#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9ERE7	uniprotkb:O75197	intact:EBI-6662606|ensembl:ENSMUSP00000091768|uniprotkb:Q8C611|uniprotkb:Q8CCX7|uniprotkb:Q91WK8|uniprotkb:Q9CVB9	intact:EBI-2466421|ensembl:ENSP00000294304|uniprotkb:Q96TD6|uniprotkb:Q9UP66|uniprotkb:Q9UES7	psi-mi:mesd_mouse(display_long)|uniprotkb:Mesd(gene name)|psi-mi:Mesd(display_short)|uniprotkb:LDLR chaperone MESD(gene name synonym)|uniprotkb:Mesdc2(gene name synonym)|uniprotkb:Mesoderm development candidate 2(gene name synonym)|uniprotkb:Mesoderm development protein(gene name synonym)	psi-mi:lrp5_human(display_long)|uniprotkb:LRP5(gene name)|psi-mi:LRP5(display_short)|uniprotkb:LRP7(gene name synonym)|uniprotkb:LR3(gene name synonym)|uniprotkb:Low-density lipoprotein receptor-related protein 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2004)	pubmed:15143163|imex:IM-20534	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6662604|imex:IM-20534-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038503(gene)|ensembl:ENSMUST00000094215(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006909"(phagocytosis)|go:"GO:0007498"(mesoderm development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR019330|mint:Q9ERE7|rcsb pdb:2I9S|rcsb pdb:2KGL|rcsb pdb:2KMI|rcsb pdb:2RQK|rcsb pdb:2RQM|rcsb pdb:3OFH|refseq:NP_075892.3|dip:DIP-59114N	ensembl:ENSG00000162337(gene)|ensembl:ENST00000294304(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048539"(bone marrow development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060764"(cell-cell signaling involved in mammary gland development)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75197|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5339717|reactome:R-HSA-5340588|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|refseq:NP_002326.2|refseq:NP_001278831.1|dip:DIP-47265N	-	-	comment:"A LRP-5 construct comprising aa 1-645 and aa 1198-1615 (deletion of the three last YWTD repeats) did also interact."	figure legend:5A/B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/05/02	2014/10/16	rogid:8ONvF1cxwse6ed0r9tgfeHj0+Ww10090	rogid:5Or5NJwtSvZrk2kM2bBAQQOCW749606	intact-crc:0405718944E70415|rigid:LDrYR/zhHJHGA6MlnkXqsle9/qo	false	his tag:c-c|flag tag:?-?|v5 tag:c-c	ha tag:c-c|mutation disrupting interaction:171-171|sufficient binding region:170..170-250..250,255..255-1615..1615,1..1-165..165	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)