#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0ABS8	uniprotkb:P03007	intact:EBI-549182|uniprotkb:P28689|ensemblbacteria:AAC74912|ensemblbacteria:BAA15650	intact:EBI-549131|ensemblbacteria:AAC73320|ensemblbacteria:BAA77886	psi-mi:hole_ecoli(display_long)|uniprotkb:holE(gene name)|psi-mi:holE(display_short)|uniprotkb:b1842(locus name)|uniprotkb:JW1831(locus name)	psi-mi:dpo3e_ecoli(display_long)|uniprotkb:dnaQ(gene name)|psi-mi:dnaQ(display_short)|uniprotkb:mutD(gene name synonym)|uniprotkb:b0215(locus name)|uniprotkb:JW0205(locus name)	psi-mi:"MI:0226"(ion exchange chromatography)	Hamdan et al. (2002)	pubmed:11955076|imex:IM-20863	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6858549|imex:IM-20863-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416356.1|refseq:WP_000916763.1|dip:DIP-39982N|ensemblbacteria:AAC74912(transcript)|ensemblbacteria:b1842(gene)|ensemblbacteria:BAA15650(gene)|ensemblbacteria:BAA15650(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0044776"(DNA polymerase III, core complex)|interpro:IPR009052(DNA polymerase III-theta, bacterial)|interpro:IPR036745|rcsb pdb:1DU2|rcsb pdb:2AE9|rcsb pdb:2AXD|rcsb pdb:2XY8|rcsb pdb:5M1S	refseq:NP_414751.1|refseq:WP_001340895.1|dip:DIP-9462N|ensemblbacteria:AAC73320(transcript)|ensemblbacteria:b0215(gene)|ensemblbacteria:BAA77886(gene)|ensemblbacteria:BAA77886(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|interpro:IPR006054(DNA polymerase III, epsilon subunit)|interpro:IPR006309(DNA polymerase 3, epsilon subunit)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|rcsb pdb:1J53|rcsb pdb:1J54|rcsb pdb:1MGZ|rcsb pdb:2GUI|rcsb pdb:2IDO|rcsb pdb:2XY8|rcsb pdb:4GX8|rcsb pdb:4GX9|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S	-	crc64:3667D87327E96556	-	figure legend:Fig. S3b, S4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/07	2014/10/16	rogid:SxpHzzC2294kTc9GlPUQNoxa9AU83333	rogid:+Xs56/RcG3EYpWsa57MFJRFspoI83333	intact-crc:B5352D0842FF0450|rigid:bPLuTfTx5pvz/vmwhh1LVV4w6Io	false	-	sufficient binding region:1-186	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
chebi:"CHEBI:74144"	uniprotkb:P03007	intact:EBI-6862818	intact:EBI-549131|ensemblbacteria:AAC73320|ensemblbacteria:BAA77886	psi-mi:pnp-tmp(display_short)|psi-mi:"CHEBI:74144"(display_long)	psi-mi:dpo3e_ecoli(display_long)|uniprotkb:dnaQ(gene name)|psi-mi:dnaQ(display_short)|uniprotkb:mutD(gene name synonym)|uniprotkb:b0215(locus name)|uniprotkb:JW0205(locus name)	psi-mi:"MI:0415"(enzymatic study)	Hamdan et al. (2002)	pubmed:11955076|imex:IM-20863	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6862881|imex:IM-20863-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_414751.1|refseq:WP_001340895.1|dip:DIP-9462N|ensemblbacteria:AAC73320(transcript)|ensemblbacteria:b0215(gene)|ensemblbacteria:BAA77886(gene)|ensemblbacteria:BAA77886(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|interpro:IPR006054(DNA polymerase III, epsilon subunit)|interpro:IPR006309(DNA polymerase 3, epsilon subunit)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|rcsb pdb:1J53|rcsb pdb:1J54|rcsb pdb:1MGZ|rcsb pdb:2GUI|rcsb pdb:2IDO|rcsb pdb:2XY8|rcsb pdb:4GX8|rcsb pdb:4GX9|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S	go:"GO:0004527"(exonuclease activity)	-	-	figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:4.3x10^-6(molar)|kcat:4.9x10^1(second -1)|km:1.2x10^-3(mol)	2013/06/07	2014/10/16	-	rogid:+Xs56/RcG3EYpWsa57MFJRFspoI83333	intact-crc:D693F5EA6C7C6D24	false	-	sufficient binding region:1-186	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15245"	uniprotkb:P03007	intact:EBI-6862912	intact:EBI-549131|ensemblbacteria:AAC73320|ensemblbacteria:BAA77886	psi-mi:tmp(display_short)|psi-mi:"CHEBI:15245"(display_long)	psi-mi:dpo3e_ecoli(display_long)|uniprotkb:dnaQ(gene name)|psi-mi:dnaQ(display_short)|uniprotkb:mutD(gene name synonym)|uniprotkb:b0215(locus name)|uniprotkb:JW0205(locus name)	psi-mi:"MI:0415"(enzymatic study)	Hamdan et al. (2002)	pubmed:11955076|imex:IM-20863	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6862881|imex:IM-20863-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_414751.1|refseq:WP_001340895.1|dip:DIP-9462N|ensemblbacteria:AAC73320(transcript)|ensemblbacteria:b0215(gene)|ensemblbacteria:BAA77886(gene)|ensemblbacteria:BAA77886(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|interpro:IPR006054(DNA polymerase III, epsilon subunit)|interpro:IPR006309(DNA polymerase 3, epsilon subunit)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|rcsb pdb:1J53|rcsb pdb:1J54|rcsb pdb:1MGZ|rcsb pdb:2GUI|rcsb pdb:2IDO|rcsb pdb:2XY8|rcsb pdb:4GX8|rcsb pdb:4GX9|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S	go:"GO:0004527"(exonuclease activity)	-	-	figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:4.3x10^-6(molar)|kcat:4.9x10^1(second -1)|km:1.2x10^-3(mol)	2013/06/07	2014/10/16	-	rogid:+Xs56/RcG3EYpWsa57MFJRFspoI83333	intact-crc:D693F5EA6C7C6D24	false	-	sufficient binding region:1-186	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03007	uniprotkb:P0ABS8	intact:EBI-549131|ensemblbacteria:AAC73320|ensemblbacteria:BAA77886	intact:EBI-549182|uniprotkb:P28689|ensemblbacteria:AAC74912|ensemblbacteria:BAA15650	psi-mi:dpo3e_ecoli(display_long)|uniprotkb:dnaQ(gene name)|psi-mi:dnaQ(display_short)|uniprotkb:mutD(gene name synonym)|uniprotkb:b0215(locus name)|uniprotkb:JW0205(locus name)	psi-mi:hole_ecoli(display_long)|uniprotkb:holE(gene name)|psi-mi:holE(display_short)|uniprotkb:b1842(locus name)|uniprotkb:JW1831(locus name)	psi-mi:"MI:0415"(enzymatic study)	Hamdan et al. (2002)	pubmed:11955076|imex:IM-20863	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6862812|imex:IM-20863-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_414751.1|refseq:WP_001340895.1|dip:DIP-9462N|ensemblbacteria:AAC73320(transcript)|ensemblbacteria:b0215(gene)|ensemblbacteria:BAA77886(gene)|ensemblbacteria:BAA77886(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|interpro:IPR006054(DNA polymerase III, epsilon subunit)|interpro:IPR006309(DNA polymerase 3, epsilon subunit)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|rcsb pdb:1J53|rcsb pdb:1J54|rcsb pdb:1MGZ|rcsb pdb:2GUI|rcsb pdb:2IDO|rcsb pdb:2XY8|rcsb pdb:4GX8|rcsb pdb:4GX9|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S	refseq:NP_416356.1|refseq:WP_000916763.1|dip:DIP-39982N|ensemblbacteria:AAC74912(transcript)|ensemblbacteria:b1842(gene)|ensemblbacteria:BAA15650(gene)|ensemblbacteria:BAA15650(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0044776"(DNA polymerase III, core complex)|interpro:IPR009052(DNA polymerase III-theta, bacterial)|interpro:IPR036745|rcsb pdb:1DU2|rcsb pdb:2AE9|rcsb pdb:2AXD|rcsb pdb:2XY8|rcsb pdb:5M1S	go:"GO:0004527"(exonuclease activity)	-	crc64:3667D87327E96556	figure legend:Fig.1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:3.6x10^1(second -1)|km:1.51x10^-3(molar)	2013/06/07	2014/10/16	rogid:+Xs56/RcG3EYpWsa57MFJRFspoI83333	rogid:SxpHzzC2294kTc9GlPUQNoxa9AU83333	intact-crc:B8924F8789CFF5BC	false	sufficient binding region:1-186	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:74144"	uniprotkb:P03007	intact:EBI-6862818	intact:EBI-549131|ensemblbacteria:AAC73320|ensemblbacteria:BAA77886	psi-mi:pnp-tmp(display_short)|psi-mi:"CHEBI:74144"(display_long)	psi-mi:dpo3e_ecoli(display_long)|uniprotkb:dnaQ(gene name)|psi-mi:dnaQ(display_short)|uniprotkb:mutD(gene name synonym)|uniprotkb:b0215(locus name)|uniprotkb:JW0205(locus name)	psi-mi:"MI:0415"(enzymatic study)	Hamdan et al. (2002)	pubmed:11955076|imex:IM-20863	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6862812|imex:IM-20863-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_414751.1|refseq:WP_001340895.1|dip:DIP-9462N|ensemblbacteria:AAC73320(transcript)|ensemblbacteria:b0215(gene)|ensemblbacteria:BAA77886(gene)|ensemblbacteria:BAA77886(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|interpro:IPR006054(DNA polymerase III, epsilon subunit)|interpro:IPR006309(DNA polymerase 3, epsilon subunit)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|rcsb pdb:1J53|rcsb pdb:1J54|rcsb pdb:1MGZ|rcsb pdb:2GUI|rcsb pdb:2IDO|rcsb pdb:2XY8|rcsb pdb:4GX8|rcsb pdb:4GX9|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S	go:"GO:0004527"(exonuclease activity)	-	-	figure legend:Fig.1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:3.6x10^1(second -1)|km:1.51x10^-3(molar)	2013/06/07	2014/10/16	-	rogid:+Xs56/RcG3EYpWsa57MFJRFspoI83333	intact-crc:B8924F8789CFF5BC	false	-	sufficient binding region:1-186	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:74144"	uniprotkb:P03007	intact:EBI-6862818	intact:EBI-549131|ensemblbacteria:AAC73320|ensemblbacteria:BAA77886	psi-mi:pnp-tmp(display_short)|psi-mi:"CHEBI:74144"(display_long)	psi-mi:dpo3e_ecoli(display_long)|uniprotkb:dnaQ(gene name)|psi-mi:dnaQ(display_short)|uniprotkb:mutD(gene name synonym)|uniprotkb:b0215(locus name)|uniprotkb:JW0205(locus name)	psi-mi:"MI:0415"(enzymatic study)	Hamdan et al. (2002)	pubmed:11955076|imex:IM-20863	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6862873|imex:IM-20863-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_414751.1|refseq:WP_001340895.1|dip:DIP-9462N|ensemblbacteria:AAC73320(transcript)|ensemblbacteria:b0215(gene)|ensemblbacteria:BAA77886(gene)|ensemblbacteria:BAA77886(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|interpro:IPR006054(DNA polymerase III, epsilon subunit)|interpro:IPR006309(DNA polymerase 3, epsilon subunit)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|rcsb pdb:1J53|rcsb pdb:1J54|rcsb pdb:1MGZ|rcsb pdb:2GUI|rcsb pdb:2IDO|rcsb pdb:2XY8|rcsb pdb:4GX8|rcsb pdb:4GX9|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S	go:"GO:0004527"(exonuclease activity)	-	-	figure legend:Fig.1, 3, 4,5|comment:Km and Kcat values are taken from Figure 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:1.08x10^-3(molar)|kcat:4.9x10^1(second -1)	2013/06/07	2014/10/16	-	rogid:+Xs56/RcG3EYpWsa57MFJRFspoI83333	intact-crc:71A39F2F5C0CDCF4	false	-	sufficient binding region:1-186	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)