#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49747	uniprotkb:P13608	intact:EBI-2531022|uniprotkb:O14592|uniprotkb:Q16388|uniprotkb:Q16389|uniprotkb:Q2NL86|uniprotkb:Q8N4T2|ensembl:ENSP00000222271|uniprotkb:B4DKJ3	intact:EBI-6259246|uniprotkb:P79117|uniprotkb:Q28159|uniprotkb:Q6XL66	psi-mi:comp_human(display_long)|uniprotkb:COMP(gene name)|psi-mi:COMP(display_short)|uniprotkb:Thrombospondin-5(gene name synonym)	psi-mi:pgca_bovin(display_long)|uniprotkb:ACAN(gene name)|psi-mi:ACAN(display_short)|uniprotkb:AGC1(gene name synonym)|uniprotkb:Cartilage-specific proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2007)	imex:IM-20950|pubmed:17588949	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6870117|imex:IM-20950-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000086.2|go:"GO:0016485"(protein processing)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0035989"(tendon development)|go:"GO:0036122"(BMP binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043588"(skin development)|go:"GO:0048844"(artery morphogenesis)|ensembl:ENSG00000105664(gene)|ensembl:ENST00000222271(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0060173"(limb development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1900047"(negative regulation of hemostasis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR018097|interpro:IPR024665|interpro:IPR028492|interpro:IPR028974|interpro:IPR039081|rcsb pdb:3FBY|reactome:R-HSA-216083|reactome:R-HSA-3000178	go:"GO:0001501"(skeletal system development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|refseq:NP_776406.1|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR018378|interpro:IPR016187(C-type lectin fold)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR018097|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR000538(Link)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179	-	-	-	figure legend:3 and 5|antagonist:C4S = bovine trachealcheal chondroitin-4 sulfate, C6S = shark cartilage chondroitin-6 sulfate,  Heparin from pig intestine.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/27	2014/10/16	rogid:PEd7Bm1+z4Pzcq6aU8JJ2ogPMyY9606	rogid:N8c0q0eezpnE88oNvhte/CjBm1Y9913	intact-crc:5248EA4A80B43065|rigid:FwrNtcSaaJCeeOY8Pxu91Y0g520	false	mutation decreasing interaction:469-469	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13608	uniprotkb:P49747	intact:EBI-6259246|uniprotkb:P79117|uniprotkb:Q28159|uniprotkb:Q6XL66	intact:EBI-2531022|uniprotkb:O14592|uniprotkb:Q16388|uniprotkb:Q16389|uniprotkb:Q2NL86|uniprotkb:Q8N4T2|ensembl:ENSP00000222271|uniprotkb:B4DKJ3	psi-mi:pgca_bovin(display_long)|uniprotkb:ACAN(gene name)|psi-mi:ACAN(display_short)|uniprotkb:AGC1(gene name synonym)|uniprotkb:Cartilage-specific proteoglycan core protein(gene name synonym)	psi-mi:comp_human(display_long)|uniprotkb:COMP(gene name)|psi-mi:COMP(display_short)|uniprotkb:Thrombospondin-5(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2007)	imex:IM-20950|pubmed:17588949	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6874625|imex:IM-20950-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001501"(skeletal system development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|refseq:NP_776406.1|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR018378|interpro:IPR016187(C-type lectin fold)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR018097|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR000538(Link)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179	refseq:NP_000086.2|go:"GO:0016485"(protein processing)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0035989"(tendon development)|go:"GO:0036122"(BMP binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043588"(skin development)|go:"GO:0048844"(artery morphogenesis)|ensembl:ENSG00000105664(gene)|ensembl:ENST00000222271(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0060173"(limb development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1900047"(negative regulation of hemostasis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR018097|interpro:IPR024665|interpro:IPR028492|interpro:IPR028974|interpro:IPR039081|rcsb pdb:3FBY|reactome:R-HSA-216083|reactome:R-HSA-3000178	-	-	-	figure legend:6 and 7|antagonist:"Partial inhibition with:  C4S = bovine trachealcheal chondroitin-4 sulfate, C6S = shark cartilage chondroitin-6 sulfate,  Heparin from pig intestine."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/27	2014/10/16	rogid:N8c0q0eezpnE88oNvhte/CjBm1Y9913	rogid:PEd7Bm1+z4Pzcq6aU8JJ2ogPMyY9606	intact-crc:41189077C037D884|rigid:FwrNtcSaaJCeeOY8Pxu91Y0g520	false	-	sufficient binding region:532..532-757(IPR008859)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)