#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14958	uniprotkb:O14958	intact:EBI-6859557|ensembl:ENSP00000261448|uniprotkb:B2R7M6|uniprotkb:Q5T1D2|uniprotkb:Q8TBW8|uniprotkb:B4DIB0	intact:EBI-6859557|ensembl:ENSP00000261448|uniprotkb:B2R7M6|uniprotkb:Q5T1D2|uniprotkb:Q8TBW8|uniprotkb:B4DIB0	psi-mi:casq2_human(display_long)|uniprotkb:CASQ2(gene name)|psi-mi:CASQ2(display_short)|uniprotkb:Calsequestrin, cardiac muscle isoform(gene name synonym)	psi-mi:casq2_human(display_long)|uniprotkb:CASQ2(gene name)|psi-mi:CASQ2(display_short)|uniprotkb:Calsequestrin, cardiac muscle isoform(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Kim et al. (2007)	pubmed:17881003|imex:IM-20996	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6859555|imex:IM-20996-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118729(gene)|refseq:NP_001223.2|ensembl:ENST00000261448(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005737"(cytoplasm)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|interpro:IPR001393(Calsequestrin)|interpro:IPR018233|interpro:IPR036249|interpro:IPR041858|interpro:IPR041859|interpro:IPR041860|rcsb pdb:2VAF|rcsb pdb:6OWV|rcsb pdb:6OWW|reactome:R-HSA-2672351|reactome:R-HSA-5578775	ensembl:ENSG00000118729(gene)|refseq:NP_001223.2|ensembl:ENST00000261448(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005737"(cytoplasm)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|interpro:IPR001393(Calsequestrin)|interpro:IPR018233|interpro:IPR036249|interpro:IPR041858|interpro:IPR041859|interpro:IPR041860|rcsb pdb:2VAF|rcsb pdb:6OWV|rcsb pdb:6OWW|reactome:R-HSA-2672351|reactome:R-HSA-5578775	-	-	-	figure legend:5|agonist:"Ca(2+)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/11	2014/10/16	rogid:CnQZDM3Uy+w0/Uu52gneFw2y7X49606	rogid:CnQZDM3Uy+w0/Uu52gneFw2y7X49606	intact-crc:AFF08C4761A7EDED|rigid:b1kZR5MDBsLoy3dsiU2TWTEcQOY	false	mutation decreasing interaction:307-307|mutation decreasing interaction:33-33|sufficient binding region:22-399|his tag:?-?	mutation decreasing interaction:307-307|mutation decreasing interaction:33-33|sufficient binding region:22-399|his tag:?-?	2	0	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)