#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9QX74	uniprotkb:P13569	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8756774|imex:IM-21824-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N	-	-	-	figure legend:Fig. 1a, Fig. 1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:3.07x10^4(per mole per second)|koff:1.73x10^-3(second -1)|kd:5.63x10^-8(molar)	2013/09/09	2014/10/16	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	intact-crc:A4A43E2C60A385A9|rigid:YAG+STQaZeIy8TugD2ILnqSVLqY	false	his tag:?-?|sufficient binding region:?-?(IPR001478)	glutathione s tranferase tag:?-?|sufficient binding region:1452-1480	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13569	uniprotkb:O14745	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	intact:EBI-349787|uniprotkb:O43552|uniprotkb:Q86WQ5|ensembl:ENSP00000262613|uniprotkb:B3KY21|intact:EBI-15579389	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:nhrf1_human(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8756778|imex:IM-21824-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N	refseq:NP_004243.1|ensembl:ENSG00000109062(gene)|ensembl:ENST00000262613(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031982"(vesicle)|go:"GO:0032415"("regulation of sodium:proton antiporter activity")|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|interpro:IPR041489|mint:O14745|rcsb pdb:1G9O|rcsb pdb:1GQ4|rcsb pdb:1GQ5|rcsb pdb:1I92|rcsb pdb:1SGH|rcsb pdb:2D10|rcsb pdb:2JXO|rcsb pdb:2KJD|rcsb pdb:2KRG|rcsb pdb:2M0T|rcsb pdb:2M0U|rcsb pdb:2M0V|rcsb pdb:2OZF|rcsb pdb:4JL7|rcsb pdb:4LMM|rcsb pdb:4N6X|rcsb pdb:4PQW|rcsb pdb:4Q3H|rcsb pdb:6RQR|rcsb pdb:4MPA|dip:DIP-29092N	-	-	-	figure legend:Fig. 1b, Fig. 1c|kinetics:"Binding kinetics were also measured for each PDZ domain of EBP50 separately. For PDZ-1 (1-139): kon = 2.56 x 10E5 M-1s-1; koff = 5.85 x 10E-3 s-1; Kd = 2.29 x 10E-8 M. For PDZ-2 (132-299): kon = 7.72 x 10E4 M-1s-1; koff = 5.71 x 10E-3 s-1; Kd = 7.39 x 10E-8 M."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:4.89x10^5(per mole per second)|koff:1.1x10^-2(second -1)|kd:2.24x10^-8(molar)	2013/09/09	2014/10/16	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rogid:03E30U6coFBcC3BeKOYnInfG/BI9606	intact-crc:F9339B451EA172A7|rigid:yqVq2xc2wz2eO00r3dzzuEfyjYg	false	glutathione s tranferase tag:?-?|sufficient binding region:1452-1480	sufficient binding region:1-139(IPR001478)|his tag:?-?|sufficient binding region:132-299(IPR001478)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QX74	uniprotkb:O14745	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	intact:EBI-349787|uniprotkb:O43552|uniprotkb:Q86WQ5|ensembl:ENSP00000262613|uniprotkb:B3KY21|intact:EBI-15579389	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:nhrf1_human(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8788469|imex:IM-21824-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	refseq:NP_004243.1|ensembl:ENSG00000109062(gene)|ensembl:ENST00000262613(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031982"(vesicle)|go:"GO:0032415"("regulation of sodium:proton antiporter activity")|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|interpro:IPR041489|mint:O14745|rcsb pdb:1G9O|rcsb pdb:1GQ4|rcsb pdb:1GQ5|rcsb pdb:1I92|rcsb pdb:1SGH|rcsb pdb:2D10|rcsb pdb:2JXO|rcsb pdb:2KJD|rcsb pdb:2KRG|rcsb pdb:2M0T|rcsb pdb:2M0U|rcsb pdb:2M0V|rcsb pdb:2OZF|rcsb pdb:4JL7|rcsb pdb:4LMM|rcsb pdb:4N6X|rcsb pdb:4PQW|rcsb pdb:4Q3H|rcsb pdb:6RQR|rcsb pdb:4MPA|dip:DIP-29092N	-	-	-	figure legend:Fig. 1d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:91.0x10^-9(molar)	2013/09/09	2014/10/16	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	rogid:03E30U6coFBcC3BeKOYnInfG/BI9606	intact-crc:FFCE9303DBC38033|rigid:2q7JU/IJDM8cPlAvgis9wbOf3gg	false	his tag:?-?|sufficient binding region:?-?(IPR001478)	glutathione s tranferase tag:?-?|sufficient binding region:1-299(IPR001478)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QX74	uniprotkb:P13569	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8788469|imex:IM-21824-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N	-	-	-	figure legend:Fig. 1d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:91.0x10^-9(molar)	2013/09/09	2014/10/16	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	intact-crc:FFCE9303DBC38033|rigid:2q7JU/IJDM8cPlAvgis9wbOf3gg	false	his tag:?-?|sufficient binding region:?-?(IPR001478)	sufficient binding region:1452-1480	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QX74	uniprotkb:P14270-8	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	intact:EBI-9032440	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:p14270-8(display_long)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE4D5(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9032450|imex:IM-21824-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	intact:EBI-8333209(isoform-parent)	-	-	isoform-comment:Contains a phosphoserine at position 52. Contains a phosphoserine at position 56.	figure legend:Fig. 3g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2013/09/09	2014/10/16	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	rogid:WLlA3iHE79hZ40v7dVtMHDdY9dg10116	intact-crc:3BDEB69DEE1DDDC2|rigid:bkHUaZm7lUuRzaz1g4SzbfN0Sq0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QX74	uniprotkb:P14270-8	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	intact:EBI-9032440	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:p14270-8(display_long)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE4D5(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9032454|imex:IM-21824-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	intact:EBI-8333209(isoform-parent)	-	-	isoform-comment:Contains a phosphoserine at position 52. Contains a phosphoserine at position 56.	figure legend:Fig. 3g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2013/09/09	2014/10/16	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	rogid:WLlA3iHE79hZ40v7dVtMHDdY9dg10116	intact-crc:EDDC14B1EE193D8E|rigid:bkHUaZm7lUuRzaz1g4SzbfN0Sq0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14270-8	uniprotkb:Q9QX74	intact:EBI-9032440	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	psi-mi:p14270-8(display_long)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE4D5(isoform synonym)	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9032460|imex:IM-21824-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8333209(isoform-parent)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	-	isoform-comment:Contains a phosphoserine at position 52. Contains a phosphoserine at position 56.	-	figure legend:Fig. 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/09	2014/10/16	rogid:WLlA3iHE79hZ40v7dVtMHDdY9dg10116	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	intact-crc:1754AACCC8B7B95A|rigid:bkHUaZm7lUuRzaz1g4SzbfN0Sq0	false	-	glutathione s tranferase tag:?-?|necessary binding region:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14270	uniprotkb:Q9QX74	intact:EBI-8333209|uniprotkb:A1E347|uniprotkb:A1EC59|uniprotkb:F1M1H7|uniprotkb:O35470|intact:MINT-8432590|uniprotkb:Q6TRI0|uniprotkb:Q8CG04|uniprotkb:Q8CG06	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	psi-mi:pde4d_rat(display_long)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790480|imex:IM-21824-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008758943.1|refseq:XP_008758944.1|refseq:XP_008758945.1|refseq:NP_058728.1|refseq:NP_001106803.1|interpro:IPR023174|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR023088|refseq:NP_001106805.1|refseq:NP_001106799.1|refseq:NP_001106800.1|rgd:3281|reactome:R-RNO-180024|reactome:R-RNO-418555|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR036971|interpro:IPR040844|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0004112"(cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030016"(myofibril)|go:"GO:0030324"(lung development)|go:"GO:0030552"(cAMP binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0034704"(calcium channel complex)|go:"GO:0034705"(potassium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086024"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901363"(heterocyclic compound binding)|go:"GO:1901898"(negative regulation of relaxation of cardiac muscle)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	go:"GO:0045177"(apical part of cell)	comment:mint	-	figure legend:Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-colon)|taxid:10116(rat colon)	-	2013/09/09	2014/10/16	rogid:tAcTCNfcSldJQPH0SuHYk+obwgY10116	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	intact-crc:7B24971C197877D3|rigid:i3PMghujQQM8RDfEvDDTS0Wf2Is	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q08499	uniprotkb:Q9UPX8	intact:EBI-1642831|uniprotkb:O43433|uniprotkb:Q13549|uniprotkb:Q13550|uniprotkb:Q13551|uniprotkb:Q7Z2L8|uniprotkb:Q8IV84|uniprotkb:Q8IVA9|uniprotkb:Q8IVD2|uniprotkb:Q8IVD3|uniprotkb:Q96HL4|uniprotkb:Q9HCX7|ensembl:ENSP00000345502	intact:EBI-1570571|uniprotkb:Q3Y8G9|uniprotkb:Q52LK2|uniprotkb:Q9UKP1|uniprotkb:C0SPG8|uniprotkb:C0SPG9|ensembl:ENSP00000499561	psi-mi:pde4d_human(display_long)|uniprotkb:PDE4D(gene name)|psi-mi:PDE4D(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE43(gene name synonym)	psi-mi:shan2_human(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:SHANK2(gene name)|psi-mi:SHANK2(display_short)|uniprotkb:CORTBP1(gene name synonym)|uniprotkb:KIAA1022(gene name synonym)|uniprotkb:PROSAP1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790451|imex:IM-21824-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541773.1|refseq:XP_011541775.1|refseq:NP_001098101.1|refseq:NP_001159371.1|refseq:NP_001184147.1|refseq:NP_001184148.1|refseq:NP_001184149.1|refseq:NP_001184150.1|refseq:NP_001184151.1|refseq:NP_001184152.1|refseq:NP_006194.2|refseq:XP_016865055.1|refseq:XP_005248595.1|dip:DIP-41115N|ensembl:ENSG00000113448(gene)|ensembl:ENST00000340635(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030552"(cAMP binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034704"(calcium channel complex)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086024"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901363"(heterocyclic compound binding)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901898"(negative regulation of relaxation of cardiac muscle)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR036971|interpro:IPR040844|mint:Q08499|rcsb pdb:1E9K|rcsb pdb:1MKD|rcsb pdb:1OYN|rcsb pdb:1PTW|rcsb pdb:1Q9M|rcsb pdb:1TB7|rcsb pdb:1TBB|rcsb pdb:1XOM|rcsb pdb:1XON|rcsb pdb:1XOQ|rcsb pdb:1XOR|rcsb pdb:1Y2B|rcsb pdb:1Y2C|rcsb pdb:1Y2D|rcsb pdb:1Y2E|rcsb pdb:1Y2K|rcsb pdb:1ZKN|rcsb pdb:2FM0|rcsb pdb:2FM5|rcsb pdb:2PW3|rcsb pdb:2QYN|rcsb pdb:3G4G|rcsb pdb:3G4I|rcsb pdb:3G4K|rcsb pdb:3G4L|rcsb pdb:3G58|rcsb pdb:3IAD|rcsb pdb:3IAK|rcsb pdb:3K4S|rcsb pdb:3SL3|rcsb pdb:3SL4|rcsb pdb:3SL5|rcsb pdb:3SL6|rcsb pdb:3SL8|rcsb pdb:3V9B|rcsb pdb:4OGB|rcsb pdb:4W1O|rcsb pdb:4WCU|rcsb pdb:5K1I|rcsb pdb:5K32|rcsb pdb:5LBO|rcsb pdb:5TKB|rcsb pdb:5WH5|rcsb pdb:5WH6|rcsb pdb:5WQA|rcsb pdb:6AKR|rcsb pdb:6BOJ|rcsb pdb:6F6U|rcsb pdb:6F8R|rcsb pdb:6F8T|rcsb pdb:6F8U|rcsb pdb:6F8V|rcsb pdb:6F8W|rcsb pdb:6F8X|rcsb pdb:6FDC|rcsb pdb:6FDI|rcsb pdb:6FE7|rcsb pdb:6FEB|rcsb pdb:6FET|rcsb pdb:6FT0|rcsb pdb:6FTA|rcsb pdb:6FTW|rcsb pdb:6FW3|rcsb pdb:6HWO|rcsb pdb:6IAG|rcsb pdb:6IBF|rcsb pdb:6IM6|rcsb pdb:6IMB|rcsb pdb:6IMD|rcsb pdb:6IMI|rcsb pdb:6IMO|rcsb pdb:6IMR|rcsb pdb:6IMT|rcsb pdb:6IND|rcsb pdb:6INK|rcsb pdb:6INM|rcsb pdb:6KJZ|rcsb pdb:6KK0|rcsb pdb:6LRM|rcsb pdb:6NJH|rcsb pdb:6NJI|rcsb pdb:6NJJ|rcsb pdb:6RCW|rcsb pdb:6ZBA|rcsb pdb:7AY6|rcsb pdb:7B9H|rcsb pdb:7CBJ|rcsb pdb:7CBQ|reactome:R-HSA-180024|reactome:R-HSA-418555	refseq:NP_573573.2|refseq:XP_005277989.1|refseq:NP_036441.2|refseq:XP_016872876.1|refseq:XP_016872877.1|dip:DIP-52255N|ensembl:ENSG00000162105(gene)|ensembl:ENST00000656230(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9UPX8|reactome:R-HSA-6794361	-	-	-	figure legend:Fig. 5b|agonist:"Forskolin (10 microM) (an activator of adenylyl cyclase, stimulating the cAMP/PKA pathway)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t84)|taxid:9606(Homo sapiens colon carcinoma)	-	2013/09/09	2014/10/16	rogid:Vt17V/Avstf55ZLmURcuv+JcJYA9606	rogid:GdGFkOKF29mMX0CkE2CM7ZYtkBI9606	intact-crc:9BDB2E614718DFF2|rigid:THhzE6X4pd6TvZHeNIQF/09d3JQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01063	uniprotkb:Q80Z38	intact:EBI-7764239|ensembl:ENSMUSP00000113488|ensembl:ENSMUSP00000136485|uniprotkb:Q8CG05|uniprotkb:Q8C4Q7|intact:UNK-5385073|uniprotkb:B2KF58|uniprotkb:Q6TRH9	intact:EBI-770338|uniprotkb:E9QPH7|uniprotkb:Q3UTK4|uniprotkb:Q5DU07	psi-mi:pde4d_mouse(display_long)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)	psi-mi:shan2_mouse(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)|uniprotkb:Kiaa1022(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790506|imex:IM-21824-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021699(gene)|ensembl:ENSMUST00000122041(transcript)|ensembl:ENSMUST00000177907(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007568"(aging)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034704"(calcium channel complex)|go:"GO:0034705"(potassium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901898"(negative regulation of relaxation of cardiac muscle)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR036971|interpro:IPR040844|mint:Q01063|reactome:R-MMU-180024|reactome:R-MMU-418555|go:"GO:0050900"(leukocyte migration)|refseq:NP_035186.1|refseq:XP_006517710.1|dip:DIP-29706N	refseq:NP_001074839.2|refseq:NP_001106844.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001452(Src homology-3)|refseq:XP_006508596.1|reactome:R-MMU-6794361|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0043005"(neuron projection)	-	comment:mint|function:Regulates the levels of cAMP in the cell	-	figure legend:Fig. 5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2013/09/09	2014/10/16	rogid:AccySsTfwmeaWakWyiGRFhqJ+4Y10090	rogid:OTohbAMxKtx7/WWwWXDc+c24HvQ10090	intact-crc:7FF5940B4AC2FA24|rigid:EMaaFFM/pEfvSNFmoU4JLFeRdaY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14270-5	uniprotkb:Q9QX74	intact:EBI-8790567	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	psi-mi:p14270-5(display_long)|uniprotkb:PDE4D4(isoform synonym)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790574|imex:IM-21824-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8333209(isoform-parent)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	intact:EBI-8790600(see-also)|intact:EBI-8790605(see-also)	-	-	figure legend:Fig. 4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/09/09	2014/10/16	rogid:tAcTCNfcSldJQPH0SuHYk+obwgY10116	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	intact-crc:440EE782CC41C31B|rigid:i3PMghujQQM8RDfEvDDTS0Wf2Is	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QX74	uniprotkb:P14270-2	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	intact:EBI-8790618	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:p14270-2(display_long)|uniprotkb:PDE3.1(isoform synonym)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790625|imex:IM-21824-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	intact:EBI-8333209(isoform-parent)	intact:EBI-8790600(see-also)|intact:EBI-8790605(see-also)	-	-	figure legend:Fig. 4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/09/09	2014/10/16	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	rogid:q1y7m3C7jFUWiBNXEKZWVaeisxg10116	intact-crc:C2D589D3CD04D649|rigid:zBodc0Bq85wST9Jz33t0j7btITw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14270-1	uniprotkb:Q9QX74	intact:EBI-8790631	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	psi-mi:p14270-1(display_long)|uniprotkb:PDE4D3(isoform synonym)|uniprotkb:PDE3.3(isoform synonym)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790629|imex:IM-21824-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8333209(isoform-parent)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	intact:EBI-8790600(see-also)|intact:EBI-8790605(see-also)	-	-	figure legend:Fig. 4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/09/09	2014/10/16	rogid:r7RaPv9YYMQ4T46fkSBmNYGhRco10116	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	intact-crc:CA7702437B46B2D8|rigid:IHB4v0W96YeHh9rmJQYJlpL82rk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QX74	uniprotkb:P14270-4	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	intact:EBI-8790647	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:p14270-4(display_long)|uniprotkb:PDE4D7(isoform synonym)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790654|imex:IM-21824-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	intact:EBI-8333209(isoform-parent)	intact:EBI-8790600(see-also)|intact:EBI-8790605(see-also)	-	-	figure legend:Fig. 4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/09/09	2014/10/16	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	rogid:F9v8kJaOxSY3jicwARthH6hsrHs10116	intact-crc:D3909EF2A1801F6B|rigid:XcnNRxnvIF0F0gSQQPGcI+ez6uU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14270-6	uniprotkb:Q9QX74	intact:EBI-8790673	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	psi-mi:p14270-6(display_long)|uniprotkb:PDE4D9(isoform synonym)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8790671|imex:IM-21824-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8333209(isoform-parent)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	intact:EBI-8790600(see-also)|intact:EBI-8790605(see-also)	-	-	figure legend:Fig. 4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/09/09	2014/10/16	rogid:0eLIGTpwH7XVYxtxcda5N9YjoDE10116	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	intact-crc:4CAC6C127A03A78A|rigid:wJLKEGrCs3Fp0RSvl21fAd63qc8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14270-8	uniprotkb:Q9QX74	intact:EBI-9032440	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	psi-mi:p14270-8(display_long)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE4D5(isoform synonym)	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9032523|imex:IM-21824-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8333209(isoform-parent)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	intact:EBI-8790600(see-also)|intact:EBI-8790605(see-also)	isoform-comment:Contains a phosphoserine at position 52. Contains a phosphoserine at position 56.	-	figure legend:Fig. 4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/09/09	2014/10/16	rogid:WLlA3iHE79hZ40v7dVtMHDdY9dg10116	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	intact-crc:B0ECA4DF581087D2|rigid:bkHUaZm7lUuRzaz1g4SzbfN0Sq0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QX74	uniprotkb:P14270-9	intact:EBI-397902|ensembl:ENSRNOP00000067841|uniprotkb:Q9WUW0|uniprotkb:O70470|uniprotkb:Q6WB19|uniprotkb:Q9QX93|uniprotkb:Q9QZZ9|uniprotkb:Q9WUV9|uniprotkb:Q9WV46	intact:EBI-9055244|ensembl:ENSRNOP00000063446	psi-mi:shan2_rat(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:p14270-9(display_long)|uniprotkb:PDE4D8(isoform synonym)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2007)	pubmed:17244609|imex:IM-21824	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9032559|imex:IM-21824-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628772|refseq:NP_001004133.1|refseq:NP_597684.1|refseq:NP_597685.1|refseq:NP_958738.1|ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000071741(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|mint:Q9QX74|rcsb pdb:6CPJ|reactome:R-RNO-6794361|refseq:XP_017444213.1	intact:EBI-8333209(isoform-parent)|ensembl:ENSRNOG00000042536(gene)|ensembl:ENSRNOT00000066384(transcript)	intact:EBI-8790600(see-also)|intact:EBI-8790605(see-also)	-	-	figure legend:Fig. 4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/09/09	2014/10/16	rogid:rSjkRiT94GNUbX9ul/buccWjgcM10116	rogid:kJElz4eOo7QiCsK8nhKoNVx5jwg10116	intact-crc:7FD370F831A72CF7|rigid:ncw6PJLtaPpxi5SslL/qXbWhivY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)