#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P23297	uniprotkb:Q15109	intact:EBI-743686|uniprotkb:Q5T7Y3|uniprotkb:B2R5D9|ensembl:ENSP00000292169	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	psi-mi:s10a1_human(display_long)|uniprotkb:S100 calcium-binding protein A1(gene name synonym)|uniprotkb:S-100 protein subunit alpha(gene name synonym)|uniprotkb:S-100 protein alpha chain(gene name synonym)|uniprotkb:S100A1(gene name)|psi-mi:S100A1(display_short)|uniprotkb:S100A(gene name synonym)	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Leclerc et al. (2007)	pubmed:17726019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6479165	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006262.1|ensembl:ENSG00000160678(gene)|ensembl:ENST00000292169(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044548"(S100 protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR028486|mint:P23297|rcsb pdb:2L0P|rcsb pdb:2LHL|rcsb pdb:2LLS|rcsb pdb:2LLT|rcsb pdb:2LLU|rcsb pdb:2LP2|rcsb pdb:2LP3|rcsb pdb:2LUX|rcsb pdb:2M3W|rcsb pdb:5K89|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|interpro:IPR018247	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	-	-	comment:"Soluble AGER (sRAGE) has been used. sRAGE is procuced by proteolytic cleavage and/or alternative splicing and cannot be mapped to a UniProt AcNo."	figure legend:1|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/16	2014/10/16	rogid:cELa51qDGFnYHPBnpUhMDGYPfOk9606	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	intact-crc:544389176116DB09|rigid:SpiHIzijbJlouwkto3DQN5SsSjc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04271	uniprotkb:Q15109	intact:EBI-458391|ensembl:ENSP00000291700|ensembl:ENSP00000380769|uniprotkb:D3DSN6	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	psi-mi:s100b_human(display_long)|uniprotkb:S100B(gene name)|psi-mi:S100B(display_short)|uniprotkb:S100 calcium-binding protein B(gene name synonym)|uniprotkb:S-100 protein subunit beta(gene name synonym)|uniprotkb:S-100 protein beta chain(gene name synonym)	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Leclerc et al. (2007)	pubmed:17726019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6479170	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160307(gene)|ensembl:ENST00000291700(transcript)|ensembl:ENST00000397648(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007409"(axonogenesis)|go:"GO:0007417"(central nervous system development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044548"(S100 protein binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0051597"(response to methylmercury)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:2001015"(negative regulation of skeletal muscle cell differentiation)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028481|mint:P04271|rcsb pdb:1MQ1|rcsb pdb:1UWO|rcsb pdb:2H61|rcsb pdb:2M49|rcsb pdb:2PRU|rcsb pdb:3CZT|rcsb pdb:3D0Y|rcsb pdb:3D10|rcsb pdb:3HCM|rcsb pdb:4XYN|rcsb pdb:5CSF|rcsb pdb:5CSI|rcsb pdb:5CSJ|rcsb pdb:5CSN|rcsb pdb:5D7F|go:"GO:0051384"(response to glucocorticoid)|reactome:R-HSA-1251985|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|refseq:NP_006263.1|refseq:XP_016883913.1	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	-	-	comment:"Soluble AGER (sRAGE) has been used. sRAGE is procuced by proteolytic cleavage and/or alternative splicing and cannot be mapped to a UniProt AcNo."	figure legend:1|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/16	2014/10/16	rogid:e6p9zHV5sa8+lIZgYW1aiAAfq3s9606	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	intact-crc:00263AFA82DFF5E7|rigid:F/R4xqWKKorYgTZkAtWhyA6OxRw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)