#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15370	uniprotkb:Q15369	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837421|imex:IM-21757-1|rcsb pdb:1LQB	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N	-	-	-	figure legend:Fig. 1,Fig. 2a, Fig. 2b, Fig. 3, Suppl. table 2|3d-resolution:2.0A|3d-r-factors:working 22.6%, free 27.8%|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/28	2014/10/16	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:9813BAADF54DA7F7|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	-	sufficient binding region:17-112(IPR011333)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15370	uniprotkb:Q16665	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837421|imex:IM-21757-1|rcsb pdb:1LQB	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	-	-	-	figure legend:Fig. 1,Fig. 2a, Fig. 2b, Fig. 3, Suppl. table 2|3d-resolution:2.0A|3d-r-factors:working 22.6%, free 27.8%|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/28	2014/10/16	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	intact-crc:9813BAADF54DA7F7|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	-	sufficient binding region:549-582(DEG_ODPH_VHL_1)|4-hydroxy-L-proline:564-564	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15370	uniprotkb:P40337	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	intact:EBI-301246|uniprotkb:Q13599|uniprotkb:B2RE45|uniprotkb:Q6PDA9|ensembl:ENSP00000256474	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:vhl_human(display_long)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:pVHL(gene name synonym)|uniprotkb:Protein G7(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837421|imex:IM-21757-1|rcsb pdb:1LQB	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N	rcsb pdb:6BVB|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:4W9I|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:4W9J|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:4W9K|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6SIS|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-1234176|reactome:R-HSA-3232142|rcsb pdb:4W9L|reactome:R-HSA-8951664|rcsb pdb:4WQO|reactome:R-HSA-9682706|reactome:R-HSA-9694686|reactome:R-HSA-9706019|reactome:R-HSA-983168|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|ensembl:ENSG00000134086(gene)|ensembl:ENST00000256474(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050821"(protein stabilization)|go:"GO:0061418"(regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002714(Tumour suppressor protein, von Hippel-Lindau disease)|interpro:IPR022772|interpro:IPR024048|interpro:IPR024053|interpro:IPR036208|interpro:IPR037139|interpro:IPR037140|mint:P40337|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|refseq:NP_000542.1|refseq:NP_937799.1|dip:DIP-32585N	-	-	-	figure legend:Fig. 1,Fig. 2a, Fig. 2b, Fig. 3, Suppl. table 2|3d-resolution:2.0A|3d-r-factors:working 22.6%, free 27.8%|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/28	2014/10/16	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	rogid:KaCKDTSj0xPG9YmfFsXIbkRt3A89606	intact-crc:9813BAADF54DA7F7|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	-	sufficient binding region:54-213(IPR022772)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16665	uniprotkb:P40337	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	intact:EBI-301246|uniprotkb:Q13599|uniprotkb:B2RE45|uniprotkb:Q6PDA9|ensembl:ENSP00000256474	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:vhl_human(display_long)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:pVHL(gene name synonym)|uniprotkb:Protein G7(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837447|imex:IM-21757-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	rcsb pdb:6BVB|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:4W9I|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:4W9J|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:4W9K|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6SIS|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-1234176|reactome:R-HSA-3232142|rcsb pdb:4W9L|reactome:R-HSA-8951664|rcsb pdb:4WQO|reactome:R-HSA-9682706|reactome:R-HSA-9694686|reactome:R-HSA-9706019|reactome:R-HSA-983168|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|ensembl:ENSG00000134086(gene)|ensembl:ENST00000256474(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050821"(protein stabilization)|go:"GO:0061418"(regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002714(Tumour suppressor protein, von Hippel-Lindau disease)|interpro:IPR022772|interpro:IPR024048|interpro:IPR024053|interpro:IPR036208|interpro:IPR037139|interpro:IPR037140|mint:P40337|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|refseq:NP_000542.1|refseq:NP_937799.1|dip:DIP-32585N	-	-	-	figure legend:Table 1, Suppl. Fig. S1b|kinetic_conditions:Temp = 25C|kinetics:"Kinetic parameters for binding of Hif1a to VHL-elonginB/C complex were determined for different Hif1a peptides. For Hif1a (residues 549-582): kon = 7.0 +/- 0.02 x 10E+5 M-1 s-1, koff = 2.2 +/- 0.01 x 10E-2 s-1 and Kd = 3.1 x 10E-8 molar. For Hif1a (residues 556-574): kon = 8.4 +/- 0.06 x 10E+5 M-1 s-1, koff = 2.7 +/- 0.03 x 10E-2 s-1 and Kd = 3.3 x 10E-8 molar. For Hif1a (residues 558-569): kon = 6.6 +/- 0.05 x 10E+5 M-1 s-1, koff = 4.2 +/- 0.02 x 10E-2 s-1 and Kd = 6.4 x 10E-8 molar."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.1x10^-8(molar)|kon:7.0x10^5 ~0.02(per mole per second)|koff:2.2x10^-2 ~0.01(second -1)	2013/10/28	2014/10/16	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rogid:KaCKDTSj0xPG9YmfFsXIbkRt3A89606	intact-crc:6CCD3D710D0D58B1|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	4-hydroxy-L-proline:564-564|sufficient binding region:558-569(DEG_ODPH_VHL_1)|biotin tag:n-n	sufficient binding region:54-213(IPR022772)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16665	uniprotkb:Q15370	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837447|imex:IM-21757-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N	-	-	-	figure legend:Table 1, Suppl. Fig. S1b|kinetic_conditions:Temp = 25C|kinetics:"Kinetic parameters for binding of Hif1a to VHL-elonginB/C complex were determined for different Hif1a peptides. For Hif1a (residues 549-582): kon = 7.0 +/- 0.02 x 10E+5 M-1 s-1, koff = 2.2 +/- 0.01 x 10E-2 s-1 and Kd = 3.1 x 10E-8 molar. For Hif1a (residues 556-574): kon = 8.4 +/- 0.06 x 10E+5 M-1 s-1, koff = 2.7 +/- 0.03 x 10E-2 s-1 and Kd = 3.3 x 10E-8 molar. For Hif1a (residues 558-569): kon = 6.6 +/- 0.05 x 10E+5 M-1 s-1, koff = 4.2 +/- 0.02 x 10E-2 s-1 and Kd = 6.4 x 10E-8 molar."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.1x10^-8(molar)|kon:7.0x10^5 ~0.02(per mole per second)|koff:2.2x10^-2 ~0.01(second -1)	2013/10/28	2014/10/16	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	intact-crc:6CCD3D710D0D58B1|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	4-hydroxy-L-proline:564-564|sufficient binding region:558-569(DEG_ODPH_VHL_1)|biotin tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16665	uniprotkb:Q15369	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837447|imex:IM-21757-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N	-	-	-	figure legend:Table 1, Suppl. Fig. S1b|kinetic_conditions:Temp = 25C|kinetics:"Kinetic parameters for binding of Hif1a to VHL-elonginB/C complex were determined for different Hif1a peptides. For Hif1a (residues 549-582): kon = 7.0 +/- 0.02 x 10E+5 M-1 s-1, koff = 2.2 +/- 0.01 x 10E-2 s-1 and Kd = 3.1 x 10E-8 molar. For Hif1a (residues 556-574): kon = 8.4 +/- 0.06 x 10E+5 M-1 s-1, koff = 2.7 +/- 0.03 x 10E-2 s-1 and Kd = 3.3 x 10E-8 molar. For Hif1a (residues 558-569): kon = 6.6 +/- 0.05 x 10E+5 M-1 s-1, koff = 4.2 +/- 0.02 x 10E-2 s-1 and Kd = 6.4 x 10E-8 molar."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.1x10^-8(molar)|kon:7.0x10^5 ~0.02(per mole per second)|koff:2.2x10^-2 ~0.01(second -1)	2013/10/28	2014/10/16	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:6CCD3D710D0D58B1|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	4-hydroxy-L-proline:564-564|sufficient binding region:558-569(DEG_ODPH_VHL_1)|biotin tag:n-n	sufficient binding region:17-112(IPR011333)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16665	uniprotkb:Q15370	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837467|imex:IM-21757-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N	-	-	-	figure legend:Table 1|kinetic_conditions:Temp = 25C|kinetics:"Kinetic parameters for binding of Hif1a to VHL-elonginB/C complex were determined for different Hif1a peptides. For Hif1a (residues 390-417): kon = 7.9 +/- 0.07 x 10E+5 M-1 s-1, koff = 4.1 +/- 0.03 x 10E-2 s-1 and Kd = 5.2 x 10E-8 molar. For Hif1a (residues 395-406): kon = 4.9 +/- 0.02 x 10E+5 M-1 s-1, koff = 4.5 +/- 0.01 x 10E-2 s-1 and Kd = 9.3 x 10E-8 molar."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:7.9x10^5 ~0.07(per mole per second)|kd:5.2x10^-8(molar)|koff:4.1x10^-2 ~0.03(second -1)	2013/10/28	2014/10/16	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	intact-crc:36337C1749B1E8A6|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	4-hydroxy-L-proline:402-402|biotin tag:n-n|sufficient binding region:395-406(DEG_ODPH_VHL_1)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16665	uniprotkb:P40337	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	intact:EBI-301246|uniprotkb:Q13599|uniprotkb:B2RE45|uniprotkb:Q6PDA9|ensembl:ENSP00000256474	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:vhl_human(display_long)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:pVHL(gene name synonym)|uniprotkb:Protein G7(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837467|imex:IM-21757-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	rcsb pdb:6BVB|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:4W9I|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:4W9J|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:4W9K|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6SIS|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-1234176|reactome:R-HSA-3232142|rcsb pdb:4W9L|reactome:R-HSA-8951664|rcsb pdb:4WQO|reactome:R-HSA-9682706|reactome:R-HSA-9694686|reactome:R-HSA-9706019|reactome:R-HSA-983168|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|ensembl:ENSG00000134086(gene)|ensembl:ENST00000256474(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050821"(protein stabilization)|go:"GO:0061418"(regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002714(Tumour suppressor protein, von Hippel-Lindau disease)|interpro:IPR022772|interpro:IPR024048|interpro:IPR024053|interpro:IPR036208|interpro:IPR037139|interpro:IPR037140|mint:P40337|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|refseq:NP_000542.1|refseq:NP_937799.1|dip:DIP-32585N	-	-	-	figure legend:Table 1|kinetic_conditions:Temp = 25C|kinetics:"Kinetic parameters for binding of Hif1a to VHL-elonginB/C complex were determined for different Hif1a peptides. For Hif1a (residues 390-417): kon = 7.9 +/- 0.07 x 10E+5 M-1 s-1, koff = 4.1 +/- 0.03 x 10E-2 s-1 and Kd = 5.2 x 10E-8 molar. For Hif1a (residues 395-406): kon = 4.9 +/- 0.02 x 10E+5 M-1 s-1, koff = 4.5 +/- 0.01 x 10E-2 s-1 and Kd = 9.3 x 10E-8 molar."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:7.9x10^5 ~0.07(per mole per second)|kd:5.2x10^-8(molar)|koff:4.1x10^-2 ~0.03(second -1)	2013/10/28	2014/10/16	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rogid:KaCKDTSj0xPG9YmfFsXIbkRt3A89606	intact-crc:36337C1749B1E8A6|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	4-hydroxy-L-proline:402-402|biotin tag:n-n|sufficient binding region:395-406(DEG_ODPH_VHL_1)	sufficient binding region:54-213(IPR022772)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16665	uniprotkb:Q15369	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837467|imex:IM-21757-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N	-	-	-	figure legend:Table 1|kinetic_conditions:Temp = 25C|kinetics:"Kinetic parameters for binding of Hif1a to VHL-elonginB/C complex were determined for different Hif1a peptides. For Hif1a (residues 390-417): kon = 7.9 +/- 0.07 x 10E+5 M-1 s-1, koff = 4.1 +/- 0.03 x 10E-2 s-1 and Kd = 5.2 x 10E-8 molar. For Hif1a (residues 395-406): kon = 4.9 +/- 0.02 x 10E+5 M-1 s-1, koff = 4.5 +/- 0.01 x 10E-2 s-1 and Kd = 9.3 x 10E-8 molar."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:7.9x10^5 ~0.07(per mole per second)|kd:5.2x10^-8(molar)|koff:4.1x10^-2 ~0.03(second -1)	2013/10/28	2014/10/16	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:36337C1749B1E8A6|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	4-hydroxy-L-proline:402-402|biotin tag:n-n|sufficient binding region:395-406(DEG_ODPH_VHL_1)	sufficient binding region:17-112(IPR011333)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:G5EGD2	uniprotkb:P40337	intact:EBI-319821|ensemblmetazoa:F38A6.3a.1|intact:EBI-2409218|uniprotkb:G5ECE6|uniprotkb:G5EDZ3|uniprotkb:G5EE28|uniprotkb:Q8I4D0	intact:EBI-301246|uniprotkb:Q13599|uniprotkb:B2RE45|uniprotkb:Q6PDA9|ensembl:ENSP00000256474	psi-mi:hif1_caeel(display_long)|uniprotkb:hif-1(gene name)|psi-mi:hif-1(display_short)|uniprotkb:Hypoxia-induced factor 1(gene name synonym)|uniprotkb:F38A6.3(orf name)	psi-mi:vhl_human(display_long)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:pVHL(gene name synonym)|uniprotkb:Protein G7(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837492|imex:IM-21757-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q9TVM0(uniprot-removed-ac)|ensemblmetazoa:F38A6.3a.1(transcript)|ensemblmetazoa:WBGene00001851(gene)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010286"(heat acclimation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048678"(response to axon injury)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0061433"(cellular response to caloric restriction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|wormbase:F38A6.3a|wormbase:F38A6.3b|wormbase:F38A6.3c|wormbase:F38A6.3d|wormbase:F38A6.3e|interpro:IPR000014(PAS)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|refseq:NP_001023891.2|refseq:NP_001023892.1|refseq:NP_001023893.1|refseq:NP_508008.4|refseq:NP_001023894.2|reactome:R-CEL-1234158|reactome:R-CEL-1234176|interpro:IPR035965|reactome:R-CEL-8951664|reactome:R-CEL-5689880	rcsb pdb:6BVB|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:4W9I|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:4W9J|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:4W9K|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6SIS|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-1234176|reactome:R-HSA-3232142|rcsb pdb:4W9L|reactome:R-HSA-8951664|rcsb pdb:4WQO|reactome:R-HSA-9682706|reactome:R-HSA-9694686|reactome:R-HSA-9706019|reactome:R-HSA-983168|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|ensembl:ENSG00000134086(gene)|ensembl:ENST00000256474(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050821"(protein stabilization)|go:"GO:0061418"(regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002714(Tumour suppressor protein, von Hippel-Lindau disease)|interpro:IPR022772|interpro:IPR024048|interpro:IPR024053|interpro:IPR036208|interpro:IPR037139|interpro:IPR037140|mint:P40337|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|refseq:NP_000542.1|refseq:NP_937799.1|dip:DIP-32585N	-	-	-	figure legend:Table 1, Suppl. Fig. S1a|kinetic_conditions:Temp = 25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.9x10^-8(molar)|kon:7.6x10^5 ~0.03(per mole per second)|koff:2.2x10^-2 ~0.01(second -1)	2013/10/28	2014/10/16	rogid:lxa2pZKZKX36zeQ2hCVZH0i5phk6239	rogid:KaCKDTSj0xPG9YmfFsXIbkRt3A89606	intact-crc:5C0C9555742DF2BB|rigid:7NRFQcKvLJjOU1NcC+p5SSptDg0	false	sufficient binding region:607-634(DEG_ODPH_VHL_1)|4-hydroxy-L-proline:621-621|biotin tag:n-n	sufficient binding region:54-213(IPR022772)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:G5EGD2	uniprotkb:Q15369	intact:EBI-319821|ensemblmetazoa:F38A6.3a.1|intact:EBI-2409218|uniprotkb:G5ECE6|uniprotkb:G5EDZ3|uniprotkb:G5EE28|uniprotkb:Q8I4D0	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:hif1_caeel(display_long)|uniprotkb:hif-1(gene name)|psi-mi:hif-1(display_short)|uniprotkb:Hypoxia-induced factor 1(gene name synonym)|uniprotkb:F38A6.3(orf name)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837492|imex:IM-21757-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q9TVM0(uniprot-removed-ac)|ensemblmetazoa:F38A6.3a.1(transcript)|ensemblmetazoa:WBGene00001851(gene)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010286"(heat acclimation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048678"(response to axon injury)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0061433"(cellular response to caloric restriction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|wormbase:F38A6.3a|wormbase:F38A6.3b|wormbase:F38A6.3c|wormbase:F38A6.3d|wormbase:F38A6.3e|interpro:IPR000014(PAS)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|refseq:NP_001023891.2|refseq:NP_001023892.1|refseq:NP_001023893.1|refseq:NP_508008.4|refseq:NP_001023894.2|reactome:R-CEL-1234158|reactome:R-CEL-1234176|interpro:IPR035965|reactome:R-CEL-8951664|reactome:R-CEL-5689880	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N	-	-	-	figure legend:Table 1, Suppl. Fig. S1a|kinetic_conditions:Temp = 25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.9x10^-8(molar)|kon:7.6x10^5 ~0.03(per mole per second)|koff:2.2x10^-2 ~0.01(second -1)	2013/10/28	2014/10/16	rogid:lxa2pZKZKX36zeQ2hCVZH0i5phk6239	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:5C0C9555742DF2BB|rigid:7NRFQcKvLJjOU1NcC+p5SSptDg0	false	sufficient binding region:607-634(DEG_ODPH_VHL_1)|4-hydroxy-L-proline:621-621|biotin tag:n-n	sufficient binding region:17-112(IPR011333)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:G5EGD2	uniprotkb:Q15370	intact:EBI-319821|ensemblmetazoa:F38A6.3a.1|intact:EBI-2409218|uniprotkb:G5ECE6|uniprotkb:G5EDZ3|uniprotkb:G5EE28|uniprotkb:Q8I4D0	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	psi-mi:hif1_caeel(display_long)|uniprotkb:hif-1(gene name)|psi-mi:hif-1(display_short)|uniprotkb:Hypoxia-induced factor 1(gene name synonym)|uniprotkb:F38A6.3(orf name)	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8837492|imex:IM-21757-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q9TVM0(uniprot-removed-ac)|ensemblmetazoa:F38A6.3a.1(transcript)|ensemblmetazoa:WBGene00001851(gene)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010286"(heat acclimation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048678"(response to axon injury)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0061433"(cellular response to caloric restriction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|wormbase:F38A6.3a|wormbase:F38A6.3b|wormbase:F38A6.3c|wormbase:F38A6.3d|wormbase:F38A6.3e|interpro:IPR000014(PAS)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|refseq:NP_001023891.2|refseq:NP_001023892.1|refseq:NP_001023893.1|refseq:NP_508008.4|refseq:NP_001023894.2|reactome:R-CEL-1234158|reactome:R-CEL-1234176|interpro:IPR035965|reactome:R-CEL-8951664|reactome:R-CEL-5689880	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N	-	-	-	figure legend:Table 1, Suppl. Fig. S1a|kinetic_conditions:Temp = 25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.9x10^-8(molar)|kon:7.6x10^5 ~0.03(per mole per second)|koff:2.2x10^-2 ~0.01(second -1)	2013/10/28	2014/10/16	rogid:lxa2pZKZKX36zeQ2hCVZH0i5phk6239	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	intact-crc:5C0C9555742DF2BB|rigid:7NRFQcKvLJjOU1NcC+p5SSptDg0	false	sufficient binding region:607-634(DEG_ODPH_VHL_1)|4-hydroxy-L-proline:621-621|biotin tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16665	uniprotkb:P40337	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	intact:EBI-301246|uniprotkb:Q13599|uniprotkb:B2RE45|uniprotkb:Q6PDA9|ensembl:ENSP00000256474	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:vhl_human(display_long)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:pVHL(gene name synonym)|uniprotkb:Protein G7(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9003926|imex:IM-21757-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	rcsb pdb:6BVB|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:4W9I|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:4W9J|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:4W9K|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6SIS|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-1234176|reactome:R-HSA-3232142|rcsb pdb:4W9L|reactome:R-HSA-8951664|rcsb pdb:4WQO|reactome:R-HSA-9682706|reactome:R-HSA-9694686|reactome:R-HSA-9706019|reactome:R-HSA-983168|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|ensembl:ENSG00000134086(gene)|ensembl:ENST00000256474(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050821"(protein stabilization)|go:"GO:0061418"(regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002714(Tumour suppressor protein, von Hippel-Lindau disease)|interpro:IPR022772|interpro:IPR024048|interpro:IPR024053|interpro:IPR036208|interpro:IPR037139|interpro:IPR037140|mint:P40337|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|refseq:NP_000542.1|refseq:NP_937799.1|dip:DIP-32585N	-	-	-	figure legend:Table 1|inhibition:"Binding of biotinylated Hif1a (residues 390-417) to VHL-elonginB/C complex is competitively inhibited by Hif1a peptide (residues 549-582) and Hif1a peptide (residues 562-566) with IC50 values of 1.0 x 10E-6 molar and 1.3 x 10E-6 molar, respectively."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.0x10^-6(molar)	2013/10/28	2014/10/16	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rogid:KaCKDTSj0xPG9YmfFsXIbkRt3A89606	intact-crc:CCBA25E53D06D217|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	biotin tag:n-n|sufficient binding region:390-417(DEG_ODPH_VHL_1)|4-hydroxy-L-proline:402-402	sufficient binding region:54-213(IPR022772)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16665	uniprotkb:Q15370	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9003926|imex:IM-21757-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N	-	-	-	figure legend:Table 1|inhibition:"Binding of biotinylated Hif1a (residues 390-417) to VHL-elonginB/C complex is competitively inhibited by Hif1a peptide (residues 549-582) and Hif1a peptide (residues 562-566) with IC50 values of 1.0 x 10E-6 molar and 1.3 x 10E-6 molar, respectively."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.0x10^-6(molar)	2013/10/28	2014/10/16	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606	intact-crc:CCBA25E53D06D217|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	biotin tag:n-n|sufficient binding region:390-417(DEG_ODPH_VHL_1)|4-hydroxy-L-proline:402-402	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16665	uniprotkb:Q16665	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9003926|imex:IM-21757-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	-	-	-	figure legend:Table 1|inhibition:"Binding of biotinylated Hif1a (residues 390-417) to VHL-elonginB/C complex is competitively inhibited by Hif1a peptide (residues 549-582) and Hif1a peptide (residues 562-566) with IC50 values of 1.0 x 10E-6 molar and 1.3 x 10E-6 molar, respectively."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.0x10^-6(molar)	2013/10/28	2014/10/16	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	intact-crc:CCBA25E53D06D217|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	biotin tag:n-n|sufficient binding region:390-417(DEG_ODPH_VHL_1)|4-hydroxy-L-proline:402-402	sufficient binding region:562-567(DEG_ODPH_VHL_1)|4-hydroxy-L-proline:564-564	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16665	uniprotkb:Q15369	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hon et al. (2002)	pubmed:12050673|imex:IM-21757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9003926|imex:IM-21757-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N	-	-	-	figure legend:Table 1|inhibition:"Binding of biotinylated Hif1a (residues 390-417) to VHL-elonginB/C complex is competitively inhibited by Hif1a peptide (residues 549-582) and Hif1a peptide (residues 562-566) with IC50 values of 1.0 x 10E-6 molar and 1.3 x 10E-6 molar, respectively."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.0x10^-6(molar)	2013/10/28	2014/10/16	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606	intact-crc:CCBA25E53D06D217|rigid:2BuTqY/uHQYVmxz2qeqeqnnhetg	false	biotin tag:n-n|sufficient binding region:390-417(DEG_ODPH_VHL_1)|4-hydroxy-L-proline:402-402	sufficient binding region:17-112(IPR011333)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)