#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P66817	uniprotkb:P66817	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Keyamura et al. (2007)	pubmed:17699754|imex:IM-18680	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6548063|wwpdb:2yva|imex:IM-18680-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	go:"GO:0043234"|go:"GO:0006270"(DNA replication initiation)	-	-	figure legend:Fig. 1b, c, S1|3d-r-factors:Rwork = 0.18; Rfree = 0.21|3d-resolution:1.85A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/20	2014/10/16	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	intact-crc:60775944D51D12B6|rigid:wMQikI/tnvk69fUkVQb1A+2MqsU	false	his tag:n-n	his tag:n-n	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P66817	uniprotkb:P66817	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Keyamura et al. (2007)	pubmed:17699754|imex:IM-18680	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6548450|imex:IM-18680-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	-	-	-	figure legend:Fig.s 3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/20	2014/10/16	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	intact-crc:4EA3A57D8DEA21E0|rigid:wMQikI/tnvk69fUkVQb1A+2MqsU	false	mutation:101-101|mutation:83-83|his tag:n-n	mutation:101-101|mutation:83-83|his tag:n-n	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P66817	uniprotkb:P66817	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Keyamura et al. (2007)	pubmed:17699754|imex:IM-18680	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6548442|imex:IM-18680-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	go:"GO:0043234"|go:"GO:0006270"(DNA replication initiation)	-	-	figure legend:Fig.s 3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/20	2014/10/16	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	intact-crc:9A323E3E7B592C17|rigid:aFKX3fhSfxAP77C6XyNQKKP1Tt8	false	his tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P66817	uniprotkb:P66817	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Keyamura et al. (2007)	pubmed:17699754|imex:IM-18680	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6548481|imex:IM-18680-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	go:"GO:0043234"|go:"GO:0006270"(DNA replication initiation)	-	-	figure legend:Fig.s 3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/20	2014/10/16	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	intact-crc:E0803CE2A8A8CED6|rigid:wMQikI/tnvk69fUkVQb1A+2MqsU	false	his tag:n-n	his tag:n-n	4	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P66817	uniprotkb:P66817	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Keyamura et al. (2007)	pubmed:17699754|imex:IM-18680	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6548489|imex:IM-18680-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	go:"GO:0043234"|go:"GO:0006270"(DNA replication initiation)	-	-	figure legend:Fig.s 3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/20	2014/10/16	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	intact-crc:5054AAB8786B834F|rigid:wMQikI/tnvk69fUkVQb1A+2MqsU	false	his tag:n-n|mutation:101-101|mutation:83-83	his tag:n-n|mutation:101-101|mutation:83-83	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P66817	uniprotkb:P03004	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	intact:EBI-548951|uniprotkb:P78122|uniprotkb:Q2M814|ensemblbacteria:AAC76725|ensemblbacteria:BAE77592	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:dnaa_ecoli(display_long)|uniprotkb:dnaA(gene name)|psi-mi:dnaA(display_short)|uniprotkb:b3702(locus name)|uniprotkb:JW3679(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Keyamura et al. (2007)	pubmed:17699754|imex:IM-18680	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6548675|imex:IM-18680-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	refseq:NP_418157.1|refseq:WP_000059111.1|dip:DIP-9455N|ensemblbacteria:AAC76725(transcript)|ensemblbacteria:b3702(gene)|ensemblbacteria:BAE77592(gene)|ensemblbacteria:BAE77592(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010921(Trp repressor/replication initiator)|interpro:IPR013159(Chromosomal replication initiator, DnaA C-terminal)|interpro:IPR013317(Chromosomal replication initiator, DnaA)|interpro:IPR018312|interpro:IPR020591|interpro:IPR024633|interpro:IPR027417|interpro:IPR038454|rcsb pdb:1J1V|rcsb pdb:2E0G|interpro:IPR001957(Bacterial chromosomal replication initiator protein, DnaA)	go:"GO:0043234"|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)	-	-	figure legend:Fig. 6a|comment:This is a 2-stage anti-tag coip using a restricted amount of biotin-tagged DnaA in the first pulldown and excess amounts of untagged DnaA in the second pulldown before visualising the complex on SDS-PAGE.  This allowed for several different DnaA molecules to be pulled down by one DiaA homotetramer.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/20	2014/10/16	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	rogid:p07cXpfl7bzSh/kImTD/+Zr0Ma883333	intact-crc:4A8C5E97FCCE87C6|rigid:XFN1kY4F7YYXj4Y4eg5HFv6KiRs	false	mutation decreasing interaction:83-83|his tag:n-n|mutation disrupting interaction:190-190|mutation decreasing interaction:52-52	biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P66817	uniprotkb:P03004	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	intact:EBI-548951|uniprotkb:P78122|uniprotkb:Q2M814|ensemblbacteria:AAC76725|ensemblbacteria:BAE77592	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:dnaa_ecoli(display_long)|uniprotkb:dnaA(gene name)|psi-mi:dnaA(display_short)|uniprotkb:b3702(locus name)|uniprotkb:JW3679(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Keyamura et al. (2007)	pubmed:17699754|imex:IM-18680	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6548505|imex:IM-18680-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	refseq:NP_418157.1|refseq:WP_000059111.1|dip:DIP-9455N|ensemblbacteria:AAC76725(transcript)|ensemblbacteria:b3702(gene)|ensemblbacteria:BAE77592(gene)|ensemblbacteria:BAE77592(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010921(Trp repressor/replication initiator)|interpro:IPR013159(Chromosomal replication initiator, DnaA C-terminal)|interpro:IPR013317(Chromosomal replication initiator, DnaA)|interpro:IPR018312|interpro:IPR020591|interpro:IPR024633|interpro:IPR027417|interpro:IPR038454|rcsb pdb:1J1V|rcsb pdb:2E0G|interpro:IPR001957(Bacterial chromosomal replication initiator protein, DnaA)	go:"GO:0043234"|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)	-	-	figure legend:Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/20	2014/10/16	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	rogid:p07cXpfl7bzSh/kImTD/+Zr0Ma883333	intact-crc:0D65A252720EAE88|rigid:XFN1kY4F7YYXj4Y4eg5HFv6KiRs	false	mutation disrupting interaction:191-191|mutation disrupting interaction:191-191|his tag:n-n|mutation disrupting interaction:190-190|mutation decreasing interaction:83-83|mutation decreasing interaction:72-72|mutation decreasing interaction:72-72|mutation disrupting interaction:190-190|mutation decreasing interaction:101-101	biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03004	uniprotkb:P66817	intact:EBI-548951|uniprotkb:P78122|uniprotkb:Q2M814|ensemblbacteria:AAC76725|ensemblbacteria:BAE77592	intact:EBI-1125806|uniprotkb:P45466|uniprotkb:Q2M961|ensemblbacteria:AAC76183|ensemblbacteria:BAE77195	psi-mi:dnaa_ecoli(display_long)|uniprotkb:dnaA(gene name)|psi-mi:dnaA(display_short)|uniprotkb:b3702(locus name)|uniprotkb:JW3679(locus name)	psi-mi:diaa_ecoli(display_long)|uniprotkb:diaA(gene name)|psi-mi:diaA(display_short)|uniprotkb:b3149(locus name)|uniprotkb:JW3118(locus name)|uniprotkb:yraO(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Keyamura et al. (2007)	pubmed:17699754|imex:IM-18680	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6548694|imex:IM-18680-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418157.1|refseq:WP_000059111.1|dip:DIP-9455N|ensemblbacteria:AAC76725(transcript)|ensemblbacteria:b3702(gene)|ensemblbacteria:BAE77592(gene)|ensemblbacteria:BAE77592(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010921(Trp repressor/replication initiator)|interpro:IPR013159(Chromosomal replication initiator, DnaA C-terminal)|interpro:IPR013317(Chromosomal replication initiator, DnaA)|interpro:IPR018312|interpro:IPR020591|interpro:IPR024633|interpro:IPR027417|interpro:IPR038454|rcsb pdb:1J1V|rcsb pdb:2E0G|interpro:IPR001957(Bacterial chromosomal replication initiator protein, DnaA)	refseq:NP_417618.1|refseq:WP_001158034.1|ensemblbacteria:AAC76183(transcript)|ensemblbacteria:b3149(gene)|ensemblbacteria:BAE77195(gene)|ensemblbacteria:BAE77195(transcript)|go:"GO:0006260"(DNA replication)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1901135"(carbohydrate derivative metabolic process)|interpro:IPR001347("Sugar isomerase (SIS)")|interpro:IPR023070|interpro:IPR035461|rcsb pdb:2YVA|rcsb pdb:4U6N|dip:DIP-35981N	go:"GO:0043234"|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)	-	-	figure legend:Fig. 6b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/20	2014/10/16	rogid:p07cXpfl7bzSh/kImTD/+Zr0Ma883333	rogid:3jq14weesr4LJN6LOVzdQ3Sk3G483333	intact-crc:4E8B084F58AFAAD4|rigid:XFN1kY4F7YYXj4Y4eg5HFv6KiRs	false	biotin tag:n-n	his tag:n-n	2	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)