#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O60832 uniprotkb:Q96HR8 intact:EBI-713091|ensembl:ENSP00000358563|uniprotkb:O43845|uniprotkb:Q96G67|uniprotkb:Q9Y505|uniprotkb:F5BSB3 intact:EBI-2515597|ensembl:ENSP00000274054|uniprotkb:D3DP28|uniprotkb:E9PAZ2 psi-mi:dkc1_human(display_long)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:CBF5 homolog(gene name synonym)|uniprotkb:DKC1(gene name)|psi-mi:DKC1(display_short)|uniprotkb:NOLA4(gene name synonym) psi-mi:naf1_human(display_long)|uniprotkb:NAF1(gene name)|psi-mi:NAF1(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8786926|imex:IM-22138-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR004521(Uncharacterized domain 2)|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR012960(DKCLD)|interpro:IPR015947(PUA-like)|interpro:IPR020103|interpro:IPR032819|interpro:IPR036974|mint:O60832|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-6790901|interpro:IPR002478(PUA)|ensembl:ENSG00000130826(gene)|ensembl:ENST00000369550(transcript)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0072589"(box H/ACA scaRNP complex)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis)|go:"GO:0006396"(RNA processing)|refseq:NP_001354.1|refseq:NP_001135935.1|refseq:NP_001275676.1|dip:DIP-40645N ensembl:ENSG00000145414(gene)|ensembl:ENST00000274054(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000493"(box H/ACA snoRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|interpro:IPR040309|mint:Q96HR8|rcsb pdb:2EQN|interpro:IPR007504(Gar1 protein RNA-binding region)|refseq:XP_011530712.1|refseq:NP_001122403.1|refseq:NP_612395.2 go:"GO:0005634"(nucleus) - - figure legend:Figure 2A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-143b)|taxid:9606(Human bone osteosarcoma 143B) - 2013/10/03 2014/10/16 rogid:njIdhtX9m37BslwxyAAV/JoRrHo9606 rogid:RN78Bx9nJvfGDvaezT/U4TUf2KY9606 intact-crc:627C7862F3BA95EA|rigid:+4/Ta6NcPRPJlH6wxBKYziE7uWM false - fusion protein:?-? - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:P40615 uniprotkb:Q96HR8 intact:EBI-5746997|uniprotkb:Q499M9 intact:EBI-2515597|ensembl:ENSP00000274054|uniprotkb:D3DP28|uniprotkb:E9PAZ2 psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:naf1_human(display_long)|uniprotkb:NAF1(gene name)|psi-mi:NAF1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9029854|imex:IM-22138-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) ensembl:ENSG00000145414(gene)|ensembl:ENST00000274054(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000493"(box H/ACA snoRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|interpro:IPR040309|mint:Q96HR8|rcsb pdb:2EQN|interpro:IPR007504(Gar1 protein RNA-binding region)|refseq:XP_011530712.1|refseq:NP_001122403.1|refseq:NP_612395.2 - - - figure legend:Figure 1 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 rogid:RN78Bx9nJvfGDvaezT/U4TUf2KY9606 intact-crc:5C7793272060C08C|rigid:aa3jCohYgVY8L4APxVOImQNNPDg false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40615 uniprotkb:B1WC56 intact:EBI-5746997|uniprotkb:Q499M9 intact:EBI-8792005|ensembl:ENSRNOP00000067439 psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:b1wc56_rat(display_long)|uniprotkb:Nhp2(gene name)|psi-mi:Nhp2(display_short)|uniprotkb:Nola2(gene name synonym)|uniprotkb:Nola2_predicted(gene name synonym)|uniprotkb:rCG_34668(orf name)|uniprotkb:LOC103690013(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9029833|imex:IM-22138-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) ensembl:ENSRNOT00000073317(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|reactome:R-RNO-171319|ensembl:ENSRNOG00000049622(gene)|rgd:1309435|rgd:9459675|refseq:XP_003750866.1|refseq:XP_006246302.1|refseq:XP_017459543.1 - - - figure legend:Figure 1 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 rogid:d/Ic1om2/9tmpSp3u3CIt/eeAOM10116 intact-crc:83AC6E708907FC83|rigid:AEPpPiM763lAkSpihDrXtFWOdfA false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40615 uniprotkb:D3ZMP6 intact:EBI-5746997|uniprotkb:Q499M9 intact:EBI-8792072|ensembl:ENSRNOP00000006887 psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:d3zmp6_rat(display_long)|uniprotkb:Nop10(gene name)|psi-mi:Nop10(display_short)|uniprotkb:LOC100360065(gene name synonym)|uniprotkb:rCG_26998(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9029833|imex:IM-22138-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) rgd:1582780|ensembl:ENSRNOG00000005184(gene)|ensembl:ENSRNOT00000006887(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016604"(nuclear body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR007264(Nucleolar RNA-binding protein Nop10p)|interpro:IPR036756|reactome:R-RNO-171319|refseq:NP_001119572.1 - - - figure legend:Figure 1 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 rogid:gBAwyGcfJTBMf8Q+fQZ/fDcPEBc10116 intact-crc:83AC6E708907FC83|rigid:AEPpPiM763lAkSpihDrXtFWOdfA false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40615 uniprotkb:Q96HR8 intact:EBI-5746997|uniprotkb:Q499M9 intact:EBI-2515597|ensembl:ENSP00000274054|uniprotkb:D3DP28|uniprotkb:E9PAZ2 psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:naf1_human(display_long)|uniprotkb:NAF1(gene name)|psi-mi:NAF1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9029833|imex:IM-22138-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) ensembl:ENSG00000145414(gene)|ensembl:ENST00000274054(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000493"(box H/ACA snoRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|interpro:IPR040309|mint:Q96HR8|rcsb pdb:2EQN|interpro:IPR007504(Gar1 protein RNA-binding region)|refseq:XP_011530712.1|refseq:NP_001122403.1|refseq:NP_612395.2 - - - figure legend:Figure 1 A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 rogid:RN78Bx9nJvfGDvaezT/U4TUf2KY9606 intact-crc:83AC6E708907FC83|rigid:AEPpPiM763lAkSpihDrXtFWOdfA false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40615 uniprotkb:B1WC56 intact:EBI-5746997|uniprotkb:Q499M9 intact:EBI-8792005|ensembl:ENSRNOP00000067439 psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:b1wc56_rat(display_long)|uniprotkb:Nhp2(gene name)|psi-mi:Nhp2(display_short)|uniprotkb:Nola2(gene name synonym)|uniprotkb:Nola2_predicted(gene name synonym)|uniprotkb:rCG_34668(orf name)|uniprotkb:LOC103690013(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8790848|imex:IM-22138-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) ensembl:ENSRNOT00000073317(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|reactome:R-RNO-171319|ensembl:ENSRNOG00000049622(gene)|rgd:1309435|rgd:9459675|refseq:XP_003750866.1|refseq:XP_006246302.1|refseq:XP_017459543.1 - - - figure legend:Figure 1 D & E|comment:Figure 1 E shows that Increasing the concentration of NAF1 results in reduced binding between GAR1 and NAP57 indicating that NAF1 and GAR1 bind competitively to NAP57.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 rogid:d/Ic1om2/9tmpSp3u3CIt/eeAOM10116 intact-crc:CEC2AB28B9CCD6D1|rigid:H0xLjg1dhncMmnM3dD963uG2aeU false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40615 uniprotkb:D3ZMP6 intact:EBI-5746997|uniprotkb:Q499M9 intact:EBI-8792072|ensembl:ENSRNOP00000006887 psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:d3zmp6_rat(display_long)|uniprotkb:Nop10(gene name)|psi-mi:Nop10(display_short)|uniprotkb:LOC100360065(gene name synonym)|uniprotkb:rCG_26998(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8790848|imex:IM-22138-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) rgd:1582780|ensembl:ENSRNOG00000005184(gene)|ensembl:ENSRNOT00000006887(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016604"(nuclear body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR007264(Nucleolar RNA-binding protein Nop10p)|interpro:IPR036756|reactome:R-RNO-171319|refseq:NP_001119572.1 - - - figure legend:Figure 1 D & E|comment:Figure 1 E shows that Increasing the concentration of NAF1 results in reduced binding between GAR1 and NAP57 indicating that NAF1 and GAR1 bind competitively to NAP57.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 rogid:gBAwyGcfJTBMf8Q+fQZ/fDcPEBc10116 intact-crc:CEC2AB28B9CCD6D1|rigid:H0xLjg1dhncMmnM3dD963uG2aeU false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40615 uniprotkb:Q96HR8 intact:EBI-5746997|uniprotkb:Q499M9 intact:EBI-2515597|ensembl:ENSP00000274054|uniprotkb:D3DP28|uniprotkb:E9PAZ2 psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:naf1_human(display_long)|uniprotkb:NAF1(gene name)|psi-mi:NAF1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8790848|imex:IM-22138-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) ensembl:ENSG00000145414(gene)|ensembl:ENST00000274054(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000493"(box H/ACA snoRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|interpro:IPR040309|mint:Q96HR8|rcsb pdb:2EQN|interpro:IPR007504(Gar1 protein RNA-binding region)|refseq:XP_011530712.1|refseq:NP_001122403.1|refseq:NP_612395.2 - - - figure legend:Figure 1 D & E|comment:Figure 1 E shows that Increasing the concentration of NAF1 results in reduced binding between GAR1 and NAP57 indicating that NAF1 and GAR1 bind competitively to NAP57.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 rogid:RN78Bx9nJvfGDvaezT/U4TUf2KY9606 intact-crc:CEC2AB28B9CCD6D1|rigid:H0xLjg1dhncMmnM3dD963uG2aeU false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40615 uniprotkb:Q9CY66 intact:EBI-5746997|uniprotkb:Q499M9 intact:EBI-6260856|ensembl:ENSMUSP00000029643|uniprotkb:Q80X93|uniprotkb:Q8VDH0|uniprotkb:Q8C6C5 psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:gar1_mouse(display_long)|uniprotkb:Nola1(gene name synonym)|uniprotkb:Nucleolar protein family A member 1(gene name synonym)|uniprotkb:snoRNP protein GAR1(gene name synonym)|uniprotkb:Gar1(gene name)|psi-mi:Gar1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8790848|imex:IM-22138-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) ensembl:ENSMUSG00000028010(gene)|ensembl:ENSMUST00000029643(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0015030"(Cajal body)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR007504(Gar1 protein RNA-binding region)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|mint:Q9CY66|reactome:R-MMU-171319|refseq:XP_011238510.1|refseq:NP_080854.1 - - - figure legend:Figure 1 D & E|comment:Figure 1 E shows that Increasing the concentration of NAF1 results in reduced binding between GAR1 and NAP57 indicating that NAF1 and GAR1 bind competitively to NAP57.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 rogid:w4y7W3rVMnGQfiS3g/wM6wJtDmc10090 intact-crc:CEC2AB28B9CCD6D1|rigid:H0xLjg1dhncMmnM3dD963uG2aeU false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40615 uniprotkb:D3ZMP6 intact:EBI-5746997|uniprotkb:Q499M9 intact:EBI-8792072|ensembl:ENSRNOP00000006887 psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:d3zmp6_rat(display_long)|uniprotkb:Nop10(gene name)|psi-mi:Nop10(display_short)|uniprotkb:LOC100360065(gene name synonym)|uniprotkb:rCG_26998(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8792603|imex:IM-22138-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) rgd:1582780|ensembl:ENSRNOG00000005184(gene)|ensembl:ENSRNOT00000006887(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016604"(nuclear body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR007264(Nucleolar RNA-binding protein Nop10p)|interpro:IPR036756|reactome:R-RNO-171319|refseq:NP_001119572.1 - - - figure legend:Figure 1 C Lane 4|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 rogid:gBAwyGcfJTBMf8Q+fQZ/fDcPEBc10116 intact-crc:F8994435AE93D9DD|rigid:goCqXs/fVU+rxAFmsS4BjOBJbEQ false 35s radiolabel:?-? 35s radiolabel:?-?|ha tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:D3ZMP6 uniprotkb:B1WC56 intact:EBI-8792072|ensembl:ENSRNOP00000006887 intact:EBI-8792005|ensembl:ENSRNOP00000067439 psi-mi:d3zmp6_rat(display_long)|uniprotkb:Nop10(gene name)|psi-mi:Nop10(display_short)|uniprotkb:LOC100360065(gene name synonym)|uniprotkb:rCG_26998(orf name) psi-mi:b1wc56_rat(display_long)|uniprotkb:Nhp2(gene name)|psi-mi:Nhp2(display_short)|uniprotkb:Nola2(gene name synonym)|uniprotkb:Nola2_predicted(gene name synonym)|uniprotkb:rCG_34668(orf name)|uniprotkb:LOC103690013(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8790965|imex:IM-22138-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1582780|ensembl:ENSRNOG00000005184(gene)|ensembl:ENSRNOT00000006887(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016604"(nuclear body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR007264(Nucleolar RNA-binding protein Nop10p)|interpro:IPR036756|reactome:R-RNO-171319|refseq:NP_001119572.1 ensembl:ENSRNOT00000073317(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|reactome:R-RNO-171319|ensembl:ENSRNOG00000049622(gene)|rgd:1309435|rgd:9459675|refseq:XP_003750866.1|refseq:XP_006246302.1|refseq:XP_017459543.1 - - - figure legend:Figure 1 C Lanes 6 & 8|comment:Presence of NAP57 is essential for these interactions to take place.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:gBAwyGcfJTBMf8Q+fQZ/fDcPEBc10116 rogid:d/Ic1om2/9tmpSp3u3CIt/eeAOM10116 intact-crc:31F4C7BFB3BD6483|rigid:AEPpPiM763lAkSpihDrXtFWOdfA false 35s radiolabel:?-?|ha tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:D3ZMP6 uniprotkb:Q96HR8 intact:EBI-8792072|ensembl:ENSRNOP00000006887 intact:EBI-2515597|ensembl:ENSP00000274054|uniprotkb:D3DP28|uniprotkb:E9PAZ2 psi-mi:d3zmp6_rat(display_long)|uniprotkb:Nop10(gene name)|psi-mi:Nop10(display_short)|uniprotkb:LOC100360065(gene name synonym)|uniprotkb:rCG_26998(orf name) psi-mi:naf1_human(display_long)|uniprotkb:NAF1(gene name)|psi-mi:NAF1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8790965|imex:IM-22138-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1582780|ensembl:ENSRNOG00000005184(gene)|ensembl:ENSRNOT00000006887(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016604"(nuclear body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR007264(Nucleolar RNA-binding protein Nop10p)|interpro:IPR036756|reactome:R-RNO-171319|refseq:NP_001119572.1 ensembl:ENSG00000145414(gene)|ensembl:ENST00000274054(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000493"(box H/ACA snoRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|interpro:IPR040309|mint:Q96HR8|rcsb pdb:2EQN|interpro:IPR007504(Gar1 protein RNA-binding region)|refseq:XP_011530712.1|refseq:NP_001122403.1|refseq:NP_612395.2 - - - figure legend:Figure 1 C Lanes 6 & 8|comment:Presence of NAP57 is essential for these interactions to take place.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:gBAwyGcfJTBMf8Q+fQZ/fDcPEBc10116 rogid:RN78Bx9nJvfGDvaezT/U4TUf2KY9606 intact-crc:31F4C7BFB3BD6483|rigid:AEPpPiM763lAkSpihDrXtFWOdfA false 35s radiolabel:?-?|ha tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:D3ZMP6 uniprotkb:P40615 intact:EBI-8792072|ensembl:ENSRNOP00000006887 intact:EBI-5746997|uniprotkb:Q499M9 psi-mi:d3zmp6_rat(display_long)|uniprotkb:Nop10(gene name)|psi-mi:Nop10(display_short)|uniprotkb:LOC100360065(gene name synonym)|uniprotkb:rCG_26998(orf name) psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8790965|imex:IM-22138-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1582780|ensembl:ENSRNOG00000005184(gene)|ensembl:ENSRNOT00000006887(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016604"(nuclear body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR007264(Nucleolar RNA-binding protein Nop10p)|interpro:IPR036756|reactome:R-RNO-171319|refseq:NP_001119572.1 interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) - - - figure legend:Figure 1 C Lanes 6 & 8|comment:Presence of NAP57 is essential for these interactions to take place.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:gBAwyGcfJTBMf8Q+fQZ/fDcPEBc10116 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 intact-crc:31F4C7BFB3BD6483|rigid:AEPpPiM763lAkSpihDrXtFWOdfA false 35s radiolabel:?-?|ha tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B1WC56 uniprotkb:P40615 intact:EBI-8792005|ensembl:ENSRNOP00000067439 intact:EBI-5746997|uniprotkb:Q499M9 psi-mi:b1wc56_rat(display_long)|uniprotkb:Nhp2(gene name)|psi-mi:Nhp2(display_short)|uniprotkb:Nola2(gene name synonym)|uniprotkb:Nola2_predicted(gene name synonym)|uniprotkb:rCG_34668(orf name)|uniprotkb:LOC103690013(gene name synonym) psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8792581|imex:IM-22138-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOT00000073317(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|reactome:R-RNO-171319|ensembl:ENSRNOG00000049622(gene)|rgd:1309435|rgd:9459675|refseq:XP_003750866.1|refseq:XP_006246302.1|refseq:XP_017459543.1 interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) - - - figure legend:Figure 1 B Lanes 4 & 10|comment:Presence of NOP10 is essential for these interactions to take place.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:d/Ic1om2/9tmpSp3u3CIt/eeAOM10116 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 intact-crc:B92394966E499BA0|rigid:sQIj+3NZt0N7sCNDeLEWtBIATtg false ha tag:?-?|35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B1WC56 uniprotkb:D3ZMP6 intact:EBI-8792005|ensembl:ENSRNOP00000067439 intact:EBI-8792072|ensembl:ENSRNOP00000006887 psi-mi:b1wc56_rat(display_long)|uniprotkb:Nhp2(gene name)|psi-mi:Nhp2(display_short)|uniprotkb:Nola2(gene name synonym)|uniprotkb:Nola2_predicted(gene name synonym)|uniprotkb:rCG_34668(orf name)|uniprotkb:LOC103690013(gene name synonym) psi-mi:d3zmp6_rat(display_long)|uniprotkb:Nop10(gene name)|psi-mi:Nop10(display_short)|uniprotkb:LOC100360065(gene name synonym)|uniprotkb:rCG_26998(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8792581|imex:IM-22138-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOT00000073317(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|reactome:R-RNO-171319|ensembl:ENSRNOG00000049622(gene)|rgd:1309435|rgd:9459675|refseq:XP_003750866.1|refseq:XP_006246302.1|refseq:XP_017459543.1 rgd:1582780|ensembl:ENSRNOG00000005184(gene)|ensembl:ENSRNOT00000006887(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016604"(nuclear body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR007264(Nucleolar RNA-binding protein Nop10p)|interpro:IPR036756|reactome:R-RNO-171319|refseq:NP_001119572.1 - - - figure legend:Figure 1 B Lanes 4 & 10|comment:Presence of NOP10 is essential for these interactions to take place.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:d/Ic1om2/9tmpSp3u3CIt/eeAOM10116 rogid:gBAwyGcfJTBMf8Q+fQZ/fDcPEBc10116 intact-crc:B92394966E499BA0|rigid:sQIj+3NZt0N7sCNDeLEWtBIATtg false ha tag:?-?|35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B1WC56 uniprotkb:D3ZMP6 intact:EBI-8792005|ensembl:ENSRNOP00000067439 intact:EBI-8792072|ensembl:ENSRNOP00000006887 psi-mi:b1wc56_rat(display_long)|uniprotkb:Nhp2(gene name)|psi-mi:Nhp2(display_short)|uniprotkb:Nola2(gene name synonym)|uniprotkb:Nola2_predicted(gene name synonym)|uniprotkb:rCG_34668(orf name)|uniprotkb:LOC103690013(gene name synonym) psi-mi:d3zmp6_rat(display_long)|uniprotkb:Nop10(gene name)|psi-mi:Nop10(display_short)|uniprotkb:LOC100360065(gene name synonym)|uniprotkb:rCG_26998(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8790961|imex:IM-22138-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOT00000073317(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|reactome:R-RNO-171319|ensembl:ENSRNOG00000049622(gene)|rgd:1309435|rgd:9459675|refseq:XP_003750866.1|refseq:XP_006246302.1|refseq:XP_017459543.1 rgd:1582780|ensembl:ENSRNOG00000005184(gene)|ensembl:ENSRNOT00000006887(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016604"(nuclear body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR007264(Nucleolar RNA-binding protein Nop10p)|interpro:IPR036756|reactome:R-RNO-171319|refseq:NP_001119572.1 - - - figure legend:Figure 1 B Lanes 8 & 12|comment:Presence of NOP10 is essential for these interactions to take place.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:d/Ic1om2/9tmpSp3u3CIt/eeAOM10116 rogid:gBAwyGcfJTBMf8Q+fQZ/fDcPEBc10116 intact-crc:4C87BAA8AAA754E6|rigid:AEPpPiM763lAkSpihDrXtFWOdfA false ha tag:?-?|35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B1WC56 uniprotkb:Q96HR8 intact:EBI-8792005|ensembl:ENSRNOP00000067439 intact:EBI-2515597|ensembl:ENSP00000274054|uniprotkb:D3DP28|uniprotkb:E9PAZ2 psi-mi:b1wc56_rat(display_long)|uniprotkb:Nhp2(gene name)|psi-mi:Nhp2(display_short)|uniprotkb:Nola2(gene name synonym)|uniprotkb:Nola2_predicted(gene name synonym)|uniprotkb:rCG_34668(orf name)|uniprotkb:LOC103690013(gene name synonym) psi-mi:naf1_human(display_long)|uniprotkb:NAF1(gene name)|psi-mi:NAF1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8790961|imex:IM-22138-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOT00000073317(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|reactome:R-RNO-171319|ensembl:ENSRNOG00000049622(gene)|rgd:1309435|rgd:9459675|refseq:XP_003750866.1|refseq:XP_006246302.1|refseq:XP_017459543.1 ensembl:ENSG00000145414(gene)|ensembl:ENST00000274054(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000493"(box H/ACA snoRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|interpro:IPR040309|mint:Q96HR8|rcsb pdb:2EQN|interpro:IPR007504(Gar1 protein RNA-binding region)|refseq:XP_011530712.1|refseq:NP_001122403.1|refseq:NP_612395.2 - - - figure legend:Figure 1 B Lanes 8 & 12|comment:Presence of NOP10 is essential for these interactions to take place.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:d/Ic1om2/9tmpSp3u3CIt/eeAOM10116 rogid:RN78Bx9nJvfGDvaezT/U4TUf2KY9606 intact-crc:4C87BAA8AAA754E6|rigid:AEPpPiM763lAkSpihDrXtFWOdfA false ha tag:?-?|35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B1WC56 uniprotkb:P40615 intact:EBI-8792005|ensembl:ENSRNOP00000067439 intact:EBI-5746997|uniprotkb:Q499M9 psi-mi:b1wc56_rat(display_long)|uniprotkb:Nhp2(gene name)|psi-mi:Nhp2(display_short)|uniprotkb:Nola2(gene name synonym)|uniprotkb:Nola2_predicted(gene name synonym)|uniprotkb:rCG_34668(orf name)|uniprotkb:LOC103690013(gene name synonym) psi-mi:dkc1_rat(display_long)|uniprotkb:Dkc1(gene name)|psi-mi:Dkc1(display_short)|uniprotkb:Nap57(gene name synonym)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8790961|imex:IM-22138-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOT00000073317(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|reactome:R-RNO-171319|ensembl:ENSRNOG00000049622(gene)|rgd:1309435|rgd:9459675|refseq:XP_003750866.1|refseq:XP_006246302.1|refseq:XP_017459543.1 interpro:IPR036974|interpro:IPR032819|rgd:621780|refseq:NP_596910.1|interpro:IPR012960(DKCLD)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR002478(PUA)|interpro:IPR015947(PUA-like)|interpro:IPR004521(Uncharacterized domain 2)|reactome:R-RNO-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis) - - - figure legend:Figure 1 B Lanes 8 & 12|comment:Presence of NOP10 is essential for these interactions to take place.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/03 2014/10/16 rogid:d/Ic1om2/9tmpSp3u3CIt/eeAOM10116 rogid:Y2cQ0teKlyFHGklxUD70aP87t+I10116 intact-crc:4C87BAA8AAA754E6|rigid:AEPpPiM763lAkSpihDrXtFWOdfA false ha tag:?-?|35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96HR8 intact:EBI-9027498 intact:EBI-2515597|ensembl:ENSP00000274054|uniprotkb:D3DP28|uniprotkb:E9PAZ2 - psi-mi:naf1_human(display_long)|uniprotkb:NAF1(gene name)|psi-mi:NAF1(display_short) psi-mi:snorna_e3_e3-2_rat(display_short)|psi-mi:EBI-9027498(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8792783|imex:IM-22138-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0609"(small nucleolar rna) ensembl:ENSG00000145414(gene)|ensembl:ENST00000274054(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000493"(box H/ACA snoRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|interpro:IPR040309|mint:Q96HR8|rcsb pdb:2EQN|interpro:IPR007504(Gar1 protein RNA-binding region)|refseq:XP_011530712.1|refseq:NP_001122403.1|refseq:NP_612395.2 - - - comment:like EBI-9027461 figure legend:Figure 5 F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-143b)|taxid:9606(Human bone osteosarcoma 143B) - 2013/10/03 2014/10/16 rogid:RN78Bx9nJvfGDvaezT/U4TUf2KY9606 - intact-crc:D3A07187A8C943E8 false green fluorescent protein tag:?-? - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:O60832 intact:EBI-9027498 intact:EBI-713091|ensembl:ENSP00000358563|uniprotkb:O43845|uniprotkb:Q96G67|uniprotkb:Q9Y505|uniprotkb:F5BSB3 - psi-mi:dkc1_human(display_long)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:CBF5 homolog(gene name synonym)|uniprotkb:DKC1(gene name)|psi-mi:DKC1(display_short)|uniprotkb:NOLA4(gene name synonym) psi-mi:snorna_e3_e3-2_rat(display_short)|psi-mi:EBI-9027498(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Darzacq et al. (2006) pubmed:16618814|imex:IM-22138 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-8792786|imex:IM-22138-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0609"(small nucleolar rna) interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR004521(Uncharacterized domain 2)|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR012960(DKCLD)|interpro:IPR015947(PUA-like)|interpro:IPR020103|interpro:IPR032819|interpro:IPR036974|mint:O60832|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-6790901|interpro:IPR002478(PUA)|ensembl:ENSG00000130826(gene)|ensembl:ENST00000369550(transcript)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0072589"(box H/ACA scaRNP complex)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis)|go:"GO:0006396"(RNA processing)|refseq:NP_001354.1|refseq:NP_001135935.1|refseq:NP_001275676.1|dip:DIP-40645N - - - comment:like EBI-9027461 figure legend:Figure 5 F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-143b)|taxid:9606(Human bone osteosarcoma 143B) - 2013/10/03 2014/10/16 rogid:njIdhtX9m37BslwxyAAV/JoRrHo9606 - intact-crc:7557946D04F1B6D6 false green fluorescent protein tag:?-? - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr)