|refseq:NP_001258996.1|refseq:NP_001258997.1|refseq:NP_001259011.1|refseq:NP_001259012.1|refseq:NP_001258994.1|refseq:XP_005265262.1|ensembl:ENSG00000164054(gene)|ensembl:ENST00000296444(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050699"(WW domain binding)|interpro:IPR026910|reactome:R-HSA-381426|reactome:R-HSA-8957275	-	-	-	figure legend:Fig. 3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2013/05/29	2014/10/16	rogid:JgwCqMEgIZ12mnBk898EvUlOQOc10090	rogid:MLYJ9JCjKJoqnxTae9YhMWaWOM49606	intact-crc:3760FAE6A016844F|rigid:E9m6bi20KzPvRmuH91C4Z3FjJig	false	ha tag:n-n	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12815	uniprotkb:Q8N114	intact:EBI-309164|uniprotkb:Q545I0|uniprotkb:Q61145|ensembl:ENSMUSP00000022060|intact:EBI-6896040	intact:EBI-2115556|uniprotkb:Q69YY9|uniprotkb:Q7Z433|uniprotkb:Q8NHL9|uniprotkb:Q96MW8|uniprotkb:Q9BV58|uniprotkb:B3KW99|uniprotkb:F8W9N8|intact:EBI-28987597|ensembl:ENSP00000296444	psi-mi:pdcd6_mouse(display_long)|uniprotkb:Pdcd6(gene name)|psi-mi:Pdcd6(display_short)|uniprotkb:Alg2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein(gene name synonym)|uniprotkb:PMP41(gene name synonym)|uniprotkb:ALG-257(gene name synonym)	psi-mi:shsa5_human(display_long)|uniprotkb:SHISA5(gene name)|psi-mi:SHISA5(display_short)|uniprotkb:SCOTIN(gene name synonym)|uniprotkb:Scotin(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 120(gene name synonym)|uniprotkb:PSEC0133(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draeby et al. (2007)	imex:IM-20894|pubmed:17889823	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6857409|imex:IM-20894-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035181.1|refseq:XP_006517219.1|ensembl:ENSMUSG00000021576(gene)|ensembl:ENSMUST00000022060(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1HQV|rcsb pdb:5JJG	refseq:XP_011532098.1|refseq:NP_057563.3|refseq:XP_006713251.1|ensembl:ENSP00000296444|ensembl:ENST00000426002|ensembl:ENSP00000390388|ensembl:ENST00000442747|ensembl:ENSP00000408223|ensembl:ENST00000443308|ensembl:ENSP00000395373|ensembl:ENST00000444115|ensembl:ENSP00000407957|ensembl:ENST00000619810|ensembl:ENSP00000484992|refseq:NP_001258995.1|refseq:NP_001258996.1|refseq:NP_001258997.1|refseq:NP_001259011.1|refseq:NP_001259012.1|refseq:NP_001258994.1|refseq:XP_005265262.1|ensembl:ENSG00000164054(gene)|ensembl:ENST00000296444(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050699"(WW domain binding)|interpro:IPR026910|reactome:R-HSA-381426|reactome:R-HSA-8957275	intact:EBI-6857432(see-also)	-	-	figure legend:Fig. 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2013/05/29	2014/10/16	rogid:JgwCqMEgIZ12mnBk898EvUlOQOc10090	rogid:MLYJ9JCjKJoqnxTae9YhMWaWOM49606	intact-crc:FE18237B7786A581|rigid:E9m6bi20KzPvRmuH91C4Z3FjJig	false	mutation disrupting interaction strength:47-47,114-114|enhanced green fluorescent protein tag:?-?	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12815	uniprotkb:Q8N114	intact:EBI-309164|uniprotkb:Q545I0|uniprotkb:Q61145|ensembl:ENSMUSP00000022060|intact:EBI-6896040	intact:EBI-2115556|uniprotkb:Q69YY9|uniprotkb:Q7Z433|uniprotkb:Q8NHL9|uniprotkb:Q96MW8|uniprotkb:Q9BV58|uniprotkb:B3KW99|uniprotkb:F8W9N8|intact:EBI-28987597|ensembl:ENSP00000296444	psi-mi:pdcd6_mouse(display_long)|uniprotkb:Pdcd6(gene name)|psi-mi:Pdcd6(display_short)|uniprotkb:Alg2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein(gene name synonym)|uniprotkb:PMP41(gene name synonym)|uniprotkb:ALG-257(gene name synonym)	psi-mi:shsa5_human(display_long)|uniprotkb:SHISA5(gene name)|psi-mi:SHISA5(display_short)|uniprotkb:SCOTIN(gene name synonym)|uniprotkb:Scotin(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 120(gene name synonym)|uniprotkb:PSEC0133(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Draeby et al. (2007)	imex:IM-20894|pubmed:17889823	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6857465|imex:IM-20894-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035181.1|refseq:XP_006517219.1|ensembl:ENSMUSG00000021576(gene)|ensembl:ENSMUST00000022060(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1HQV|rcsb pdb:5JJG	refseq:XP_011532098.1|refseq:NP_057563.3|refseq:XP_006713251.1|ensembl:ENSP00000296444|ensembl:ENST00000426002|ensembl:ENSP00000390388|ensembl:ENST00000442747|ensembl:ENSP00000408223|ensembl:ENST00000443308|ensembl:ENSP00000395373|ensembl:ENST00000444115|ensembl:ENSP00000407957|ensembl:ENST00000619810|ensembl:ENSP00000484992|refseq:NP_001258995.1|refseq:NP_001258996.1|refseq:NP_001258997.1|refseq:NP_001259011.1|refseq:NP_001259012.1|refseq:NP_001258994.1|refseq:XP_005265262.1|ensembl:ENSG00000164054(gene)|ensembl:ENST00000296444(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050699"(WW domain binding)|interpro:IPR026910|reactome:R-HSA-381426|reactome:R-HSA-8957275	intact:EBI-6857486(see-also)	-	-	figure legend:Fig 3c|agonist:"Treatment of cells with ionomycin (2 micromolar), which increases the intracellular calcium level, further stimulates the interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/05/29	2014/10/16	rogid:JgwCqMEgIZ12mnBk898EvUlOQOc10090	rogid:MLYJ9JCjKJoqnxTae9YhMWaWOM49606	intact-crc:B8B3E64D16D55D48|rigid:E9m6bi20KzPvRmuH91C4Z3FjJig	false	mutation disrupting interaction strength:47-47,114-114|enhanced green fluorescent protein tag:?-?	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12815	uniprotkb:Q9D7I0	intact:EBI-309164|uniprotkb:Q545I0|uniprotkb:Q61145|ensembl:ENSMUSP00000022060|intact:EBI-6896040	intact:EBI-6857565|uniprotkb:Q8BJ86|uniprotkb:Q8BJ87|uniprotkb:Q8BLE9|uniprotkb:Q8K4W3|uniprotkb:Q91Z37|uniprotkb:Q9CQP5|ensembl:ENSMUSP00000026737	psi-mi:pdcd6_mouse(display_long)|uniprotkb:Pdcd6(gene name)|psi-mi:Pdcd6(display_short)|uniprotkb:Alg2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein(gene name synonym)|uniprotkb:PMP41(gene name synonym)|uniprotkb:ALG-257(gene name synonym)	psi-mi:shsa5_mouse(display_long)|uniprotkb:Shisa5(gene name)|psi-mi:Shisa5(display_short)|uniprotkb:Scotin(gene name synonym)|uniprotkb:Scotin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Draeby et al. (2007)	imex:IM-20894|pubmed:17889823	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6857545|imex:IM-20894-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035181.1|refseq:XP_006517219.1|ensembl:ENSMUSG00000021576(gene)|ensembl:ENSMUST00000022060(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1HQV|rcsb pdb:5JJG	refseq:NP_001271261.1|refseq:NP_080134.1|refseq:NP_080657.1|ensembl:ENSMUSG00000025647(gene)|ensembl:ENSMUST00000026737(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0050699"(WW domain binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|interpro:IPR026910|reactome:R-MMU-381426|reactome:R-MMU-8957275	intact:EBI-6857612(see-also)	-	-	figure legend:Fig. 4|stimulant:"Interaction is Ca2+ dependent. It occurs in the presence of 10 micromolar CaCl2 but not in the presence of 1mM ethylene glycol tetraacetate (EGTA) chelating agent."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/29	2014/10/16	rogid:JgwCqMEgIZ12mnBk898EvUlOQOc10090	rogid:ZjVdG/yCMNXHIZvqC4Dd3D5LmZE10090	intact-crc:C6AE38274C4BF290|rigid:zXJUi2ojxlkAGyg1zxtFkdkrQSA	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12815	uniprotkb:Q9WU78	intact:EBI-309164|uniprotkb:Q545I0|uniprotkb:Q61145|ensembl:ENSMUSP00000022060|intact:EBI-6896040	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	psi-mi:pdcd6_mouse(display_long)|uniprotkb:Pdcd6(gene name)|psi-mi:Pdcd6(display_short)|uniprotkb:Alg2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein(gene name synonym)|uniprotkb:PMP41(gene name synonym)|uniprotkb:ALG-257(gene name synonym)	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:"MI:0096"(pull down)	Draeby et al. (2007)	imex:IM-20894|pubmed:17889823	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6857545|imex:IM-20894-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035181.1|refseq:XP_006517219.1|ensembl:ENSMUSG00000021576(gene)|ensembl:ENSMUST00000022060(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1HQV|rcsb pdb:5JJG	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	intact:EBI-6857612(see-also)	-	-	figure legend:Fig. 4|stimulant:"Interaction is Ca2+ dependent. It occurs in the presence of 10 micromolar CaCl2 but not in the presence of 1mM ethylene glycol tetraacetate (EGTA) chelating agent."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/29	2014/10/16	rogid:JgwCqMEgIZ12mnBk898EvUlOQOc10090	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	intact-crc:C6AE38274C4BF290|rigid:zXJUi2ojxlkAGyg1zxtFkdkrQSA	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12815	uniprotkb:Q61187	intact:EBI-309164|uniprotkb:Q545I0|uniprotkb:Q61145|ensembl:ENSMUSP00000022060|intact:EBI-6896040	intact:EBI-1202711|ensembl:ENSMUSP00000014546	psi-mi:pdcd6_mouse(display_long)|uniprotkb:Pdcd6(gene name)|psi-mi:Pdcd6(display_short)|uniprotkb:Alg2(gene name synonym)|uniprotkb:Apoptosis-linked gene 2 protein(gene name synonym)|uniprotkb:PMP41(gene name synonym)|uniprotkb:ALG-257(gene name synonym)	psi-mi:ts101_mouse(display_long)|uniprotkb:Tsg101(gene name)|psi-mi:Tsg101(display_short)|uniprotkb:ESCRT-I complex subunit TSG101(gene name synonym)	psi-mi:"MI:0096"(pull down)	Draeby et al. (2007)	imex:IM-20894|pubmed:17889823	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6857545|imex:IM-20894-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035181.1|refseq:XP_006517219.1|ensembl:ENSMUSG00000021576(gene)|ensembl:ENSMUST00000022060(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1HQV|rcsb pdb:5JJG	refseq:NP_068684.1|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046755"(viral budding)|go:"GO:0046790"(virion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|go:"GO:1990182"(exosomal secretion)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR008883(Tumour susceptibility gene 101)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR017916|interpro:IPR037202|reactome:R-MMU-917729|ensembl:ENSMUSG00000014402(gene)|ensembl:ENSMUST00000014546(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006858"(extracellular transport)|go:"GO:0007049"(cell cycle)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0005815"(microtubule organizing center)	intact:EBI-6857612(see-also)	-	-	figure legend:Fig. 4|stimulant:"Interaction is Ca2+ dependent. It occurs in the presence of 10 micromolar CaCl2 but not in the presence of 1mM ethylene glycol tetraacetate (EGTA) chelating agent."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/29	2014/10/16	rogid:JgwCqMEgIZ12mnBk898EvUlOQOc10090	rogid:xaaLuoyhyn1UgchT9KTyD5FCTHg10090	intact-crc:C6AE38274C4BF290|rigid:zXJUi2ojxlkAGyg1zxtFkdkrQSA	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)