#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04487	uniprotkb:P19525	intact:EBI-6150681	intact:EBI-640775|uniprotkb:D6W584|uniprotkb:Q52M43|uniprotkb:Q9UIR4|uniprotkb:A8K3P0|ensembl:ENSP00000233057|ensembl:ENSP00000378559|ensembl:ENSP00000497534|ensembl:ENSP00000505138|ensembl:ENSP00000505772|ensembl:ENSP00000506024|uniprotkb:E9PC80|uniprotkb:Q7Z6F6	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:e2ak2_human(display_long)|uniprotkb:Interferon-inducible RNA-dependent protein kinase(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 2(gene name synonym)|uniprotkb:Protein kinase RNA-activated(gene name synonym)|uniprotkb:p68 kinase(gene name synonym)|uniprotkb:P1/eIF-2A protein kinase(gene name synonym)|uniprotkb:EIF2AK2(gene name)|psi-mi:EIF2AK2(display_short)|uniprotkb:PKR(gene name synonym)|uniprotkb:PRKR(gene name synonym)|uniprotkb:Tyrosine-protein kinase EIF2AK2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cassady et al. (2002)	pubmed:11836380|imex:IM-20953	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6880922|imex:IM-20953-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	refseq:NP_001129124.1|refseq:NP_001129123.1|refseq:NP_002750.1|ensembl:ENSG00000055332(gene)|ensembl:ENST00000233057(transcript)|ensembl:ENST00000395127(transcript)|ensembl:ENST00000647926(transcript)|ensembl:ENST00000679507(transcript)|ensembl:ENST00000681463(transcript)|ensembl:ENST00000681507(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044452|interpro:IPR044453|mint:P19525|rcsb pdb:1QU6|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3UIU|rcsb pdb:6D3K|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6D3L|reactome:R-HSA-1169408|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-169131|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900225"(regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902033"(regulation of hematopoietic stem cell proliferation)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-2657N|refseq:XP_011531289.1	go:"GO:0005737"(cytoplasm)	-	-	figure legend:1, 2 and 3|comment:Association is disrupted by RNase treatment|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/07/09	2014/10/16	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	rogid:2Pc405Bc/xKDHC1O24GhGC5JJzU9606	intact-crc:E93D5E01389ABBA8|rigid:iqj3yZIkc/EAq3Hg+AWmeTggEbM	false	necessary binding region:91-121	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19525	uniprotkb:P04487	intact:EBI-640775|uniprotkb:D6W584|uniprotkb:Q52M43|uniprotkb:Q9UIR4|uniprotkb:A8K3P0|ensembl:ENSP00000233057|ensembl:ENSP00000378559|ensembl:ENSP00000497534|ensembl:ENSP00000505138|ensembl:ENSP00000505772|ensembl:ENSP00000506024|uniprotkb:E9PC80|uniprotkb:Q7Z6F6	intact:EBI-6150681	psi-mi:e2ak2_human(display_long)|uniprotkb:Interferon-inducible RNA-dependent protein kinase(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 2(gene name synonym)|uniprotkb:Protein kinase RNA-activated(gene name synonym)|uniprotkb:p68 kinase(gene name synonym)|uniprotkb:P1/eIF-2A protein kinase(gene name synonym)|uniprotkb:EIF2AK2(gene name)|psi-mi:EIF2AK2(display_short)|uniprotkb:PKR(gene name synonym)|uniprotkb:PRKR(gene name synonym)|uniprotkb:Tyrosine-protein kinase EIF2AK2(gene name synonym)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Cassady et al. (2002)	pubmed:11836380|imex:IM-20953	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6880968|imex:IM-20953-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129124.1|refseq:NP_001129123.1|refseq:NP_002750.1|ensembl:ENSG00000055332(gene)|ensembl:ENST00000233057(transcript)|ensembl:ENST00000395127(transcript)|ensembl:ENST00000647926(transcript)|ensembl:ENST00000679507(transcript)|ensembl:ENST00000681463(transcript)|ensembl:ENST00000681507(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044452|interpro:IPR044453|mint:P19525|rcsb pdb:1QU6|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3UIU|rcsb pdb:6D3K|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6D3L|reactome:R-HSA-1169408|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-169131|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900225"(regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902033"(regulation of hematopoietic stem cell proliferation)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-2657N|refseq:XP_011531289.1	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	-	-	-	figure legend:5|resulting-ptm:Phosphorylation of US11|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/09	2014/10/16	rogid:2Pc405Bc/xKDHC1O24GhGC5JJzU9606	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:3791388B69CC33E9|rigid:iqj3yZIkc/EAq3Hg+AWmeTggEbM	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P19525	uniprotkb:P04487	intact:EBI-640775|uniprotkb:D6W584|uniprotkb:Q52M43|uniprotkb:Q9UIR4|uniprotkb:A8K3P0|ensembl:ENSP00000233057|ensembl:ENSP00000378559|ensembl:ENSP00000497534|ensembl:ENSP00000505138|ensembl:ENSP00000505772|ensembl:ENSP00000506024|uniprotkb:E9PC80|uniprotkb:Q7Z6F6	intact:EBI-6150681	psi-mi:e2ak2_human(display_long)|uniprotkb:Interferon-inducible RNA-dependent protein kinase(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 2(gene name synonym)|uniprotkb:Protein kinase RNA-activated(gene name synonym)|uniprotkb:p68 kinase(gene name synonym)|uniprotkb:P1/eIF-2A protein kinase(gene name synonym)|uniprotkb:EIF2AK2(gene name)|psi-mi:EIF2AK2(display_short)|uniprotkb:PKR(gene name synonym)|uniprotkb:PRKR(gene name synonym)|uniprotkb:Tyrosine-protein kinase EIF2AK2(gene name synonym)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0028"(cosedimentation in solution)	Cassady et al. (2002)	pubmed:11836380|imex:IM-20953	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6880951|imex:IM-20953-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129124.1|refseq:NP_001129123.1|refseq:NP_002750.1|ensembl:ENSG00000055332(gene)|ensembl:ENST00000233057(transcript)|ensembl:ENST00000395127(transcript)|ensembl:ENST00000647926(transcript)|ensembl:ENST00000679507(transcript)|ensembl:ENST00000681463(transcript)|ensembl:ENST00000681507(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044452|interpro:IPR044453|mint:P19525|rcsb pdb:1QU6|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3UIU|rcsb pdb:6D3K|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6D3L|reactome:R-HSA-1169408|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-169131|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900225"(regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902033"(regulation of hematopoietic stem cell proliferation)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-2657N|refseq:XP_011531289.1	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)	go:"GO:0005840"(ribosome)	-	-	figure legend:4|comment:Proteins coelute at high salt concentration|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/07/09	2014/10/16	rogid:2Pc405Bc/xKDHC1O24GhGC5JJzU9606	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:C66DA38508371DFA|rigid:iqj3yZIkc/EAq3Hg+AWmeTggEbM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)