#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P34152	uniprotkb:Q99JY9	intact:EBI-77070|uniprotkb:Q5DTH7|uniprotkb:Q8C513|uniprotkb:Q8CFH7|uniprotkb:Q8CHM2|uniprotkb:Q8K2S0|uniprotkb:Q9DAW3|intact:EBI-644981|uniprotkb:O08578|ensembl:ENSMUSP00000105663	intact:EBI-773994|uniprotkb:Q9DC56|ensembl:ENSMUSP00000027579|ensembl:ENSMUSP00000137503	psi-mi:fak1_mouse(display_long)|uniprotkb:Ptk2(gene name)|psi-mi:Ptk2(display_short)|uniprotkb:Fadk(gene name synonym)|uniprotkb:Fak(gene name synonym)|uniprotkb:Fak1(gene name synonym)|uniprotkb:Kiaa4203(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:arp3_mouse(display_long)|uniprotkb:Actin-like protein 3(gene name synonym)|uniprotkb:Actr3(gene name)|psi-mi:Actr3(display_short)|uniprotkb:Arp3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Serrels et al. (2007)	pubmed:17721515|imex:IM-20798	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6675060|imex:IM-20798-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123881.1|refseq:NP_032008.2|refseq:XP_006520496.1|dip:DIP-31045N|ensembl:ENSMUSG00000022607(gene)|ensembl:ENSMUST00000110036(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001764"(neuron migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007097"(nuclear migration)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:P34152|rcsb pdb:1K40|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:5F28|rcsb pdb:6BZ3|reactome:R-MMU-111465|reactome:R-MMU-2029482|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-8874081|reactome:R-MMU-9009391	refseq:NP_001192314.1|refseq:NP_001192315.1|refseq:NP_076224.1|ensembl:ENSMUSG00000026341(gene)|ensembl:ENSMUST00000027579(transcript)|ensembl:ENSMUST00000178474(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0030027"(lamellipodium)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060271"(cilium assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061825"(podosome core)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0061832"(basal ectoplasmic specialization)|go:"GO:0061851"(leading edge of lamellipodium)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904171"(negative regulation of bleb assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|mint:Q99JY9|rcsb pdb:7AQK|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213|reactome:R-MMU-8856828	-	-	-	figure legend:"Fig 2a, 2b (lanes 1 and 5), 2c (middle panel, lanes 2,3)."|comment:"The interaction of FAK with Arp3 was stronger in suspended MEFs, compared with adherent cells (Fig 2b, lane 1 Vs lane 5). The interaction decreased with increasing times after the suspended cells were re-plated on Fibronectin surfaces (Fig 2C, lane 3 Vs lane 4)."|comment:"Arp3 interacted only with dephosphorylated forms of FAK in suspended cells or immediately after replating on  fibronectin surfaces (Fig 2c, middle panel Vs bottom panel)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/05/17	2019/02/20	rogid:ZO/rmkDeJv5vec4ug3C3YrIwSIM10090	rogid:FBCctn7WChHon0MhVlJUO4ctinE10090	intact-crc:E2AF896B9778B13F|rigid:2n6N2Oxhsw2EhZ5REb6L7tsLHTw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P34152	uniprotkb:Q91YD9	intact:EBI-77070|uniprotkb:Q5DTH7|uniprotkb:Q8C513|uniprotkb:Q8CFH7|uniprotkb:Q8CHM2|uniprotkb:Q8K2S0|uniprotkb:Q9DAW3|intact:EBI-644981|uniprotkb:O08578|ensembl:ENSMUSP00000105663	intact:EBI-642417|ensembl:ENSMUSP00000031695	psi-mi:fak1_mouse(display_long)|uniprotkb:Ptk2(gene name)|psi-mi:Ptk2(display_short)|uniprotkb:Fadk(gene name synonym)|uniprotkb:Fak(gene name synonym)|uniprotkb:Fak1(gene name synonym)|uniprotkb:Kiaa4203(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:wasl_mouse(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Serrels et al. (2007)	pubmed:17721515|imex:IM-20798	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6675097|imex:IM-20798-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123881.1|refseq:NP_032008.2|refseq:XP_006520496.1|dip:DIP-31045N|ensembl:ENSMUSG00000022607(gene)|ensembl:ENSMUST00000110036(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001764"(neuron migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007097"(nuclear migration)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:P34152|rcsb pdb:1K40|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:5F28|rcsb pdb:6BZ3|reactome:R-MMU-111465|reactome:R-MMU-2029482|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-8874081|reactome:R-MMU-9009391	refseq:NP_082735.2|ensembl:ENSMUSG00000029684(gene)|ensembl:ENSMUST00000031695(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010324"(membrane invagination)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045010"(actin nucleation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:Q91YD9|rcsb pdb:3M3N|rcsb pdb:6UHC|dip:DIP-29788N	-	-	-	figure legend:"Fig S2b (lane 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/05/17	2019/02/20	rogid:ZO/rmkDeJv5vec4ug3C3YrIwSIM10090	rogid:TXI8wfugOptN0kVS3yEJxaM4uq810090	intact-crc:2C65450AA48ED579|rigid:8jsvaTof2MST6w7bw5LjzLMs1ZU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P34152	uniprotkb:Q99JY9	intact:EBI-77070|uniprotkb:Q5DTH7|uniprotkb:Q8C513|uniprotkb:Q8CFH7|uniprotkb:Q8CHM2|uniprotkb:Q8K2S0|uniprotkb:Q9DAW3|intact:EBI-644981|uniprotkb:O08578|ensembl:ENSMUSP00000105663	intact:EBI-773994|uniprotkb:Q9DC56|ensembl:ENSMUSP00000027579|ensembl:ENSMUSP00000137503	psi-mi:fak1_mouse(display_long)|uniprotkb:Ptk2(gene name)|psi-mi:Ptk2(display_short)|uniprotkb:Fadk(gene name synonym)|uniprotkb:Fak(gene name synonym)|uniprotkb:Fak1(gene name synonym)|uniprotkb:Kiaa4203(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:arp3_mouse(display_long)|uniprotkb:Actin-like protein 3(gene name synonym)|uniprotkb:Actr3(gene name)|psi-mi:Actr3(display_short)|uniprotkb:Arp3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Serrels et al. (2007)	pubmed:17721515|imex:IM-20798	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6675150|imex:IM-20798-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123881.1|refseq:NP_032008.2|refseq:XP_006520496.1|dip:DIP-31045N|ensembl:ENSMUSG00000022607(gene)|ensembl:ENSMUST00000110036(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001764"(neuron migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007097"(nuclear migration)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:P34152|rcsb pdb:1K40|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:5F28|rcsb pdb:6BZ3|reactome:R-MMU-111465|reactome:R-MMU-2029482|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-8874081|reactome:R-MMU-9009391	refseq:NP_001192314.1|refseq:NP_001192315.1|refseq:NP_076224.1|ensembl:ENSMUSG00000026341(gene)|ensembl:ENSMUST00000027579(transcript)|ensembl:ENSMUST00000178474(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0030027"(lamellipodium)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060271"(cilium assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061825"(podosome core)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0061832"(basal ectoplasmic specialization)|go:"GO:0061851"(leading edge of lamellipodium)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904171"(negative regulation of bleb assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|mint:Q99JY9|rcsb pdb:7AQK|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213|reactome:R-MMU-8856828	-	-	-	figure legend:Fig 1,  fig 3.|comment:"Colocalization of Arp3 with FAK is observed at the tips in control cells (Fig. 1d; arrows) -early spreading adhesions. After 2h Arp3 no longer colocalized with FAK. There would appear to be increased Arp3/FAK co-localisation with the FAKY397F mutant as shown by the increased intensity of yellow/orange colouration."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/05/17	2019/02/20	rogid:ZO/rmkDeJv5vec4ug3C3YrIwSIM10090	rogid:FBCctn7WChHon0MhVlJUO4ctinE10090	intact-crc:0B32086E58A10E84|rigid:2n6N2Oxhsw2EhZ5REb6L7tsLHTw	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q00944	uniprotkb:P61157	intact:EBI-2896409|ensembl:ENSGALP00000044406	intact:EBI-351419|uniprotkb:A5PJ90|uniprotkb:P32391|uniprotkb:Q08DS8|ensembl:ENSBTAP00000066597	psi-mi:fak1_chick(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:arp3_bovin(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)|uniprotkb:Actin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Serrels et al. (2007)	pubmed:17721515|imex:IM-20798	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6692630|imex:IM-20798-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000031741(gene)|ensembl:ENSGALT00000072414(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|rcsb pdb:2JKO|rcsb pdb:2JKQ|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|go:"GO:0005524"(ATP binding)|rcsb pdb:3ZDT|rcsb pdb:4BRX|rcsb pdb:4C7T|rcsb pdb:4CYE|rcsb pdb:4D4R|rcsb pdb:4D4S|rcsb pdb:4D4V|rcsb pdb:4D4Y|rcsb pdb:4D55|rcsb pdb:4D58|rcsb pdb:4D5H|rcsb pdb:4D5K|rcsb pdb:6CB0|rcsb pdb:6GCR|rcsb pdb:6GCX|rcsb pdb:6TY3|rcsb pdb:6TY4|reactome:R-GGA-111465|reactome:R-GGA-2029482|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-3928662|reactome:R-GGA-418885|reactome:R-GGA-4420097|reactome:R-GGA-5663213|reactome:R-GGA-8874081|reactome:R-GGA-9009391|rcsb pdb:6GCW|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009268"(response to pH)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:1KTM|rcsb pdb:1PV3|rcsb pdb:1QVX|rcsb pdb:2AEH|rcsb pdb:2AL6|rcsb pdb:2J0J|rcsb pdb:2J0K|rcsb pdb:2J0L|rcsb pdb:2J0M|rcsb pdb:2JKK|rcsb pdb:2JKM|refseq:NP_990766.1	refseq:NP_776651.1|ensembl:ENSBTAG00000003401(gene)|ensembl:ENSBTAT00000070638(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060271"(cilium assembly)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:1K8K|rcsb pdb:1TYQ|rcsb pdb:1U2V|rcsb pdb:2P9I|rcsb pdb:2P9K|rcsb pdb:2P9L|rcsb pdb:2P9N|rcsb pdb:2P9P|rcsb pdb:2P9S|rcsb pdb:2P9U|rcsb pdb:3DXK|rcsb pdb:3DXM|rcsb pdb:3RSE|rcsb pdb:3UKR|rcsb pdb:3UKU|rcsb pdb:3ULE|rcsb pdb:4JD2|rcsb pdb:4XEI|rcsb pdb:4XF2|rcsb pdb:6DEC|dip:DIP-29790N	-	-	-	figure legend:Fig  5A, 4C, 4D, 6A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/17	2014/10/16	rogid:SNqKiUJ1MN55zVMmZ7LCQXCvVXs9031	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9913	intact-crc:B1BC95CECF7ECA9F|rigid:fYV07rRVBHB7qMnXAIz7WZGNusw	false	sufficient binding region:13-125|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00944	uniprotkb:P61157	intact:EBI-2896409|ensembl:ENSGALP00000044406	intact:EBI-351419|uniprotkb:A5PJ90|uniprotkb:P32391|uniprotkb:Q08DS8|ensembl:ENSBTAP00000066597	psi-mi:fak1_chick(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:arp3_bovin(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)|uniprotkb:Actin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Serrels et al. (2007)	pubmed:17721515|imex:IM-20798	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6694259|imex:IM-20798-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000031741(gene)|ensembl:ENSGALT00000072414(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|rcsb pdb:2JKO|rcsb pdb:2JKQ|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|go:"GO:0005524"(ATP binding)|rcsb pdb:3ZDT|rcsb pdb:4BRX|rcsb pdb:4C7T|rcsb pdb:4CYE|rcsb pdb:4D4R|rcsb pdb:4D4S|rcsb pdb:4D4V|rcsb pdb:4D4Y|rcsb pdb:4D55|rcsb pdb:4D58|rcsb pdb:4D5H|rcsb pdb:4D5K|rcsb pdb:6CB0|rcsb pdb:6GCR|rcsb pdb:6GCX|rcsb pdb:6TY3|rcsb pdb:6TY4|reactome:R-GGA-111465|reactome:R-GGA-2029482|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-3928662|reactome:R-GGA-418885|reactome:R-GGA-4420097|reactome:R-GGA-5663213|reactome:R-GGA-8874081|reactome:R-GGA-9009391|rcsb pdb:6GCW|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009268"(response to pH)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:1KTM|rcsb pdb:1PV3|rcsb pdb:1QVX|rcsb pdb:2AEH|rcsb pdb:2AL6|rcsb pdb:2J0J|rcsb pdb:2J0K|rcsb pdb:2J0L|rcsb pdb:2J0M|rcsb pdb:2JKK|rcsb pdb:2JKM|refseq:NP_990766.1	refseq:NP_776651.1|ensembl:ENSBTAG00000003401(gene)|ensembl:ENSBTAT00000070638(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060271"(cilium assembly)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:1K8K|rcsb pdb:1TYQ|rcsb pdb:1U2V|rcsb pdb:2P9I|rcsb pdb:2P9K|rcsb pdb:2P9L|rcsb pdb:2P9N|rcsb pdb:2P9P|rcsb pdb:2P9S|rcsb pdb:2P9U|rcsb pdb:3DXK|rcsb pdb:3DXM|rcsb pdb:3RSE|rcsb pdb:3UKR|rcsb pdb:3UKU|rcsb pdb:3ULE|rcsb pdb:4JD2|rcsb pdb:4XEI|rcsb pdb:4XF2|rcsb pdb:6DEC|dip:DIP-29790N	-	-	-	figure legend:Fig 4c, 4d.|comment:The FAK-FERM domain [37-413] binds to Arp3, only when the tyrosine at 397 is mutated to a non-phosphorylated amino acid phenylalanine [Y397F]. The wild type FAK-FERM [37-378] with a phosphorylated tyrosine at 397, does not bind to Arp3 [Fig 4c, 4d].|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/17	2014/10/16	rogid:SNqKiUJ1MN55zVMmZ7LCQXCvVXs9031	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9913	intact-crc:BEA67D43BA69877D|rigid:fYV07rRVBHB7qMnXAIz7WZGNusw	false	mutation:397-397|glutathione s tranferase tag:n-n|mutation increasing interaction:397-397|sufficient binding region:37-413	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00944	uniprotkb:Q00944	intact:EBI-2896409|ensembl:ENSGALP00000044406	intact:EBI-2896409|ensembl:ENSGALP00000044406	psi-mi:fak1_chick(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:fak1_chick(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Serrels et al. (2007)	pubmed:17721515|imex:IM-20798	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6694278|imex:IM-20798-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000031741(gene)|ensembl:ENSGALT00000072414(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|rcsb pdb:2JKO|rcsb pdb:2JKQ|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|go:"GO:0005524"(ATP binding)|rcsb pdb:3ZDT|rcsb pdb:4BRX|rcsb pdb:4C7T|rcsb pdb:4CYE|rcsb pdb:4D4R|rcsb pdb:4D4S|rcsb pdb:4D4V|rcsb pdb:4D4Y|rcsb pdb:4D55|rcsb pdb:4D58|rcsb pdb:4D5H|rcsb pdb:4D5K|rcsb pdb:6CB0|rcsb pdb:6GCR|rcsb pdb:6GCX|rcsb pdb:6TY3|rcsb pdb:6TY4|reactome:R-GGA-111465|reactome:R-GGA-2029482|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-3928662|reactome:R-GGA-418885|reactome:R-GGA-4420097|reactome:R-GGA-5663213|reactome:R-GGA-8874081|reactome:R-GGA-9009391|rcsb pdb:6GCW|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009268"(response to pH)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:1KTM|rcsb pdb:1PV3|rcsb pdb:1QVX|rcsb pdb:2AEH|rcsb pdb:2AL6|rcsb pdb:2J0J|rcsb pdb:2J0K|rcsb pdb:2J0L|rcsb pdb:2J0M|rcsb pdb:2JKK|rcsb pdb:2JKM|refseq:NP_990766.1	ensembl:ENSGALG00000031741(gene)|ensembl:ENSGALT00000072414(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|rcsb pdb:2JKO|rcsb pdb:2JKQ|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|go:"GO:0005524"(ATP binding)|rcsb pdb:3ZDT|rcsb pdb:4BRX|rcsb pdb:4C7T|rcsb pdb:4CYE|rcsb pdb:4D4R|rcsb pdb:4D4S|rcsb pdb:4D4V|rcsb pdb:4D4Y|rcsb pdb:4D55|rcsb pdb:4D58|rcsb pdb:4D5H|rcsb pdb:4D5K|rcsb pdb:6CB0|rcsb pdb:6GCR|rcsb pdb:6GCX|rcsb pdb:6TY3|rcsb pdb:6TY4|reactome:R-GGA-111465|reactome:R-GGA-2029482|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-3928662|reactome:R-GGA-418885|reactome:R-GGA-4420097|reactome:R-GGA-5663213|reactome:R-GGA-8874081|reactome:R-GGA-9009391|rcsb pdb:6GCW|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009268"(response to pH)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:1KTM|rcsb pdb:1PV3|rcsb pdb:1QVX|rcsb pdb:2AEH|rcsb pdb:2AL6|rcsb pdb:2J0J|rcsb pdb:2J0K|rcsb pdb:2J0L|rcsb pdb:2J0M|rcsb pdb:2JKK|rcsb pdb:2JKM|refseq:NP_990766.1	-	-	-	figure legend:Fig 6a.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/17	2014/10/16	rogid:SNqKiUJ1MN55zVMmZ7LCQXCvVXs9031	rogid:SNqKiUJ1MN55zVMmZ7LCQXCvVXs9031	intact-crc:ADD666547910448B|rigid:fYV07rRVBHB7qMnXAIz7WZGNusw	false	sufficient binding region:37-378|glutathione s tranferase tag:n-n	sufficient binding region:36-40,83-87	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00944	uniprotkb:P61157	intact:EBI-2896409|ensembl:ENSGALP00000044406	intact:EBI-351419|uniprotkb:A5PJ90|uniprotkb:P32391|uniprotkb:Q08DS8|ensembl:ENSBTAP00000066597	psi-mi:fak1_chick(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:arp3_bovin(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)|uniprotkb:Actin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Serrels et al. (2007)	pubmed:17721515|imex:IM-20798	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6694278|imex:IM-20798-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000031741(gene)|ensembl:ENSGALT00000072414(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|rcsb pdb:2JKO|rcsb pdb:2JKQ|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|go:"GO:0005524"(ATP binding)|rcsb pdb:3ZDT|rcsb pdb:4BRX|rcsb pdb:4C7T|rcsb pdb:4CYE|rcsb pdb:4D4R|rcsb pdb:4D4S|rcsb pdb:4D4V|rcsb pdb:4D4Y|rcsb pdb:4D55|rcsb pdb:4D58|rcsb pdb:4D5H|rcsb pdb:4D5K|rcsb pdb:6CB0|rcsb pdb:6GCR|rcsb pdb:6GCX|rcsb pdb:6TY3|rcsb pdb:6TY4|reactome:R-GGA-111465|reactome:R-GGA-2029482|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-3928662|reactome:R-GGA-418885|reactome:R-GGA-4420097|reactome:R-GGA-5663213|reactome:R-GGA-8874081|reactome:R-GGA-9009391|rcsb pdb:6GCW|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009268"(response to pH)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:1KTM|rcsb pdb:1PV3|rcsb pdb:1QVX|rcsb pdb:2AEH|rcsb pdb:2AL6|rcsb pdb:2J0J|rcsb pdb:2J0K|rcsb pdb:2J0L|rcsb pdb:2J0M|rcsb pdb:2JKK|rcsb pdb:2JKM|refseq:NP_990766.1	refseq:NP_776651.1|ensembl:ENSBTAG00000003401(gene)|ensembl:ENSBTAT00000070638(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060271"(cilium assembly)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:1K8K|rcsb pdb:1TYQ|rcsb pdb:1U2V|rcsb pdb:2P9I|rcsb pdb:2P9K|rcsb pdb:2P9L|rcsb pdb:2P9N|rcsb pdb:2P9P|rcsb pdb:2P9S|rcsb pdb:2P9U|rcsb pdb:3DXK|rcsb pdb:3DXM|rcsb pdb:3RSE|rcsb pdb:3UKR|rcsb pdb:3UKU|rcsb pdb:3ULE|rcsb pdb:4JD2|rcsb pdb:4XEI|rcsb pdb:4XF2|rcsb pdb:6DEC|dip:DIP-29790N	-	-	-	figure legend:Fig 6a.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/17	2014/10/16	rogid:SNqKiUJ1MN55zVMmZ7LCQXCvVXs9031	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9913	intact-crc:ADD666547910448B|rigid:fYV07rRVBHB7qMnXAIz7WZGNusw	false	sufficient binding region:37-378|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00944	uniprotkb:A7MB62	intact:EBI-2896409|ensembl:ENSGALP00000044406	intact:EBI-6162748|ensembl:ENSBTAP00000012872	psi-mi:fak1_chick(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:arp2_bovin(display_long)|uniprotkb:ACTR2(gene name)|psi-mi:ACTR2(display_short)|uniprotkb:ARP2(gene name synonym)|uniprotkb:Actin-like protein 2(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Serrels et al. (2007)	pubmed:17721515|imex:IM-20798	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6692672|imex:IM-20798-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000031741(gene)|ensembl:ENSGALT00000072414(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|rcsb pdb:2JKO|rcsb pdb:2JKQ|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|go:"GO:0005524"(ATP binding)|rcsb pdb:3ZDT|rcsb pdb:4BRX|rcsb pdb:4C7T|rcsb pdb:4CYE|rcsb pdb:4D4R|rcsb pdb:4D4S|rcsb pdb:4D4V|rcsb pdb:4D4Y|rcsb pdb:4D55|rcsb pdb:4D58|rcsb pdb:4D5H|rcsb pdb:4D5K|rcsb pdb:6CB0|rcsb pdb:6GCR|rcsb pdb:6GCX|rcsb pdb:6TY3|rcsb pdb:6TY4|reactome:R-GGA-111465|reactome:R-GGA-2029482|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-3928662|reactome:R-GGA-418885|reactome:R-GGA-4420097|reactome:R-GGA-5663213|reactome:R-GGA-8874081|reactome:R-GGA-9009391|rcsb pdb:6GCW|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009268"(response to pH)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:1KTM|rcsb pdb:1PV3|rcsb pdb:1QVX|rcsb pdb:2AEH|rcsb pdb:2AL6|rcsb pdb:2J0J|rcsb pdb:2J0K|rcsb pdb:2J0L|rcsb pdb:2J0M|rcsb pdb:2JKK|rcsb pdb:2JKM|refseq:NP_990766.1	refseq:NP_001095683.1|dip:DIP-29789N|ensembl:ENSBTAG00000009761(gene)|ensembl:ENSBTAT00000012872(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:1K8K|rcsb pdb:1TYQ|rcsb pdb:1U2V|rcsb pdb:2P9I|rcsb pdb:2P9K|rcsb pdb:2P9L|rcsb pdb:2P9N|rcsb pdb:2P9P|rcsb pdb:2P9S|rcsb pdb:2P9U|rcsb pdb:3DXK|rcsb pdb:3DXM|rcsb pdb:3RSE|rcsb pdb:3UKR|rcsb pdb:3UKU|rcsb pdb:3ULE|rcsb pdb:4JD2|rcsb pdb:4XEI|rcsb pdb:4XF2|rcsb pdb:6DEC	-	-	-	figure legend:Fig 4e.|comment:GST-FAK-FERM bound more strongly to the Arp3 component and less strongly to the Arp2 component of the Arp2/3 complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/17	2014/10/16	rogid:SNqKiUJ1MN55zVMmZ7LCQXCvVXs9031	rogid:URQsZpIsMtsFZAnpLYDDvgKcPqA9913	intact-crc:E90905BE84A13D5B|rigid:UUkC2W1TUKw+w6zqJoLZAXkk9Kc	false	glutathione s tranferase tag:?-?|sufficient binding region:37-378	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00944	uniprotkb:P61157	intact:EBI-2896409|ensembl:ENSGALP00000044406	intact:EBI-351419|uniprotkb:A5PJ90|uniprotkb:P32391|uniprotkb:Q08DS8|ensembl:ENSBTAP00000066597	psi-mi:fak1_chick(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:arp3_bovin(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)|uniprotkb:Actin-2(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Serrels et al. (2007)	pubmed:17721515|imex:IM-20798	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6692672|imex:IM-20798-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000031741(gene)|ensembl:ENSGALT00000072414(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|rcsb pdb:2JKO|rcsb pdb:2JKQ|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|go:"GO:0005524"(ATP binding)|rcsb pdb:3ZDT|rcsb pdb:4BRX|rcsb pdb:4C7T|rcsb pdb:4CYE|rcsb pdb:4D4R|rcsb pdb:4D4S|rcsb pdb:4D4V|rcsb pdb:4D4Y|rcsb pdb:4D55|rcsb pdb:4D58|rcsb pdb:4D5H|rcsb pdb:4D5K|rcsb pdb:6CB0|rcsb pdb:6GCR|rcsb pdb:6GCX|rcsb pdb:6TY3|rcsb pdb:6TY4|reactome:R-GGA-111465|reactome:R-GGA-2029482|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-3928662|reactome:R-GGA-418885|reactome:R-GGA-4420097|reactome:R-GGA-5663213|reactome:R-GGA-8874081|reactome:R-GGA-9009391|rcsb pdb:6GCW|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009268"(response to pH)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:1KTM|rcsb pdb:1PV3|rcsb pdb:1QVX|rcsb pdb:2AEH|rcsb pdb:2AL6|rcsb pdb:2J0J|rcsb pdb:2J0K|rcsb pdb:2J0L|rcsb pdb:2J0M|rcsb pdb:2JKK|rcsb pdb:2JKM|refseq:NP_990766.1	refseq:NP_776651.1|ensembl:ENSBTAG00000003401(gene)|ensembl:ENSBTAT00000070638(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060271"(cilium assembly)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:1K8K|rcsb pdb:1TYQ|rcsb pdb:1U2V|rcsb pdb:2P9I|rcsb pdb:2P9K|rcsb pdb:2P9L|rcsb pdb:2P9N|rcsb pdb:2P9P|rcsb pdb:2P9S|rcsb pdb:2P9U|rcsb pdb:3DXK|rcsb pdb:3DXM|rcsb pdb:3RSE|rcsb pdb:3UKR|rcsb pdb:3UKU|rcsb pdb:3ULE|rcsb pdb:4JD2|rcsb pdb:4XEI|rcsb pdb:4XF2|rcsb pdb:6DEC|dip:DIP-29790N	-	-	-	figure legend:Fig 4e.|comment:GST-FAK-FERM bound more strongly to the Arp3 component and less strongly to the Arp2 component of the Arp2/3 complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/17	2014/10/16	rogid:SNqKiUJ1MN55zVMmZ7LCQXCvVXs9031	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9913	intact-crc:E90905BE84A13D5B|rigid:UUkC2W1TUKw+w6zqJoLZAXkk9Kc	false	glutathione s tranferase tag:?-?|sufficient binding region:37-378	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00944	uniprotkb:P61157	intact:EBI-2896409|ensembl:ENSGALP00000044406	intact:EBI-351419|uniprotkb:A5PJ90|uniprotkb:P32391|uniprotkb:Q08DS8|ensembl:ENSBTAP00000066597	psi-mi:fak1_chick(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:arp3_bovin(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)|uniprotkb:Actin-2(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Serrels et al. (2007)	pubmed:17721515|imex:IM-20798	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6692732|imex:IM-20798-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000031741(gene)|ensembl:ENSGALT00000072414(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|rcsb pdb:2JKO|rcsb pdb:2JKQ|rcsb pdb:2L6F|rcsb pdb:2L6G|rcsb pdb:2L6H|go:"GO:0005524"(ATP binding)|rcsb pdb:3ZDT|rcsb pdb:4BRX|rcsb pdb:4C7T|rcsb pdb:4CYE|rcsb pdb:4D4R|rcsb pdb:4D4S|rcsb pdb:4D4V|rcsb pdb:4D4Y|rcsb pdb:4D55|rcsb pdb:4D58|rcsb pdb:4D5H|rcsb pdb:4D5K|rcsb pdb:6CB0|rcsb pdb:6GCR|rcsb pdb:6GCX|rcsb pdb:6TY3|rcsb pdb:6TY4|reactome:R-GGA-111465|reactome:R-GGA-2029482|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-3928662|reactome:R-GGA-418885|reactome:R-GGA-4420097|reactome:R-GGA-5663213|reactome:R-GGA-8874081|reactome:R-GGA-9009391|rcsb pdb:6GCW|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009268"(response to pH)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:1KTM|rcsb pdb:1PV3|rcsb pdb:1QVX|rcsb pdb:2AEH|rcsb pdb:2AL6|rcsb pdb:2J0J|rcsb pdb:2J0K|rcsb pdb:2J0L|rcsb pdb:2J0M|rcsb pdb:2JKK|rcsb pdb:2JKM|refseq:NP_990766.1	refseq:NP_776651.1|ensembl:ENSBTAG00000003401(gene)|ensembl:ENSBTAT00000070638(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060271"(cilium assembly)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:1K8K|rcsb pdb:1TYQ|rcsb pdb:1U2V|rcsb pdb:2P9I|rcsb pdb:2P9K|rcsb pdb:2P9L|rcsb pdb:2P9N|rcsb pdb:2P9P|rcsb pdb:2P9S|rcsb pdb:2P9U|rcsb pdb:3DXK|rcsb pdb:3DXM|rcsb pdb:3RSE|rcsb pdb:3UKR|rcsb pdb:3UKU|rcsb pdb:3ULE|rcsb pdb:4JD2|rcsb pdb:4XEI|rcsb pdb:4XF2|rcsb pdb:6DEC|dip:DIP-29790N	-	-	-	figure legend:Fig 5b, 5c.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/17	2014/10/16	rogid:SNqKiUJ1MN55zVMmZ7LCQXCvVXs9031	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9913	intact-crc:1A353F30614029FD|rigid:fYV07rRVBHB7qMnXAIz7WZGNusw	false	glutathione s tranferase tag:n-n|sufficient binding region:36-40|sufficient binding region:83-87	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)