#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y6R1	uniprotkb:P22748	intact:EBI-2801393|uniprotkb:C4B714|uniprotkb:Q9UIC1|uniprotkb:Q9H262|uniprotkb:Q9UP50|uniprotkb:Q8NEJ2|uniprotkb:Q9NRZ1|uniprotkb:Q9UIC0|uniprotkb:O15153|ensembl:ENSP00000264485|ensembl:ENSP00000497468	intact:EBI-3906285|uniprotkb:Q6FHI7|ensembl:ENSP00000300900|uniprotkb:B4DQA4	psi-mi:s4a4_human(display_long)|uniprotkb:NBC(gene name synonym)|uniprotkb:NBC1(gene name synonym)|uniprotkb:NBCE1(gene name synonym)|uniprotkb:"Na(+)/HCO3(-) cotransporter"(gene name synonym)|uniprotkb:Solute carrier family 4 member 4(gene name synonym)|uniprotkb:kNBC1(gene name synonym)|uniprotkb:SLC4A4(gene name)|psi-mi:SLC4A4(display_short)	psi-mi:cah4_human(display_long)|uniprotkb:CA4(gene name)|psi-mi:CA4(display_short)|uniprotkb:Carbonate dehydratase IV(gene name synonym)|uniprotkb:Carbonic anhydrase IV(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Yang et al. (2005)	pubmed:15563508|imex:IM-20868	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6859406|imex:IM-20868-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001091954.1|refseq:NP_003750.1|ensembl:ENSG00000080493(gene)|ensembl:ENST00000264485(transcript)|ensembl:ENST00000649996(transcript)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0008510"("sodium:bicarbonate symporter activity")|go:"GO:0009986"(cell surface)|go:"GO:0015293"(symporter activity)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR003024(Sodium bicarbonate cotransporter)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|rcsb pdb:6CAA|reactome:R-HSA-425381|reactome:R-HSA-5619054|dip:DIP-59373N	refseq:NP_000708.1|ensembl:ENSG00000167434(gene)|ensembl:ENST00000300900(transcript)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018338|interpro:IPR018343|interpro:IPR023561|interpro:IPR036398|interpro:IPR041874|rcsb pdb:1ZNC|rcsb pdb:3F7B|rcsb pdb:3F7U|rcsb pdb:3FW3|rcsb pdb:5IPZ|rcsb pdb:5JN8|rcsb pdb:5JN9|rcsb pdb:5JNA|rcsb pdb:5JNC|rcsb pdb:5KU6|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-1475029|refseq:XP_016880501.1	-	-	-	figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-choriocapillaris)|taxid:9606(Homo sapiens)	-	2013/06/10	2014/10/16	rogid:LfsjZERD6wTfLGru+DB4dgqrU449606	rogid:BIoSJjPGq5xalERuqhZzBpsu7Dk9606	intact-crc:2676C7540365D776|rigid:iT34KQRtpgU8hxAh14WjeBe9zGQ	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9Y6R1	uniprotkb:P22748	intact:EBI-2801393|uniprotkb:C4B714|uniprotkb:Q9UIC1|uniprotkb:Q9H262|uniprotkb:Q9UP50|uniprotkb:Q8NEJ2|uniprotkb:Q9NRZ1|uniprotkb:Q9UIC0|uniprotkb:O15153|ensembl:ENSP00000264485|ensembl:ENSP00000497468	intact:EBI-3906285|uniprotkb:Q6FHI7|ensembl:ENSP00000300900|uniprotkb:B4DQA4	psi-mi:s4a4_human(display_long)|uniprotkb:NBC(gene name synonym)|uniprotkb:NBC1(gene name synonym)|uniprotkb:NBCE1(gene name synonym)|uniprotkb:"Na(+)/HCO3(-) cotransporter"(gene name synonym)|uniprotkb:Solute carrier family 4 member 4(gene name synonym)|uniprotkb:kNBC1(gene name synonym)|uniprotkb:SLC4A4(gene name)|psi-mi:SLC4A4(display_short)	psi-mi:cah4_human(display_long)|uniprotkb:CA4(gene name)|psi-mi:CA4(display_short)|uniprotkb:Carbonate dehydratase IV(gene name synonym)|uniprotkb:Carbonic anhydrase IV(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Yang et al. (2005)	pubmed:15563508|imex:IM-20868	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6859417|imex:IM-20868-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001091954.1|refseq:NP_003750.1|ensembl:ENSG00000080493(gene)|ensembl:ENST00000264485(transcript)|ensembl:ENST00000649996(transcript)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0008510"("sodium:bicarbonate symporter activity")|go:"GO:0009986"(cell surface)|go:"GO:0015293"(symporter activity)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR003024(Sodium bicarbonate cotransporter)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|rcsb pdb:6CAA|reactome:R-HSA-425381|reactome:R-HSA-5619054|dip:DIP-59373N	refseq:NP_000708.1|ensembl:ENSG00000167434(gene)|ensembl:ENST00000300900(transcript)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018338|interpro:IPR018343|interpro:IPR023561|interpro:IPR036398|interpro:IPR041874|rcsb pdb:1ZNC|rcsb pdb:3F7B|rcsb pdb:3F7U|rcsb pdb:3FW3|rcsb pdb:5IPZ|rcsb pdb:5JN8|rcsb pdb:5JN9|rcsb pdb:5JNA|rcsb pdb:5JNC|rcsb pdb:5KU6|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-1475029|refseq:XP_016880501.1	-	-	-	figure legend:4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/10	2014/10/16	rogid:LfsjZERD6wTfLGru+DB4dgqrU449606	rogid:BIoSJjPGq5xalERuqhZzBpsu7Dk9606	intact-crc:EC948A283BA83006|rigid:iT34KQRtpgU8hxAh14WjeBe9zGQ	false	-	mutation decreasing interaction:14-14	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)