#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61088	uniprotkb:Q98SN7	intact:EBI-7987880|intact:MINT-1779328|ensembl:ENSMUSP00000049852	intact:EBI-9075015|uniprotkb:Q9PUI3	psi-mi:fzd4_mouse(display_long)|uniprotkb:Fzd4(gene name)|psi-mi:Fzd4(display_short)	psi-mi:wnt2b_chick(display_long)|uniprotkb:WNT2B(gene name)|psi-mi:WNT2B(display_short)	psi-mi:"MI:0096"(pull down)	Kubo et al. (2003)	pubmed:12490564|imex:IM-22145	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9075013|imex:IM-22145-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032081.3|dip:DIP-41623N|reactome:R-MMU-4608870|reactome:R-MMU-4641263|reactome:R-MMU-5099900|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-4086398|ensembl:ENSMUSG00000049791(gene)|ensembl:ENSMUST00000058755(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001553"(luteinization)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)	refseq:NP_989667.2|interpro:IPR005817(Wnt superfamily)|interpro:IPR009140(Wnt-2 protein)|interpro:IPR018161|interpro:IPR043158|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003407"(neural retina development)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010842"(retina layer formation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030182"(neuron differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045686"(negative regulation of glial cell differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060900"(embryonic camera-type eye formation)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0090270"(regulation of fibroblast growth factor production)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)	-	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	-	figure legend:Fig. 1E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/12/20	2014/10/16	rogid:IMze54UHJy045NV/Gryg5DOH9xY10090	rogid:vRto8NX2yY8QRZB6oQD+0maT26M9031	intact-crc:68D47E6557E198A5|rigid:WXGs5RYprsF/jZHB5yNToTBJMJ8	false	myc tag:?-?|sufficient binding region:?-?(IPR020067)	fc-igg tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13467	uniprotkb:Q98SN7	intact:EBI-3913027|uniprotkb:Q53R22|intact:EBI-28987270|ensembl:ENSP00000354607|uniprotkb:A8K2X1|uniprotkb:B2RCZ1	intact:EBI-9075015|uniprotkb:Q9PUI3	psi-mi:fzd5_human(display_long)|uniprotkb:FZD5(gene name)|psi-mi:FZD5(display_short)|uniprotkb:C2orf31(gene name synonym)|uniprotkb:FzE5(gene name synonym)	psi-mi:wnt2b_chick(display_long)|uniprotkb:WNT2B(gene name)|psi-mi:WNT2B(display_short)	psi-mi:"MI:0096"(pull down)	Kubo et al. (2003)	pubmed:12490564|imex:IM-22145	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9080307|imex:IM-22145-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003459.2|ensembl:ENSP00000354607|ensembl:ENSG00000163251(gene)|ensembl:ENST00000295417(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007416"(synapse assembly)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|go:"GO:0045202"(synapse)|interpro:IPR036790|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|interpro:IPR037441|rcsb pdb:5URY|rcsb pdb:5URZ|rcsb pdb:6O39|rcsb pdb:6WW2|go:"GO:0048471"(perinuclear region of cytoplasm)|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|reactome:R-HSA-4641263|reactome:R-HSA-5140745|reactome:R-HSA-5340588|go:"GO:0060061"(Spemann organizer formation)	refseq:NP_989667.2|interpro:IPR005817(Wnt superfamily)|interpro:IPR009140(Wnt-2 protein)|interpro:IPR018161|interpro:IPR043158|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003407"(neural retina development)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010842"(retina layer formation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030182"(neuron differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045686"(negative regulation of glial cell differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060900"(embryonic camera-type eye formation)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0090270"(regulation of fibroblast growth factor production)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)	-	-	-	figure legend:Fig. 1E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/12/20	2014/10/16	rogid:MoGzsWpiGoqv/NtqWfqL9ZmJXyA9606	rogid:vRto8NX2yY8QRZB6oQD+0maT26M9031	intact-crc:AA1464A963945132|rigid:ikziKgKhycXS75jK0Wm5Tas9pZE	false	myc tag:?-?|sufficient binding region:?-?(IPR020067)	fc-igg tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)