#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9R0G6	uniprotkb:P58397	intact:EBI-9028018|uniprotkb:G3X8Q4|ensembl:ENSMUSP00000003659	intact:EBI-9028051|uniprotkb:A2RRN9|uniprotkb:A5D6V6|uniprotkb:Q6UWL3|ensembl:ENSP00000422554	psi-mi:comp_mouse(display_long)|uniprotkb:Comp(gene name)|psi-mi:Comp(display_short)	psi-mi:ats12_human(display_long)|uniprotkb:ADAMTS12(gene name)|psi-mi:ADAMTS12(display_short)|uniprotkb:UNQ1918/PRO4389(orf name)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2006)	pubmed:16611630|imex:IM-22116	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9028016|imex:IM-22116-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057894.2|ensembl:ENSMUSG00000031849(gene)|ensembl:ENSMUST00000003659(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005499"(vitamin D binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0016485"(protein processing)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0035989"(tendon development)|go:"GO:0036122"(BMP binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043588"(skin development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051216"(cartilage development)|go:"GO:0055001"(muscle cell development)|go:"GO:0060173"(limb development)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0098868"(bone growth)|go:"GO:1900047"(negative regulation of hemostasis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR018097|interpro:IPR024665|interpro:IPR028492|interpro:IPR028974|rcsb pdb:1MZ9|rcsb pdb:3V2N|rcsb pdb:3V2P|rcsb pdb:3V2Q|rcsb pdb:3V2R|reactome:R-MMU-216083|reactome:R-MMU-3000178|interpro:IPR039081	refseq:NP_001311440.1|refseq:NP_001311441.1|refseq:NP_112217.2|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902203"(negative regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:2001113"(negative regulation of cellular response to hepatocyte growth factor stimulus)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0030198"(extracellular matrix organization)|ensembl:ENSG00000151388(gene)|ensembl:ENST00000504830(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0030167"(proteoglycan catabolic process)	-	-	-	figure legend:Fig 1B, 3, 4|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/12/06	2014/10/16	rogid:7jQUoC+K/yULoK0IA7dXL2KdpUg10090	rogid:57HLvuGr2HDfZ9M7Sc9e2E0jc2o9606	intact-crc:7CF2CE17D2785203|rigid:T+8NQmk553+QbwZw6NBwlxvKPUQ	false	necessary binding region:84-261(IPR009030)	necessary binding region:1316-1530(IPR000884)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKP4	uniprotkb:Q9R0G6	intact:EBI-9028319|uniprotkb:Q14F51|uniprotkb:Q6P7J9|ensembl:ENSP00000373472	intact:EBI-9028018|uniprotkb:G3X8Q4|ensembl:ENSMUSP00000003659	psi-mi:ats7_human(display_long)|uniprotkb:ADAMTS7(gene name)|psi-mi:ADAMTS7(display_short)|uniprotkb:COMPase(gene name synonym)	psi-mi:comp_mouse(display_long)|uniprotkb:Comp(gene name)|psi-mi:Comp(display_short)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2006)	pubmed:16611630|imex:IM-22116	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9028191|imex:IM-22116-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055087.2|ensembl:ENSG00000136378(gene)|ensembl:ENST00000388820(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071773"(cellular response to BMP stimulus)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|reactome:R-HSA-5083635|reactome:R-HSA-5173214	refseq:NP_057894.2|ensembl:ENSMUSG00000031849(gene)|ensembl:ENSMUST00000003659(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005499"(vitamin D binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0016485"(protein processing)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0035989"(tendon development)|go:"GO:0036122"(BMP binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043588"(skin development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051216"(cartilage development)|go:"GO:0055001"(muscle cell development)|go:"GO:0060173"(limb development)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0098868"(bone growth)|go:"GO:1900047"(negative regulation of hemostasis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR018097|interpro:IPR024665|interpro:IPR028492|interpro:IPR028974|rcsb pdb:1MZ9|rcsb pdb:3V2N|rcsb pdb:3V2P|rcsb pdb:3V2Q|rcsb pdb:3V2R|reactome:R-MMU-216083|reactome:R-MMU-3000178|interpro:IPR039081	-	-	-	figure legend:Fig 3B|comment:"Human ADAMTS-7 published by this group in PMID:16585064 therefore this construct annotated as human"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/12/06	2014/10/16	rogid:3KuKb7vTBuorVryXEfheolRq38s9606	rogid:7jQUoC+K/yULoK0IA7dXL2KdpUg10090	intact-crc:8B1EC5E32C5876E9|rigid:k7NUviEqXr+x2/Jir/qiCTHL6Qg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P58397	uniprotkb:Q9R0G6	intact:EBI-9028051|uniprotkb:A2RRN9|uniprotkb:A5D6V6|uniprotkb:Q6UWL3|ensembl:ENSP00000422554	intact:EBI-9028018|uniprotkb:G3X8Q4|ensembl:ENSMUSP00000003659	psi-mi:ats12_human(display_long)|uniprotkb:ADAMTS12(gene name)|psi-mi:ADAMTS12(display_short)|uniprotkb:UNQ1918/PRO4389(orf name)	psi-mi:comp_mouse(display_long)|uniprotkb:Comp(gene name)|psi-mi:Comp(display_short)	psi-mi:"MI:0096"(pull down)	Liu et al. (2006)	pubmed:16611630|imex:IM-22116	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9028122|imex:IM-22116-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001311440.1|refseq:NP_001311441.1|refseq:NP_112217.2|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902203"(negative regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:2001113"(negative regulation of cellular response to hepatocyte growth factor stimulus)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0030198"(extracellular matrix organization)|ensembl:ENSG00000151388(gene)|ensembl:ENST00000504830(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0030167"(proteoglycan catabolic process)	refseq:NP_057894.2|ensembl:ENSMUSG00000031849(gene)|ensembl:ENSMUST00000003659(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005499"(vitamin D binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0016485"(protein processing)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0035989"(tendon development)|go:"GO:0036122"(BMP binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043588"(skin development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051216"(cartilage development)|go:"GO:0055001"(muscle cell development)|go:"GO:0060173"(limb development)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0098868"(bone growth)|go:"GO:1900047"(negative regulation of hemostasis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR018097|interpro:IPR024665|interpro:IPR028492|interpro:IPR028974|rcsb pdb:1MZ9|rcsb pdb:3V2N|rcsb pdb:3V2P|rcsb pdb:3V2Q|rcsb pdb:3V2R|reactome:R-MMU-216083|reactome:R-MMU-3000178|interpro:IPR039081	-	-	-	figure legend:Fig 2A and 2B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/06	2014/10/16	rogid:57HLvuGr2HDfZ9M7Sc9e2E0jc2o9606	rogid:7jQUoC+K/yULoK0IA7dXL2KdpUg10090	intact-crc:0C1C57910039435C|rigid:T+8NQmk553+QbwZw6NBwlxvKPUQ	false	ha tag:?-?	sufficient binding region:84-261(IPR009030)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P58397	uniprotkb:Q9R0G6	intact:EBI-9028051|uniprotkb:A2RRN9|uniprotkb:A5D6V6|uniprotkb:Q6UWL3|ensembl:ENSP00000422554	intact:EBI-9028018|uniprotkb:G3X8Q4|ensembl:ENSMUSP00000003659	psi-mi:ats12_human(display_long)|uniprotkb:ADAMTS12(gene name)|psi-mi:ADAMTS12(display_short)|uniprotkb:UNQ1918/PRO4389(orf name)	psi-mi:comp_mouse(display_long)|uniprotkb:Comp(gene name)|psi-mi:Comp(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Liu et al. (2006)	pubmed:16611630|imex:IM-22116	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9028150|imex:IM-22116-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001311440.1|refseq:NP_001311441.1|refseq:NP_112217.2|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902203"(negative regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:2001113"(negative regulation of cellular response to hepatocyte growth factor stimulus)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0030198"(extracellular matrix organization)|ensembl:ENSG00000151388(gene)|ensembl:ENST00000504830(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0030167"(proteoglycan catabolic process)	refseq:NP_057894.2|ensembl:ENSMUSG00000031849(gene)|ensembl:ENSMUST00000003659(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005499"(vitamin D binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0016485"(protein processing)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0035989"(tendon development)|go:"GO:0036122"(BMP binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043588"(skin development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051216"(cartilage development)|go:"GO:0055001"(muscle cell development)|go:"GO:0060173"(limb development)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:0098868"(bone growth)|go:"GO:1900047"(negative regulation of hemostasis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR018097|interpro:IPR024665|interpro:IPR028492|interpro:IPR028974|rcsb pdb:1MZ9|rcsb pdb:3V2N|rcsb pdb:3V2P|rcsb pdb:3V2Q|rcsb pdb:3V2R|reactome:R-MMU-216083|reactome:R-MMU-3000178|interpro:IPR039081	-	comment:"A cDNA segment encoding the four C-terminal TSP motifs (His-TS12C4TSP) of hADAMTS-12 (amino acids 1316–1530) was subcloned into the pBAD TOPO vector per the manufacturer's protocol."	-	figure legend:Fig 2C|comment:"as COMP is purified I have assumed it was the construct described in the section: Expression and Purification of GST and His-tagged Proteins, and would therefore be the pGEX-COMP-EGF plasmid. However COMP is described as COMP in the text, not as a COMP-fragment"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/06	2014/10/16	rogid:57HLvuGr2HDfZ9M7Sc9e2E0jc2o9606	rogid:7jQUoC+K/yULoK0IA7dXL2KdpUg10090	intact-crc:B64D5765F4ADEDA8|rigid:T+8NQmk553+QbwZw6NBwlxvKPUQ	false	sufficient binding region:1316-1530(IPR000884)|his tag:?-?	sufficient binding region:84-261(IPR009030)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P49747	uniprotkb:P58397	intact:EBI-2531022|uniprotkb:O14592|uniprotkb:Q16388|uniprotkb:Q16389|uniprotkb:Q2NL86|uniprotkb:Q8N4T2|ensembl:ENSP00000222271|uniprotkb:B4DKJ3	intact:EBI-9028051|uniprotkb:A2RRN9|uniprotkb:A5D6V6|uniprotkb:Q6UWL3|ensembl:ENSP00000422554	psi-mi:comp_human(display_long)|uniprotkb:COMP(gene name)|psi-mi:COMP(display_short)|uniprotkb:Thrombospondin-5(gene name synonym)	psi-mi:ats12_human(display_long)|uniprotkb:ADAMTS12(gene name)|psi-mi:ADAMTS12(display_short)|uniprotkb:UNQ1918/PRO4389(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2006)	pubmed:16611630|imex:IM-22116	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9028177|imex:IM-22116-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000086.2|go:"GO:0016485"(protein processing)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0035989"(tendon development)|go:"GO:0036122"(BMP binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043588"(skin development)|go:"GO:0048844"(artery morphogenesis)|ensembl:ENSG00000105664(gene)|ensembl:ENST00000222271(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0060173"(limb development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1900047"(negative regulation of hemostasis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR018097|interpro:IPR024665|interpro:IPR028492|interpro:IPR028974|interpro:IPR039081|rcsb pdb:3FBY|reactome:R-HSA-216083|reactome:R-HSA-3000178	refseq:NP_001311440.1|refseq:NP_001311441.1|refseq:NP_112217.2|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902203"(negative regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:2001113"(negative regulation of cellular response to hepatocyte growth factor stimulus)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0030198"(extracellular matrix organization)|ensembl:ENSG00000151388(gene)|ensembl:ENST00000504830(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0030167"(proteoglycan catabolic process)	-	-	-	figure legend:Fig 2D|comment:"It seems likely that full length COMP is human - see PMID: 16585064 published the same year as this one by these authors \"(purified from HEK293 cells stably transfected with an expression plasmid encoding full-length human COMP)\""|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/12/06	2014/10/16	rogid:PEd7Bm1+z4Pzcq6aU8JJ2ogPMyY9606	rogid:57HLvuGr2HDfZ9M7Sc9e2E0jc2o9606	intact-crc:720835ED6CD3934E|rigid:wsC/tq/gNHtd+kSjdkSg1dRjhIs	false	-	ha tag:?-?	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P58397	uniprotkb:P49747	intact:EBI-9028051|uniprotkb:A2RRN9|uniprotkb:A5D6V6|uniprotkb:Q6UWL3|ensembl:ENSP00000422554	intact:EBI-2531022|uniprotkb:O14592|uniprotkb:Q16388|uniprotkb:Q16389|uniprotkb:Q2NL86|uniprotkb:Q8N4T2|ensembl:ENSP00000222271|uniprotkb:B4DKJ3	psi-mi:ats12_human(display_long)|uniprotkb:ADAMTS12(gene name)|psi-mi:ADAMTS12(display_short)|uniprotkb:UNQ1918/PRO4389(orf name)	psi-mi:comp_human(display_long)|uniprotkb:COMP(gene name)|psi-mi:COMP(display_short)|uniprotkb:Thrombospondin-5(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Liu et al. (2006)	pubmed:16611630|imex:IM-22116	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9028243|imex:IM-22116-6	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001311440.1|refseq:NP_001311441.1|refseq:NP_112217.2|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902203"(negative regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:2001113"(negative regulation of cellular response to hepatocyte growth factor stimulus)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0030198"(extracellular matrix organization)|ensembl:ENSG00000151388(gene)|ensembl:ENST00000504830(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0030167"(proteoglycan catabolic process)	refseq:NP_000086.2|go:"GO:0016485"(protein processing)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0035989"(tendon development)|go:"GO:0036122"(BMP binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043588"(skin development)|go:"GO:0048844"(artery morphogenesis)|ensembl:ENSG00000105664(gene)|ensembl:ENST00000222271(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0060173"(limb development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1900047"(negative regulation of hemostasis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR018097|interpro:IPR024665|interpro:IPR028492|interpro:IPR028974|interpro:IPR039081|rcsb pdb:3FBY|reactome:R-HSA-216083|reactome:R-HSA-3000178	go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)	-	comment:"full length COMP is mostly likely to be human see PMID 16585064, by same authors who describe: \"were incubated with 0.5 μg of human COMP (purified from HEK293 cells stably transfected with an expression plasmid encoding full-length human COMP)\" published the same year as this one enzyme/enzyme target biological roles."	figure legend:Fig 5|kinetic_conditions:2 mm of ZnCl2, pH 7.5 to pH 9.5|causality statement:P58397 increases degradation at protein level of Q9R0G6|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/06	2014/10/16	rogid:57HLvuGr2HDfZ9M7Sc9e2E0jc2o9606	rogid:PEd7Bm1+z4Pzcq6aU8JJ2ogPMyY9606	intact-crc:D5DBA17194E66E45|rigid:wsC/tq/gNHtd+kSjdkSg1dRjhIs	false	sufficient binding region:241-464(IPR024079)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)