#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q08464	uniprotkb:Q08464	intact:EBI-7402050|intact:MINT-1780823	intact:EBI-7402050|intact:MINT-1780823	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:"MI:0010"(beta galactosidase complementation)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8767267|imex:IM-22155-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	-	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	figure legend:"Fig. S4c (labelled wrongly S4a in the main text)"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/20	2014/10/16	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	intact-crc:75CDF9B4CA9B1E19|rigid:x0nJbhonfbhr3qBSfVeJ3Tm55H8	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08463	uniprotkb:Q08463	intact:EBI-8766455	intact:EBI-8766455	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:"MI:0010"(beta galactosidase complementation)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8766727|imex:IM-22155-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	-	comment:"This mutant lacks CRD (cysteine-rich domain): PMID: 11452312"	-	figure legend:Fig. 1e, 2b|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/20	2014/10/16	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	intact-crc:14EFD815BED02E39|rigid:Iu05UNge92yyNTDRjyejIF5F5TU	false	fusion protein:?-?|sufficient binding region:220..220-641|firefly luciferase protein tag:?-?	fusion protein:?-?(Q47336)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08464	uniprotkb:Q08463	intact:EBI-7402050|intact:MINT-1780823	intact:EBI-8766455	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:"MI:0010"(beta galactosidase complementation)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8767304|imex:IM-22155-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	-	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	-	figure legend:"Fig. S4c (labelled wrongly S4a in the main text)"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/20	2014/10/16	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	intact-crc:7533D6BB16050D7E|rigid:Y70U/lqhwjiC6MgwTZGMlLwXPRc	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08464	uniprotkb:Q08463	intact:EBI-7402050|intact:MINT-1780823	intact:EBI-8766455	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:"MI:0010"(beta galactosidase complementation)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8766739|imex:IM-22155-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	-	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	-	figure legend:Fig. 1e|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/20	2014/10/16	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	intact-crc:8E8A79BBA213E543|rigid:Y70U/lqhwjiC6MgwTZGMlLwXPRc	false	fusion protein:?-?|firefly luciferase protein tag:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08464	uniprotkb:Q08463	intact:EBI-7402050|intact:MINT-1780823	intact:EBI-8766455	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:"MI:0010"(beta galactosidase complementation)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8767273|imex:IM-22155-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	-	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	-	figure legend:"Fig. S4c (labelled wrongly S4a in the main text)"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/20	2014/10/16	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	intact-crc:E78BE9E2F6C4BCD4|rigid:Y70U/lqhwjiC6MgwTZGMlLwXPRc	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08464	uniprotkb:Q08464	intact:EBI-7402050|intact:MINT-1780823	intact:EBI-7402050|intact:MINT-1780823	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:"MI:0010"(beta galactosidase complementation)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8766749|imex:IM-22155-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	-	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	figure legend:Fig. 1e|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/20	2014/10/16	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	intact-crc:3B9EE6EFAEDDA80A|rigid:x0nJbhonfbhr3qBSfVeJ3Tm55H8	false	fusion protein:?-?	firefly luciferase protein tag:?-?|fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08463	uniprotkb:Q08463	intact:EBI-8766455	intact:EBI-8766455	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:"MI:0010"(beta galactosidase complementation)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8767251|imex:IM-22155-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	-	-	-	figure legend:"Fig. S4c (labelled wrongly S4a in the main text)"|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/20	2014/10/16	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	intact-crc:A105A9297981FC81|rigid:Iu05UNge92yyNTDRjyejIF5F5TU	false	fusion protein:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9ULV1	uniprotkb:Q9ULV1	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:"MI:0010"(beta galactosidase complementation)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8783967|imex:IM-22155-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	-	-	-	figure legend:Fig. 4a|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/20	2014/10/16	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	intact-crc:C2942CB6A7380E86|rigid:lqOUmNdpIv1nrZUtuYT5YR665CI	false	fusion protein:?-?|firefly luciferase protein tag:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08464	uniprotkb:Q08463	intact:EBI-7402050|intact:MINT-1780823	intact:EBI-8766455	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8767155|imex:IM-22155-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	-	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	-	figure legend:Fig. 1f|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/09/20	2014/10/16	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	intact-crc:94B177C1DD125E25|rigid:Y70U/lqhwjiC6MgwTZGMlLwXPRc	false	firefly luciferase protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q08464	uniprotkb:Q08464	intact:EBI-7402050|intact:MINT-1780823	intact:EBI-7402050|intact:MINT-1780823	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8767157|imex:IM-22155-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	-	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	figure legend:Fig. 1f|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/09/20	2014/10/16	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	intact-crc:399C7FB23B126D82|rigid:x0nJbhonfbhr3qBSfVeJ3Tm55H8	false	firefly luciferase protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q08463	uniprotkb:Q08463	intact:EBI-8766455	intact:EBI-8766455	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8767159|imex:IM-22155-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	-	-	-	figure legend:Fig. 1f|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/09/20	2014/10/16	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	intact-crc:62CF2894D0CB2FB4|rigid:Iu05UNge92yyNTDRjyejIF5F5TU	false	green fluorescent protein tag:?-?	firefly luciferase protein tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q08464	uniprotkb:Q08463	intact:EBI-7402050|intact:MINT-1780823	intact:EBI-8766455	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8767238|imex:IM-22155-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	-	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	-	figure legend:Fig. 1f|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/09/20	2014/10/16	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	intact-crc:859A45621455BDEC|rigid:Y70U/lqhwjiC6MgwTZGMlLwXPRc	false	green fluorescent protein tag:?-?	firefly luciferase protein tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q08463	uniprotkb:Q08463	intact:EBI-8766455	intact:EBI-8766455	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8766453|imex:IM-22155-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 1B, S1a,b, S2|comment:IP in the presence of BS, a cell-impermeable cros-linker showed that the interaction takes place in the plasma membrane.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/20	2014/10/16	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	intact-crc:7BE14CC6D755E258|rigid:Iu05UNge92yyNTDRjyejIF5F5TU	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08464	uniprotkb:Q08463	intact:EBI-7402050|intact:MINT-1780823	intact:EBI-8766455	psi-mi:fzd2_rat(display_long)|uniprotkb:Fzd2(gene name)|psi-mi:Fzd2(display_short)	psi-mi:fzd1_rat(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kaykas et al. (2004)	pubmed:14688793|imex:IM-22155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8766497|imex:IM-22155-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q08464|rgd:71012|refseq:NP_742032.1|interpro:IPR017981|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026550|interpro:IPR000539(Frizzled protein)|go:"GO:0001775"(cell activation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|reactome:R-RNO-4086398|reactome:R-RNO-4608870|reactome:R-RNO-4641262|reactome:R-RNO-5140745|go:"GO:0005886"(plasma membrane)|interpro:IPR036790|interpro:IPR041778	interpro:IPR026550|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR017981|rgd:61916|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|reactome:R-RNO-4086400|reactome:R-RNO-4608870|reactome:R-RNO-4641262	go:"GO:0005886"(plasma membrane)	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	-	figure legend:Fig. 1B, S1a,b|comment:IP in the presence of BS, a cell-impermeable cross linker  showed that the interaction takes place at the plasma membrane.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/20	2014/10/16	rogid:2EuU2YJ/z/lIjENrsYm2GzBtT4Q10116	rogid:Ie/0hHT/knJEXuvFpkbRdymShRE10116	intact-crc:14ABDE1A398BE272|rigid:Y70U/lqhwjiC6MgwTZGMlLwXPRc	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)