#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:43458"	uniprotkb:P45568	intact:EBI-6476052	intact:EBI-1114368|uniprotkb:P77209|uniprotkb:Q8KMY5|ensemblbacteria:AAC73284|ensemblbacteria:BAA77848	psi-mi:imb(display_short)|psi-mi:"CHEBI:43458"(display_long)	psi-mi:dxr_ecoli(display_long)|uniprotkb:yaeM(gene name synonym)|uniprotkb:1-deoxyxylulose-5-phosphate reductoisomerase(gene name synonym)|uniprotkb:2-C-methyl-D-erythritol 4-phosphate synthase(gene name synonym)|uniprotkb:dxr(gene name)|psi-mi:dxr(display_short)|uniprotkb:ispC(gene name synonym)|uniprotkb:b0173(locus name)|uniprotkb:JW0168(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Yajima et al. (2004)	pubmed:15339150|imex:IM-18620	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6475844|rcsb pdb:1t1r|imex:IM-18620-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_414715.1|refseq:WP_000811923.1|ensemblbacteria:AAC73284(transcript)|ensemblbacteria:b0173(gene)|ensemblbacteria:BAA77848(gene)|ensemblbacteria:BAA77848(transcript)|go:"GO:0019288"(isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030604"(1-deoxy-D-xylulose-5-phosphate reductoisomerase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051484"(isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process)|go:"GO:0070402"(NADPH binding)|interpro:IPR003821(1-deoxy-D-xylulose 5-phosphate reductoisomerase)|interpro:IPR013512(1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal)|interpro:IPR013644(1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal)|interpro:IPR026877|interpro:IPR036169|interpro:IPR036291|rcsb pdb:1JVS|rcsb pdb:1K5H|rcsb pdb:1ONN|rcsb pdb:1ONO|rcsb pdb:1ONP|rcsb pdb:1Q0H|rcsb pdb:1Q0L|rcsb pdb:1T1R|rcsb pdb:1T1S|rcsb pdb:2EGH|rcsb pdb:3ANL|rcsb pdb:3ANM|rcsb pdb:3ANN|rcsb pdb:3R0I|rcsb pdb:1Q0Q|dip:DIP-9484N	go:"GO:0043234"|go:"GO:0030604"(1-deoxy-D-xylulose-5-phosphate reductoisomerase activity)|go:"GO:0055114"(obsolete oxidation-reduction process)	-	-	figure legend:Fig. S1, 2a|3d-r-factors:Rworking = 0.22, Rfree = 0.27|3d-resolution:2.3 A|assembly:homodimer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2013/01/09	2019/01/30	-	rogid:vmYapb2Qnkr73k/Yte3mmXFZy+I83333	intact-crc:1B94F41C4BC92450	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:47304"	uniprotkb:P45568	intact:EBI-6471956	intact:EBI-1114368|uniprotkb:P77209|uniprotkb:Q8KMY5|ensemblbacteria:AAC73284|ensemblbacteria:BAA77848	psi-mi:cbq(display_short)|psi-mi:"CHEBI:47304"(display_long)	psi-mi:dxr_ecoli(display_long)|uniprotkb:yaeM(gene name synonym)|uniprotkb:1-deoxyxylulose-5-phosphate reductoisomerase(gene name synonym)|uniprotkb:2-C-methyl-D-erythritol 4-phosphate synthase(gene name synonym)|uniprotkb:dxr(gene name)|psi-mi:dxr(display_short)|uniprotkb:ispC(gene name synonym)|uniprotkb:b0173(locus name)|uniprotkb:JW0168(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Yajima et al. (2004)	pubmed:15339150|imex:IM-18620	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6471948|rcsb pdb:1t1s|imex:IM-18620-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_414715.1|refseq:WP_000811923.1|ensemblbacteria:AAC73284(transcript)|ensemblbacteria:b0173(gene)|ensemblbacteria:BAA77848(gene)|ensemblbacteria:BAA77848(transcript)|go:"GO:0019288"(isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030604"(1-deoxy-D-xylulose-5-phosphate reductoisomerase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051484"(isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process)|go:"GO:0070402"(NADPH binding)|interpro:IPR003821(1-deoxy-D-xylulose 5-phosphate reductoisomerase)|interpro:IPR013512(1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal)|interpro:IPR013644(1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal)|interpro:IPR026877|interpro:IPR036169|interpro:IPR036291|rcsb pdb:1JVS|rcsb pdb:1K5H|rcsb pdb:1ONN|rcsb pdb:1ONO|rcsb pdb:1ONP|rcsb pdb:1Q0H|rcsb pdb:1Q0L|rcsb pdb:1T1R|rcsb pdb:1T1S|rcsb pdb:2EGH|rcsb pdb:3ANL|rcsb pdb:3ANM|rcsb pdb:3ANN|rcsb pdb:3R0I|rcsb pdb:1Q0Q|dip:DIP-9484N	go:"GO:0030604"(1-deoxy-D-xylulose-5-phosphate reductoisomerase activity)|go:"GO:0043234"|go:"GO:0055114"(obsolete oxidation-reduction process)	-	-	figure legend:Fig.s 1, 2b|3d-r-factors:Rworking = 0.21, Rfree = 0.26|3d-resolution:2.4 A|assembly:homodimer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2013/01/09	2019/01/30	-	rogid:vmYapb2Qnkr73k/Yte3mmXFZy+I83333	intact-crc:7B33C0B01B4F08CA	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)